Click here to switch to the map view.

The map label for this gene is bfmBAB [H]

Identifier: 222524729

GI number: 222524729

Start: 1841946

End: 1842932

Strand: Reverse

Name: bfmBAB [H]

Synonym: Chy400_1456

Alternate gene names: 222524729

Gene position: 1842932-1841946 (Counterclockwise)

Preceding gene: 222524730

Following gene: 222524728

Centisome position: 34.98

GC content: 45.9

Gene sequence:

>987_bases
ATGCGTGAAATTACTTATGTCGAAGCAATTCGTGAAGCCCTACGGCAGAAGATGAAAGAAGATGAAACGGTTTTTTTGAT
TGGCGAAGATATTGGCTTGTATGGTGGTGCATTCGGTGCAACAGCAGGGTTAATCGAAGAATTCGGCGAAGATCGGGTTA
TCGACACTCCGATTTCGGAAGCTGGTATTGCTGGCGCTTGCATTGGTGCAGCATTAACAGGTTTTCGTCCTGTAGGGGAG
ATTCAATTCATGGATTTTGTTACCCTCAGTATGGAGCAGTTAGTATTGCAGGCAGCGAAGATTCGTTTCATGTTCGGTGG
TAAAGCCAGCGTACCCTTCGTTTTGCGCATGCCGGGTGGTGCAGGTACCGGAGCGGCAGCTCAGCATTCAGAAAGTTTGG
AGAATTGGTTTGTTCATATACCGGGCTTGAAAGTAGTAATGCCTGCAACACCCTACGATGCGAAGGGATTGCTCATCGCA
TCGATTGAAGACAATAACCCTGTCATATTTATCGAACATAAGCTTTTGTATAAAACAAAAGGTGTTGTACCAGAAGATAT
ATATCGAGTTCCTCTTGGAAAGAGTCACGTAGTTCGCCAGGGTCGTGATGTCACAATTGTTGCCACTTCGGTGATGGTAC
AACGAGCACTTGAAGCTGCTGAACAATTGGCTCGAGAAGGAATAGAAGCAGAAATCATTGATCCGCGAACGTTGCGACCT
TTAGATGATGAACCAATTCTAGAGTCGGTGGTAAAAACCGGTAAGGTGTTAATAGTGCATGAAGCTGTTAAGATGGCTGG
CTTTGGTGGCGAGATCGCTGCTCGGATCGCTGAAAGTACGGCCTTTGATTACCTCGAGGCGCCTATTTGCCGACTTGGTG
GACTCGATATTCCCATCCCATATAACCGAACTCTTGAATATCACGCAGTGCCTCAGATTGAAAATATTATTGCGGCTGCT
CGTGATTTAGTAGCATTAAGAGTGTGA

Upstream 100 bases:

>100_bases
AAAGCTATCGTTGATCAAGCTCGGACTATGATCGAGGAAGCGGTCGAATTTGCTCAGGCCAGTCCGGAACCTGATCCTGA
TACTATTTTTGAGGGATTGT

Downstream 100 bases:

>100_bases
GGAAACAATGGTGCGTGAAGTAATTATGCCAAAATTTGGCTTTACCCAGGAGACTGCAGAAATTGTTCGCTGGATTAAAC
GTGAGGGTGATTTGGTTGAT

Product: transketolase central subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MREITYVEAIREALRQKMKEDETVFLIGEDIGLYGGAFGATAGLIEEFGEDRVIDTPISEAGIAGACIGAALTGFRPVGE
IQFMDFVTLSMEQLVLQAAKIRFMFGGKASVPFVLRMPGGAGTGAAAQHSESLENWFVHIPGLKVVMPATPYDAKGLLIA
SIEDNNPVIFIEHKLLYKTKGVVPEDIYRVPLGKSHVVRQGRDVTIVATSVMVQRALEAAEQLAREGIEAEIIDPRTLRP
LDDEPILESVVKTGKVLIVHEAVKMAGFGGEIAARIAESTAFDYLEAPICRLGGLDIPIPYNRTLEYHAVPQIENIIAAA
RDLVALRV

Sequences:

>Translated_328_residues
MREITYVEAIREALRQKMKEDETVFLIGEDIGLYGGAFGATAGLIEEFGEDRVIDTPISEAGIAGACIGAALTGFRPVGE
IQFMDFVTLSMEQLVLQAAKIRFMFGGKASVPFVLRMPGGAGTGAAAQHSESLENWFVHIPGLKVVMPATPYDAKGLLIA
SIEDNNPVIFIEHKLLYKTKGVVPEDIYRVPLGKSHVVRQGRDVTIVATSVMVQRALEAAEQLAREGIEAEIIDPRTLRP
LDDEPILESVVKTGKVLIVHEAVKMAGFGGEIAARIAESTAFDYLEAPICRLGGLDIPIPYNRTLEYHAVPQIENIIAAA
RDLVALRV
>Mature_328_residues
MREITYVEAIREALRQKMKEDETVFLIGEDIGLYGGAFGATAGLIEEFGEDRVIDTPISEAGIAGACIGAALTGFRPVGE
IQFMDFVTLSMEQLVLQAAKIRFMFGGKASVPFVLRMPGGAGTGAAAQHSESLENWFVHIPGLKVVMPATPYDAKGLLIA
SIEDNNPVIFIEHKLLYKTKGVVPEDIYRVPLGKSHVVRQGRDVTIVATSVMVQRALEAAEQLAREGIEAEIIDPRTLRP
LDDEPILESVVKTGKVLIVHEAVKMAGFGGEIAARIAESTAFDYLEAPICRLGGLDIPIPYNRTLEYHAVPQIENIIAAA
RDLVALRV

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=328, Percent_Identity=41.7682926829268, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI291084858, Length=323, Percent_Identity=39.6284829721362, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4557353, Length=327, Percent_Identity=39.4495412844037, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI34101272, Length=327, Percent_Identity=39.4495412844037, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17538422, Length=322, Percent_Identity=43.4782608695652, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=40.7975460122699, Blast_Score=216, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6319698, Length=330, Percent_Identity=40.9090909090909, Blast_Score=266, Evalue=2e-72,
Organism=Drosophila melanogaster, GI21358145, Length=322, Percent_Identity=42.2360248447205, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24650940, Length=322, Percent_Identity=42.2360248447205, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI160714828, Length=329, Percent_Identity=39.209726443769, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI160714832, Length=327, Percent_Identity=39.4495412844037, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24650943, Length=100, Percent_Identity=38, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650945, Length=100, Percent_Identity=38, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35593; Mature: 35593

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREITYVEAIREALRQKMKEDETVFLIGEDIGLYGGAFGATAGLIEEFGEDRVIDTPISE
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCHH
AGIAGACIGAALTGFRPVGEIQFMDFVTLSMEQLVLQAAKIRFMFGGKASVPFVLRMPGG
CCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCC
AGTGAAAQHSESLENWFVHIPGLKVVMPATPYDAKGLLIASIEDNNPVIFIEHKLLYKTK
CCCCCHHHHHHHHHHEEEECCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEEEEHHC
GVVPEDIYRVPLGKSHVVRQGRDVTIVATSVMVQRALEAAEQLAREGIEAEIIDPRTLRP
CCCHHHHEECCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
LDDEPILESVVKTGKVLIVHEAVKMAGFGGEIAARIAESTAFDYLEAPICRLGGLDIPIP
CCCCHHHHHHHHCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
YNRTLEYHAVPQIENIIAAARDLVALRV
CCCCEEEECCCHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MREITYVEAIREALRQKMKEDETVFLIGEDIGLYGGAFGATAGLIEEFGEDRVIDTPISE
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCHH
AGIAGACIGAALTGFRPVGEIQFMDFVTLSMEQLVLQAAKIRFMFGGKASVPFVLRMPGG
CCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCC
AGTGAAAQHSESLENWFVHIPGLKVVMPATPYDAKGLLIASIEDNNPVIFIEHKLLYKTK
CCCCCHHHHHHHHHHEEEECCCEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEEEEHHC
GVVPEDIYRVPLGKSHVVRQGRDVTIVATSVMVQRALEAAEQLAREGIEAEIIDPRTLRP
CCCHHHHEECCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
LDDEPILESVVKTGKVLIVHEAVKMAGFGGEIAARIAESTAFDYLEAPICRLGGLDIPIP
CCCCHHHHHHHHCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
YNRTLEYHAVPQIENIIAAARDLVALRV
CCCCEEEECCCHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]