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The map label for this gene is proA

Identifier: 222525018

GI number: 222525018

Start: 2216083

End: 2217351

Strand: Direct

Name: proA

Synonym: Chy400_1753

Alternate gene names: 222525018

Gene position: 2216083-2217351 (Clockwise)

Preceding gene: 222525017

Following gene: 222525019

Centisome position: 42.06

GC content: 57.76

Gene sequence:

>1269_bases
ATGGTTGACCTGGAAGCAATTGGCCGCCGGGCAAAGACGGCGGCTCGTGCGTTGGCGAAGCTCTCAACTGAACAGAAAAA
TGCAGCCCTGTGCGCAATTGCTGATGGATTGCTGGCGAGACAAGATAAGATTCTGGCTGCCAACGCTGCCGATGTCGCCG
ATGCAGAAAAGGGTGGGACGCCACCGGCGATTGTTGATCGCATGCTGCTGACGCCGGCGCGTCTGGCGGCGATTGCCGGC
GATTGTCGGCAAGTGGCATCTTTGCCTGATCCAGTTGGTGAAATCTTTGATCGGCGTGAACTGCCGTCCGGGTTGCGCCT
CTATAAACGGCGGGTGCCGATTGGGGTGATCGGTGCGATTTACGAAGCCCGCCCAAATGTGACCGTTGATATTGCGTCGC
TCTGTCTGAAGGCCGGTAATGCCGTTATTTTGCGTGGTGGGAGTGATATTGCGCGCAGTGTGGCGGCAACAACAGAGGTG
ATTGCGCTGGCGTTGGAACAGGCCGGTTTGCCGGCGTTTGCTGTGCAAAGTATTATCGATCCCGACCGTGAACTGGTGCG
GCAATTGCTACGCCTCGACCGTTACGTTGATATGATTATCCCGCGCGGCGGTGCCGGTCTGCACCGTTTCTGTGTCGAAA
ACGCGACGGTGCCGGTGATTGTTGGGGGAATGGGGGTCAGCCATATCTATGTTGAGCCGAGTGCCGACTTTGCCCGCGCT
GTACCGGTGATTGTCAATGCCAAGGTGCAACGTCCGGGTGCCTGCAATGCACTTGATACGCTTCTGGTGCATCGGGCGGC
GGCATCGACCTTTCTGCCGCTGGTAGCCGCTGCCCTCGCTCAGCACGGCGTGGAGTTGCGCTGTGATCTGGAAGCCCTGG
CCATCCTCGCCGATGCGCCTGGGCACGAAGCCTGGAACCTGAAACCGGCCAGCCCAACCGATTTTGGCTGCGAGTTTCTG
GCCTTGATCGTTGCAATCAAGATTGTAGGCAGCATTGATGAAGCACTTGATCATATCGCTCTGTACGGCGGTCATTCCGA
AGCCATTCTGACCGGCGATCCGATCAGTGCTGAGCGCTTTACCCGTGAAGTTGATGCCACTGCTGTCTTTGTCAATGCCA
GCACGCGCTTCAACGATGGTGGTCAGTTTGGTCTGGGTGCCGAGGTGGCAATTTCAACCAATCGCCTGCACGCACGTGGC
CCGATGGGGTTGCAGGAATTGACGACCTATACCTGGATTGGTGAAGGCGATTATCTGGTGCGAGCCTGA

Upstream 100 bases:

>100_bases
TATCAACGCGGTGAACTGGCAGACCGCTTCGAGCGCGCCCGTGACTACCTGGAATCGGAACGACGTCGCTATGACGAGCA
GGATCGGGGAGGATCGCACG

Downstream 100 bases:

>100_bases
ACGTATGAACCTAACCCTGCGTTTGGCCCATCTCTACCCGGAACATATGAATGTGTATGGCGACCGTGGCAACGTGATCG
CGTTGCGCCAGCGTTGCCAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MVDLEAIGRRAKTAARALAKLSTEQKNAALCAIADGLLARQDKILAANAADVADAEKGGTPPAIVDRMLLTPARLAAIAG
DCRQVASLPDPVGEIFDRRELPSGLRLYKRRVPIGVIGAIYEARPNVTVDIASLCLKAGNAVILRGGSDIARSVAATTEV
IALALEQAGLPAFAVQSIIDPDRELVRQLLRLDRYVDMIIPRGGAGLHRFCVENATVPVIVGGMGVSHIYVEPSADFARA
VPVIVNAKVQRPGACNALDTLLVHRAAASTFLPLVAAALAQHGVELRCDLEALAILADAPGHEAWNLKPASPTDFGCEFL
ALIVAIKIVGSIDEALDHIALYGGHSEAILTGDPISAERFTREVDATAVFVNASTRFNDGGQFGLGAEVAISTNRLHARG
PMGLQELTTYTWIGEGDYLVRA

Sequences:

>Translated_422_residues
MVDLEAIGRRAKTAARALAKLSTEQKNAALCAIADGLLARQDKILAANAADVADAEKGGTPPAIVDRMLLTPARLAAIAG
DCRQVASLPDPVGEIFDRRELPSGLRLYKRRVPIGVIGAIYEARPNVTVDIASLCLKAGNAVILRGGSDIARSVAATTEV
IALALEQAGLPAFAVQSIIDPDRELVRQLLRLDRYVDMIIPRGGAGLHRFCVENATVPVIVGGMGVSHIYVEPSADFARA
VPVIVNAKVQRPGACNALDTLLVHRAAASTFLPLVAAALAQHGVELRCDLEALAILADAPGHEAWNLKPASPTDFGCEFL
ALIVAIKIVGSIDEALDHIALYGGHSEAILTGDPISAERFTREVDATAVFVNASTRFNDGGQFGLGAEVAISTNRLHARG
PMGLQELTTYTWIGEGDYLVRA
>Mature_422_residues
MVDLEAIGRRAKTAARALAKLSTEQKNAALCAIADGLLARQDKILAANAADVADAEKGGTPPAIVDRMLLTPARLAAIAG
DCRQVASLPDPVGEIFDRRELPSGLRLYKRRVPIGVIGAIYEARPNVTVDIASLCLKAGNAVILRGGSDIARSVAATTEV
IALALEQAGLPAFAVQSIIDPDRELVRQLLRLDRYVDMIIPRGGAGLHRFCVENATVPVIVGGMGVSHIYVEPSADFARA
VPVIVNAKVQRPGACNALDTLLVHRAAASTFLPLVAAALAQHGVELRCDLEALAILADAPGHEAWNLKPASPTDFGCEFL
ALIVAIKIVGSIDEALDHIALYGGHSEAILTGDPISAERFTREVDATAVFVNASTRFNDGGQFGLGAEVAISTNRLHARG
PMGLQELTTYTWIGEGDYLVRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=423, Percent_Identity=36.6430260047281, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI21361368, Length=423, Percent_Identity=36.6430260047281, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1786438, Length=420, Percent_Identity=57.3809523809524, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17569969, Length=419, Percent_Identity=34.6062052505967, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17569967, Length=419, Percent_Identity=34.6062052505967, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=34.1801385681293, Blast_Score=237, Evalue=2e-63,
Organism=Drosophila melanogaster, GI21357643, Length=419, Percent_Identity=36.0381861575179, Blast_Score=245, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CHLAA (A9WBM7)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001635223.1
- ProteinModelPortal:   A9WBM7
- SMR:   A9WBM7
- GeneID:   5826062
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_1616
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44516; Mature: 44516

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLEAIGRRAKTAARALAKLSTEQKNAALCAIADGLLARQDKILAANAADVADAEKGGT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCEEECCCCHHCCCCCCCC
PPAIVDRMLLTPARLAAIAGDCRQVASLPDPVGEIFDRRELPSGLRLYKRRVPIGVIGAI
CHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHH
YEARPNVTVDIASLCLKAGNAVILRGGSDIARSVAATTEVIALALEQAGLPAFAVQSIID
HHCCCCCEEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
PDRELVRQLLRLDRYVDMIIPRGGAGLHRFCVENATVPVIVGGMGVSHIYVEPSADFARA
CCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCEEEEEECCCEEEEEECCCCCHHHH
VPVIVNAKVQRPGACNALDTLLVHRAAASTFLPLVAAALAQHGVELRCDLEALAILADAP
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHEEEECCC
GHEAWNLKPASPTDFGCEFLALIVAIKIVGSIDEALDHIALYGGHSEAILTGDPISAERF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCHHHH
TREVDATAVFVNASTRFNDGGQFGLGAEVAISTNRLHARGPMGLQELTTYTWIGEGDYLV
HHHCCCEEEEEECCCCCCCCCCCCCCCEEEEECCEEECCCCCCHHHHCEEEEECCCCEEE
RA
EC
>Mature Secondary Structure
MVDLEAIGRRAKTAARALAKLSTEQKNAALCAIADGLLARQDKILAANAADVADAEKGGT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCEEECCCCHHCCCCCCCC
PPAIVDRMLLTPARLAAIAGDCRQVASLPDPVGEIFDRRELPSGLRLYKRRVPIGVIGAI
CHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHH
YEARPNVTVDIASLCLKAGNAVILRGGSDIARSVAATTEVIALALEQAGLPAFAVQSIID
HHCCCCCEEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
PDRELVRQLLRLDRYVDMIIPRGGAGLHRFCVENATVPVIVGGMGVSHIYVEPSADFARA
CCHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCEEEEEECCCEEEEEECCCCCHHHH
VPVIVNAKVQRPGACNALDTLLVHRAAASTFLPLVAAALAQHGVELRCDLEALAILADAP
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHEEEECCC
GHEAWNLKPASPTDFGCEFLALIVAIKIVGSIDEALDHIALYGGHSEAILTGDPISAERF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCHHHH
TREVDATAVFVNASTRFNDGGQFGLGAEVAISTNRLHARGPMGLQELTTYTWIGEGDYLV
HHHCCCEEEEEECCCCCCCCCCCCCCCEEEEECCEEECCCCCCHHHHCEEEEECCCCEEE
RA
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA