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The map label for this gene is pleC [H]

Identifier: 222524660

GI number: 222524660

Start: 1766774

End: 1768213

Strand: Reverse

Name: pleC [H]

Synonym: Chy400_1387

Alternate gene names: 222524660

Gene position: 1768213-1766774 (Counterclockwise)

Preceding gene: 222524661

Following gene: 222524659

Centisome position: 33.56

GC content: 56.53

Gene sequence:

>1440_bases
ATGGTTGCGCGTACTCTCAACCCCGCTCGCACTCCGGTCGCAACACCCGATGAAGGGTTGGTCACCGACCTGTTACCACC
GATGCTCATCCTGCTGGCTACGCTGGCGGGAGCGGCGACCGGTATTTTGCTCCTCAATCGCTGGAGTGGCAATTTCTGGC
CCTACCTGATTATCGGCTTACTGCTCGTCTGTCTCGCGGTGAGTGATCGGCTGCGGCGGCGAGGCGATTTACGCATGGCC
AGTATCGTTGTCGTTGCCGCGATAACATTATTGCCCGTGCTGAGTTGTGCTGCCTTTGGGTTTACAAACAATATCTTTAT
CTACCTCTCGGTACTGGGGGTTTTTGCTGCCGGGATCATAGTCTCGTCGCGCGCACCGTTTCGTGCCGGGCAGGCCGCGA
TTCTGCTGTACCTGCTTCTCTTGCTGGGTGCCGACCTGATCGGGCAGCCACGACCGACCTGGTTCGAGGTGATCGGTCAT
CTGTTGCTGCTGATCGCCTTGTTGTTCGGCGCAGCGACGCTCAGTTGGGCGGCAGCCTATGTGGTGCGCGGGACGATCAG
TTGGGCGATTGATACGGCTCAAAAATCCGAGCGGCGTGAGCAGTTGCTGCGAGAGACGCAGGCGACGCTGGAGCGGGCAC
TGCTTGAGCGTGATCTCTTGAATGAGCAGCTCTACCGTACCACGCTTGAGCTTGAAGAAGCGCGTGCTGCTGCCGAAGCG
GCGTATCGCTCGAAATCCAATTTTATGGCCACAATGTCGCACGAATTGCGTACTCCGCTCAACATTATTATCGGTTTCAG
CACGGCGATGCTGGAACATCCTGAAATGTACGGTGATGTTCGGATTGATGAGCAGGTACTGCAAGACATCGCCGAAATCC
GGCGGAGTGGTCAGCATCTGTTAGGGCTGATCAACGACATCCTCGATCTGGCGAAGGTTGAGGCCGGGAAACTTGAGCTG
AACAAGACAAATCTGGCACTAGGCCCACTCCTTGAAGAAACGCTTCGTACTGCGCAGGCACTGATCAACGACCGCCCTAT
CCAGTTGCGCCGCGAGTATCGCGAACCATTGCCGACGGTGTTTGCCGATGAGGTGCGGGTACGGCAGGTCTTGCTGAACC
TGGTTTCAAATGCCTGTAAGTTTACGCATGCAGGTGAGATTGCCGTTGGTGCTCGTGTCGATACCAATGAGATTGTGCTT
TGGGTGCGTGATACCGGTATCGGCATCGCACCGGCAGATCAAGAGCGTATCTTCCAGCAATTTGAGCAGATCGAAAATGC
CGACACTCGCCAGCATGCCGGTACCGGGCTTGGTCTCTCGATCTGCCGCTGGTTAGTTGAACTGCACGGTGGTCGGATGT
GGGTAGAGAGTGAATTGGGTAAAGGCAGCATCTTCTTCTTCTCGCTACCGCGGACACGGGCCGGTAGTGAACCGGCGTAA

Upstream 100 bases:

>100_bases
TCCGGCCTCTTTCATCATTTTTCAATCTTTATGACAGGTACACAACAGCTACAATACGAACAGGCAATCCATTCATAACG
CTCGCGAAGGATAAAGGCCA

Downstream 100 bases:

>100_bases
GGCGAGAGGTTGATTGACCGGCAATGTCGTTGGTTATCTATCACCGGTGATGGTTGGGTTAGCAAAGGAGCAAGAACGAT
GGCCCGAATTCTCCTTGTCG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MVARTLNPARTPVATPDEGLVTDLLPPMLILLATLAGAATGILLLNRWSGNFWPYLIIGLLLVCLAVSDRLRRRGDLRMA
SIVVVAAITLLPVLSCAAFGFTNNIFIYLSVLGVFAAGIIVSSRAPFRAGQAAILLYLLLLLGADLIGQPRPTWFEVIGH
LLLLIALLFGAATLSWAAAYVVRGTISWAIDTAQKSERREQLLRETQATLERALLERDLLNEQLYRTTLELEEARAAAEA
AYRSKSNFMATMSHELRTPLNIIIGFSTAMLEHPEMYGDVRIDEQVLQDIAEIRRSGQHLLGLINDILDLAKVEAGKLEL
NKTNLALGPLLEETLRTAQALINDRPIQLRREYREPLPTVFADEVRVRQVLLNLVSNACKFTHAGEIAVGARVDTNEIVL
WVRDTGIGIAPADQERIFQQFEQIENADTRQHAGTGLGLSICRWLVELHGGRMWVESELGKGSIFFFSLPRTRAGSEPA

Sequences:

>Translated_479_residues
MVARTLNPARTPVATPDEGLVTDLLPPMLILLATLAGAATGILLLNRWSGNFWPYLIIGLLLVCLAVSDRLRRRGDLRMA
SIVVVAAITLLPVLSCAAFGFTNNIFIYLSVLGVFAAGIIVSSRAPFRAGQAAILLYLLLLLGADLIGQPRPTWFEVIGH
LLLLIALLFGAATLSWAAAYVVRGTISWAIDTAQKSERREQLLRETQATLERALLERDLLNEQLYRTTLELEEARAAAEA
AYRSKSNFMATMSHELRTPLNIIIGFSTAMLEHPEMYGDVRIDEQVLQDIAEIRRSGQHLLGLINDILDLAKVEAGKLEL
NKTNLALGPLLEETLRTAQALINDRPIQLRREYREPLPTVFADEVRVRQVLLNLVSNACKFTHAGEIAVGARVDTNEIVL
WVRDTGIGIAPADQERIFQQFEQIENADTRQHAGTGLGLSICRWLVELHGGRMWVESELGKGSIFFFSLPRTRAGSEPA
>Mature_479_residues
MVARTLNPARTPVATPDEGLVTDLLPPMLILLATLAGAATGILLLNRWSGNFWPYLIIGLLLVCLAVSDRLRRRGDLRMA
SIVVVAAITLLPVLSCAAFGFTNNIFIYLSVLGVFAAGIIVSSRAPFRAGQAAILLYLLLLLGADLIGQPRPTWFEVIGH
LLLLIALLFGAATLSWAAAYVVRGTISWAIDTAQKSERREQLLRETQATLERALLERDLLNEQLYRTTLELEEARAAAEA
AYRSKSNFMATMSHELRTPLNIIIGFSTAMLEHPEMYGDVRIDEQVLQDIAEIRRSGQHLLGLINDILDLAKVEAGKLEL
NKTNLALGPLLEETLRTAQALINDRPIQLRREYREPLPTVFADEVRVRQVLLNLVSNACKFTHAGEIAVGARVDTNEIVL
WVRDTGIGIAPADQERIFQQFEQIENADTRQHAGTGLGLSICRWLVELHGGRMWVESELGKGSIFFFSLPRTRAGSEPA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=292, Percent_Identity=36.986301369863, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI87081816, Length=264, Percent_Identity=36.7424242424242, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=36.8421052631579, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI48994928, Length=249, Percent_Identity=35.3413654618474, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1788713, Length=260, Percent_Identity=34.6153846153846, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=34.2105263157895, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786912, Length=297, Percent_Identity=29.96632996633, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=27.2340425531915, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=32.1888412017167, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=27.8969957081545, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=30.0448430493274, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788279, Length=227, Percent_Identity=26.431718061674, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=28.5087719298246, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=26.2931034482759, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=240, Percent_Identity=27.5, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=26.4957264957265, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=73, Percent_Identity=50.6849315068493, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52896; Mature: 52896

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARTLNPARTPVATPDEGLVTDLLPPMLILLATLAGAATGILLLNRWSGNFWPYLIIGL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHH
LLVCLAVSDRLRRRGDLRMASIVVVAAITLLPVLSCAAFGFTNNIFIYLSVLGVFAAGII
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VSSRAPFRAGQAAILLYLLLLLGADLIGQPRPTWFEVIGHLLLLIALLFGAATLSWAAAY
HCCCCCCCCCHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRGTISWAIDTAQKSERREQLLRETQATLERALLERDLLNEQLYRTTLELEEARAAAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYRSKSNFMATMSHELRTPLNIIIGFSTAMLEHPEMYGDVRIDEQVLQDIAEIRRSGQHL
HHHHHCCHHHHHHHHHCCCHHHEEEHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHH
LGLINDILDLAKVEAGKLELNKTNLALGPLLEETLRTAQALINDRPIQLRREYREPLPTV
HHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHH
FADEVRVRQVLLNLVSNACKFTHAGEIAVGARVDTNEIVLWVRDTGIGIAPADQERIFQQ
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCEECCCCEEEEEECCCCCCCCCCHHHHHHH
FEQIENADTRQHAGTGLGLSICRWLVELHGGRMWVESELGKGSIFFFSLPRTRAGSEPA
HHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVARTLNPARTPVATPDEGLVTDLLPPMLILLATLAGAATGILLLNRWSGNFWPYLIIGL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHH
LLVCLAVSDRLRRRGDLRMASIVVVAAITLLPVLSCAAFGFTNNIFIYLSVLGVFAAGII
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VSSRAPFRAGQAAILLYLLLLLGADLIGQPRPTWFEVIGHLLLLIALLFGAATLSWAAAY
HCCCCCCCCCHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRGTISWAIDTAQKSERREQLLRETQATLERALLERDLLNEQLYRTTLELEEARAAAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYRSKSNFMATMSHELRTPLNIIIGFSTAMLEHPEMYGDVRIDEQVLQDIAEIRRSGQHL
HHHHHCCHHHHHHHHHCCCHHHEEEHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHH
LGLINDILDLAKVEAGKLELNKTNLALGPLLEETLRTAQALINDRPIQLRREYREPLPTV
HHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHH
FADEVRVRQVLLNLVSNACKFTHAGEIAVGARVDTNEIVLWVRDTGIGIAPADQERIFQQ
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCEECCCCEEEEEECCCCCCCCCCHHHHHHH
FEQIENADTRQHAGTGLGLSICRWLVELHGGRMWVESELGKGSIFFFSLPRTRAGSEPA
HHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]