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The map label for this gene is yiaY [H]

Identifier: 222525066

GI number: 222525066

Start: 2280728

End: 2281882

Strand: Reverse

Name: yiaY [H]

Synonym: Chy400_1803

Alternate gene names: 222525066

Gene position: 2281882-2280728 (Counterclockwise)

Preceding gene: 222525067

Following gene: 222525063

Centisome position: 43.31

GC content: 56.8

Gene sequence:

>1155_bases
ATGCAAGACTTTTTTGAATTTAGTCTTGGTGCCAGAGTGTTATACCAGATGGGTCTGGCCAGTGAATTAGGGCAGGTCAT
CAGCAATGCGTTGCCGCAACGGCGGGCTTTTATTGTGGCCGATAAGGGAGTGGTACAGGCCGGCCTGCTCGAACCAATCC
GGGCCGGCCTGGCACCTATAGAGCTGGTCGGTATTTTCGACGATGTACCGGCCAATTCGTCGGTGGCAAAAGTCGCAGAA
GGCGCTGAACTGGCACGTGTAGCCGGTGCCGACCTGTTGATTGCAGTCGGTGGCGGTAGCCCCATCGATACGGCCAAGGG
TATCCGTATCGTCCTTACGCTGGGCGGATCAATCCCCGATTACGAAGGCTACAATGTGATTGAAACTCCGCTCACACCGC
TGATAGCAATCCCAACAACCGCCGGTACCGGTAGTGAGGTGACACCAATTGCTGTGATTCTTGATGAAGAAGGTCAACGT
AAAATAAGTATTGTGAGCCGTTATGTGACTCCTACCCTGGCCATTCTCGATCCGCTCATGACCCGCACCTTACCGCCGCG
CCTGACAGCGGCCACGGGAATGGACGCGCTCTCGCACGCGATTGAGACGTATGTTTCAACCGAAAACAACCCCTTGAGCG
ATAGTCTGGCGCTGGCAGCGATTGACATGATTGCCACCTATCTACGCGATGCAGTCCACGACGGCGAAAATATGGAGGCC
CGTAGCCAGTTGTTGATTGCGGCGACGATGGCCGGTATTGCCTGTGGTAATAGCCTGTTTGGGGTTGTGCATGCGCTGTC
ACACGCACTGGGTGGCAAATTCCCCGTTCATCACGGCACGGCGAACGCGATCTTCTTGCCGCCGGGTATGCGCTTCAACA
GCGAGGTAGTGCCGGAACGGTATGTCCGCATCGCCCGGGCAATGGGAGTCAATGTTGGTGGCCGGAGCAACGCCGAGGTG
ATTGCTGATGGTATTGCGGCGGTACGCACCCTGACTGCCGACTGCGGGTTACCCACTACGCTCCGTGAAGTCGGTGTCCC
ACGTGAAGCGCTGCCGGAGCTGGCCGAACTGGCGGCAGTTGAACCGGCCATTTTCAACAATCCCCGTCCGGCAACGCCTG
AAGAGTTACTTGCTATGCTTGAAGAGGTGTGGTGA

Upstream 100 bases:

>100_bases
CTGTGATGAGGTGGTTAGAACACAACCATTTCCTGAACCTCTTGCCTCGCGGTCGTATAATAAACGTAGGGGTCTTTTAT
GCAGAAAAAAGGGTAAGCCA

Downstream 100 bases:

>100_bases
TCACCCGGTAGGGGGCGAGCGATAGTGTTCGCCCCCCTTCGATCAGCTCTTCTCACCGGCAACCCGATGGGCAAAGAGTT
TCTGAAACTTCGCCACTTTC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MQDFFEFSLGARVLYQMGLASELGQVISNALPQRRAFIVADKGVVQAGLLEPIRAGLAPIELVGIFDDVPANSSVAKVAE
GAELARVAGADLLIAVGGGSPIDTAKGIRIVLTLGGSIPDYEGYNVIETPLTPLIAIPTTAGTGSEVTPIAVILDEEGQR
KISIVSRYVTPTLAILDPLMTRTLPPRLTAATGMDALSHAIETYVSTENNPLSDSLALAAIDMIATYLRDAVHDGENMEA
RSQLLIAATMAGIACGNSLFGVVHALSHALGGKFPVHHGTANAIFLPPGMRFNSEVVPERYVRIARAMGVNVGGRSNAEV
IADGIAAVRTLTADCGLPTTLREVGVPREALPELAELAAVEPAIFNNPRPATPEELLAMLEEVW

Sequences:

>Translated_384_residues
MQDFFEFSLGARVLYQMGLASELGQVISNALPQRRAFIVADKGVVQAGLLEPIRAGLAPIELVGIFDDVPANSSVAKVAE
GAELARVAGADLLIAVGGGSPIDTAKGIRIVLTLGGSIPDYEGYNVIETPLTPLIAIPTTAGTGSEVTPIAVILDEEGQR
KISIVSRYVTPTLAILDPLMTRTLPPRLTAATGMDALSHAIETYVSTENNPLSDSLALAAIDMIATYLRDAVHDGENMEA
RSQLLIAATMAGIACGNSLFGVVHALSHALGGKFPVHHGTANAIFLPPGMRFNSEVVPERYVRIARAMGVNVGGRSNAEV
IADGIAAVRTLTADCGLPTTLREVGVPREALPELAELAAVEPAIFNNPRPATPEELLAMLEEVW
>Mature_384_residues
MQDFFEFSLGARVLYQMGLASELGQVISNALPQRRAFIVADKGVVQAGLLEPIRAGLAPIELVGIFDDVPANSSVAKVAE
GAELARVAGADLLIAVGGGSPIDTAKGIRIVLTLGGSIPDYEGYNVIETPLTPLIAIPTTAGTGSEVTPIAVILDEEGQR
KISIVSRYVTPTLAILDPLMTRTLPPRLTAATGMDALSHAIETYVSTENNPLSDSLALAAIDMIATYLRDAVHDGENMEA
RSQLLIAATMAGIACGNSLFGVVHALSHALGGKFPVHHGTANAIFLPPGMRFNSEVVPERYVRIARAMGVNVGGRSNAEV
IADGIAAVRTLTADCGLPTTLREVGVPREALPELAELAAVEPAIFNNPRPATPEELLAMLEEVW

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=425, Percent_Identity=27.7647058823529, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI48994951, Length=346, Percent_Identity=41.907514450867, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789163, Length=362, Percent_Identity=39.7790055248619, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=34.8958333333333, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI1787493, Length=397, Percent_Identity=33.5012594458438, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789386, Length=364, Percent_Identity=26.3736263736264, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17537053, Length=413, Percent_Identity=27.1186440677966, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=370, Percent_Identity=37.027027027027, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24657991, Length=428, Percent_Identity=29.9065420560748, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40294; Mature: 40294

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDFFEFSLGARVLYQMGLASELGQVISNALPQRRAFIVADKGVVQAGLLEPIRAGLAPI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCE
ELVGIFDDVPANSSVAKVAEGAELARVAGADLLIAVGGGSPIDTAKGIRIVLTLGGSIPD
EEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCC
YEGYNVIETPLTPLIAIPTTAGTGSEVTPIAVILDEEGQRKISIVSRYVTPTLAILDPLM
CCCCEEECCCCCCEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
TRTLPPRLTAATGMDALSHAIETYVSTENNPLSDSLALAAIDMIATYLRDAVHDGENMEA
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
RSQLLIAATMAGIACGNSLFGVVHALSHALGGKFPVHHGTANAIFLPPGMRFNSEVVPER
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCHHH
YVRIARAMGVNVGGRSNAEVIADGIAAVRTLTADCGLPTTLREVGVPREALPELAELAAV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHC
EPAIFNNPRPATPEELLAMLEEVW
CHHHCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MQDFFEFSLGARVLYQMGLASELGQVISNALPQRRAFIVADKGVVQAGLLEPIRAGLAPI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCE
ELVGIFDDVPANSSVAKVAEGAELARVAGADLLIAVGGGSPIDTAKGIRIVLTLGGSIPD
EEEEECCCCCCCCHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCC
YEGYNVIETPLTPLIAIPTTAGTGSEVTPIAVILDEEGQRKISIVSRYVTPTLAILDPLM
CCCCEEECCCCCCEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
TRTLPPRLTAATGMDALSHAIETYVSTENNPLSDSLALAAIDMIATYLRDAVHDGENMEA
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
RSQLLIAATMAGIACGNSLFGVVHALSHALGGKFPVHHGTANAIFLPPGMRFNSEVVPER
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCHHH
YVRIARAMGVNVGGRSNAEVIADGIAAVRTLTADCGLPTTLREVGVPREALPELAELAAV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHC
EPAIFNNPRPATPEELLAMLEEVW
CHHHCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]