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The map label for this gene is yqeC [H]

Identifier: 222523828

GI number: 222523828

Start: 640391

End: 641293

Strand: Direct

Name: yqeC [H]

Synonym: Chy400_0536

Alternate gene names: 222523828

Gene position: 640391-641293 (Clockwise)

Preceding gene: 222523826

Following gene: 222523829

Centisome position: 12.15

GC content: 56.15

Gene sequence:

>903_bases
ATGGAAGTAGGTTTGATCGGACTTGGTCGGATGGGCGCGAACATGGCAATTCGCTTGCGGCGCGGCGGTCATCGGGTGAT
TGTATATAACCGGACGGTGGCCAAAGCGCGCGAACTGGCGGCAGAACACGATTTGATCGCAGCCGAAGAGCTGTCCGACC
TGGTAGCAATGCTCACCCCACCGCGTGTTGTCTGGTTGATGCTACCGGCTGGTAGCGCAACTGATGAGCATCTGGCAGCC
CTAACCCCGCTCCTGACGCCGGGAGATATTGTGATCGACGGTGCCAACAACAACTATAAAGCCAGCATCGCTCATGCCGA
ACAGTTGACAGCCCAGGGGCTGCGCTTCCTCGATATCGGGGTAAGTGGTGGTATCTGGGGTTTGCAAATCGGCTACTGCC
TGATGGTCGGCGGTGACGAAGAAACCTTCCACTACGTTGAGCCACTCTTGCAAACGCTCGCGCCACCAGAGGGATACCTC
CTCTGTGGGCCGCATGGTGCCGGACACTTCGTCAAAATGATCCACAACGGCATTGAATACGGTATGATGCAAGCGTATGC
CGAAGGTTTTGAAATCTTGCGCCAGTCCCGCTACGATTTCGACCTCGCCAAAATCAGTCATCTCTGGAACCAGGGCAGTG
TCGTTCGTTCGTGGTTGCTGGAATTAGCCGAACGTGCGTTCACAGCCGATGCCGATCTGTCCAGTATCCGGGGCTATGTT
GAAGACAGTGGTGAAGGGCGCTGGACAGTTCAGGAGAGCATCGATCTCGATGTACCGGCACCAATTATCACCCTGTCGTT
ACAGATGCGTTTCCGTTCACGGCAAGAAGACAGCTTCAGCATGAAGGTGCTGGCCGCTTTGCGCCAGCAGTTTGGTGGCC
ACGCCGTCAAGAAGGTGGAGTAG

Upstream 100 bases:

>100_bases
CGCTCGCTTCAGTGTTGTGACCGATCACTGATATAGTGTGGCGCGTACTAACCTTAATCTCGGTCAATTGAATGAGATTG
AAGCATGTGAGGAGCACATC

Downstream 100 bases:

>100_bases
ATCAACGTGACAACCAATGTCCTGGACAATCCGCTCCGGGCCGGACTACGGATAGGGCGTACCCCTGAACCCTGTACAAT
GGTCATCTTCGGCGCCAGTG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: CO2; Nicotinamide adenine dinucleotide phosphate - reduced; D-Ribulose 5-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MEVGLIGLGRMGANMAIRLRRGGHRVIVYNRTVAKARELAAEHDLIAAEELSDLVAMLTPPRVVWLMLPAGSATDEHLAA
LTPLLTPGDIVIDGANNNYKASIAHAEQLTAQGLRFLDIGVSGGIWGLQIGYCLMVGGDEETFHYVEPLLQTLAPPEGYL
LCGPHGAGHFVKMIHNGIEYGMMQAYAEGFEILRQSRYDFDLAKISHLWNQGSVVRSWLLELAERAFTADADLSSIRGYV
EDSGEGRWTVQESIDLDVPAPIITLSLQMRFRSRQEDSFSMKVLAALRQQFGGHAVKKVE

Sequences:

>Translated_300_residues
MEVGLIGLGRMGANMAIRLRRGGHRVIVYNRTVAKARELAAEHDLIAAEELSDLVAMLTPPRVVWLMLPAGSATDEHLAA
LTPLLTPGDIVIDGANNNYKASIAHAEQLTAQGLRFLDIGVSGGIWGLQIGYCLMVGGDEETFHYVEPLLQTLAPPEGYL
LCGPHGAGHFVKMIHNGIEYGMMQAYAEGFEILRQSRYDFDLAKISHLWNQGSVVRSWLLELAERAFTADADLSSIRGYV
EDSGEGRWTVQESIDLDVPAPIITLSLQMRFRSRQEDSFSMKVLAALRQQFGGHAVKKVE
>Mature_300_residues
MEVGLIGLGRMGANMAIRLRRGGHRVIVYNRTVAKARELAAEHDLIAAEELSDLVAMLTPPRVVWLMLPAGSATDEHLAA
LTPLLTPGDIVIDGANNNYKASIAHAEQLTAQGLRFLDIGVSGGIWGLQIGYCLMVGGDEETFHYVEPLLQTLAPPEGYL
LCGPHGAGHFVKMIHNGIEYGMMQAYAEGFEILRQSRYDFDLAKISHLWNQGSVVRSWLLELAERAFTADADLSSIRGYV
EDSGEGRWTVQESIDLDVPAPIITLSLQMRFRSRQEDSFSMKVLAALRQQFGGHAVKKVE

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=311, Percent_Identity=33.1189710610932, Blast_Score=148, Evalue=6e-36,
Organism=Escherichia coli, GI1788341, Length=318, Percent_Identity=34.2767295597484, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1786719, Length=231, Percent_Identity=28.1385281385281, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=292, Percent_Identity=32.5342465753425, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321695, Length=301, Percent_Identity=35.5481727574751, Blast_Score=166, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321977, Length=277, Percent_Identity=35.3790613718412, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24639279, Length=290, Percent_Identity=36.8965517241379, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24655230, Length=223, Percent_Identity=28.2511210762332, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922568, Length=223, Percent_Identity=28.2511210762332, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44 [C]

Molecular weight: Translated: 32984; Mature: 32984

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00895 3_HYDROXYISOBUT_DH ; PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGLIGLGRMGANMAIRLRRGGHRVIVYNRTVAKARELAAEHDLIAAEELSDLVAMLTP
CCEEEEECCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PRVVWLMLPAGSATDEHLAALTPLLTPGDIVIDGANNNYKASIAHAEQLTAQGLRFLDIG
CEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEECCCCCEEEEHHHHHHHHHCCCEEEEEC
VSGGIWGLQIGYCLMVGGDEETFHYVEPLLQTLAPPEGYLLCGPHGAGHFVKMIHNGIEY
CCCCCHHEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
GMMQAYAEGFEILRQSRYDFDLAKISHLWNQGSVVRSWLLELAERAFTADADLSSIRGYV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EDSGEGRWTVQESIDLDVPAPIITLSLQMRFRSRQEDSFSMKVLAALRQQFGGHAVKKVE
CCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEVGLIGLGRMGANMAIRLRRGGHRVIVYNRTVAKARELAAEHDLIAAEELSDLVAMLTP
CCEEEEECCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PRVVWLMLPAGSATDEHLAALTPLLTPGDIVIDGANNNYKASIAHAEQLTAQGLRFLDIG
CEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEECCCCCEEEEHHHHHHHHHCCCEEEEEC
VSGGIWGLQIGYCLMVGGDEETFHYVEPLLQTLAPPEGYLLCGPHGAGHFVKMIHNGIEY
CCCCCHHEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
GMMQAYAEGFEILRQSRYDFDLAKISHLWNQGSVVRSWLLELAERAFTADADLSSIRGYV
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EDSGEGRWTVQESIDLDVPAPIITLSLQMRFRSRQEDSFSMKVLAALRQQFGGHAVKKVE
CCCCCCEEEEECCCCCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-Phospho-D-gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Specific reaction: 6-Phospho-D-gluconate + Nicotinamide adenine dinucleotide phosphate --> CO2 + Nicotinamide adenine dinucleotide phosphate - reduced + D-Ribulose 5-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]