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The map label for this gene is bdhA [H]

Identifier: 222152044

GI number: 222152044

Start: 1936467

End: 1937120

Strand: Direct

Name: bdhA [H]

Synonym: MCCL_1801

Alternate gene names: 222152044

Gene position: 1936467-1937120 (Clockwise)

Preceding gene: 222152042

Following gene: 222152045

Centisome position: 92.11

GC content: 40.98

Gene sequence:

>654_bases
ATGAAAGCAGCAGTATGGCATGGTAAAAAAGACATTAGAGTTGAAGACAGAGAAATCCGTGAAATGCGTGATAATGAGGT
ACGCGTCAAAGTCGGATATGCTGGAATTTGTGGTAGTGACTTACATGAGTATCAAGAAGGACCAGTATTCGTTCCCGTAG
ACAAAGAGGATGAGCTTACTGGGGGTAAAGCGCCTTTAATTATGGGTCATGAGTTTTCAGGCACAGTTGTTGAAGTAGGC
AAAGAGGTTAAAGATTTCAAAGTTGGCGATCGTGTTTCAGTAAATCCAACTGTGACATATGGTAAAAATACAGACGAATT
AGATGTTTATGACGGTTTCAGCTTCCTCGGTCTACATACAGATGGAGGTTTTACTGACTTAGTTAATGTACCAGAAACTA
ATCTTTATCATTTACCAGATTCATTATCTTTACGTGTAGCAGCAACTATCGAGCCATTAGCGGTGGGGGTTCAAGCTGTT
AAAGAAAGCGGCTTAGAGTTCGGAGATACTGTGGCTATCTTTGGTGCAGGTCCTATCGGTATCTATACAACCCTTGCAGC
TCGTGCAGCTGGTGCAAGTAAAATTATTGTACTCGATCTTTCTAAAGAACGTCCTAGAAAAAGCAAAAGAATGTGGCGCA
ACGCATATCATTAA

Upstream 100 bases:

>100_bases
TCTAAAAAATTCACATACTTTTTCTGGAATATATAGTTTGTGAATTTAGTATCAAAGTTGTATACTAATATTGTAAATAA
ATATCTGGAGGGATCATTAC

Downstream 100 bases:

>100_bases
CTCAGGTGAGGTAGATGCGGTAAAAGCAATCAAAGAAATCGTTCCAGGTGGAGTAGATCGCTCATTTGAAGTAGCCGGTG
TAACACCTACATTTGTACAA

Product: zinc-dependent dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKAAVWHGKKDIRVEDREIREMRDNEVRVKVGYAGICGSDLHEYQEGPVFVPVDKEDELTGGKAPLIMGHEFSGTVVEVG
KEVKDFKVGDRVSVNPTVTYGKNTDELDVYDGFSFLGLHTDGGFTDLVNVPETNLYHLPDSLSLRVAATIEPLAVGVQAV
KESGLEFGDTVAIFGAGPIGIYTTLAARAAGASKIIVLDLSKERPRKSKRMWRNAYH

Sequences:

>Translated_217_residues
MKAAVWHGKKDIRVEDREIREMRDNEVRVKVGYAGICGSDLHEYQEGPVFVPVDKEDELTGGKAPLIMGHEFSGTVVEVG
KEVKDFKVGDRVSVNPTVTYGKNTDELDVYDGFSFLGLHTDGGFTDLVNVPETNLYHLPDSLSLRVAATIEPLAVGVQAV
KESGLEFGDTVAIFGAGPIGIYTTLAARAAGASKIIVLDLSKERPRKSKRMWRNAYH
>Mature_217_residues
MKAAVWHGKKDIRVEDREIREMRDNEVRVKVGYAGICGSDLHEYQEGPVFVPVDKEDELTGGKAPLIMGHEFSGTVVEVG
KEVKDFKVGDRVSVNPTVTYGKNTDELDVYDGFSFLGLHTDGGFTDLVNVPETNLYHLPDSLSLRVAATIEPLAVGVQAV
KESGLEFGDTVAIFGAGPIGIYTTLAARAAGASKIIVLDLSKERPRKSKRMWRNAYH

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=218, Percent_Identity=36.697247706422, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI4501929, Length=239, Percent_Identity=28.4518828451883, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1788073, Length=207, Percent_Identity=34.2995169082126, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1787863, Length=215, Percent_Identity=33.0232558139535, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI226510992, Length=209, Percent_Identity=31.5789473684211, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790045, Length=204, Percent_Identity=29.9019607843137, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788407, Length=210, Percent_Identity=31.4285714285714, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790718, Length=221, Percent_Identity=32.1266968325792, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI87082125, Length=218, Percent_Identity=27.5229357798165, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788075, Length=199, Percent_Identity=30.1507537688442, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87081918, Length=218, Percent_Identity=28.8990825688073, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=208, Percent_Identity=36.0576923076923, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562876, Length=218, Percent_Identity=35.3211009174312, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=189, Percent_Identity=28.042328042328, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=238, Percent_Identity=38.2352941176471, Blast_Score=145, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=234, Percent_Identity=37.1794871794872, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322619, Length=213, Percent_Identity=37.0892018779343, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=213, Percent_Identity=37.0892018779343, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=216, Percent_Identity=31.0185185185185, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=240, Percent_Identity=26.25, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=188, Percent_Identity=30.8510638297872, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324486, Length=193, Percent_Identity=29.5336787564767, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=215, Percent_Identity=38.1395348837209, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17737897, Length=215, Percent_Identity=38.6046511627907, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI221457811, Length=176, Percent_Identity=26.7045454545455, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550770, Length=176, Percent_Identity=26.7045454545455, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551930, Length=176, Percent_Identity=26.7045454545455, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 23763; Mature: 23763

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVWHGKKDIRVEDREIREMRDNEVRVKVGYAGICGSDLHEYQEGPVFVPVDKEDELT
CCCCEECCCCCCEECHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCEEEECCCCCCCC
GGKAPLIMGHEFSGTVVEVGKEVKDFKVGDRVSVNPTVTYGKNTDELDVYDGFSFLGLHT
CCCCCEEECCCCCCHHHHHCCHHHHCCCCCEEECCCEEEECCCCCEEEEECCEEEEEEEC
DGGFTDLVNVPETNLYHLPDSLSLRVAATIEPLAVGVQAVKESGLEFGDTVAIFGAGPIG
CCCCEEEECCCCCCEEECCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCHH
IYTTLAARAAGASKIIVLDLSKERPRKSKRMWRNAYH
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKAAVWHGKKDIRVEDREIREMRDNEVRVKVGYAGICGSDLHEYQEGPVFVPVDKEDELT
CCCCEECCCCCCEECHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCEEEECCCCCCCC
GGKAPLIMGHEFSGTVVEVGKEVKDFKVGDRVSVNPTVTYGKNTDELDVYDGFSFLGLHT
CCCCCEEECCCCCCHHHHHCCHHHHCCCCCEEECCCEEEECCCCCEEEEECCEEEEEEEC
DGGFTDLVNVPETNLYHLPDSLSLRVAATIEPLAVGVQAVKESGLEFGDTVAIFGAGPIG
CCCCEEEECCCCCCEEECCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCHH
IYTTLAARAAGASKIIVLDLSKERPRKSKRMWRNAYH
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]