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The map label for this gene is patB [H]

Identifier: 222525049

GI number: 222525049

Start: 2253587

End: 2254774

Strand: Reverse

Name: patB [H]

Synonym: Chy400_1785

Alternate gene names: 222525049

Gene position: 2254774-2253587 (Counterclockwise)

Preceding gene: 222525050

Following gene: 222525048

Centisome position: 42.79

GC content: 56.82

Gene sequence:

>1188_bases
GTGAACAGATTCAACTTCGATCAGATCATTCCTCGTCGCGGAACCGGGAGTATCAAGTGGGAACAGTATCCGGCTGATGT
CTTGCCGATGTGGGTCGCCGATATGGATTTTGCCTCACCGCCGGCCGTGGTCGCAGCCCTGCACGAACGAGCAGCGCACG
CAGTGTTTGGGTATCCCGCTCATCCTGAACGCCTGACAGAGGTTATTTGTGAGCGCATGGCTCATCTGTACCAATGGGAA
ATTCAACCGGAACACATCCTCTTCCTGCCCGGATTGGTTTCGGCGATTAATGTCCTCTGCCGGGCTTTCGGTGAACCCGG
TGATAGCGTGCTGACCCTCACGCCAGCCTATCCACCCTTCTTGAGCGCACCCCGTAATCAACAACGACAGATCGACACCT
GTGAATTGTCACTCAGCATTTCTGGTTCTATCCTTTCCTACGCTATCGATTTCGATGCCTTGCGGGCGGCAATTCATGAA
CGCACTCGACTCTTGCTGCTCAGCCATCCACACAATCCGGTCGGTCTCGAATACGATCCACCAACCCTGCGCCGGTTGGC
CGAGATGTGTCTCGACCGTAACGTTATCATCTGTTCCGATGAGATTCACTGCGATTTGTTGCTCGGTGAAACACGCCACA
CCCCACTGGCAGCGCTCGATCCGGCCATCGCCGACCGCACTATCACCCTTATGGCACCCAGCAAGACATTCAATTTACCC
GGACTCGGTTGCAGTATGGCGATCATTCCCAATCCCGAACTGCGCCGTCAGGTGAGTCGGGCCGCAGCCGGAATTGTGCC
GCACGTGAATGTGTTTGGCTTTGCCGGCGCACTGGCTGCCTACGAGCACGGGGCTGAATGGCTGGCTGCGTTGTTGGAGT
ATCTGACAGCGAATCGCGATCACTATGTCAGGCGCGTTACCTCCGAACTGGCTCCGCTTCGCTGCACTATCCCCCAGGCT
ACCTACCTCGGCTGGATTGACTGCCGCGAATTGCCTCTGTCAACCAGCCCATATCGCTTCTTCCTCAACGAAGCGCGGGT
AGCTTTCTCTGATGGCGCGGCATTCGGCCCTGGTGGTGAAGGATTTGTTCGCATCAACTTTGGCTGCCCACGTGCCCAGC
TCGATGAGGCGTTGGATCGGGTTGCTGCCGCTTTACAGCGACTGGCCGACACTCAGGCAAACACATGA

Upstream 100 bases:

>100_bases
ATTTCTTTGGTCGAATGTAGTGATGAACAGGTGATGGTTGTCTGGCGCGTGGCCTGAACGTTCGGCTGCCACGCGCCTTT
TGTTGCAAGAGGATGGAACA

Downstream 100 bases:

>100_bases
GCGATGTTTTCAGTACTATATACCTAGCCACGACATAATGACATTTTATTCATCAAGTGCTAATCTAGCTGCGGGCATGC
AGATGAGTGTGACTCAAGCA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNRFNFDQIIPRRGTGSIKWEQYPADVLPMWVADMDFASPPAVVAALHERAAHAVFGYPAHPERLTEVICERMAHLYQWE
IQPEHILFLPGLVSAINVLCRAFGEPGDSVLTLTPAYPPFLSAPRNQQRQIDTCELSLSISGSILSYAIDFDALRAAIHE
RTRLLLLSHPHNPVGLEYDPPTLRRLAEMCLDRNVIICSDEIHCDLLLGETRHTPLAALDPAIADRTITLMAPSKTFNLP
GLGCSMAIIPNPELRRQVSRAAAGIVPHVNVFGFAGALAAYEHGAEWLAALLEYLTANRDHYVRRVTSELAPLRCTIPQA
TYLGWIDCRELPLSTSPYRFFLNEARVAFSDGAAFGPGGEGFVRINFGCPRAQLDEALDRVAAALQRLADTQANT

Sequences:

>Translated_395_residues
MNRFNFDQIIPRRGTGSIKWEQYPADVLPMWVADMDFASPPAVVAALHERAAHAVFGYPAHPERLTEVICERMAHLYQWE
IQPEHILFLPGLVSAINVLCRAFGEPGDSVLTLTPAYPPFLSAPRNQQRQIDTCELSLSISGSILSYAIDFDALRAAIHE
RTRLLLLSHPHNPVGLEYDPPTLRRLAEMCLDRNVIICSDEIHCDLLLGETRHTPLAALDPAIADRTITLMAPSKTFNLP
GLGCSMAIIPNPELRRQVSRAAAGIVPHVNVFGFAGALAAYEHGAEWLAALLEYLTANRDHYVRRVTSELAPLRCTIPQA
TYLGWIDCRELPLSTSPYRFFLNEARVAFSDGAAFGPGGEGFVRINFGCPRAQLDEALDRVAAALQRLADTQANT
>Mature_395_residues
MNRFNFDQIIPRRGTGSIKWEQYPADVLPMWVADMDFASPPAVVAALHERAAHAVFGYPAHPERLTEVICERMAHLYQWE
IQPEHILFLPGLVSAINVLCRAFGEPGDSVLTLTPAYPPFLSAPRNQQRQIDTCELSLSISGSILSYAIDFDALRAAIHE
RTRLLLLSHPHNPVGLEYDPPTLRRLAEMCLDRNVIICSDEIHCDLLLGETRHTPLAALDPAIADRTITLMAPSKTFNLP
GLGCSMAIIPNPELRRQVSRAAAGIVPHVNVFGFAGALAAYEHGAEWLAALLEYLTANRDHYVRRVTSELAPLRCTIPQA
TYLGWIDCRELPLSTSPYRFFLNEARVAFSDGAAFGPGGEGFVRINFGCPRAQLDEALDRVAAALQRLADTQANT

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=213, Percent_Identity=24.8826291079812, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI56713256, Length=213, Percent_Identity=24.8826291079812, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI95147551, Length=289, Percent_Identity=22.8373702422145, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI169881279, Length=289, Percent_Identity=22.8373702422145, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787909, Length=385, Percent_Identity=30.9090909090909, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788627, Length=182, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786816, Length=230, Percent_Identity=23.0434782608696, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=235, Percent_Identity=24.6808510638298, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=235, Percent_Identity=24.6808510638298, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=233, Percent_Identity=22.7467811158798, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=277, Percent_Identity=23.4657039711191, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573069, Length=345, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646114, Length=345, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28573067, Length=345, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28573065, Length=345, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43669; Mature: 43669

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFNFDQIIPRRGTGSIKWEQYPADVLPMWVADMDFASPPAVVAALHERAAHAVFGYPA
CCCCCCHHHCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCC
HPERLTEVICERMAHLYQWEIQPEHILFLPGLVSAINVLCRAFGEPGDSVLTLTPAYPPF
CHHHHHHHHHHHHHHHHEECCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
LSAPRNQQRQIDTCELSLSISGSILSYAIDFDALRAAIHERTRLLLLSHPHNPVGLEYDP
CCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCC
PTLRRLAEMCLDRNVIICSDEIHCDLLLGETRHTPLAALDPAIADRTITLMAPSKTFNLP
HHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCHHHCCHHHCCCEEEEEECCCCCCCC
GLGCSMAIIPNPELRRQVSRAAAGIVPHVNVFGFAGALAAYEHGAEWLAALLEYLTANRD
CCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
HYVRRVTSELAPLRCTIPQATYLGWIDCRELPLSTSPYRFFLNEARVAFSDGAAFGPGGE
HHHHHHHHHCCCEEEECCCHHHEECEECCCCCCCCCCHHEEHHCCEEEECCCCCCCCCCC
GFVRINFGCPRAQLDEALDRVAAALQRLADTQANT
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRFNFDQIIPRRGTGSIKWEQYPADVLPMWVADMDFASPPAVVAALHERAAHAVFGYPA
CCCCCCHHHCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCCC
HPERLTEVICERMAHLYQWEIQPEHILFLPGLVSAINVLCRAFGEPGDSVLTLTPAYPPF
CHHHHHHHHHHHHHHHHEECCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
LSAPRNQQRQIDTCELSLSISGSILSYAIDFDALRAAIHERTRLLLLSHPHNPVGLEYDP
CCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCC
PTLRRLAEMCLDRNVIICSDEIHCDLLLGETRHTPLAALDPAIADRTITLMAPSKTFNLP
HHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCHHHCCHHHCCCEEEEEECCCCCCCC
GLGCSMAIIPNPELRRQVSRAAAGIVPHVNVFGFAGALAAYEHGAEWLAALLEYLTANRD
CCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCH
HYVRRVTSELAPLRCTIPQATYLGWIDCRELPLSTSPYRFFLNEARVAFSDGAAFGPGGE
HHHHHHHHHCCCEEEECCCHHHEECEECCCCCCCCCCHHEEHHCCEEEECCCCCCCCCCC
GFVRINFGCPRAQLDEALDRVAAALQRLADTQANT
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]