Click here to switch to the map view.

The map label for this gene is upp [H]

Identifier: 222524929

GI number: 222524929

Start: 2093158

End: 2093787

Strand: Direct

Name: upp [H]

Synonym: Chy400_1663

Alternate gene names: 222524929

Gene position: 2093158-2093787 (Clockwise)

Preceding gene: 222524928

Following gene: 222524930

Centisome position: 39.73

GC content: 54.92

Gene sequence:

>630_bases
ATGTCTTCAGCAGTATTTGTATCACGGCATCCACTGGTTCAACATAAGCTGGCCCTTTTGCGTAGTAAATGGACTGAACC
GAAGAAGTTTCGCGAACTGGTACGTGAAATTGCTCAACTGTTGTTCTACGAAGCCACTCAGGACCTGGCACTGGCACCAT
TAACGGTTGAAACACCGCTAGCGACATGCGCCGGCTATGAGGTGGCTGAACGCATCGGGATCATTCCGATTCTGCGTGCC
GGTTTGGGCATGGCAGAGGCGATTGTCGAGATTTTACCGACCGTTCATGTATGGCATCTCGGCCTGTATCGGGACCACGA
GACCCTGCAACCGGTAACGTACTATAACAAGCTACCGAGCAAGCCGGACATCGATCTGACGATTATCGTCGATCCAATGC
TGGCAACCGGTGGTTCGGCGGTTGCTGCGGTAGATATTCTCAAGCAGTGGGGTGCGCAGCGCATCAAGTTTCTGGGCCTG
ATTGCTGCTCCAGAAGGGGTTCGGGCACTGAGCGAAGCCCACCCCGATGTTGCGATCCATCTGGCCGCGATTGACAGTCA
TCTCAACGAGCGGGGCTATATTGTGCCGGGGTTGGGAGACGCCGGTGATCGTCAGTTCGGGACGGGGTAA

Upstream 100 bases:

>100_bases
GCGGGGTAGGGTACAAACTTGAACGGCTTTAGGCCAATAATCACCCGATCAACACCACAAGCGTCGAGTGCGGTGCTTCT
GTATACCGCAGGATAGGACT

Downstream 100 bases:

>100_bases
AAAATAATATCCTACGGAGCGGGTTTCCGGAGAGATTAGGTTCCGAAGGCGGGCACGGGCGCTTGCCGGTGCTACGGTAC
CAGCGGAAACAGTAGCACCA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSSAVFVSRHPLVQHKLALLRSKWTEPKKFRELVREIAQLLFYEATQDLALAPLTVETPLATCAGYEVAERIGIIPILRA
GLGMAEAIVEILPTVHVWHLGLYRDHETLQPVTYYNKLPSKPDIDLTIIVDPMLATGGSAVAAVDILKQWGAQRIKFLGL
IAAPEGVRALSEAHPDVAIHLAAIDSHLNERGYIVPGLGDAGDRQFGTG

Sequences:

>Translated_209_residues
MSSAVFVSRHPLVQHKLALLRSKWTEPKKFRELVREIAQLLFYEATQDLALAPLTVETPLATCAGYEVAERIGIIPILRA
GLGMAEAIVEILPTVHVWHLGLYRDHETLQPVTYYNKLPSKPDIDLTIIVDPMLATGGSAVAAVDILKQWGAQRIKFLGL
IAAPEGVRALSEAHPDVAIHLAAIDSHLNERGYIVPGLGDAGDRQFGTG
>Mature_208_residues
SSAVFVSRHPLVQHKLALLRSKWTEPKKFRELVREIAQLLFYEATQDLALAPLTVETPLATCAGYEVAERIGIIPILRAG
LGMAEAIVEILPTVHVWHLGLYRDHETLQPVTYYNKLPSKPDIDLTIIVDPMLATGGSAVAAVDILKQWGAQRIKFLGLI
AAPEGVRALSEAHPDVAIHLAAIDSHLNERGYIVPGLGDAGDRQFGTG

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.6930693069307, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.6930693069307, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI87082118, Length=201, Percent_Identity=50.7462686567164, Blast_Score=210, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17539892, Length=137, Percent_Identity=30.6569343065693, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=137, Percent_Identity=30.6569343065693, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=214, Percent_Identity=34.5794392523364, Blast_Score=111, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28573516, Length=207, Percent_Identity=28.9855072463768, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573514, Length=207, Percent_Identity=28.9855072463768, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28573512, Length=207, Percent_Identity=28.9855072463768, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550449, Length=207, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22797; Mature: 22666

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAVFVSRHPLVQHKLALLRSKWTEPKKFRELVREIAQLLFYEATQDLALAPLTVETPL
CCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCH
ATCAGYEVAERIGIIPILRAGLGMAEAIVEILPTVHVWHLGLYRDHETLQPVTYYNKLPS
HHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHCHHHHHHHHEECCCCCCCHHHHHHCCCC
KPDIDLTIIVDPMLATGGSAVAAVDILKQWGAQRIKFLGLIAAPEGVRALSEAHPDVAIH
CCCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCEEE
LAAIDSHLNERGYIVPGLGDAGDRQFGTG
HHHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SSAVFVSRHPLVQHKLALLRSKWTEPKKFRELVREIAQLLFYEATQDLALAPLTVETPL
CCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCH
ATCAGYEVAERIGIIPILRAGLGMAEAIVEILPTVHVWHLGLYRDHETLQPVTYYNKLPS
HHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHCHHHHHHHHEECCCCCCCHHHHHHCCCC
KPDIDLTIIVDPMLATGGSAVAAVDILKQWGAQRIKFLGLIAAPEGVRALSEAHPDVAIH
CCCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCEEE
LAAIDSHLNERGYIVPGLGDAGDRQFGTG
HHHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA