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The map label for this gene is pabA [H]

Identifier: 222525137

GI number: 222525137

Start: 2370418

End: 2370990

Strand: Direct

Name: pabA [H]

Synonym: Chy400_1875

Alternate gene names: 222525137

Gene position: 2370418-2370990 (Clockwise)

Preceding gene: 222525136

Following gene: 222525139

Centisome position: 44.99

GC content: 57.94

Gene sequence:

>573_bases
ATGCGCGTTCTCCTGATCGACAACTACGACTCGTTTACATACAATCTGTACCAGTATCTTTGTGAACTGGGCGCTGACGT
TGAGGTGGTGCGGAACGACCAGATAACCGTTGCCGATGTCGCATCCCGCGCTCCTGACCGAATCGTGATTAGCCCTGGCC
CCTGTACGCCGGCAGAGGCGGGGATCAGTGTTGACGTGATCCGCCAGTTAGGTGGGCACATCCCCATTCTCGGCGTCTGC
CTTGGGCATCAGGCCATCGGCGCTGCCTACGGTGGAGCAGTCGTGCGGGCACCACTGGTGATGCACGGCAAACTATCACC
CATCTACCATCAGGGTCAGGGCGTGTTTGCCGGCCTTCCCTCGCCATTCCGCGCCACCCGTTACCATTCGTTGATCGTGC
GCCGTGAGGATTTGCCCGCTGAACTAGAGGTCACCGCGTGGACGGACGATGGCATCATTATGGGTCTGCGCCATCGCACA
TTACCGGTAGAAGGTGTCCAGTTTCACCCTGAGTCGATCATGACCGAGGGTGGAAAACAGATGCTGGCCAATTTTCTAAA
TCACGGTCGCTGA

Upstream 100 bases:

>100_bases
CATGTGTGGAAGCGCTGATTCGGGCACGGGCGAAAGGGGCTATCCTGACCCAAGATGAACGTGAACAGGCAATTGCATCG
CAGACGATGGAGTGATAATT

Downstream 100 bases:

>100_bases
TGGGTTGGTTAACGGTCGTTGCATGATCGTGGTGTACGTACTGAGGACTATTGACCGCAGCGGAAAGGGGCGCACAGCCG
TGCGCCCCTTTCCTACGCAC

Product: glutamine amidotransferase of anthranilate synthase

Products: NA

Alternate protein names: ADC synthase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRVLLIDNYDSFTYNLYQYLCELGADVEVVRNDQITVADVASRAPDRIVISPGPCTPAEAGISVDVIRQLGGHIPILGVC
LGHQAIGAAYGGAVVRAPLVMHGKLSPIYHQGQGVFAGLPSPFRATRYHSLIVRREDLPAELEVTAWTDDGIIMGLRHRT
LPVEGVQFHPESIMTEGGKQMLANFLNHGR

Sequences:

>Translated_190_residues
MRVLLIDNYDSFTYNLYQYLCELGADVEVVRNDQITVADVASRAPDRIVISPGPCTPAEAGISVDVIRQLGGHIPILGVC
LGHQAIGAAYGGAVVRAPLVMHGKLSPIYHQGQGVFAGLPSPFRATRYHSLIVRREDLPAELEVTAWTDDGIIMGLRHRT
LPVEGVQFHPESIMTEGGKQMLANFLNHGR
>Mature_190_residues
MRVLLIDNYDSFTYNLYQYLCELGADVEVVRNDQITVADVASRAPDRIVISPGPCTPAEAGISVDVIRQLGGHIPILGVC
LGHQAIGAAYGGAVVRAPLVMHGKLSPIYHQGQGVFAGLPSPFRATRYHSLIVRREDLPAELEVTAWTDDGIIMGLRHRT
LPVEGVQFHPESIMTEGGKQMLANFLNHGR

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789760, Length=185, Percent_Identity=65.945945945946, Blast_Score=260, Evalue=3e-71,
Organism=Escherichia coli, GI1787517, Length=187, Percent_Identity=44.3850267379679, Blast_Score=150, Evalue=4e-38,
Organism=Escherichia coli, GI1786215, Length=160, Percent_Identity=30, Blast_Score=67, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322638, Length=186, Percent_Identity=53.2258064516129, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324361, Length=211, Percent_Identity=33.6492890995261, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281365319, Length=144, Percent_Identity=32.6388888888889, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 20695; Mature: 20695

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIDNYDSFTYNLYQYLCELGADVEVVRNDQITVADVASRAPDRIVISPGPCTPAEA
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCEEEEHHHCCCCCEEEECCCCCCCCCC
GISVDVIRQLGGHIPILGVCLGHQAIGAAYGGAVVRAPLVMHGKLSPIYHQGQGVFAGLP
CCCHHHHHHHCCCCCEEEEECCCHHHHHHHCCHHHCCCEEEECCCCCEEECCCEEEECCC
SPFRATRYHSLIVRREDLPAELEVTAWTDDGIIMGLRHRTLPVEGVQFHPESIMTEGGKQ
CCHHHHHHHEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCEECCHHHHHCCHHH
MLANFLNHGR
HHHHHHHCCC
>Mature Secondary Structure
MRVLLIDNYDSFTYNLYQYLCELGADVEVVRNDQITVADVASRAPDRIVISPGPCTPAEA
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCEEEEHHHCCCCCEEEECCCCCCCCCC
GISVDVIRQLGGHIPILGVCLGHQAIGAAYGGAVVRAPLVMHGKLSPIYHQGQGVFAGLP
CCCHHHHHHHCCCCCEEEEECCCHHHHHHHCCHHHCCCEEEECCCCCEEECCCEEEECCC
SPFRATRYHSLIVRREDLPAELEVTAWTDDGIIMGLRHRTLPVEGVQFHPESIMTEGGKQ
CCHHHHHHHEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCEECCHHHHHCCHHH
MLANFLNHGR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350604; 2403545; 9278503; 2546924; 8096767 [H]