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The map label for this gene is gmk [H]

Identifier: 222524955

GI number: 222524955

Start: 2134601

End: 2135230

Strand: Direct

Name: gmk [H]

Synonym: Chy400_1690

Alternate gene names: 222524955

Gene position: 2134601-2135230 (Clockwise)

Preceding gene: 222524951

Following gene: 222524956

Centisome position: 40.51

GC content: 55.08

Gene sequence:

>630_bases
ATGGAACCATTTCTCAATCCGATTTTACAGGGCAAACCACCACAGCCACTGCTCGTCGTCATTTCAGGGCCATCGGGTGT
GGGCAAAGACTCGGTCTTGATGCGCATGCGCGAGCTAGGCTTTCCGTTTCACTTTGTCGTCACGGCGAACAGTCGACCGC
AGCGACCGGGCGAGATTGACGGTGTTGACTACCATTTTGTCACGACCGAGCGTTTTCGCGAGATGATCGAGAACGATGAA
CTGCTGGAGTGGGCCGAGGTCTACGGCCAGTATAAAGGGATTCCCAAATTCGAGATTCGGCAGGCAATGGCCAGTGGTCG
CGATGTTATTCTACGAATTAACGTTGATGGTGCAGCAACAATTAAGCGGTTGGCTCCCGAAGCCGTCTTTATTTTTCTGG
CGCCGGCTTCGCTCGACGAGCTACGCCACCGGCTCTTGCTCCGCCGAACCGAGTCGCCGGCGGAAGTGGAACGGCGGTTA
GCCATGGTTGCCGATGAATTGGCCCAGTTACCCAATTTCGATTACGTCGTTATCAATCACGCCGACCGACTTGACGAAGC
GGTTGGTCAGATCCGTGCCATTATTAGCGCTGAAAAGGCGCGCGTGTACCCGCGTCGAATTTCCCTCTAG

Upstream 100 bases:

>100_bases
CTTCCACGACGGCAGTCAAAGTCAGGGCATCAAAGTACATATAACCACAAGTAATACGAGAACCGACACCTTTGGCAGGA
TACCACAATCGGGTACAGGC

Downstream 100 bases:

>100_bases
CTTTTTGAACCGGGGAGTACTACAATGAGTATTCAAGAGCGCTTAACGAATGATTTGAAAGAGGCAATGCGTGCCGGCGA
CAAGGTTCGCGTAAATGCGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MEPFLNPILQGKPPQPLLVVISGPSGVGKDSVLMRMRELGFPFHFVVTANSRPQRPGEIDGVDYHFVTTERFREMIENDE
LLEWAEVYGQYKGIPKFEIRQAMASGRDVILRINVDGAATIKRLAPEAVFIFLAPASLDELRHRLLLRRTESPAEVERRL
AMVADELAQLPNFDYVVINHADRLDEAVGQIRAIISAEKARVYPRRISL

Sequences:

>Translated_209_residues
MEPFLNPILQGKPPQPLLVVISGPSGVGKDSVLMRMRELGFPFHFVVTANSRPQRPGEIDGVDYHFVTTERFREMIENDE
LLEWAEVYGQYKGIPKFEIRQAMASGRDVILRINVDGAATIKRLAPEAVFIFLAPASLDELRHRLLLRRTESPAEVERRL
AMVADELAQLPNFDYVVINHADRLDEAVGQIRAIISAEKARVYPRRISL
>Mature_209_residues
MEPFLNPILQGKPPQPLLVVISGPSGVGKDSVLMRMRELGFPFHFVVTANSRPQRPGEIDGVDYHFVTTERFREMIENDE
LLEWAEVYGQYKGIPKFEIRQAMASGRDVILRINVDGAATIKRLAPEAVFIFLAPASLDELRHRLLLRRTESPAEVERRL
AMVADELAQLPNFDYVVINHADRLDEAVGQIRAIISAEKARVYPRRISL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=37.037037037037, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=37.037037037037, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=37.037037037037, Blast_Score=101, Evalue=4e-22,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=37.17277486911, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=194, Percent_Identity=32.4742268041237, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=32.5966850828729, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320662, Length=186, Percent_Identity=38.7096774193548, Blast_Score=132, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21356141, Length=188, Percent_Identity=34.5744680851064, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161077626, Length=165, Percent_Identity=30.3030303030303, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007136, Length=165, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85724806, Length=165, Percent_Identity=30.3030303030303, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554489, Length=165, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640542, Length=165, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45554481, Length=165, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23688; Mature: 23688

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPFLNPILQGKPPQPLLVVISGPSGVGKDSVLMRMRELGFPFHFVVTANSRPQRPGEID
CCCHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
GVDYHFVTTERFREMIENDELLEWAEVYGQYKGIPKFEIRQAMASGRDVILRINVDGAAT
CCEEEEECHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCHHH
IKRLAPEAVFIFLAPASLDELRHRLLLRRTESPAEVERRLAMVADELAQLPNFDYVVINH
HHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEC
ADRLDEAVGQIRAIISAEKARVYPRRISL
HHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MEPFLNPILQGKPPQPLLVVISGPSGVGKDSVLMRMRELGFPFHFVVTANSRPQRPGEID
CCCHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
GVDYHFVTTERFREMIENDELLEWAEVYGQYKGIPKFEIRQAMASGRDVILRINVDGAAT
CCEEEEECHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCHHH
IKRLAPEAVFIFLAPASLDELRHRLLLRRTESPAEVERRLAMVADELAQLPNFDYVVINH
HHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEC
ADRLDEAVGQIRAIISAEKARVYPRRISL
HHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA