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The map label for this gene is glmU [H]

Identifier: 222525206

GI number: 222525206

Start: 2470279

End: 2471451

Strand: Direct

Name: glmU [H]

Synonym: Chy400_1946

Alternate gene names: 222525206

Gene position: 2470279-2471451 (Clockwise)

Preceding gene: 222525205

Following gene: 222525215

Centisome position: 46.88

GC content: 62.83

Gene sequence:

>1173_bases
ATGTCTAGTGCCAAACACGCCGTGATCCTGGTTGCCGGTGCTTCGACCCGCACGCGCCCGTTGACCGACCAGCGTCCGAA
GCCGCTGATTCCGCTGCTCGGTAAGCCGTTGCTGGCCCACATCCTCGATGAACTGGTCGGGCTGGTGGAACGGGTGACGC
TGGTGGTTGGCTATCGCGCCGATCAGATTGTCGCGACCTTTGGTGAAACATACCGTGGTATGGCAATCCGTTATGTATAC
CAGACGACCATCAACGGCACGGCGGGCGCGTTGCTGGCGGCGGCACCGATTGACGAGCCGTTTTTTCTGTTGTACGGCGA
TAATCTGATTGATCGCGCCGATGTAATCGGGGTCGGTCAGTTCCGCTACGCCCTGGCCGGGCTGCGCCTGCCCGATCTGC
GCTCGTTTGGTGTGCTCGATGTCCACGATGGCCTGGTGCAGCGGATCATCGAGAAGCCGACCCAACCCCCACCCGATGCC
CTTGCCAATCCCGGTATCTACCATTTCGATGCCGAAGTCTTTCCGCTCCTGCACCGGATCACGCCTTCCCCACGCGGTGA
GCTGGAGTTGACCGACCTGATTGCGCTGCTGGCTGAACAGCATCCGGTGGCCTGCCACGTCTGTACCGGGCACTGGCTGC
CGGTCGGCACCCCGTGGGAAGCGCTCCTGGCCGCCCGTTTTCTGCTGGCGCGGCAGGCCCACACGCAGCCCCTGCCGCAG
ATCGCGCCGAATGCCCACATCGCTCCCCAGGCCGATCTGGAAGGGTCAGTCGTGGTGAGCGACGGAGCATCCATCGATCA
GGGTGCCCGCATTGTTGGCCCGGCCTGGATCGGGCCAGGCGCAGTGATCGGGTCGGGTGCGCTGATTATTGCCTCGGTGA
TCGAAGCCGGCGCCACGATTGGGGCCGAAGCAATGATCGGTGGCTCGGTGATCGGTGCCCAAACAGCAGTTGGTGCTCAG
GCGTCGATCAGTCACTCCTGGCTTGATGAACGGGTGCAGATCGGCTATCAGGCTGTGTGCCAGGCCGCTGAATACCGCGA
TGCGCCGGTCAACGTCGTTGTCAATGGCTTGTTGACAGAAGATGACCTGATCACCCGTGGGGTGGTGGTTGCTGCTGGGG
TAGCGATTGCCCCGCAGAGCGTGATTGCCGCAGGGAGCATTGTCCGTCTGTGA

Upstream 100 bases:

>100_bases
CACTCCCCACTCCCCGCCCCTTCATGGTATCCTACAACCGAGTGTGCGCACGCCGGTGAGTTGCAACAGTAATGTGCGCA
CGGGCTTGTAGGAGAGAGCC

Downstream 100 bases:

>100_bases
CCGATAGCAACCCTCACACCGGTTGCCCAAAGACCTCGCTGATGATCTCCTCGATGGGTGGCTCGGCGATGTTGACATCG
GCAACCGGTAGCGCGGTCAA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSSAKHAVILVAGASTRTRPLTDQRPKPLIPLLGKPLLAHILDELVGLVERVTLVVGYRADQIVATFGETYRGMAIRYVY
QTTINGTAGALLAAAPIDEPFFLLYGDNLIDRADVIGVGQFRYALAGLRLPDLRSFGVLDVHDGLVQRIIEKPTQPPPDA
LANPGIYHFDAEVFPLLHRITPSPRGELELTDLIALLAEQHPVACHVCTGHWLPVGTPWEALLAARFLLARQAHTQPLPQ
IAPNAHIAPQADLEGSVVVSDGASIDQGARIVGPAWIGPGAVIGSGALIIASVIEAGATIGAEAMIGGSVIGAQTAVGAQ
ASISHSWLDERVQIGYQAVCQAAEYRDAPVNVVVNGLLTEDDLITRGVVVAAGVAIAPQSVIAAGSIVRL

Sequences:

>Translated_390_residues
MSSAKHAVILVAGASTRTRPLTDQRPKPLIPLLGKPLLAHILDELVGLVERVTLVVGYRADQIVATFGETYRGMAIRYVY
QTTINGTAGALLAAAPIDEPFFLLYGDNLIDRADVIGVGQFRYALAGLRLPDLRSFGVLDVHDGLVQRIIEKPTQPPPDA
LANPGIYHFDAEVFPLLHRITPSPRGELELTDLIALLAEQHPVACHVCTGHWLPVGTPWEALLAARFLLARQAHTQPLPQ
IAPNAHIAPQADLEGSVVVSDGASIDQGARIVGPAWIGPGAVIGSGALIIASVIEAGATIGAEAMIGGSVIGAQTAVGAQ
ASISHSWLDERVQIGYQAVCQAAEYRDAPVNVVVNGLLTEDDLITRGVVVAAGVAIAPQSVIAAGSIVRL
>Mature_389_residues
SSAKHAVILVAGASTRTRPLTDQRPKPLIPLLGKPLLAHILDELVGLVERVTLVVGYRADQIVATFGETYRGMAIRYVYQ
TTINGTAGALLAAAPIDEPFFLLYGDNLIDRADVIGVGQFRYALAGLRLPDLRSFGVLDVHDGLVQRIIEKPTQPPPDAL
ANPGIYHFDAEVFPLLHRITPSPRGELELTDLIALLAEQHPVACHVCTGHWLPVGTPWEALLAARFLLARQAHTQPLPQI
APNAHIAPQADLEGSVVVSDGASIDQGARIVGPAWIGPGAVIGSGALIIASVIEAGATIGAEAMIGGSVIGAQTAVGAQA
SISHSWLDERVQIGYQAVCQAAEYRDAPVNVVVNGLLTEDDLITRGVVVAAGVAIAPQSVIAAGSIVRL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=385, Percent_Identity=25.4545454545455, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI11761621, Length=326, Percent_Identity=26.0736196319018, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790224, Length=242, Percent_Identity=26.0330578512397, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788351, Length=255, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=334, Percent_Identity=28.1437125748503, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17509979, Length=405, Percent_Identity=28.1481481481481, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17509981, Length=395, Percent_Identity=27.5949367088608, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=329, Percent_Identity=27.9635258358663, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21355443, Length=336, Percent_Identity=29.4642857142857, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24644084, Length=336, Percent_Identity=29.4642857142857, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 40983; Mature: 40852

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAKHAVILVAGASTRTRPLTDQRPKPLIPLLGKPLLAHILDELVGLVERVTLVVGYRA
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCH
DQIVATFGETYRGMAIRYVYQTTINGTAGALLAAAPIDEPFFLLYGDNLIDRADVIGVGQ
HHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEECCCCCCEEEEECCCCCCCHHEEECCH
FRYALAGLRLPDLRSFGVLDVHDGLVQRIIEKPTQPPPDALANPGIYHFDAEVFPLLHRI
HHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCHHHCCCCEEEECHHHHHHHHHC
TPSPRGELELTDLIALLAEQHPVACHVCTGHWLPVGTPWEALLAARFLLARQAHTQPLPQ
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEECCCCCHHHHHHHHHHHHHHHCCCCCCC
IAPNAHIAPQADLEGSVVVSDGASIDQGARIVGPAWIGPGAVIGSGALIIASVIEAGATI
CCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCHHHCCCHHHHHHHHHHCCCC
GAEAMIGGSVIGAQTAVGAQASISHSWLDERVQIGYQAVCQAAEYRDAPVNVVVNGLLTE
CCHHHCCCCEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
DDLITRGVVVAAGVAIAPQSVIAAGSIVRL
CHHHHCCHHHHCCCCCCCHHHHHCCCEECC
>Mature Secondary Structure 
SSAKHAVILVAGASTRTRPLTDQRPKPLIPLLGKPLLAHILDELVGLVERVTLVVGYRA
CCCCEEEEEEECCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCH
DQIVATFGETYRGMAIRYVYQTTINGTAGALLAAAPIDEPFFLLYGDNLIDRADVIGVGQ
HHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEECCCCCCEEEEECCCCCCCHHEEECCH
FRYALAGLRLPDLRSFGVLDVHDGLVQRIIEKPTQPPPDALANPGIYHFDAEVFPLLHRI
HHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCCHHHCCCCEEEECHHHHHHHHHC
TPSPRGELELTDLIALLAEQHPVACHVCTGHWLPVGTPWEALLAARFLLARQAHTQPLPQ
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEECCCCCHHHHHHHHHHHHHHHCCCCCCC
IAPNAHIAPQADLEGSVVVSDGASIDQGARIVGPAWIGPGAVIGSGALIIASVIEAGATI
CCCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCCCCHHHCCCHHHHHHHHHHCCCC
GAEAMIGGSVIGAQTAVGAQASISHSWLDERVQIGYQAVCQAAEYRDAPVNVVVNGLLTE
CCHHHCCCCEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
DDLITRGVVVAAGVAIAPQSVIAAGSIVRL
CHHHHCCHHHHCCCCCCCHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]