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The map label for this gene is hisA

Identifier: 222523665

GI number: 222523665

Start: 437956

End: 438681

Strand: Direct

Name: hisA

Synonym: Chy400_0371

Alternate gene names: 222523665

Gene position: 437956-438681 (Clockwise)

Preceding gene: 222523664

Following gene: 222523666

Centisome position: 8.31

GC content: 58.54

Gene sequence:

>726_bases
ATGGAGATTATTCCGGCAATTGATATAAAAGATGGTCGCTGCGTCCGCTTGTATCAAGGCGATTTTGCCCAAATGACGGT
CTACGCCGACGATCCGGTTGCGGTGGCCCGAAGCTGGGAAGCGCAAGGCGCCACCAGACTGCACCTGGTCGATCTCGACG
GTGCCCGTGCCGGACACCCGCAGAATGTCGACGCCATTCTTGCTATCACACAGGCGGTGCAGATTCCAGTGCAGTTAGGC
GGTGGTTTGCGCCGAGAGCAGGATGTTGAGTCGGCATTAGCCCTCGGCGTCGAGCGCGTTATCATCGGTACGGCGGCTAT
TGCCGAAACAGACCTGGTTGCCCGCCTACTCGACCGCTTCGGCGAGCAGATCGTGATCGGGATCGATGCCCGCAACGGCC
TGGTAGCTACCGATGGCTGGACAGTAACCTCTTCGGTCAAAGCAACCGTGCTGGCTGAACAGATGGCAAACCTCGGTGCC
CGACGCATCATCTACACCGACATCAGTCGTGATGGCGCACTCAGTGGGCCGAACTTTGCAGCCTTAAGCGAATTGATCAC
ACCGCACGGCCCGGCGATCATCGCCAGCGGCGGGATTGCCAGTATCGACCACGTGCGCCAGCTTGCCCAGCTCGGCGTTG
AAGGAGCGATTATCGGCAAGGCATTGTACGTTGGTGCAGTAAAACTGGCTGAAGCGATGGCCGTTGCCCACATGACTAAT
GTATAG

Upstream 100 bases:

>100_bases
CAGTACAGTTCCATCCCGAAAAGAGTGGCGACTATGGCTTGCGCCTGCTGGCCAATTTCGTGCGCTGGAGCGAGGCCGTC
CAGCCAAAAGGAGTGTGACA

Downstream 100 bases:

>100_bases
CTACCGGGTGGGCATGCCAGAGCGATGGCAAGCTGTTTACCTGCAATACCACACAACCAGGAGTTGTTATGTCAAATTCA
GACCTGACGGCGCGCTATGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MEIIPAIDIKDGRCVRLYQGDFAQMTVYADDPVAVARSWEAQGATRLHLVDLDGARAGHPQNVDAILAITQAVQIPVQLG
GGLRREQDVESALALGVERVIIGTAAIAETDLVARLLDRFGEQIVIGIDARNGLVATDGWTVTSSVKATVLAEQMANLGA
RRIIYTDISRDGALSGPNFAALSELITPHGPAIIASGGIASIDHVRQLAQLGVEGAIIGKALYVGAVKLAEAMAVAHMTN
V

Sequences:

>Translated_241_residues
MEIIPAIDIKDGRCVRLYQGDFAQMTVYADDPVAVARSWEAQGATRLHLVDLDGARAGHPQNVDAILAITQAVQIPVQLG
GGLRREQDVESALALGVERVIIGTAAIAETDLVARLLDRFGEQIVIGIDARNGLVATDGWTVTSSVKATVLAEQMANLGA
RRIIYTDISRDGALSGPNFAALSELITPHGPAIIASGGIASIDHVRQLAQLGVEGAIIGKALYVGAVKLAEAMAVAHMTN
V
>Mature_241_residues
MEIIPAIDIKDGRCVRLYQGDFAQMTVYADDPVAVARSWEAQGATRLHLVDLDGARAGHPQNVDAILAITQAVQIPVQLG
GGLRREQDVESALALGVERVIIGTAAIAETDLVARLLDRFGEQIVIGIDARNGLVATDGWTVTSSVKATVLAEQMANLGA
RRIIYTDISRDGALSGPNFAALSELITPHGPAIIASGGIASIDHVRQLAQLGVEGAIIGKALYVGAVKLAEAMAVAHMTN
V

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=40, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788336, Length=244, Percent_Identity=24.5901639344262, Blast_Score=81, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CHLAA (A9WD26)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001633984.1
- ProteinModelPortal:   A9WD26
- SMR:   A9WD26
- GeneID:   5827957
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0344
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25274; Mature: 25274

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPAIDIKDGRCVRLYQGDFAQMTVYADDPVAVARSWEAQGATRLHLVDLDGARAGHP
CCCCCCEECCCCCEEEEEECCCEEEEEEECCCEEEHCCCCCCCCEEEEEEECCCCCCCCC
QNVDAILAITQAVQIPVQLGGGLRREQDVESALALGVERVIIGTAAIAETDLVARLLDRF
CCCHHHHHHHHHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEQIVIGIDARNGLVATDGWTVTSSVKATVLAEQMANLGARRIIYTDISRDGALSGPNFA
CCEEEEEEECCCCEEEECCEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHH
ALSELITPHGPAIIASGGIASIDHVRQLAQLGVEGAIIGKALYVGAVKLAEAMAVAHMTN
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
V
C
>Mature Secondary Structure
MEIIPAIDIKDGRCVRLYQGDFAQMTVYADDPVAVARSWEAQGATRLHLVDLDGARAGHP
CCCCCCEECCCCCEEEEEECCCEEEEEEECCCEEEHCCCCCCCCEEEEEEECCCCCCCCC
QNVDAILAITQAVQIPVQLGGGLRREQDVESALALGVERVIIGTAAIAETDLVARLLDRF
CCCHHHHHHHHHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEQIVIGIDARNGLVATDGWTVTSSVKATVLAEQMANLGARRIIYTDISRDGALSGPNFA
CCEEEEEEECCCCEEEECCEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHH
ALSELITPHGPAIIASGGIASIDHVRQLAQLGVEGAIIGKALYVGAVKLAEAMAVAHMTN
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA