Click here to switch to the map view.

The map label for this gene is nrdZ [H]

Identifier: 222525156

GI number: 222525156

Start: 2395925

End: 2398393

Strand: Direct

Name: nrdZ [H]

Synonym: Chy400_1894

Alternate gene names: 222525156

Gene position: 2395925-2398393 (Clockwise)

Preceding gene: 222525153

Following gene: 222525157

Centisome position: 45.47

GC content: 59.01

Gene sequence:

>2469_bases
ATGATGAAACAAGAGCTTGCCCCCGCCAATCTGACCGACATTGCCCGTACTGTGCTCAAAAAGCGCTATCTGTTGAAGAA
TGAGCACGGTGATGTGATCGAAACCCCCGAAACGATGTTTTGGCGGGTGGCCGAGACCATCGCCGCCGTCGATGCTCGCT
ACGGGGCGTCAGCCGAGCAGGTCGAGGAGCGTGCCGAACGATTTTATCATCTGATGACCCAGGGCTATTTTGAACCAAAC
AGCCCAACCCTGATGAATGCCGGGCGGCCATTGGGGCAATTGAGTGCCTGCTTCGTCCTGCCTATCGACGACAATCTGAC
CAGTATCTACGAGACGCTCAAACATCAGGCACTGATCCATCAGAGTGGTGGCGGGACCGGCTTTAGCTTCTCGCGGCTGC
GTCCGCGCAACGATGTGGTGCGCAGTACGATGGGGGTGGCCAGCGGCCCGGTGAGTTTTATGGATGTCTATAATCACTCC
ACCGAGGCGATTAAACAGGGTGGAACGCGCCGTGGCGCAAATATGGGTATTCTGCGCTGCGATCATCCTGATATTCTTGA
GTTTATTACCTGCAAACTCGATACAACGAAAATCACGAATTTCAATATCTCGGTGGCGATTACCGATGCGTTCATGCGTG
CCGTTGAGCGCGACGAGGAGTATGACCTGATCAACCCGCGCACCGGTCTGGGGCAGATTGCGTCGCGTGATGGTCTCAAG
CATCCGCTCACCGGCGAGGTGCTCGTTCCCGCCGGTCAACCGATGCGCTTGCGGGCCCGCATGGTCTTCGATCTGATTGT
GCAGTGCGCCCACGCCACCGGTGAACCCGGTCTCTTCTTCATCGACCGGGCCAACGAGTACAATCCGGTACCCCACCTTG
GCGAATACGAAGCGACCAATCCCTGCGGTGAACAACCGTTGCTGGCCTATGACGTGTGCAACCTCGGTTCGATCAATCTG
GGGAAATTCGTCACCGATGCCGGCACCATTGATTGGGAATCGCTGCGTGACGTGGTGCATGAGAGCACCCGCTTTCTCGA
TAATGTGATCGACGCCAATCACTATCCGCTCGAACAGATTACGCAGCTCAGCCAGCGGATTCGCCGCATCGGCCTTGGGG
TGATGGGATGGGCCGATATGCTGGTGCGTCTGGGCATTCCGTACAATTCAGCGCAAGCGATTGATCTGGCGCGACAGGTG
ATGCGCTTTATCGACGAAGAGAGCAAAGTGGCGTCCGAGCAGCTTGCCCGCGAGCGTGGTCCCTTCCCGGAATGGGAGTA
CAGCATCTGGGGACCTGATGCGACCTGCGCCCGTCGCCCCGATGGATCGCGCATTCGGCCCCAACGCCTGCTCCGCAATT
GTAACGTCACCACCGTTGCCCCAACCGGCACGATCAGCATTATCGCCGGCTGCTCATCCGGCATCGAGCCACTGTTTGCG
ATTGCGTTCTGGCGCTACCAGGCCGACACCCGCATGCTCGACATCAATCAGGACTTTGTCGCCCAGGCCAAACGTGAGGG
ATGGTACAGCGATGAACTGATGGAGCGGATTGCGGACACCGGTCATATCCATCACCCGGAAGTACCGGCCTCGGTGCAGC
GGGTGTGGGTCACTGCCCACGATATTGCCCCAGAGTGGCACGTGCGCATGCAGGCAGCGTTCCAGGAGTACACCGATAGT
GCGATCTCGAAGACGATTAACTTCCCGCACGAAGCAACCCCCGACCAGGTTCGCGAAGCCTACGAGCTGGCCTTCCGCCT
TGGCTGCAAGGGGATCACCGTCTATCGTGACGGATCGCGCGCAAACCAGGTGCTCTCAACCGGCTCAACCGGTAAGAGTG
CGGAGCCGGCGCCGGCCTCCGATCAACCGGTGGAGCTGAAGCCGCGCCCGGTCCCGGCTGAGGGATTGCCCAGCCACTCC
TTCCCTGTTGTTACGCCACTCGGCAAACTGCGCCTCTTCGTGACCGAGCTGGACGGGAAGCCGTTCGAGGTCTTTGCCAT
CATCGGGCGCGCCGGCAGCGATGTTACCGCCTTCACCGAAGCCATTGGCCGCCTGATTTCACTCGCCCTCCGGTGTGGAG
TCCCGGTGAAACTCATTGCCGAGCAACTGCGCGGCATCGGTGGTTCGCGCTCGGCGGGCTTCGGCCCGGATCGGGTACGT
TCGGTGCCTGACGCAATAGGCAAGGTATTGCTCGATCATTACGTGAAAAACGGGAACGGGAATGGCAATGGGAATGGCAA
CGGTAATGGGCATGACTACGAGTACGGCAACGGCGAAACCGATACGAGTCGGACGTACACCAATGGAGCCAGCGAGGCTA
CAGCCACAACACCGGTAAGCCATCCCCATAGCGATCATGGTCACGGCACAATTGAAGCCGCCGAGATTTGCCCTGAATGC
CAGAATGCGACCATGCTGAACGAAGAAGGGTGTCGGAAGTGCCACTCGTGCGGTTATAGCGAGTGCTAA

Upstream 100 bases:

>100_bases
TGTGACCTGATTTGTCGTTAATAAACCTTTTACAATTAAGTGCACCCCTATTGGTTCCTGCACGTGTGAGAGGTCTGTCC
TGAAGAGGAGCATCCAACCA

Downstream 100 bases:

>100_bases
TAGCATGTCGTGAAACACGTGTGCCGGGGTGAGAATGATCATCCCGGCACGTTATATAACCCGAGTTGCTACCTTTGTCA
CCACAGAGACACGGAGGACA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 822

Protein sequence:

>822_residues
MMKQELAPANLTDIARTVLKKRYLLKNEHGDVIETPETMFWRVAETIAAVDARYGASAEQVEERAERFYHLMTQGYFEPN
SPTLMNAGRPLGQLSACFVLPIDDNLTSIYETLKHQALIHQSGGGTGFSFSRLRPRNDVVRSTMGVASGPVSFMDVYNHS
TEAIKQGGTRRGANMGILRCDHPDILEFITCKLDTTKITNFNISVAITDAFMRAVERDEEYDLINPRTGLGQIASRDGLK
HPLTGEVLVPAGQPMRLRARMVFDLIVQCAHATGEPGLFFIDRANEYNPVPHLGEYEATNPCGEQPLLAYDVCNLGSINL
GKFVTDAGTIDWESLRDVVHESTRFLDNVIDANHYPLEQITQLSQRIRRIGLGVMGWADMLVRLGIPYNSAQAIDLARQV
MRFIDEESKVASEQLARERGPFPEWEYSIWGPDATCARRPDGSRIRPQRLLRNCNVTTVAPTGTISIIAGCSSGIEPLFA
IAFWRYQADTRMLDINQDFVAQAKREGWYSDELMERIADTGHIHHPEVPASVQRVWVTAHDIAPEWHVRMQAAFQEYTDS
AISKTINFPHEATPDQVREAYELAFRLGCKGITVYRDGSRANQVLSTGSTGKSAEPAPASDQPVELKPRPVPAEGLPSHS
FPVVTPLGKLRLFVTELDGKPFEVFAIIGRAGSDVTAFTEAIGRLISLALRCGVPVKLIAEQLRGIGGSRSAGFGPDRVR
SVPDAIGKVLLDHYVKNGNGNGNGNGNGNGHDYEYGNGETDTSRTYTNGASEATATTPVSHPHSDHGHGTIEAAEICPEC
QNATMLNEEGCRKCHSCGYSEC

Sequences:

>Translated_822_residues
MMKQELAPANLTDIARTVLKKRYLLKNEHGDVIETPETMFWRVAETIAAVDARYGASAEQVEERAERFYHLMTQGYFEPN
SPTLMNAGRPLGQLSACFVLPIDDNLTSIYETLKHQALIHQSGGGTGFSFSRLRPRNDVVRSTMGVASGPVSFMDVYNHS
TEAIKQGGTRRGANMGILRCDHPDILEFITCKLDTTKITNFNISVAITDAFMRAVERDEEYDLINPRTGLGQIASRDGLK
HPLTGEVLVPAGQPMRLRARMVFDLIVQCAHATGEPGLFFIDRANEYNPVPHLGEYEATNPCGEQPLLAYDVCNLGSINL
GKFVTDAGTIDWESLRDVVHESTRFLDNVIDANHYPLEQITQLSQRIRRIGLGVMGWADMLVRLGIPYNSAQAIDLARQV
MRFIDEESKVASEQLARERGPFPEWEYSIWGPDATCARRPDGSRIRPQRLLRNCNVTTVAPTGTISIIAGCSSGIEPLFA
IAFWRYQADTRMLDINQDFVAQAKREGWYSDELMERIADTGHIHHPEVPASVQRVWVTAHDIAPEWHVRMQAAFQEYTDS
AISKTINFPHEATPDQVREAYELAFRLGCKGITVYRDGSRANQVLSTGSTGKSAEPAPASDQPVELKPRPVPAEGLPSHS
FPVVTPLGKLRLFVTELDGKPFEVFAIIGRAGSDVTAFTEAIGRLISLALRCGVPVKLIAEQLRGIGGSRSAGFGPDRVR
SVPDAIGKVLLDHYVKNGNGNGNGNGNGNGHDYEYGNGETDTSRTYTNGASEATATTPVSHPHSDHGHGTIEAAEICPEC
QNATMLNEEGCRKCHSCGYSEC
>Mature_822_residues
MMKQELAPANLTDIARTVLKKRYLLKNEHGDVIETPETMFWRVAETIAAVDARYGASAEQVEERAERFYHLMTQGYFEPN
SPTLMNAGRPLGQLSACFVLPIDDNLTSIYETLKHQALIHQSGGGTGFSFSRLRPRNDVVRSTMGVASGPVSFMDVYNHS
TEAIKQGGTRRGANMGILRCDHPDILEFITCKLDTTKITNFNISVAITDAFMRAVERDEEYDLINPRTGLGQIASRDGLK
HPLTGEVLVPAGQPMRLRARMVFDLIVQCAHATGEPGLFFIDRANEYNPVPHLGEYEATNPCGEQPLLAYDVCNLGSINL
GKFVTDAGTIDWESLRDVVHESTRFLDNVIDANHYPLEQITQLSQRIRRIGLGVMGWADMLVRLGIPYNSAQAIDLARQV
MRFIDEESKVASEQLARERGPFPEWEYSIWGPDATCARRPDGSRIRPQRLLRNCNVTTVAPTGTISIIAGCSSGIEPLFA
IAFWRYQADTRMLDINQDFVAQAKREGWYSDELMERIADTGHIHHPEVPASVQRVWVTAHDIAPEWHVRMQAAFQEYTDS
AISKTINFPHEATPDQVREAYELAFRLGCKGITVYRDGSRANQVLSTGSTGKSAEPAPASDQPVELKPRPVPAEGLPSHS
FPVVTPLGKLRLFVTELDGKPFEVFAIIGRAGSDVTAFTEAIGRLISLALRCGVPVKLIAEQLRGIGGSRSAGFGPDRVR
SVPDAIGKVLLDHYVKNGNGNGNGNGNGNGHDYEYGNGETDTSRTYTNGASEATATTPVSHPHSDHGHGTIEAAEICPEC
QNATMLNEEGCRKCHSCGYSEC

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=588, Percent_Identity=29.421768707483, Blast_Score=216, Evalue=7e-56,
Organism=Escherichia coli, GI1789030, Length=582, Percent_Identity=24.5704467353952, Blast_Score=137, Evalue=4e-33,
Organism=Escherichia coli, GI2367133, Length=628, Percent_Identity=20.7006369426752, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17555242, Length=585, Percent_Identity=29.4017094017094, Blast_Score=225, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6320914, Length=578, Percent_Identity=27.8546712802768, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6322123, Length=647, Percent_Identity=26.1205564142195, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17352481, Length=644, Percent_Identity=26.8633540372671, Blast_Score=198, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90497; Mature: 90497

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKQELAPANLTDIARTVLKKRYLLKNEHGDVIETPETMFWRVAETIAAVDARYGASAEQ
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHH
VEERAERFYHLMTQGYFEPNSPTLMNAGRPLGQLSACFVLPIDDNLTSIYETLKHQALIH
HHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHEE
QSGGGTGFSFSRLRPRNDVVRSTMGVASGPVSFMDVYNHSTEAIKQGGTRRGANMGILRC
ECCCCCCCCHHCCCCHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCEEEC
DHPDILEFITCKLDTTKITNFNISVAITDAFMRAVERDEEYDLINPRTGLGQIASRDGLK
CCCHHHHHHHEECCCEEEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCC
HPLTGEVLVPAGQPMRLRARMVFDLIVQCAHATGEPGLFFIDRANEYNPVPHLGEYEATN
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCC
PCGEQPLLAYDVCNLGSINLGKFVTDAGTIDWESLRDVVHESTRFLDNVIDANHYPLEQI
CCCCCCEEEEECCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TQLSQRIRRIGLGVMGWADMLVRLGIPYNSAQAIDLARQVMRFIDEESKVASEQLARERG
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
PFPEWEYSIWGPDATCARRPDGSRIRPQRLLRNCNVTTVAPTGTISIIAGCSSGIEPLFA
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEECCCCCEEEEECCCCCHHHHHH
IAFWRYQADTRMLDINQDFVAQAKREGWYSDELMERIADTGHIHHPEVPASVQRVWVTAH
HHHHHEECCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHEEEEEHH
DIAPEWHVRMQAAFQEYTDSAISKTINFPHEATPDQVREAYELAFRLGCKGITVYRDGSR
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCH
ANQVLSTGSTGKSAEPAPASDQPVELKPRPVPAEGLPSHSFPVVTPLGKLRLFVTELDGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCC
PFEVFAIIGRAGSDVTAFTEAIGRLISLALRCGVPVKLIAEQLRGIGGSRSAGFGPDRVR
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
SVPDAIGKVLLDHYVKNGNGNGNGNGNGNGHDYEYGNGETDTSRTYTNGASEATATTPVS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HPHSDHGHGTIEAAEICPECQNATMLNEEGCRKCHSCGYSEC
CCCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMKQELAPANLTDIARTVLKKRYLLKNEHGDVIETPETMFWRVAETIAAVDARYGASAEQ
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHH
VEERAERFYHLMTQGYFEPNSPTLMNAGRPLGQLSACFVLPIDDNLTSIYETLKHQALIH
HHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHEE
QSGGGTGFSFSRLRPRNDVVRSTMGVASGPVSFMDVYNHSTEAIKQGGTRRGANMGILRC
ECCCCCCCCHHCCCCHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCEEEC
DHPDILEFITCKLDTTKITNFNISVAITDAFMRAVERDEEYDLINPRTGLGQIASRDGLK
CCCHHHHHHHEECCCEEEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCC
HPLTGEVLVPAGQPMRLRARMVFDLIVQCAHATGEPGLFFIDRANEYNPVPHLGEYEATN
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCC
PCGEQPLLAYDVCNLGSINLGKFVTDAGTIDWESLRDVVHESTRFLDNVIDANHYPLEQI
CCCCCCEEEEECCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TQLSQRIRRIGLGVMGWADMLVRLGIPYNSAQAIDLARQVMRFIDEESKVASEQLARERG
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
PFPEWEYSIWGPDATCARRPDGSRIRPQRLLRNCNVTTVAPTGTISIIAGCSSGIEPLFA
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEECCCCCEEEEECCCCCHHHHHH
IAFWRYQADTRMLDINQDFVAQAKREGWYSDELMERIADTGHIHHPEVPASVQRVWVTAH
HHHHHEECCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCHHEEEEEHH
DIAPEWHVRMQAAFQEYTDSAISKTINFPHEATPDQVREAYELAFRLGCKGITVYRDGSR
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCH
ANQVLSTGSTGKSAEPAPASDQPVELKPRPVPAEGLPSHSFPVVTPLGKLRLFVTELDGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCC
PFEVFAIIGRAGSDVTAFTEAIGRLISLALRCGVPVKLIAEQLRGIGGSRSAGFGPDRVR
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
SVPDAIGKVLLDHYVKNGNGNGNGNGNGNGHDYEYGNGETDTSRTYTNGASEATATTPVS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HPHSDHGHGTIEAAEICPECQNATMLNEEGCRKCHSCGYSEC
CCCCCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]