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The map label for this gene is hpaG [H]

Identifier: 222524279

GI number: 222524279

Start: 1279531

End: 1280550

Strand: Direct

Name: hpaG [H]

Synonym: Chy400_1002

Alternate gene names: 222524279

Gene position: 1279531-1280550 (Clockwise)

Preceding gene: 222524277

Following gene: 222524280

Centisome position: 24.28

GC content: 56.57

Gene sequence:

>1020_bases
ATGATTGTGCGTCTTGTGAGTTTTATTCCTCCTGCCGGAGGCGATGTTCGTAGTGGCGTATTACTGGGTGATACGATCAT
TGATCTGGCTACGGCTGCACCTTTGGTTAGTGAGGATATTGTTGATGCGCCCTGGGATATGCTCACGTTGCTCAGCGGTA
GCCATCCTGATGTTACCCTGGCTACAGCCGCCGATATTGTGCAGGCGGTGGTGAGTTTGATGGGTAGCGAGGAACCGATG
AACGAACCCTCAACCAGCTTTTCCTGGCATGATGGTCTCGTCATTGGTGAGGATGCATTAGTTGTACCGGTGTCGCAGGT
ACGTCTGGTGTCACCGTTACCGCGAGTGGTGTCACTGCGTGAATTTGATGCCTTTGTCGATGATCAAGCAGCGGCTCTGC
GCCAGGCAGCAGGCTACTGGATCGGTGATCGCCGGCACCCCGCCTTCCGTTTTGCCGCTCATACCGCGATTTACGGCCCT
GATGAGTCAGTCGAATTACCGGCCTCTGCCCCCCTCGATTGTGGGATGGCCCTGGGATGTGTGATTGGGCAGACCGGGCG
CGATATTTCACCCGCCGAAGCCGATGCGTATATCGCCGGCTATCTGCTGGCAAATGCCTGGACAATCCGCGACCCTCTCC
TGGCAGCTCTGCGCCCGCGTGATGTTGCCACATCGCTCGGCCCCTGGCTGGTCACTGCTGATGAGCTGGAGTATTACCGT
GACGACGATGGCCGTTTGCTCTTGACGTTGCGTCTGCTGATCAATGGCCAGGAAGTGAGTCGCTATCATACCGGACGGAT
GCGGTTTTCGTTTGCCGAACTGATTGCCTTTGCCAGCCAGGATACGTGGTTGCAACCAGGCGAGATTATCCTCAGTGGCG
TGGCTGCCGGAGGATGCCTGCTCGACATTCAGGGTGATAGTGGGCCATGGCTTCGTGATGGTGATGAGGTGATCATCGAA
TGTCCGGAACTGGGCCAGCTTCGTTCGCCGGTTGGATGGTTCGCCGGTAGTGATTATTGA

Upstream 100 bases:

>100_bases
GTCACGAACATGCCTGCTGCCATGATCCGGTATGATATGAGCAGTCTGGTCAGTATACGGTGTTTACGCCGGTGTGCACA
CCATGCAACCAGAGAAGGGG

Downstream 100 bases:

>100_bases
TGACGTACATATGCCAGCTTGCCATTCTTTTTGCTATCTGGTATAGTCCGCCCGATTATGGAAAAGAATGAGTACACAAC
AATGGCAGCCGTTGAGCTGC

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; HHDD isomerase; 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; OPET decarboxylase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIVRLVSFIPPAGGDVRSGVLLGDTIIDLATAAPLVSEDIVDAPWDMLTLLSGSHPDVTLATAADIVQAVVSLMGSEEPM
NEPSTSFSWHDGLVIGEDALVVPVSQVRLVSPLPRVVSLREFDAFVDDQAAALRQAAGYWIGDRRHPAFRFAAHTAIYGP
DESVELPASAPLDCGMALGCVIGQTGRDISPAEADAYIAGYLLANAWTIRDPLLAALRPRDVATSLGPWLVTADELEYYR
DDDGRLLLTLRLLINGQEVSRYHTGRMRFSFAELIAFASQDTWLQPGEIILSGVAAGGCLLDIQGDSGPWLRDGDEVIIE
CPELGQLRSPVGWFAGSDY

Sequences:

>Translated_339_residues
MIVRLVSFIPPAGGDVRSGVLLGDTIIDLATAAPLVSEDIVDAPWDMLTLLSGSHPDVTLATAADIVQAVVSLMGSEEPM
NEPSTSFSWHDGLVIGEDALVVPVSQVRLVSPLPRVVSLREFDAFVDDQAAALRQAAGYWIGDRRHPAFRFAAHTAIYGP
DESVELPASAPLDCGMALGCVIGQTGRDISPAEADAYIAGYLLANAWTIRDPLLAALRPRDVATSLGPWLVTADELEYYR
DDDGRLLLTLRLLINGQEVSRYHTGRMRFSFAELIAFASQDTWLQPGEIILSGVAAGGCLLDIQGDSGPWLRDGDEVIIE
CPELGQLRSPVGWFAGSDY
>Mature_339_residues
MIVRLVSFIPPAGGDVRSGVLLGDTIIDLATAAPLVSEDIVDAPWDMLTLLSGSHPDVTLATAADIVQAVVSLMGSEEPM
NEPSTSFSWHDGLVIGEDALVVPVSQVRLVSPLPRVVSLREFDAFVDDQAAALRQAAGYWIGDRRHPAFRFAAHTAIYGP
DESVELPASAPLDCGMALGCVIGQTGRDISPAEADAYIAGYLLANAWTIRDPLLAALRPRDVATSLGPWLVTADELEYYR
DDDGRLLLTLRLLINGQEVSRYHTGRMRFSFAELIAFASQDTWLQPGEIILSGVAAGGCLLDIQGDSGPWLRDGDEVIIE
CPELGQLRSPVGWFAGSDY

Specific function: Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5- tricarboxylic acid) into HHDD (2-hydroxy-hept-2,4-diene-1,7- dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate) [H]

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI40786394, Length=190, Percent_Identity=33.1578947368421, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI156231349, Length=184, Percent_Identity=33.1521739130435, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234
- InterPro:   IPR012684
- InterPro:   IPR012686 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =5.3.3.10; =4.1.1.68 [H]

Molecular weight: Translated: 36427; Mature: 36427

Theoretical pI: Translated: 4.07; Mature: 4.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVRLVSFIPPAGGDVRSGVLLGDTIIDLATAAPLVSEDIVDAPWDMLTLLSGSHPDVTL
CEEEEEECCCCCCCCCCCCEEECHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCCCCCEEH
ATAADIVQAVVSLMGSEEPMNEPSTSFSWHDGLVIGEDALVVPVSQVRLVSPLPRVVSLR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHCCCHHHHHHH
EFDAFVDDQAAALRQAAGYWIGDRRHPAFRFAAHTAIYGPDESVELPASAPLDCGMALGC
HHHHHHCHHHHHHHHHHCCCCCCCCCCCEEEEEHEEEECCCCCEECCCCCCCCCCHHHHH
VIGQTGRDISPAEADAYIAGYLLANAWTIRDPLLAALRPRDVATSLGPWLVTADELEYYR
HCCCCCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHCCCCHHHHCCCCEEEEHHHHHHEE
DDDGRLLLTLRLLINGQEVSRYHTGRMRFSFAELIAFASQDTWLQPGEIILSGVAAGGCL
CCCCEEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHEEEEECCCCEE
LDIQGDSGPWLRDGDEVIIECPELGQLRSPVGWFAGSDY
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIVRLVSFIPPAGGDVRSGVLLGDTIIDLATAAPLVSEDIVDAPWDMLTLLSGSHPDVTL
CEEEEEECCCCCCCCCCCCEEECHHHHHHHHHCCHHHHHHHCCCHHHHHHHCCCCCCEEH
ATAADIVQAVVSLMGSEEPMNEPSTSFSWHDGLVIGEDALVVPVSQVRLVSPLPRVVSLR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHCCCHHHHHHH
EFDAFVDDQAAALRQAAGYWIGDRRHPAFRFAAHTAIYGPDESVELPASAPLDCGMALGC
HHHHHHCHHHHHHHHHHCCCCCCCCCCCEEEEEHEEEECCCCCEECCCCCCCCCCHHHHH
VIGQTGRDISPAEADAYIAGYLLANAWTIRDPLLAALRPRDVATSLGPWLVTADELEYYR
HCCCCCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHCCCCHHHHCCCCEEEEHHHHHHEE
DDDGRLLLTLRLLINGQEVSRYHTGRMRFSFAELIAFASQDTWLQPGEIILSGVAAGGCL
CCCCEEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHEEEEECCCCEE
LDIQGDSGPWLRDGDEVIIECPELGQLRSPVGWFAGSDY
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA