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The map label for this gene is glcD [H]

Identifier: 222524531

GI number: 222524531

Start: 1598915

End: 1600360

Strand: Reverse

Name: glcD [H]

Synonym: Chy400_1255

Alternate gene names: 222524531

Gene position: 1600360-1598915 (Counterclockwise)

Preceding gene: 222524532

Following gene: 222524530

Centisome position: 30.37

GC content: 60.65

Gene sequence:

>1446_bases
ATGCGTGATGACCTGATAACCGCTCTCCTGAGCGTCGTTGATCCGGCAATTGTGCTGCGCCGGCCAGAAGAGCTGATGCT
CTACGAGTACGATGGCTCAGCCCTTGATCAGGGTATGCCGGAGGTGGTCGTTGTGCCGCGCACTACTGCCGAAGTTGCGG
CCTGTGTGCAGGTGGCAGCTCAGCTTGGCGTGCCAATCGTTGCCCGTGGTGCGGGCACCGGTCTGGCCGGTGGCTCGGTA
CCCGAACAGGGTGGGCTGGTCATTTCCCTAACCCGCCTCAATCGGATTCTAGCCATCGACCCGGTGGCGCGTACTGCTCG
CGTGCAACCCGGTGTAGTCAACACCGATCTTAGTCTCGCTGCTGCACCTTACGGTCTCCACTTTGCTCCTGATCCCAGTA
GCCAGCGCGCCAGTACCATCGGCGGCAATATTGCTACCAACGCTGGTGGTCCGCACTGTCTGAAGTATGGCGTCACCACC
AACCATGTCCTGGCGGTAGCGCTAGTCTTGGGTGATGGGCGGGTGATCGAGGTGAGTCGCGCTGCCCTTGATGCGCCAGG
CTACGATCTGCTGGGGGTTGTGGTGGGCAGTGAAGGAACCCTCGGGATCGTCACCGAAGCAGTGGTGAAATTAACGCCAA
ATCCCGAGTCGATCTACACCTTTCTGGCCATCTACGACGATCTCGACGCAGCCAGCGAGACAGTATCCGCGATTATTGCC
CATGGCATCATTCCCGCTGCGCTTGAGATGCTGGTTGGGCAGGGCATCGCCGCTGTCGAAGCCGCAGTCCAGGCGGGGTA
TCCGTCTGATGCGCGGGCGGTATTGTTGATCGAGCTGGATGGGTTGCGCGAAGAGGTTATTGCCCAGGCGCAAGCGATTG
AACAGATCTGCCACCATTATGGGGTGCGCGAGTTGCGGGCGGCGCAAGATGCCCATCAGCGCGAGAAGTTGTGGGCCGGT
CGTAAAGGCGCTCTGGCGGCCTGCGCACGGATTGCCCCGCACTATCACATTCAGGACGGCGTCGTGCCGCGGTCGCGTCT
GCCGGAACTGTTGCGTCTGACCGAAGAGGTGGCGGCCCGCCACCAGATCACGATTGTCAATATTTTTCACGCCGGTGATG
GTAATCTCCACCCGCTATTGCTGTTCGATCTCCGTCACGCCGGTGCGCTTGAGCGGGCAGTTGCCGCCAGTGAAGAGATT
TTGCAGGCGTGTGTTGCTGCCGGCGGTACGATCAGTGGTGAACATGGTATCGGGATTGAGAAGCGTAATTATCTGGGCTG
GATTTTTGGCCCGTCCGATCTGGCCGCCTTCGCCGACCTGCGCGCCATCTTCGATGCGAATGGGGTGATGAACCCCTGTA
AACTGCTGCCGGGGGGCAGTAGTTGTGCCGACATCCGGTTTGCTCGCGGTGCTCTGCGTGCGCTTGACCGGGGGGCGTGG
ATTTAG

Upstream 100 bases:

>100_bases
TGGCACTGGTCTTGCGTTCATATCCTCGCGGTACGCTCGACATCCTGACGTTTCGCCGGCCGGTTTTTGATCTGAAGCGC
CGTGTACGGACAAAATGACA

Downstream 100 bases:

>100_bases
ACTGGTATGAATGCCTTGCCTTTTTCAACCAGGCCATCGCCGACAACGTATGCATTGGCTGATCAACAACCGCAGCAGGT
TGTGCAGCCGACATCCGTCG

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRDDLITALLSVVDPAIVLRRPEELMLYEYDGSALDQGMPEVVVVPRTTAEVAACVQVAAQLGVPIVARGAGTGLAGGSV
PEQGGLVISLTRLNRILAIDPVARTARVQPGVVNTDLSLAAAPYGLHFAPDPSSQRASTIGGNIATNAGGPHCLKYGVTT
NHVLAVALVLGDGRVIEVSRAALDAPGYDLLGVVVGSEGTLGIVTEAVVKLTPNPESIYTFLAIYDDLDAASETVSAIIA
HGIIPAALEMLVGQGIAAVEAAVQAGYPSDARAVLLIELDGLREEVIAQAQAIEQICHHYGVRELRAAQDAHQREKLWAG
RKGALAACARIAPHYHIQDGVVPRSRLPELLRLTEEVAARHQITIVNIFHAGDGNLHPLLLFDLRHAGALERAVAASEEI
LQACVAAGGTISGEHGIGIEKRNYLGWIFGPSDLAAFADLRAIFDANGVMNPCKLLPGGSSCADIRFARGALRALDRGAW
I

Sequences:

>Translated_481_residues
MRDDLITALLSVVDPAIVLRRPEELMLYEYDGSALDQGMPEVVVVPRTTAEVAACVQVAAQLGVPIVARGAGTGLAGGSV
PEQGGLVISLTRLNRILAIDPVARTARVQPGVVNTDLSLAAAPYGLHFAPDPSSQRASTIGGNIATNAGGPHCLKYGVTT
NHVLAVALVLGDGRVIEVSRAALDAPGYDLLGVVVGSEGTLGIVTEAVVKLTPNPESIYTFLAIYDDLDAASETVSAIIA
HGIIPAALEMLVGQGIAAVEAAVQAGYPSDARAVLLIELDGLREEVIAQAQAIEQICHHYGVRELRAAQDAHQREKLWAG
RKGALAACARIAPHYHIQDGVVPRSRLPELLRLTEEVAARHQITIVNIFHAGDGNLHPLLLFDLRHAGALERAVAASEEI
LQACVAAGGTISGEHGIGIEKRNYLGWIFGPSDLAAFADLRAIFDANGVMNPCKLLPGGSSCADIRFARGALRALDRGAW
I
>Mature_481_residues
MRDDLITALLSVVDPAIVLRRPEELMLYEYDGSALDQGMPEVVVVPRTTAEVAACVQVAAQLGVPIVARGAGTGLAGGSV
PEQGGLVISLTRLNRILAIDPVARTARVQPGVVNTDLSLAAAPYGLHFAPDPSSQRASTIGGNIATNAGGPHCLKYGVTT
NHVLAVALVLGDGRVIEVSRAALDAPGYDLLGVVVGSEGTLGIVTEAVVKLTPNPESIYTFLAIYDDLDAASETVSAIIA
HGIIPAALEMLVGQGIAAVEAAVQAGYPSDARAVLLIELDGLREEVIAQAQAIEQICHHYGVRELRAAQDAHQREKLWAG
RKGALAACARIAPHYHIQDGVVPRSRLPELLRLTEEVAARHQITIVNIFHAGDGNLHPLLLFDLRHAGALERAVAASEEI
LQACVAAGGTISGEHGIGIEKRNYLGWIFGPSDLAAFADLRAIFDANGVMNPCKLLPGGSSCADIRFARGALRALDRGAW
I

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=32.1513002364066, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=30.7174887892377, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI119964728, Length=450, Percent_Identity=28.8888888888889, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4501993, Length=470, Percent_Identity=22.7659574468085, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1789351, Length=464, Percent_Identity=43.9655172413793, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1787977, Length=505, Percent_Identity=24.3564356435644, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI48994907, Length=444, Percent_Identity=21.3963963963964, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71992373, Length=429, Percent_Identity=30.0699300699301, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71992381, Length=429, Percent_Identity=28.2051282051282, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71992392, Length=385, Percent_Identity=29.6103896103896, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17534361, Length=451, Percent_Identity=26.3858093126386, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17556096, Length=451, Percent_Identity=22.6164079822616, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320027, Length=434, Percent_Identity=26.7281105990783, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320023, Length=475, Percent_Identity=26.1052631578947, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=459, Percent_Identity=25.2723311546841, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18921117, Length=434, Percent_Identity=27.8801843317972, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639277, Length=434, Percent_Identity=27.8801843317972, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24639275, Length=434, Percent_Identity=27.8801843317972, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653753, Length=181, Percent_Identity=33.1491712707182, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50439; Mature: 50439

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDDLITALLSVVDPAIVLRRPEELMLYEYDGSALDQGMPEVVVVPRTTAEVAACVQVAA
CCHHHHHHHHHHHCCHHEEECCCCEEEEEECCCHHHCCCCCEEEECCCHHHHHHHHHHHH
QLGVPIVARGAGTGLAGGSVPEQGGLVISLTRLNRILAIDPVARTARVQPGVVNTDLSLA
HCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCHHHHHCCCCCEECCCCHHE
AAPYGLHFAPDPSSQRASTIGGNIATNAGGPHCLKYGVTTNHVLAVALVLGDGRVIEVSR
ECCCCCEECCCCCCCHHHHCCCCEECCCCCCCEEEECCCCHHEEEEEEEECCCCEEEEEH
AALDAPGYDLLGVVVGSEGTLGIVTEAVVKLTPNPESIYTFLAIYDDLDAASETVSAIIA
HHCCCCCCEEEEEEECCCCCCHHEEEEHEEECCCHHHHEEEEHHHHCHHHHHHHHHHHHH
HGIIPAALEMLVGQGIAAVEAAVQAGYPSDARAVLLIELDGLREEVIAQAQAIEQICHHY
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHC
GVRELRAAQDAHQREKLWAGRKGALAACARIAPHYHIQDGVVPRSRLPELLRLTEEVAAR
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHC
HQITIVNIFHAGDGNLHPLLLFDLRHAGALERAVAASEEILQACVAAGGTISGEHGIGIE
CEEEEEEEEECCCCCCCEEEEEECHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
KRNYLGWIFGPSDLAAFADLRAIFDANGVMNPCKLLPGGSSCADIRFARGALRALDRGAW
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCC
I
C
>Mature Secondary Structure
MRDDLITALLSVVDPAIVLRRPEELMLYEYDGSALDQGMPEVVVVPRTTAEVAACVQVAA
CCHHHHHHHHHHHCCHHEEECCCCEEEEEECCCHHHCCCCCEEEECCCHHHHHHHHHHHH
QLGVPIVARGAGTGLAGGSVPEQGGLVISLTRLNRILAIDPVARTARVQPGVVNTDLSLA
HCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEECCHHHHHCCCCCEECCCCHHE
AAPYGLHFAPDPSSQRASTIGGNIATNAGGPHCLKYGVTTNHVLAVALVLGDGRVIEVSR
ECCCCCEECCCCCCCHHHHCCCCEECCCCCCCEEEECCCCHHEEEEEEEECCCCEEEEEH
AALDAPGYDLLGVVVGSEGTLGIVTEAVVKLTPNPESIYTFLAIYDDLDAASETVSAIIA
HHCCCCCCEEEEEEECCCCCCHHEEEEHEEECCCHHHHEEEEHHHHCHHHHHHHHHHHHH
HGIIPAALEMLVGQGIAAVEAAVQAGYPSDARAVLLIELDGLREEVIAQAQAIEQICHHY
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHC
GVRELRAAQDAHQREKLWAGRKGALAACARIAPHYHIQDGVVPRSRLPELLRLTEEVAAR
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHC
HQITIVNIFHAGDGNLHPLLLFDLRHAGALERAVAASEEILQACVAAGGTISGEHGIGIE
CEEEEEEEEECCCCCCCEEEEEECHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
KRNYLGWIFGPSDLAAFADLRAIFDANGVMNPCKLLPGGSSCADIRFARGALRALDRGAW
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]