Click here to switch to the map view.

The map label for this gene is trpA

Identifier: 222524024

GI number: 222524024

Start: 924644

End: 925444

Strand: Direct

Name: trpA

Synonym: Chy400_0739

Alternate gene names: 222524024

Gene position: 924644-925444 (Clockwise)

Preceding gene: 222524022

Following gene: 222524025

Centisome position: 17.55

GC content: 59.8

Gene sequence:

>801_bases
ATGAGCCGAATAGCCGAAACATTTGCCAGACTCCGCGCTGCGGGGCGTATTGCGCTAATGCCATACCTGACCGTAGGTTT
TCCCGAACGCACCAGCACCCTTGAACTGGTACCGGCCCTCGAAGCAGCCGGCGCCAGTCTGTTTGAATTGGGCATCCCCT
TCTCCGATCCGCTGGCAGACGGCACGACCATTCAGCGGGCGACCCAGCGCGCTCTGGAAAACGGGATTACGATTGCCGAT
TGTATTGCAACGGTCGCCGAATTACGGGCCCGTCGGGTGGCGGCCCCCCTGCTGTTGATGGGGTACTACAACCCGTTGCT
CCGTTACGGTCTCGAACGCGCCTGTGCCGCTCTGGCGGCAGCCGGTGGCGATGGCTGGATTATTCCCGATCTGCCGCTCG
AAGAAGCAGATGATCTCCGTCAGCTTGCCGCTGCTCACCAGCTCGACCTGATAATGTTCATCGCCCCCACCACCCCACCG
GCCCGGATCAGCCAGATCACTGCCCAGGCCAGTGGCTTTCTTTACATCGTCTCGCTAACCGGTGTGACCGGTGCCCGGCA
GACTTTAGCCGGGAATCTGACCGATCTGATTGCCAATGTGCGCCAGCAGACGAATCTGCCACTGGTTGTCGGTTTTGGGA
TCAGCCAGCCAGCGCATATTGCTGAAGTAGCCAGGATTGCCGATGGAGCAATTGTTGGCAGTGCCTTGATTGATCGCCTG
GAACGTCTGCCACCTGAAGACCGGGTGAGTGGTGCCGCTGCGTATATTCGCGAACTGTTGAGCGCCGTTGCACGACCGTA
A

Upstream 100 bases:

>100_bases
CCCGGCCAGAACACACTCTTTGTCCACACCATGGCGCATGCCCGAACCTGTGGTATGATGTCAGGTACAGCGATTGACCT
CTCTACCTGTAGAACACACT

Downstream 100 bases:

>100_bases
TCAAGAGAGGAGCATTGTCATGGAAGCGCGAGCGTATGTCTTGATCGAGGCTGAGTCGGGCAAGATCGGTGAAGTATTGA
CCGCGTTGCGCGCCATTGAT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSRIAETFARLRAAGRIALMPYLTVGFPERTSTLELVPALEAAGASLFELGIPFSDPLADGTTIQRATQRALENGITIAD
CIATVAELRARRVAAPLLLMGYYNPLLRYGLERACAALAAAGGDGWIIPDLPLEEADDLRQLAAAHQLDLIMFIAPTTPP
ARISQITAQASGFLYIVSLTGVTGARQTLAGNLTDLIANVRQQTNLPLVVGFGISQPAHIAEVARIADGAIVGSALIDRL
ERLPPEDRVSGAAAYIRELLSAVARP

Sequences:

>Translated_266_residues
MSRIAETFARLRAAGRIALMPYLTVGFPERTSTLELVPALEAAGASLFELGIPFSDPLADGTTIQRATQRALENGITIAD
CIATVAELRARRVAAPLLLMGYYNPLLRYGLERACAALAAAGGDGWIIPDLPLEEADDLRQLAAAHQLDLIMFIAPTTPP
ARISQITAQASGFLYIVSLTGVTGARQTLAGNLTDLIANVRQQTNLPLVVGFGISQPAHIAEVARIADGAIVGSALIDRL
ERLPPEDRVSGAAAYIRELLSAVARP
>Mature_265_residues
SRIAETFARLRAAGRIALMPYLTVGFPERTSTLELVPALEAAGASLFELGIPFSDPLADGTTIQRATQRALENGITIADC
IATVAELRARRVAAPLLLMGYYNPLLRYGLERACAALAAAGGDGWIIPDLPLEEADDLRQLAAAHQLDLIMFIAPTTPPA
RISQITAQASGFLYIVSLTGVTGARQTLAGNLTDLIANVRQQTNLPLVVGFGISQPAHIAEVARIADGAIVGSALIDRLE
RLPPEDRVSGAAAYIRELLSAVARP

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=265, Percent_Identity=32.8301886792453, Blast_Score=142, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321412, Length=261, Percent_Identity=38.3141762452107, Blast_Score=198, Evalue=8e-52,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_CHLAA (A9WFI5)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001634312.1
- ProteinModelPortal:   A9WFI5
- SMR:   A9WFI5
- GeneID:   5828134
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0683
- HOGENOM:   HBG391690
- OMA:   VILMTYY
- ProtClustDB:   PRK13111
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28173; Mature: 28042

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIAETFARLRAAGRIALMPYLTVGFPERTSTLELVPALEAAGASLFELGIPFSDPLAD
CCHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCC
GTTIQRATQRALENGITIADCIATVAELRARRVAAPLLLMGYYNPLLRYGLERACAALAA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGDGWIIPDLPLEEADDLRQLAAAHQLDLIMFIAPTTPPARISQITAQASGFLYIVSLT
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEC
GVTGARQTLAGNLTDLIANVRQQTNLPLVVGFGISQPAHIAEVARIADGAIVGSALIDRL
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHH
ERLPPEDRVSGAAAYIRELLSAVARP
HHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRIAETFARLRAAGRIALMPYLTVGFPERTSTLELVPALEAAGASLFELGIPFSDPLAD
CHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCC
GTTIQRATQRALENGITIADCIATVAELRARRVAAPLLLMGYYNPLLRYGLERACAALAA
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGDGWIIPDLPLEEADDLRQLAAAHQLDLIMFIAPTTPPARISQITAQASGFLYIVSLT
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEC
GVTGARQTLAGNLTDLIANVRQQTNLPLVVGFGISQPAHIAEVARIADGAIVGSALIDRL
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHH
ERLPPEDRVSGAAAYIRELLSAVARP
HHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA