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The map label for this gene is fumC [H]

Identifier: 222524839

GI number: 222524839

Start: 1992352

End: 1993770

Strand: Reverse

Name: fumC [H]

Synonym: Chy400_1566

Alternate gene names: 222524839

Gene position: 1993770-1992352 (Counterclockwise)

Preceding gene: 222524840

Following gene: 222524833

Centisome position: 37.84

GC content: 59.62

Gene sequence:

>1419_bases
ATGGCTGAAGGTTATCGCATTGAACGCGACTCGTTAGGCGAGATGCAGGTACCGGCTAATGCCCTCTACGGTGCCCAAAC
GCAGCGTGCGGTGCTGAACTTCCCGGTGAGCGGGATGCGGCCCTACCCGGCCTTCGTCTGGGCCCAGACGATGATCAAAC
GAGCCGCTGCTGAAGTGAACCGCGACCTTGGTCTGCTTGATCCGCAGATCGCCAACGCCATTATTCAGGCCGCCGAAGAA
GTCCTGGCCGGCCAACACGCCGATCAGTTTGTCGTCGATCCGTTTCAGGCCGGCGCCGGTACGTCTCACAACATGAACGT
CAACGAAGTGCTGGCCAACCGGGCTAACCAGATTCTCGGCTACAGCCTCGACGATCCGAAGAAACCGGTCAGCCCGAACG
ACCACGTCAACATGGCGCAATCGACGAACGATACCATTCCAACCGCAATCCGCCTGGGTTGTTTGTGGCGTCTACCCGAA
CTGATCGCCGCTATTGATGACCTCGCCGATGCGCTTGAACAAAAAGCGATTGAATTCGACGATGTCGTCAAATCGGGGCG
CACCCACCTGCAAGATGCTGTTCCGGTGCGGCTCGGCCAGGAGTTCGGTGCATACGCCAAGGCCGTGCGCAACGACATGG
AGCGCATCGTCACTGCCGCCAATCGGCTCCGTCGGCTAGGCATCGGCGGCACAGCCACCGGCACCGGTCTCAACGCGCAC
CCGGAATACCACAGCCGCATGGTCGCCAAACTCAGTGAACTCACCGGTCATGAACTTGTCTCGTCGGGGAACCTGTTCGA
GTCGATGCAAAGCATGGCCGATCCCGCCGATTTCTCGGCCAGCCTGCGCACCCTCTGCATCACGCTGGGCCGCATCGCCA
ACGACTTCCGGCTCCTCTCTTCCGGCCCGGCGACCGGTCTCGACGAAATCCGGCTACCTGCCGTCCAACCCGGTTCCTCG
ATTATGCCGGGTAAAGTCAATCCGGTATTGGCCGAAATGCTGAACATGGCCTGCTACCACGTGCAGGGTTGTGACCTGAC
CGTAGCCCTGGCGGCACAGGCCGGTCAGCTCGAACTGAACGTGATGATGCCAATCATTGCGCACAACCTGTTTGAGATGA
TGCATGTGCTGATCGGCGCAATCAATGCCTTCACGACGAAGTGTGTGGTTGGCATCACCGCCAATCGCGAGAAGGCGGCG
GGCTGGCTGGCGAAGAATGCCATTCTGGTAACGGCGCTGAACCCCGTGATCGGATATCTGAACGGTGCAGCGGTCGCGAA
AGAGGCGATGGCTACCGGCAAAACCATCAAAGAAGTGGTGGTCGAAAAGGGTCTCCTTACCGCCGAACAGGTCGATGAAC
TCCTCGATGTACGGAAGATGACCGAAGGCGGGATTCAGGGCATTGCCGCAGCCGGTTAA

Upstream 100 bases:

>100_bases
ATCTCGCCTGCGTTATGATACAATCGCCCTGTAACGCGACACAATCCATGCGAGACAGGAATGCATGGTCGCTTCCTGCT
GCATGAAAGGAGCTGAACTC

Downstream 100 bases:

>100_bases
GGCGCTCTGACCTGAACCAGAGATACAAGCGAGGGGTGGCCTGGAGCCGCCCCTCGCTACATTATGATCTGAAACACGGT
GATTCTGACTCTTGTGATCG

Product: fumarate lyase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAEGYRIERDSLGEMQVPANALYGAQTQRAVLNFPVSGMRPYPAFVWAQTMIKRAAAEVNRDLGLLDPQIANAIIQAAEE
VLAGQHADQFVVDPFQAGAGTSHNMNVNEVLANRANQILGYSLDDPKKPVSPNDHVNMAQSTNDTIPTAIRLGCLWRLPE
LIAAIDDLADALEQKAIEFDDVVKSGRTHLQDAVPVRLGQEFGAYAKAVRNDMERIVTAANRLRRLGIGGTATGTGLNAH
PEYHSRMVAKLSELTGHELVSSGNLFESMQSMADPADFSASLRTLCITLGRIANDFRLLSSGPATGLDEIRLPAVQPGSS
IMPGKVNPVLAEMLNMACYHVQGCDLTVALAAQAGQLELNVMMPIIAHNLFEMMHVLIGAINAFTTKCVVGITANREKAA
GWLAKNAILVTALNPVIGYLNGAAVAKEAMATGKTIKEVVVEKGLLTAEQVDELLDVRKMTEGGIQGIAAAG

Sequences:

>Translated_472_residues
MAEGYRIERDSLGEMQVPANALYGAQTQRAVLNFPVSGMRPYPAFVWAQTMIKRAAAEVNRDLGLLDPQIANAIIQAAEE
VLAGQHADQFVVDPFQAGAGTSHNMNVNEVLANRANQILGYSLDDPKKPVSPNDHVNMAQSTNDTIPTAIRLGCLWRLPE
LIAAIDDLADALEQKAIEFDDVVKSGRTHLQDAVPVRLGQEFGAYAKAVRNDMERIVTAANRLRRLGIGGTATGTGLNAH
PEYHSRMVAKLSELTGHELVSSGNLFESMQSMADPADFSASLRTLCITLGRIANDFRLLSSGPATGLDEIRLPAVQPGSS
IMPGKVNPVLAEMLNMACYHVQGCDLTVALAAQAGQLELNVMMPIIAHNLFEMMHVLIGAINAFTTKCVVGITANREKAA
GWLAKNAILVTALNPVIGYLNGAAVAKEAMATGKTIKEVVVEKGLLTAEQVDELLDVRKMTEGGIQGIAAAG
>Mature_471_residues
AEGYRIERDSLGEMQVPANALYGAQTQRAVLNFPVSGMRPYPAFVWAQTMIKRAAAEVNRDLGLLDPQIANAIIQAAEEV
LAGQHADQFVVDPFQAGAGTSHNMNVNEVLANRANQILGYSLDDPKKPVSPNDHVNMAQSTNDTIPTAIRLGCLWRLPEL
IAAIDDLADALEQKAIEFDDVVKSGRTHLQDAVPVRLGQEFGAYAKAVRNDMERIVTAANRLRRLGIGGTATGTGLNAHP
EYHSRMVAKLSELTGHELVSSGNLFESMQSMADPADFSASLRTLCITLGRIANDFRLLSSGPATGLDEIRLPAVQPGSSI
MPGKVNPVLAEMLNMACYHVQGCDLTVALAAQAGQLELNVMMPIIAHNLFEMMHVLIGAINAFTTKCVVGITANREKAAG
WLAKNAILVTALNPVIGYLNGAAVAKEAMATGKTIKEVVVEKGLLTAEQVDELLDVRKMTEGGIQGIAAAG

Specific function: Unknown

COG id: COG1027

COG function: function code E; Aspartate ammonia-lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=45.6521739130435, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=45.5723542116631, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=42.5438596491228, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790398, Length=248, Percent_Identity=26.2096774193548, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=44.0087145969499, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=41.358024691358, Blast_Score=251, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324993, Length=457, Percent_Identity=43.9824945295405, Blast_Score=372, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=43.9655172413793, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=43.9655172413793, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=43.0735930735931, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=41.0869565217391, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=38.6117136659436, Blast_Score=329, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50450; Mature: 50318

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AEGYRIERDSLGEMQVPANALYGAQTQRAVLNFPVSGMRPYPAFVWAQTMIKRAAAEVN
CCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH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CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]