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The map label for this gene is hpd [H]

Identifier: 222524156

GI number: 222524156

Start: 1104352

End: 1105449

Strand: Direct

Name: hpd [H]

Synonym: Chy400_0872

Alternate gene names: 222524156

Gene position: 1104352-1105449 (Clockwise)

Preceding gene: 222524155

Following gene: 222524158

Centisome position: 20.96

GC content: 58.65

Gene sequence:

>1098_bases
ATGTGCTCCGCCGATCCGCTTGAGTTACTTGGCATTGATTATGTTGAGTTTTACGTCAGCAATGCCCGTCAGGCTGCCCA
TTTCTACCGCACCACACTCGGCCTGCGTCCGGTTGCCTACGCCGGTCTCGAAACCGGGGTGCGCGACCGGGCCAGTTATG
TGCTCGAACGCCGCAATGTCCGCTTCGTCCTGACCGCTCCCCTCCTGCCCGATCACCCGATTGCGCAGCACATTGCCCAC
CACGGCGATGGGGTGAAAGACATTGCCCTGCGCGTCCGTGATGCGGTGACTGCGTATGAAACAGCGGTTGCCCGTGGCGG
GATTCCGGTGCAGGCGCCGACCGAATATGTGGACGAACATGGCCGGATTATCAAGGCGACGATTGCCACCTATGGCGACA
CCGTCCACTCATTTATCGAGCGTGAAAACTACCAGGGAACATTCATGCCCGGCTTCCAGCCGATCACTACACCACTACCG
GTACCGGAAACCGGGATTGCCGCCATTGACCACATCGTCGGCAACGTGGAACTGGGGGCAATGAATCGTTGGGTCAACTA
CTACCGTGATGTGCTCGGCTTCAGCCAGTTGGTACACTTCGACGATCACGACATCAGCACCGAGTACAGTGCCCTCATGT
CGAAGGTGATGCAAAACGGTACCGGTCGGATCAAGTTCCCCATCAACGAACCGGCTGAGGGGCGCCGCAAGAGCCAGATC
GAAGAGTTTCTTGAGTACTACGGCGGCCCCGGTGTTCAGCACATTGCCCTGGCAACCGGCGACATCTGTGCGACCGTTGA
TGCACTGCGCGCTGCCGGTATTCCGTTTATCCACGTACCCGACGCCTACTACGATGATCTCGAAGAGCGGGTTGGCAAAA
TCGACGAGAGCCGGCAGGCCCTCCAGGAGCGGGGGATTCTGGTTGACCGTGATGAAGAGGGGTACCTGCTCCAAATCTTC
AGTCAGCCACTCCAGGATCGGCCAACCCTCTTCATCGAGATTATCCAGCGCAAAGGCAGCCGGGGCTTCGGCAAGGGTAA
TTTCAAGGCGCTCTTCGAGGCCATTGAACGCGAACAGGCCCGGCGTGGCAATTTGTAG

Upstream 100 bases:

>100_bases
TGTTACACGCCACTGAGTGTGATGCGTCCACATTCAGGGCGTGTCGGGTAACCAAACTAATCCCAGGGTGGACGCATCAC
CCTGAACGTGGAGGTGCCGT

Downstream 100 bases:

>100_bases
TGAATGATGAAGGGGGGAGGGCACGACCTCACCCCTGGCCCCTCTCCCGCGGTGTCGCGGGAGAGGGGAGAGCAGTGAGC
TGCGCTGCGACTTCCTGACG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MCSADPLELLGIDYVEFYVSNARQAAHFYRTTLGLRPVAYAGLETGVRDRASYVLERRNVRFVLTAPLLPDHPIAQHIAH
HGDGVKDIALRVRDAVTAYETAVARGGIPVQAPTEYVDEHGRIIKATIATYGDTVHSFIERENYQGTFMPGFQPITTPLP
VPETGIAAIDHIVGNVELGAMNRWVNYYRDVLGFSQLVHFDDHDISTEYSALMSKVMQNGTGRIKFPINEPAEGRRKSQI
EEFLEYYGGPGVQHIALATGDICATVDALRAAGIPFIHVPDAYYDDLEERVGKIDESRQALQERGILVDRDEEGYLLQIF
SQPLQDRPTLFIEIIQRKGSRGFGKGNFKALFEAIEREQARRGNL

Sequences:

>Translated_365_residues
MCSADPLELLGIDYVEFYVSNARQAAHFYRTTLGLRPVAYAGLETGVRDRASYVLERRNVRFVLTAPLLPDHPIAQHIAH
HGDGVKDIALRVRDAVTAYETAVARGGIPVQAPTEYVDEHGRIIKATIATYGDTVHSFIERENYQGTFMPGFQPITTPLP
VPETGIAAIDHIVGNVELGAMNRWVNYYRDVLGFSQLVHFDDHDISTEYSALMSKVMQNGTGRIKFPINEPAEGRRKSQI
EEFLEYYGGPGVQHIALATGDICATVDALRAAGIPFIHVPDAYYDDLEERVGKIDESRQALQERGILVDRDEEGYLLQIF
SQPLQDRPTLFIEIIQRKGSRGFGKGNFKALFEAIEREQARRGNL
>Mature_365_residues
MCSADPLELLGIDYVEFYVSNARQAAHFYRTTLGLRPVAYAGLETGVRDRASYVLERRNVRFVLTAPLLPDHPIAQHIAH
HGDGVKDIALRVRDAVTAYETAVARGGIPVQAPTEYVDEHGRIIKATIATYGDTVHSFIERENYQGTFMPGFQPITTPLP
VPETGIAAIDHIVGNVELGAMNRWVNYYRDVLGFSQLVHFDDHDISTEYSALMSKVMQNGTGRIKFPINEPAEGRRKSQI
EEFLEYYGGPGVQHIALATGDICATVDALRAAGIPFIHVPDAYYDDLEERVGKIDESRQALQERGILVDRDEEGYLLQIF
SQPLQDRPTLFIEIIQRKGSRGFGKGNFKALFEAIEREQARRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=366, Percent_Identity=45.6284153005465, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI285002264, Length=342, Percent_Identity=45.6140350877193, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI14249394, Length=299, Percent_Identity=29.4314381270903, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17555220, Length=368, Percent_Identity=48.0978260869565, Blast_Score=336, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17550752, Length=364, Percent_Identity=36.5384615384615, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24667510, Length=366, Percent_Identity=48.0874316939891, Blast_Score=333, Evalue=8e-92,
Organism=Drosophila melanogaster, GI21356105, Length=292, Percent_Identity=50.6849315068493, Blast_Score=281, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40817; Mature: 40817

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSADPLELLGIDYVEFYVSNARQAAHFYRTTLGLRPVAYAGLETGVRDRASYVLERRNV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCE
RFVLTAPLLPDHPIAQHIAHHGDGVKDIALRVRDAVTAYETAVARGGIPVQAPTEYVDEH
EEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
GRIIKATIATYGDTVHSFIERENYQGTFMPGFQPITTPLPVPETGIAAIDHIVGNVELGA
CCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
MNRWVNYYRDVLGFSQLVHFDDHDISTEYSALMSKVMQNGTGRIKFPINEPAEGRRKSQI
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHH
EEFLEYYGGPGVQHIALATGDICATVDALRAAGIPFIHVPDAYYDDLEERVGKIDESRQA
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCHHHHHH
LQERGILVDRDEEGYLLQIFSQPLQDRPTLFIEIIQRKGSRGFGKGNFKALFEAIEREQA
HHHCCCEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RRGNL
HCCCC
>Mature Secondary Structure
MCSADPLELLGIDYVEFYVSNARQAAHFYRTTLGLRPVAYAGLETGVRDRASYVLERRNV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCE
RFVLTAPLLPDHPIAQHIAHHGDGVKDIALRVRDAVTAYETAVARGGIPVQAPTEYVDEH
EEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHC
GRIIKATIATYGDTVHSFIERENYQGTFMPGFQPITTPLPVPETGIAAIDHIVGNVELGA
CCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
MNRWVNYYRDVLGFSQLVHFDDHDISTEYSALMSKVMQNGTGRIKFPINEPAEGRRKSQI
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHH
EEFLEYYGGPGVQHIALATGDICATVDALRAAGIPFIHVPDAYYDDLEERVGKIDESRQA
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCHHHHHH
LQERGILVDRDEEGYLLQIFSQPLQDRPTLFIEIIQRKGSRGFGKGNFKALFEAIEREQA
HHHCCCEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RRGNL
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]