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The map label for this gene is algC [H]

Identifier: 222524914

GI number: 222524914

Start: 2077959

End: 2079338

Strand: Direct

Name: algC [H]

Synonym: Chy400_1648

Alternate gene names: 222524914

Gene position: 2077959-2079338 (Clockwise)

Preceding gene: 222524897

Following gene: 222524915

Centisome position: 39.44

GC content: 57.61

Gene sequence:

>1380_bases
ATGGGCGTAGCGCTCAATCAAACGATTTTCCGGGCGTATGATATTCGCGGTATTGTTGAGGTTGATCTCGATGAGGCGAT
CTATGAACGGTTAGGGCGCGCAACCGGCACGCTCTTCCGCAACGAGGGCCGGCAGCGGATTGTCGTGGCCCGTGATGCTC
GCCTCAGTTCACCGCGATTTCAAGCAGCATTAATTCACGGCTTACGTGCCACCGGGATGGATGTGATCGATATTGGTATG
GTGGCAACGCCGGTGATGTATTTTGCGGTTGAGGCATTAGGGGCTGATGCCGGGGCCATTGTTTCGGCCAGTCACAATCC
GCCGGAATTTAATGGTCTGAAGTTACGCCGCGCAGAACCGCGCTTTGGGTCTGAACCATTACCATCGGCTGCTATTCAAG
AAGTGGGACGGATCGCCGCTTCTGGGGAGTTCGCTCAGGGGAGTGGTGGCTACGAGCAGGTGGACATCGGCCCGGCCTAT
GTCGAGTCGGCACGGCGCTGGATTGATTTCGGCGGTCGACGTCCTCGCGTTGTGCTGGATGGTGGGAATGGTGTGGCCGG
GCCGCTGGCTGTCGCAATGTATGAGGCGTTGGGGATTGAGGTTATTCCCCTCTTCATTGAGCCAGATGGTACCTTTCCCA
ACCATCATCCCGATCCGTTGAAGGTCGAGAACCTGCGCCACTTGCAGGCCGCGGTCCGCGAATACCGGGCCGATCTCGGT
ATTGGGCTTGATGGTGATGGGGATCGGCTGGGTGTAGTTGATGGTCATGGCGAGGTGGTGTTTGCCGACCGCTATCTGAT
TGTGCTGGCGAAGGCGCTCCTGGCGAAGCGCAAAGGGCCAGTGGTCTTCGATGTGAAGTGTAGTGCGGTGTTACCCCAGG
CTATCCGCGAGTTGGGTGGTGAACCGGTAATGTGGAAGACCGGCTACACCAGCCTCTCGGCGAAGATGCGCGAGATTGAT
GCCGTACTGGGGGGTGAGCTGAGCGGACATACGATCTTTCCGTTCCCCGGGCGGTACTTCGACGATGGCGCGTTTGCCGG
TGCAGTGCTCTTGCATGCGCTGTCAGAGCTGGGGCAGACGCTCAGCGAAGCATTGGCACCGTATCCGGTATTGCCTTCAA
TTGATGAAGGACGAATCCCGTTTCCTGAAGAACGGAAGTTTGCAGTGATCGATTTCTTGCGCGAGCGATTTACCGGTAAG
TATCCGATTATTGATATCGACGGGGTGCGCATCGATTTTGGTGATGGGTGGGGGCTGGTGCGTGCCTCAAATACCGAGCC
GGCAATTACGACCCGCTTCGAGGCGCAGACGTGGGAGCGCGTTCAAGCAATTCGTGATGAGATGTTGAGTGTCGTCGAGG
AGTTCCGCACACGGGCATGA

Upstream 100 bases:

>100_bases
ATTCAATCTTGACGGATGGTATGCTTTCGGCTAGGATCGAACCAACCCGATTAATATGGTGTGACGTTGGCGGGGAACGT
CGTCCACAACAGAGGTAAGC

Downstream 100 bases:

>100_bases
GCGCGTATCGACGCCCTTTCCTACAGTCGTGGGAGGCAGCGTATACTGCCGGGTTCACGCTTGAACACCTGCGTCGCCGG
GCGATGACGGTTGGTATGGC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MGVALNQTIFRAYDIRGIVEVDLDEAIYERLGRATGTLFRNEGRQRIVVARDARLSSPRFQAALIHGLRATGMDVIDIGM
VATPVMYFAVEALGADAGAIVSASHNPPEFNGLKLRRAEPRFGSEPLPSAAIQEVGRIAASGEFAQGSGGYEQVDIGPAY
VESARRWIDFGGRRPRVVLDGGNGVAGPLAVAMYEALGIEVIPLFIEPDGTFPNHHPDPLKVENLRHLQAAVREYRADLG
IGLDGDGDRLGVVDGHGEVVFADRYLIVLAKALLAKRKGPVVFDVKCSAVLPQAIRELGGEPVMWKTGYTSLSAKMREID
AVLGGELSGHTIFPFPGRYFDDGAFAGAVLLHALSELGQTLSEALAPYPVLPSIDEGRIPFPEERKFAVIDFLRERFTGK
YPIIDIDGVRIDFGDGWGLVRASNTEPAITTRFEAQTWERVQAIRDEMLSVVEEFRTRA

Sequences:

>Translated_459_residues
MGVALNQTIFRAYDIRGIVEVDLDEAIYERLGRATGTLFRNEGRQRIVVARDARLSSPRFQAALIHGLRATGMDVIDIGM
VATPVMYFAVEALGADAGAIVSASHNPPEFNGLKLRRAEPRFGSEPLPSAAIQEVGRIAASGEFAQGSGGYEQVDIGPAY
VESARRWIDFGGRRPRVVLDGGNGVAGPLAVAMYEALGIEVIPLFIEPDGTFPNHHPDPLKVENLRHLQAAVREYRADLG
IGLDGDGDRLGVVDGHGEVVFADRYLIVLAKALLAKRKGPVVFDVKCSAVLPQAIRELGGEPVMWKTGYTSLSAKMREID
AVLGGELSGHTIFPFPGRYFDDGAFAGAVLLHALSELGQTLSEALAPYPVLPSIDEGRIPFPEERKFAVIDFLRERFTGK
YPIIDIDGVRIDFGDGWGLVRASNTEPAITTRFEAQTWERVQAIRDEMLSVVEEFRTRA
>Mature_458_residues
GVALNQTIFRAYDIRGIVEVDLDEAIYERLGRATGTLFRNEGRQRIVVARDARLSSPRFQAALIHGLRATGMDVIDIGMV
ATPVMYFAVEALGADAGAIVSASHNPPEFNGLKLRRAEPRFGSEPLPSAAIQEVGRIAASGEFAQGSGGYEQVDIGPAYV
ESARRWIDFGGRRPRVVLDGGNGVAGPLAVAMYEALGIEVIPLFIEPDGTFPNHHPDPLKVENLRHLQAAVREYRADLGI
GLDGDGDRLGVVDGHGEVVFADRYLIVLAKALLAKRKGPVVFDVKCSAVLPQAIRELGGEPVMWKTGYTSLSAKMREIDA
VLGGELSGHTIFPFPGRYFDDGAFAGAVLLHALSELGQTLSEALAPYPVLPSIDEGRIPFPEERKFAVIDFLRERFTGKY
PIIDIDGVRIDFGDGWGLVRASNTEPAITTRFEAQTWERVQAIRDEMLSVVEEFRTRA

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=454, Percent_Identity=34.5814977973568, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1789566, Length=358, Percent_Identity=29.3296089385475, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50008; Mature: 49876

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVALNQTIFRAYDIRGIVEVDLDEAIYERLGRATGTLFRNEGRQRIVVARDARLSSPRF
CCCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHH
QAALIHGLRATGMDVIDIGMVATPVMYFAVEALGADAGAIVSASHNPPEFNGLKLRRAEP
HHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCC
RFGSEPLPSAAIQEVGRIAASGEFAQGSGGYEQVDIGPAYVESARRWIDFGGRRPRVVLD
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEE
GGNGVAGPLAVAMYEALGIEVIPLFIEPDGTFPNHHPDPLKVENLRHLQAAVREYRADLG
CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
IGLDGDGDRLGVVDGHGEVVFADRYLIVLAKALLAKRKGPVVFDVKCSAVLPQAIRELGG
CCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCC
EPVMWKTGYTSLSAKMREIDAVLGGELSGHTIFPFPGRYFDDGAFAGAVLLHALSELGQT
CCEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
LSEALAPYPVLPSIDEGRIPFPEERKFAVIDFLRERFTGKYPIIDIDGVRIDFGDGWGLV
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCCCEEE
RASNTEPAITTRFEAQTWERVQAIRDEMLSVVEEFRTRA
EECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVALNQTIFRAYDIRGIVEVDLDEAIYERLGRATGTLFRNEGRQRIVVARDARLSSPRF
CCCCCHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHH
QAALIHGLRATGMDVIDIGMVATPVMYFAVEALGADAGAIVSASHNPPEFNGLKLRRAEP
HHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCC
RFGSEPLPSAAIQEVGRIAASGEFAQGSGGYEQVDIGPAYVESARRWIDFGGRRPRVVLD
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCEEEEE
GGNGVAGPLAVAMYEALGIEVIPLFIEPDGTFPNHHPDPLKVENLRHLQAAVREYRADLG
CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
IGLDGDGDRLGVVDGHGEVVFADRYLIVLAKALLAKRKGPVVFDVKCSAVLPQAIRELGG
CCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHCCC
EPVMWKTGYTSLSAKMREIDAVLGGELSGHTIFPFPGRYFDDGAFAGAVLLHALSELGQT
CCEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
LSEALAPYPVLPSIDEGRIPFPEERKFAVIDFLRERFTGKYPIIDIDGVRIDFGDGWGLV
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCEEEEECCCCEEE
RASNTEPAITTRFEAQTWERVQAIRDEMLSVVEEFRTRA
EECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]