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The map label for this gene is mtaD1 [H]

Identifier: 222525314

GI number: 222525314

Start: 2607470

End: 2609440

Strand: Reverse

Name: mtaD1 [H]

Synonym: Chy400_2056

Alternate gene names: 222525314

Gene position: 2609440-2607470 (Counterclockwise)

Preceding gene: 222525317

Following gene: 222525313

Centisome position: 49.52

GC content: 59.06

Gene sequence:

>1971_bases
ATGGAGCATGTTGACACCCTACTCACCGGCGGCACGGTCGTTACGATGGACTCAGCGTGGCGTATCTTTGCCGATGGTGC
CGTCGCTATTCGTGATGGGGTTATTGTAGAGGTGGGGCCAGCCGCTGAACTAAACCAGCGGTATACGGCTACGGAGACGA
TTGATTGCCGCGATTGCGCGATCATTCCGGGGCTGATCAACGGCCACGCCCATGTGCCGATGAGCCTCTTGCGCGGCCTG
GTTGCCGACCAGCAGCTCGATGTCTGGCTCTTCGGCTATATGTTTCCGGTCGAGAGTCAGTTTGTTGACGCCGAGTTTAG
CTTCACCGGTACCCTTTTGAGCTGCGCCGAGATGATTCGTGGCGGGACGACGACCTTTGTCGATATGTACTATTTTGAAG
AAGAGGTCGCCCGTGCTGCCGATCAGGCCGGGATGCGGGCGATTTGTGGGCAGACGGTGATGCGTTTGCCCACCCCTGAT
GCCGATTCGTTCGATGCCGGGATCGAGCGGGCGCGGCGTTTTATGGCCGAGTGGCGCGGTCATCCCCGTATTATTGCGAC
GGTTGCCCCCCACGCGCCGTACACCTGCACCGATGAGATTTACCGCCAGGCGGCAGCGTTGTGTGCTGAGTTTGGTGCAC
CACTGATCACGCATCTTTCTGAAACGGCCCGCGAAGTTGAAGAGAGTATCCGTGATCGTGAAGTGACCCCAATTCGATAT
GCCAAACGGGTGGGCGCGTTCGATGTACCCTGCATTGCAGCCCACTGTGTTCACGCCACCGAAGATGATCTGCGCCTGTT
GCGCGAAGCTCAGGCCGGGGCTGTGCCTTGCCCGACCAGTAACCTCAAACTGGCGAGTGGCGTGGCACCTTTCCGCCGAA
TGATCGAAACCGGGGTGCGGGTTGGTCTCGGTACCGATGGCCCGGCGAGCAATGACGACCAGGATATGTTTACCGAGATT
CAACTGGCGGCACTCCTCCCGAAAGGCTTGAGCGGCGATCCAACGGCGGTTCCGGCACGTGAAGCCTTCGCGCTGGCCAC
CTGCTGGGGCGCTCGTGCGATTCACCTTGACCATCTGATCGGCTCGCTGGAAGCAGGGAAACGCGCCGATATTGCCGTTG
TTGAGCTGCACCGATTGCACAGCGCACCCCGCTACACCTACGCTCCCGATGCCATTTACTCCCACCTCGTCTACAGTAGT
CGGGCTGCCGATGTGCGCGATGTGCTGGTGGATGGCAACATCCTGCTCCGTGATCGTCAGTTACAGACCATTGACGAGAC
GGCAATTATTGCTCGCGCACAGGCAATTGCGACGCGCATCAACGAATTTCTTGCCACTCGCGAACGGAATCTGTTGGCCA
AGATTCTGGCCCTCGGTGGTGTGCAGCAGGCGGAAATCTTCGAGATACAGGTGAAAGCCCGCCTGCATCCGGCAGATGTC
GAGCGAGTACTGGCAGTACTCAACCATCCGGCAATCACCGTCACGAAAACCAGTGAACGCACCCAGTACGACACCTATTT
CATCTTCGCCAACGGTGAGCGCATTCGGATACGAGAGGATCACCGTACCGATCCCGGTGCCCGCCCCCAGCCCAAGTATA
CGCTCACCCTGATGGCCGAGGCGCGTCGTTTTGATCACCCCAAGGCGATGATGTTGTCACGAGCGCGGTATACCGCGCCC
GCCGATCATACCGTGCGCTTCTACCGCGAATACTTTCAGCCCGACCGGATCGAGGAGCTTGAGAAGCAGCGTCGGCGCTG
GCGCATTCTCTACCGCGATCATGATTTCGCGATCAACCTCGATACGCTCATCGGTCAGGCAGATCGCGGCCCATTCCTCG
AAATCAAGAGCCGCACCTGGAGCCGCCGTGATGCCGAGCGGCGAGCCGAACTGATCAGTGAATTGCTGGAACTGATCGGT
ATTAGCGATGACGCTCTGGTGTTGCAGGAATACGTGGAGCTGGTGGCATGA

Upstream 100 bases:

>100_bases
GCCGTCAGTATACCCGACATCGGTACTTTGGTGGATCGCACCTTTGCCCGATTTCTCGTACAATGAAAGGAAGAAGGTGA
GTGACAAAGGAGGCATTTTC

Downstream 100 bases:

>100_bases
AGCATCCCGGCATCTTTCTGATCGGTCTGACCGGCGGTATCGCCTGTGGCAAGAGCACTGTTCTGGCGATGCTGGCCGCC
CTCGGCGCGCGCACTATTGA

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase 1 [H]

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MEHVDTLLTGGTVVTMDSAWRIFADGAVAIRDGVIVEVGPAAELNQRYTATETIDCRDCAIIPGLINGHAHVPMSLLRGL
VADQQLDVWLFGYMFPVESQFVDAEFSFTGTLLSCAEMIRGGTTTFVDMYYFEEEVARAADQAGMRAICGQTVMRLPTPD
ADSFDAGIERARRFMAEWRGHPRIIATVAPHAPYTCTDEIYRQAAALCAEFGAPLITHLSETAREVEESIRDREVTPIRY
AKRVGAFDVPCIAAHCVHATEDDLRLLREAQAGAVPCPTSNLKLASGVAPFRRMIETGVRVGLGTDGPASNDDQDMFTEI
QLAALLPKGLSGDPTAVPAREAFALATCWGARAIHLDHLIGSLEAGKRADIAVVELHRLHSAPRYTYAPDAIYSHLVYSS
RAADVRDVLVDGNILLRDRQLQTIDETAIIARAQAIATRINEFLATRERNLLAKILALGGVQQAEIFEIQVKARLHPADV
ERVLAVLNHPAITVTKTSERTQYDTYFIFANGERIRIREDHRTDPGARPQPKYTLTLMAEARRFDHPKAMMLSRARYTAP
ADHTVRFYREYFQPDRIEELEKQRRRWRILYRDHDFAINLDTLIGQADRGPFLEIKSRTWSRRDAERRAELISELLELIG
ISDDALVLQEYVELVA

Sequences:

>Translated_656_residues
MEHVDTLLTGGTVVTMDSAWRIFADGAVAIRDGVIVEVGPAAELNQRYTATETIDCRDCAIIPGLINGHAHVPMSLLRGL
VADQQLDVWLFGYMFPVESQFVDAEFSFTGTLLSCAEMIRGGTTTFVDMYYFEEEVARAADQAGMRAICGQTVMRLPTPD
ADSFDAGIERARRFMAEWRGHPRIIATVAPHAPYTCTDEIYRQAAALCAEFGAPLITHLSETAREVEESIRDREVTPIRY
AKRVGAFDVPCIAAHCVHATEDDLRLLREAQAGAVPCPTSNLKLASGVAPFRRMIETGVRVGLGTDGPASNDDQDMFTEI
QLAALLPKGLSGDPTAVPAREAFALATCWGARAIHLDHLIGSLEAGKRADIAVVELHRLHSAPRYTYAPDAIYSHLVYSS
RAADVRDVLVDGNILLRDRQLQTIDETAIIARAQAIATRINEFLATRERNLLAKILALGGVQQAEIFEIQVKARLHPADV
ERVLAVLNHPAITVTKTSERTQYDTYFIFANGERIRIREDHRTDPGARPQPKYTLTLMAEARRFDHPKAMMLSRARYTAP
ADHTVRFYREYFQPDRIEELEKQRRRWRILYRDHDFAINLDTLIGQADRGPFLEIKSRTWSRRDAERRAELISELLELIG
ISDDALVLQEYVELVA
>Mature_656_residues
MEHVDTLLTGGTVVTMDSAWRIFADGAVAIRDGVIVEVGPAAELNQRYTATETIDCRDCAIIPGLINGHAHVPMSLLRGL
VADQQLDVWLFGYMFPVESQFVDAEFSFTGTLLSCAEMIRGGTTTFVDMYYFEEEVARAADQAGMRAICGQTVMRLPTPD
ADSFDAGIERARRFMAEWRGHPRIIATVAPHAPYTCTDEIYRQAAALCAEFGAPLITHLSETAREVEESIRDREVTPIRY
AKRVGAFDVPCIAAHCVHATEDDLRLLREAQAGAVPCPTSNLKLASGVAPFRRMIETGVRVGLGTDGPASNDDQDMFTEI
QLAALLPKGLSGDPTAVPAREAFALATCWGARAIHLDHLIGSLEAGKRADIAVVELHRLHSAPRYTYAPDAIYSHLVYSS
RAADVRDVLVDGNILLRDRQLQTIDETAIIARAQAIATRINEFLATRERNLLAKILALGGVQQAEIFEIQVKARLHPADV
ERVLAVLNHPAITVTKTSERTQYDTYFIFANGERIRIREDHRTDPGARPQPKYTLTLMAEARRFDHPKAMMLSRARYTAP
ADHTVRFYREYFQPDRIEELEKQRRRWRILYRDHDFAINLDTLIGQADRGPFLEIKSRTWSRRDAERRAELISELLELIG
ISDDALVLQEYVELVA

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=376, Percent_Identity=24.2021276595745, Blast_Score=106, Evalue=7e-23,
Organism=Escherichia coli, GI1789249, Length=370, Percent_Identity=29.4594594594595, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87082177, Length=435, Percent_Identity=24.8275862068966, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319963, Length=332, Percent_Identity=25.6024096385542, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24643849, Length=386, Percent_Identity=26.1658031088083, Blast_Score=127, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 73307; Mature: 73307

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHVDTLLTGGTVVTMDSAWRIFADGAVAIRDGVIVEVGPAAELNQRYTATETIDCRDCA
CCCHHHHHCCCEEEEECCCEEEEECCEEEEECCEEEEECCCHHHCCCCCCCCCCCCCCCE
IIPGLINGHAHVPMSLLRGLVADQQLDVWLFGYMFPVESQFVDAEFSFTGTLLSCAEMIR
EECHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHC
GGTTTFVDMYYFEEEVARAADQAGMRAICGQTVMRLPTPDADSFDAGIERARRFMAEWRG
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
HPRIIATVAPHAPYTCTDEIYRQAAALCAEFGAPLITHLSETAREVEESIRDREVTPIRY
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
AKRVGAFDVPCIAAHCVHATEDDLRLLREAQAGAVPCPTSNLKLASGVAPFRRMIETGVR
HHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHCCE
VGLGTDGPASNDDQDMFTEIQLAALLPKGLSGDPTAVPAREAFALATCWGARAIHLDHLI
EECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHH
GSLEAGKRADIAVVELHRLHSAPRYTYAPDAIYSHLVYSSRAADVRDVLVDGNILLRDRQ
HHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCC
LQTIDETAIIARAQAIATRINEFLATRERNLLAKILALGGVQQAEIFEIQVKARLHPADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCHHHH
ERVLAVLNHPAITVTKTSERTQYDTYFIFANGERIRIREDHRTDPGARPQPKYTLTLMAE
HHHHHHHCCCEEEEEECCCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEEH
ARRFDHPKAMMLSRARYTAPADHTVRFYREYFQPDRIEELEKQRRRWRILYRDHDFAINL
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCEEEEH
DTLIGQADRGPFLEIKSRTWSRRDAERRAELISELLELIGISDDALVLQEYVELVA
HHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MEHVDTLLTGGTVVTMDSAWRIFADGAVAIRDGVIVEVGPAAELNQRYTATETIDCRDCA
CCCHHHHHCCCEEEEECCCEEEEECCEEEEECCEEEEECCCHHHCCCCCCCCCCCCCCCE
IIPGLINGHAHVPMSLLRGLVADQQLDVWLFGYMFPVESQFVDAEFSFTGTLLSCAEMIR
EECHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHC
GGTTTFVDMYYFEEEVARAADQAGMRAICGQTVMRLPTPDADSFDAGIERARRFMAEWRG
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
HPRIIATVAPHAPYTCTDEIYRQAAALCAEFGAPLITHLSETAREVEESIRDREVTPIRY
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
AKRVGAFDVPCIAAHCVHATEDDLRLLREAQAGAVPCPTSNLKLASGVAPFRRMIETGVR
HHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHCCE
VGLGTDGPASNDDQDMFTEIQLAALLPKGLSGDPTAVPAREAFALATCWGARAIHLDHLI
EECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHH
GSLEAGKRADIAVVELHRLHSAPRYTYAPDAIYSHLVYSSRAADVRDVLVDGNILLRDRQ
HHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCC
LQTIDETAIIARAQAIATRINEFLATRERNLLAKILALGGVQQAEIFEIQVKARLHPADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCHHHH
ERVLAVLNHPAITVTKTSERTQYDTYFIFANGERIRIREDHRTDPGARPQPKYTLTLMAE
HHHHHHHCCCEEEEEECCCCCEEEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEEH
ARRFDHPKAMMLSRARYTAPADHTVRFYREYFQPDRIEELEKQRRRWRILYRDHDFAINL
HHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCEEEEH
DTLIGQADRGPFLEIKSRTWSRRDAERRAELISELLELIGISDDALVLQEYVELVA
HHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA