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The map label for this gene is era [H]

Identifier: 222523307

GI number: 222523307

Start: 7775

End: 9184

Strand: Reverse

Name: era [H]

Synonym: Chy400_0005

Alternate gene names: 222523307

Gene position: 9184-7775 (Counterclockwise)

Preceding gene: 222523308

Following gene: 222523306

Centisome position: 0.17

GC content: 54.82

Gene sequence:

>1410_bases
ATGAAATATTGTTCGCTTGATCCAGACGCCGGTACCCTCTATCTCTACTTCACCGACATTGAAGAGGGGCAGGCGACGGC
AGTAATGGAATACCCGGTTAGCCTGTTGCTTGATGCGCAAGGGGCAATCTTCGGTTGCCGACTCGATCTCGACGATGAGG
TGATTCTTAGCCAGCTCGAACTGGTGCTGGAGGGGTCGTATAACTGGCTCGACGGGGAATATGGTCATCTCTACATTCGG
ATTGCCGATGAGGATCCGGTAGAGACGATCACGTTGAGCGAGACGGCCATCCTCGATCTTGATGATGATGATCTGGTGTT
GGGGATTGAGCTGGCGTTGCCGGAAGAGTGGCGTACTCCCGAACGATTGCAACGGTTGACGCCGTTGATGGTGACATTCG
ACGATGAACCGGTTGACGGCGAAGGGCCGGTTGTGTTCACGCCGCCGGCAATCTCTGCCGATGATCTGCCTGATTCAGAC
GAAGAACCGGCAACGCCGGTTGCAGAAGAGCCGCTCCAATGGCGGTCGGGTTTTGTCGCGCTGGTCGGCAAGCCGAATGT
CGGTAAGAGTACCCTGCTCAATGCATTGTTGGGTGAAAAAGTTGCTATCGTCTCACCCCGCCCGCAGACGACGCGCGTCC
CGGTACGCGGTATTCTTTCACGACCGGGGGAGCAGATTATCTTCATCGACACACCCGGTATTCACGAACCCAGTCATCGA
TTGGGAAAACTGATGGTCGAACTGGCCGAACGCACGCTCCCCAACGCTGATGTGATCTGTTTTATGGTTGACATAAGTCA
ACCGCCTACTCGGCTTGATCGGATGATTGCGCAGCAGGTGCAGCGTGCTCGTGGGCATAAGCTGTTGGTGTTGAATAAGG
TTGATCAGAAGCCAAAACGCCCCGGTGAGAACTATCTACCCGCCTATCGTGAATTGGGTCAGTGGGAGATGGAGATTGCG
ATCTCGGCCCGACGTCGGTTAGGTCTGACAGCGTTACTGAGCGAGATTAGTGCCCGCTTACCCGAAGGCCCACCACTCTA
TCCGCTTGATCAGATGACCGATCAAACCGAGCAGCAACTGGCTGCCGAGTTTGTGCGTGAGAAAGCTCTCTTCTACCTTC
AGCAAGAGGTACCGCACGCCATTGCCATTGAAGTTGAAGAGTGGCAAGAGAAAGAGACGGCCACCTACATCCGTATGACA
ATTAATGTCGAGAAGGAGAGCCAGAAAGGTATCCTGATCGGTGCCGGTGGTGGTATGCTGAAGAAAATAGGCAGTGCTGC
CCGCGCTTCGATTGAGCGCATGCTAGGGCGACCGGTGTACCTCGATTTGTGGGTCAAGGTGCGTCCAAACTGGCGTGATG
ATCCGAGCGCATTGGGCTGGTTAGGGTACCGGGCGAAGAATTTTCTGTGA

Upstream 100 bases:

>100_bases
GATCAGCCCGAAACGCCATCTGATACCGATCAACCGCATACAGCGGCTCAGCAAGAAACGGTGACCGGTGAAGTGGCGCT
CGGTTCACAGGGATAATCGT

Downstream 100 bases:

>100_bases
TTGCAACTCAATCATTGTTATCTGCGTATTATCTTGTAGGTTCAGGCCCACTGGTTCAAATACGCGGTAACGATGATGGT
GCAACGCTCGCCTATTACAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKYCSLDPDAGTLYLYFTDIEEGQATAVMEYPVSLLLDAQGAIFGCRLDLDDEVILSQLELVLEGSYNWLDGEYGHLYIR
IADEDPVETITLSETAILDLDDDDLVLGIELALPEEWRTPERLQRLTPLMVTFDDEPVDGEGPVVFTPPAISADDLPDSD
EEPATPVAEEPLQWRSGFVALVGKPNVGKSTLLNALLGEKVAIVSPRPQTTRVPVRGILSRPGEQIIFIDTPGIHEPSHR
LGKLMVELAERTLPNADVICFMVDISQPPTRLDRMIAQQVQRARGHKLLVLNKVDQKPKRPGENYLPAYRELGQWEMEIA
ISARRRLGLTALLSEISARLPEGPPLYPLDQMTDQTEQQLAAEFVREKALFYLQQEVPHAIAIEVEEWQEKETATYIRMT
INVEKESQKGILIGAGGGMLKKIGSAARASIERMLGRPVYLDLWVKVRPNWRDDPSALGWLGYRAKNFL

Sequences:

>Translated_469_residues
MKYCSLDPDAGTLYLYFTDIEEGQATAVMEYPVSLLLDAQGAIFGCRLDLDDEVILSQLELVLEGSYNWLDGEYGHLYIR
IADEDPVETITLSETAILDLDDDDLVLGIELALPEEWRTPERLQRLTPLMVTFDDEPVDGEGPVVFTPPAISADDLPDSD
EEPATPVAEEPLQWRSGFVALVGKPNVGKSTLLNALLGEKVAIVSPRPQTTRVPVRGILSRPGEQIIFIDTPGIHEPSHR
LGKLMVELAERTLPNADVICFMVDISQPPTRLDRMIAQQVQRARGHKLLVLNKVDQKPKRPGENYLPAYRELGQWEMEIA
ISARRRLGLTALLSEISARLPEGPPLYPLDQMTDQTEQQLAAEFVREKALFYLQQEVPHAIAIEVEEWQEKETATYIRMT
INVEKESQKGILIGAGGGMLKKIGSAARASIERMLGRPVYLDLWVKVRPNWRDDPSALGWLGYRAKNFL
>Mature_469_residues
MKYCSLDPDAGTLYLYFTDIEEGQATAVMEYPVSLLLDAQGAIFGCRLDLDDEVILSQLELVLEGSYNWLDGEYGHLYIR
IADEDPVETITLSETAILDLDDDDLVLGIELALPEEWRTPERLQRLTPLMVTFDDEPVDGEGPVVFTPPAISADDLPDSD
EEPATPVAEEPLQWRSGFVALVGKPNVGKSTLLNALLGEKVAIVSPRPQTTRVPVRGILSRPGEQIIFIDTPGIHEPSHR
LGKLMVELAERTLPNADVICFMVDISQPPTRLDRMIAQQVQRARGHKLLVLNKVDQKPKRPGENYLPAYRELGQWEMEIA
ISARRRLGLTALLSEISARLPEGPPLYPLDQMTDQTEQQLAAEFVREKALFYLQQEVPHAIAIEVEEWQEKETATYIRMT
INVEKESQKGILIGAGGGMLKKIGSAARASIERMLGRPVYLDLWVKVRPNWRDDPSALGWLGYRAKNFL

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=302, Percent_Identity=29.4701986754967, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=36.3945578231293, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI87082120, Length=117, Percent_Identity=38.4615384615385, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI2367268, Length=86, Percent_Identity=40.6976744186046, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=171, Percent_Identity=28.6549707602339, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 52515; Mature: 52515

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYCSLDPDAGTLYLYFTDIEEGQATAVMEYPVSLLLDAQGAIFGCRLDLDDEVILSQLE
CCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEEEEECCCCEEEEEECCCHHHHHHHHH
LVLEGSYNWLDGEYGHLYIRIADEDPVETITLSETAILDLDDDDLVLGIELALPEEWRTP
HHHCCCCCCCCCCCCEEEEEECCCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCH
ERLQRLTPLMVTFDDEPVDGEGPVVFTPPAISADDLPDSDEEPATPVAEEPLQWRSGFVA
HHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEE
LVGKPNVGKSTLLNALLGEKVAIVSPRPQTTRVPVRGILSRPGEQIIFIDTPGIHEPSHR
EEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHH
LGKLMVELAERTLPNADVICFMVDISQPPTRLDRMIAQQVQRARGHKLLVLNKVDQKPKR
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
PGENYLPAYRELGQWEMEIAISARRRLGLTALLSEISARLPEGPPLYPLDQMTDQTEQQL
CCCCCCHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
AAEFVREKALFYLQQEVPHAIAIEVEEWQEKETATYIRMTINVEKESQKGILIGAGGGML
HHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEEEEEEEEEECCCCCCEEEECCCHHH
KKIGSAARASIERMLGRPVYLDLWVKVRPNWRDDPSALGWLGYRAKNFL
HHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKYCSLDPDAGTLYLYFTDIEEGQATAVMEYPVSLLLDAQGAIFGCRLDLDDEVILSQLE
CCCCCCCCCCCEEEEEEEECCCCCEEEEEECCEEEEEECCCCEEEEEECCCHHHHHHHHH
LVLEGSYNWLDGEYGHLYIRIADEDPVETITLSETAILDLDDDDLVLGIELALPEEWRTP
HHHCCCCCCCCCCCCEEEEEECCCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCH
ERLQRLTPLMVTFDDEPVDGEGPVVFTPPAISADDLPDSDEEPATPVAEEPLQWRSGFVA
HHHHHCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEE
LVGKPNVGKSTLLNALLGEKVAIVSPRPQTTRVPVRGILSRPGEQIIFIDTPGIHEPSHR
EEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHH
LGKLMVELAERTLPNADVICFMVDISQPPTRLDRMIAQQVQRARGHKLLVLNKVDQKPKR
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
PGENYLPAYRELGQWEMEIAISARRRLGLTALLSEISARLPEGPPLYPLDQMTDQTEQQL
CCCCCCHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
AAEFVREKALFYLQQEVPHAIAIEVEEWQEKETATYIRMTINVEKESQKGILIGAGGGML
HHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEEEEEEEEEEECCCCCCEEEECCCHHH
KKIGSAARASIERMLGRPVYLDLWVKVRPNWRDDPSALGWLGYRAKNFL
HHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA