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The map label for this gene is nupC [H]

Identifier: 222152133

GI number: 222152133

Start: 2025285

End: 2026493

Strand: Direct

Name: nupC [H]

Synonym: MCCL_1890

Alternate gene names: 222152133

Gene position: 2025285-2026493 (Clockwise)

Preceding gene: 222152103

Following gene: 222152137

Centisome position: 96.34

GC content: 35.48

Gene sequence:

>1209_bases
ATGAACTTTATAATAGGTATTATCGGACTTATTATCTTCTTGTCTCTCGCATGGATCATGAGTTCGGATAAAAAAGGTGT
AAGATGGCAATATATTGGTATCATGCTTGTAATTCAATTTATACTTGCTTTCGTCTTGCTAAAAACAACAGCTGGGATTT
GGCTCGTTACACAACTAGCAACCGGATTTGGTTATTTACTTAAGTATGCAGCAGAAGGTGTATACTTTGTATTCCCAGGT
GTTAAAAATGATGGTGTAGCTAATTCATTTTTCTTTGATGTATTGTTACCAATCACTTTTATTTCAGCATTAATAGGTAT
TCTTCAATATTTAAGAATCTTACCTTTCATCATCAAATATTTAGGCTTAGTTATTTCAAAAGTAAACGGCATGGGTAAAC
TTGAATCCTTCAATGCAGTAGCTGCAGCAATTCTTGGTCAATCAGAAGTATTCATTTCATTAAAGAAACAACTACCATTT
ATACCGAAGCATAGACTGTATACTTTAACAGCTTCAGCAATGTCTACTGTTTCGTTATCAATTGTCGGAGCATACTTTCA
GATGATTGAACCAAGATTTGTTGTTACAGCCATTGTACTTAATCTATTTGGTGGATTTATTATCGCTTCAATCATCAATC
CTTATAGAGTATCGGCTGAAGAAGAAGATGCGGTGATCATGACTGAAGATGAAAAGAAACAATCATTCTTCGAGATGCTT
GGCGAATATATTCTTGATGGATTTAAAGTTGCTATTATCGTTGCAGCAATGTTAATCGGTTATATCGCCTTAATTGCAAT
GCTTAATGGTATTGTTGATGCATTTACACCAGGCGAAATGAACTTCCAGACTATACTTGGGTATTTGTTTGCACCTCTTG
CATTCTTAACAGGAATCGCTTGGGACGATGCGGTGCGTGCAGGATCTATTATGGCTACAAAACTCGTTTCGAATGAATTT
GTTGCAATGCTAGATATTCAGTCTATTGTTAAAGGAAAGACTGGCGAATTATCAGAACATGCGGTCGGAATCGTTTCTGT
ATTCTTAGTATCTTTTGCTAACTTCTCATCTATCGGTATTATCGCAGGTGCTATTAAATCACTTAATGATAAGCAAGGTG
ATGTGGTCGCTAGATTCGGTCTGAAATTATTATACGGCGCTACACTTGTATCATTCATTTCAGCAACAATTGCAGGTTTC
TTTATATAA

Upstream 100 bases:

>100_bases
TGAACATATGTTCAAAATGAAATTAAAATTTGTTTAGCGCTTTCATAAATTATATAGTATGATATGTATAGTTAAAATTA
ATATTAAAAGGAGCGATATT

Downstream 100 bases:

>100_bases
AAGATAAGTGGACTGTTTCATAAACAGTCCACTCTTTTTTATAATAATGTTGATTTTTTCTTACAAAATTCGTCTCTAAT
TAATTATATGTCAATATTTC

Product: pyrimidine nucleoside transport protein

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MNFIIGIIGLIIFLSLAWIMSSDKKGVRWQYIGIMLVIQFILAFVLLKTTAGIWLVTQLATGFGYLLKYAAEGVYFVFPG
VKNDGVANSFFFDVLLPITFISALIGILQYLRILPFIIKYLGLVISKVNGMGKLESFNAVAAAILGQSEVFISLKKQLPF
IPKHRLYTLTASAMSTVSLSIVGAYFQMIEPRFVVTAIVLNLFGGFIIASIINPYRVSAEEEDAVIMTEDEKKQSFFEML
GEYILDGFKVAIIVAAMLIGYIALIAMLNGIVDAFTPGEMNFQTILGYLFAPLAFLTGIAWDDAVRAGSIMATKLVSNEF
VAMLDIQSIVKGKTGELSEHAVGIVSVFLVSFANFSSIGIIAGAIKSLNDKQGDVVARFGLKLLYGATLVSFISATIAGF
FI

Sequences:

>Translated_402_residues
MNFIIGIIGLIIFLSLAWIMSSDKKGVRWQYIGIMLVIQFILAFVLLKTTAGIWLVTQLATGFGYLLKYAAEGVYFVFPG
VKNDGVANSFFFDVLLPITFISALIGILQYLRILPFIIKYLGLVISKVNGMGKLESFNAVAAAILGQSEVFISLKKQLPF
IPKHRLYTLTASAMSTVSLSIVGAYFQMIEPRFVVTAIVLNLFGGFIIASIINPYRVSAEEEDAVIMTEDEKKQSFFEML
GEYILDGFKVAIIVAAMLIGYIALIAMLNGIVDAFTPGEMNFQTILGYLFAPLAFLTGIAWDDAVRAGSIMATKLVSNEF
VAMLDIQSIVKGKTGELSEHAVGIVSVFLVSFANFSSIGIIAGAIKSLNDKQGDVVARFGLKLLYGATLVSFISATIAGF
FI
>Mature_402_residues
MNFIIGIIGLIIFLSLAWIMSSDKKGVRWQYIGIMLVIQFILAFVLLKTTAGIWLVTQLATGFGYLLKYAAEGVYFVFPG
VKNDGVANSFFFDVLLPITFISALIGILQYLRILPFIIKYLGLVISKVNGMGKLESFNAVAAAILGQSEVFISLKKQLPF
IPKHRLYTLTASAMSTVSLSIVGAYFQMIEPRFVVTAIVLNLFGGFIIASIINPYRVSAEEEDAVIMTEDEKKQSFFEML
GEYILDGFKVAIIVAAMLIGYIALIAMLNGIVDAFTPGEMNFQTILGYLFAPLAFLTGIAWDDAVRAGSIMATKLVSNEF
VAMLDIQSIVKGKTGELSEHAVGIVSVFLVSFANFSSIGIIAGAIKSLNDKQGDVVARFGLKLLYGATLVSFISATIAGF
FI

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=414, Percent_Identity=24.1545893719807, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI11545853, Length=417, Percent_Identity=25.8992805755396, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI227116277, Length=420, Percent_Identity=22.8571428571429, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788737, Length=387, Percent_Identity=58.1395348837209, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788485, Length=414, Percent_Identity=31.4009661835749, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1788488, Length=414, Percent_Identity=31.4009661835749, Blast_Score=191, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17560276, Length=402, Percent_Identity=26.3681592039801, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71991794, Length=414, Percent_Identity=22.7053140096618, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552519, Length=406, Percent_Identity=23.3990147783251, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45552517, Length=406, Percent_Identity=23.3990147783251, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19921868, Length=406, Percent_Identity=23.3990147783251, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360430, Length=405, Percent_Identity=22.7160493827161, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 43753; Mature: 43753

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFIIGIIGLIIFLSLAWIMSSDKKGVRWQYIGIMLVIQFILAFVLLKTTAGIWLVTQLA
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
TGFGYLLKYAAEGVYFVFPGVKNDGVANSFFFDVLLPITFISALIGILQYLRILPFIIKY
HHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLVISKVNGMGKLESFNAVAAAILGQSEVFISLKKQLPFIPKHRLYTLTASAMSTVSLS
HHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHH
IVGAYFQMIEPRFVVTAIVLNLFGGFIIASIINPYRVSAEEEDAVIMTEDEKKQSFFEML
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHH
GEYILDGFKVAIIVAAMLIGYIALIAMLNGIVDAFTPGEMNFQTILGYLFAPLAFLTGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
WDDAVRAGSIMATKLVSNEFVAMLDIQSIVKGKTGELSEHAVGIVSVFLVSFANFSSIGI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
IAGAIKSLNDKQGDVVARFGLKLLYGATLVSFISATIAGFFI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFIIGIIGLIIFLSLAWIMSSDKKGVRWQYIGIMLVIQFILAFVLLKTTAGIWLVTQLA
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
TGFGYLLKYAAEGVYFVFPGVKNDGVANSFFFDVLLPITFISALIGILQYLRILPFIIKY
HHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLVISKVNGMGKLESFNAVAAAILGQSEVFISLKKQLPFIPKHRLYTLTASAMSTVSLS
HHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHH
IVGAYFQMIEPRFVVTAIVLNLFGGFIIASIINPYRVSAEEEDAVIMTEDEKKQSFFEML
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHH
GEYILDGFKVAIIVAAMLIGYIALIAMLNGIVDAFTPGEMNFQTILGYLFAPLAFLTGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
WDDAVRAGSIMATKLVSNEFVAMLDIQSIVKGKTGELSEHAVGIVSVFLVSFANFSSIGI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
IAGAIKSLNDKQGDVVARFGLKLLYGATLVSFISATIAGFFI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]