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The map label for this gene is pknL [H]

Identifier: 222525122

GI number: 222525122

Start: 2350058

End: 2351482

Strand: Reverse

Name: pknL [H]

Synonym: Chy400_1860

Alternate gene names: 222525122

Gene position: 2351482-2350058 (Counterclockwise)

Preceding gene: 222525123

Following gene: 222525121

Centisome position: 44.63

GC content: 56.21

Gene sequence:

>1425_bases
ATGACCTCACCTGGAACAACAAATCCGCCAGTCATCTTTGGCCGTTATCAGGTCCACGAGGCGCTCGGAGAGACACGCCT
CGCGGTGGTGTACAAAGCAACCGATTTGCGGCTTCAGCGACAGGTATTTGTGCATCTGTTACGAAAGTCTCTGCTCGGTA
ATGAACAGAAGCGGCAGCAGTTTCTCGCTGAAGCGGCCCAAAGTGCCCGCCGATCCCACCCCGTCTTCCTGGAAGTGTTC
GACAGCGGTGAAAGCAATGGTCGCCCCTTCCTGATTACCGAAGCCGCCGAAGGCCGTCCACTGTACGGAATTGGTGCCTT
AAGCGTTGCCCAGGCTCTTAGCATTGTGCGCCAGGTGGCCGATGCTATTGCGCTCTGTCAGCGCCAACGTTCAGCCGAAC
TCCCGCTGGGATTGTATCATCCCCCCATTAGCAGCGCGAACCTGTTACTTGTCGGTGATAATCAGGTCAAACTCGTCGAG
AGCTGGCTCCTTGCACCTGCCCTGGTACCCGCCGATCTGGCCTACTATCGGGCACCCGAATTAAGCACCGGTCAGACAGC
CCAGCCGGCAAGTGTGGTCTATGCATTGGGCATCTTACTCTTTGAACTGATTACCGGCCAGCGACCGATCCGCGGTGAGG
ATGCCAAAACAACTGCACTGGCCCACCTCACGCAATCGGTTCCTTCGTTGTCACAGGTACGCCCGACAATGCACGTACCT
TCACTTGACGATCTTATTGCCCAGGCGACCGCTCGCGAACCAGGGCAACGCTTCGCCGATGCCCAGGTGTTTGGCTCTGC
TATCAACAATCTCTGGCATCAGTTGACCGTGCCTACGCGCCGACTCGCTGTGAACCGACCAGAAGTGGCACAGGTTGCAT
TGCCGGTACCAGAACGAACAGCAGCGCCGGTCGGCAGTACCAACCCTGCTCGCACACCGGCTCCTTCGCGCTCGCAAGAC
CTGCGTGACCGCTTCAGCCAGGCTATAACCGCTGCCTTCGACATTGATCAATTTCGCCGCCAGGATCGGCGGCGTAGCCT
GACCGGCTGGCTTATCATGATATTGCTGTTACTCGCCGTTGCCTTTGGATCGTATTGGGCAGTAACCTGGGCCTTTGATC
GCTTGAATCTAAGTGCGCCACGCCTGCCGGAATTACCCGCATGGCAGTGGCCCGATCTGAACCTTGCCGACCAAAACACC
CAGGAACTATACGTCGTAAATATCAATGAGGGCTTAAATTTACGTTCTGCACCAGATACTCGACCGGAGACAATCATGAT
GGTTGTCCCCAACGGCACGGTCGTGCGTAAGCTGGAAGGCCCGGTGATGGCCGATAATATTCCATGGTTAAAAGTGCAGT
TTGAACTCAACGGCCAGGTGATTGAAGGCTGGATGTCAATGAACTATCTGCGTCGACAGCAGTAA

Upstream 100 bases:

>100_bases
AGTTATCTGCTGATCGACTTGAAAGACTTGTAGTAAGATCAGCAACACTATTGGTAATAGTTAAAACGATACTGTCAGAC
ACGAGTGACAGGTCTCGCGC

Downstream 100 bases:

>100_bases
GTTCCAGCAGCGTTGAAGCGTAGTTTAATCGTGGTATGATAGGAGGCGGTGTGGAGCAGGAAGCGGAGAAGCGCGAATTG
CTCGGTGAACGGGTAAAAAT

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTSPGTTNPPVIFGRYQVHEALGETRLAVVYKATDLRLQRQVFVHLLRKSLLGNEQKRQQFLAEAAQSARRSHPVFLEVF
DSGESNGRPFLITEAAEGRPLYGIGALSVAQALSIVRQVADAIALCQRQRSAELPLGLYHPPISSANLLLVGDNQVKLVE
SWLLAPALVPADLAYYRAPELSTGQTAQPASVVYALGILLFELITGQRPIRGEDAKTTALAHLTQSVPSLSQVRPTMHVP
SLDDLIAQATAREPGQRFADAQVFGSAINNLWHQLTVPTRRLAVNRPEVAQVALPVPERTAAPVGSTNPARTPAPSRSQD
LRDRFSQAITAAFDIDQFRRQDRRRSLTGWLIMILLLLAVAFGSYWAVTWAFDRLNLSAPRLPELPAWQWPDLNLADQNT
QELYVVNINEGLNLRSAPDTRPETIMMVVPNGTVVRKLEGPVMADNIPWLKVQFELNGQVIEGWMSMNYLRRQQ

Sequences:

>Translated_474_residues
MTSPGTTNPPVIFGRYQVHEALGETRLAVVYKATDLRLQRQVFVHLLRKSLLGNEQKRQQFLAEAAQSARRSHPVFLEVF
DSGESNGRPFLITEAAEGRPLYGIGALSVAQALSIVRQVADAIALCQRQRSAELPLGLYHPPISSANLLLVGDNQVKLVE
SWLLAPALVPADLAYYRAPELSTGQTAQPASVVYALGILLFELITGQRPIRGEDAKTTALAHLTQSVPSLSQVRPTMHVP
SLDDLIAQATAREPGQRFADAQVFGSAINNLWHQLTVPTRRLAVNRPEVAQVALPVPERTAAPVGSTNPARTPAPSRSQD
LRDRFSQAITAAFDIDQFRRQDRRRSLTGWLIMILLLLAVAFGSYWAVTWAFDRLNLSAPRLPELPAWQWPDLNLADQNT
QELYVVNINEGLNLRSAPDTRPETIMMVVPNGTVVRKLEGPVMADNIPWLKVQFELNGQVIEGWMSMNYLRRQQ
>Mature_473_residues
TSPGTTNPPVIFGRYQVHEALGETRLAVVYKATDLRLQRQVFVHLLRKSLLGNEQKRQQFLAEAAQSARRSHPVFLEVFD
SGESNGRPFLITEAAEGRPLYGIGALSVAQALSIVRQVADAIALCQRQRSAELPLGLYHPPISSANLLLVGDNQVKLVES
WLLAPALVPADLAYYRAPELSTGQTAQPASVVYALGILLFELITGQRPIRGEDAKTTALAHLTQSVPSLSQVRPTMHVPS
LDDLIAQATAREPGQRFADAQVFGSAINNLWHQLTVPTRRLAVNRPEVAQVALPVPERTAAPVGSTNPARTPAPSRSQDL
RDRFSQAITAAFDIDQFRRQDRRRSLTGWLIMILLLLAVAFGSYWAVTWAFDRLNLSAPRLPELPAWQWPDLNLADQNTQ
ELYVVNINEGLNLRSAPDTRPETIMMVVPNGTVVRKLEGPVMADNIPWLKVQFELNGQVIEGWMSMNYLRRQQ

Specific function: Unknown

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI193083127, Length=215, Percent_Identity=25.5813953488372, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI46852166, Length=215, Percent_Identity=25.5813953488372, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI193083129, Length=215, Percent_Identity=25.5813953488372, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI193083125, Length=215, Percent_Identity=25.5813953488372, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI153791472, Length=215, Percent_Identity=25.1162790697674, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319825, Length=274, Percent_Identity=25.5474452554745, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161077232, Length=271, Percent_Identity=23.9852398523985, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161077230, Length=271, Percent_Identity=23.9852398523985, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24655167, Length=271, Percent_Identity=23.9852398523985, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR008271 [H]

Pfam domain/function: PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 52554; Mature: 52423

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPGTTNPPVIFGRYQVHEALGETRLAVVYKATDLRLQRQVFVHLLRKSLLGNEQKRQQ
CCCCCCCCCCEEEEHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
FLAEAAQSARRSHPVFLEVFDSGESNGRPFLITEAAEGRPLYGIGALSVAQALSIVRQVA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHH
DAIALCQRQRSAELPLGLYHPPISSANLLLVGDNQVKLVESWLLAPALVPADLAYYRAPE
HHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LSTGQTAQPASVVYALGILLFELITGQRPIRGEDAKTTALAHLTQSVPSLSQVRPTMHVP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCC
SLDDLIAQATAREPGQRFADAQVFGSAINNLWHQLTVPTRRLAVNRPEVAQVALPVPERT
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEECCCCCC
AAPVGSTNPARTPAPSRSQDLRDRFSQAITAAFDIDQFRRQDRRRSLTGWLIMILLLLAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGSYWAVTWAFDRLNLSAPRLPELPAWQWPDLNLADQNTQELYVVNINEGLNLRSAPDT
HHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
RPETIMMVVPNGTVVRKLEGPVMADNIPWLKVQFELNGQVIEGWMSMNYLRRQQ
CCCEEEEECCCCCEEEEECCCEEECCCCEEEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSPGTTNPPVIFGRYQVHEALGETRLAVVYKATDLRLQRQVFVHLLRKSLLGNEQKRQQ
CCCCCCCCCEEEEHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
FLAEAAQSARRSHPVFLEVFDSGESNGRPFLITEAAEGRPLYGIGALSVAQALSIVRQVA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHH
DAIALCQRQRSAELPLGLYHPPISSANLLLVGDNQVKLVESWLLAPALVPADLAYYRAPE
HHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LSTGQTAQPASVVYALGILLFELITGQRPIRGEDAKTTALAHLTQSVPSLSQVRPTMHVP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCC
SLDDLIAQATAREPGQRFADAQVFGSAINNLWHQLTVPTRRLAVNRPEVAQVALPVPERT
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEECCCCCC
AAPVGSTNPARTPAPSRSQDLRDRFSQAITAAFDIDQFRRQDRRRSLTGWLIMILLLLAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGSYWAVTWAFDRLNLSAPRLPELPAWQWPDLNLADQNTQELYVVNINEGLNLRSAPDT
HHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
RPETIMMVVPNGTVVRKLEGPVMADNIPWLKVQFELNGQVIEGWMSMNYLRRQQ
CCCEEEEECCCCCEEEEECCCEEECCCCEEEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]