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The map label for this gene is mccB [H]

Identifier: 222152033

GI number: 222152033

Start: 1926549

End: 1927694

Strand: Direct

Name: mccB [H]

Synonym: MCCL_1790

Alternate gene names: 222152033

Gene position: 1926549-1927694 (Clockwise)

Preceding gene: 222152032

Following gene: 222152034

Centisome position: 91.64

GC content: 39.01

Gene sequence:

>1146_bases
ATGCAAAAGAAAACAATGATGATCCATGGAGGAAATACAATTGATGAATACACTGGAGCTGTGAACCCTCCAATTTACCA
AACAAGCACGTACAAACAAGATGGCATCGGAAATATGCGTCAAGGCTATGAATATTCTCGTTCCGCAAACCCAACACGTA
CAGCATTAGAATCACTAATCAGAGACCTGGAATCAGGTGATGCTGGCTTTGCATTTGGTTCTGGTATGGCTGCAATATCT
TCTGTAATCATGTTACTCAATGCTGGCGATCATATCGTTGTTGGTAGCGATGTATACGGCGGAACTTATCGCGTATTCAC
AAAAGTCTTCGAACGCATCGGTATTAAATCAACATTCGTTGACACAACCGATATTGAAGCGGTTGAAGCGGCAATCAGCG
AGAATACTAAGATGCTTTATATTGAAACCCCTACGAATCCATTACTTAATGTAACGGATATTCGTAAAATGGTCGAAATT
TCTAAAGCACACAACTTAATTTCTGTTGTAGACAACACATTTATGACACCTTTCTTCCAGAATCCGCTTGAACTTGGTGC
AGATATCGTGTTACATTCAGCAACGAAATATATTGGTGGACACAGTGACGTTGTTGCCGGACTTGTTGTTACTCGTACAC
CTGAACTTTCTGAAGCAGTTGGTTTTATTCAGAATTCAGTAGGTGGTGTACTTGGACCTCAAGATAGTTTCTTACTCGTG
CGTGGTATTAAGACGCTTGCAATTCGAATGGAACAAACCGAACAAACAACATTAAAAATTATCGAATTTCTCCAAAAACA
AAATGTCGTAACAAACATCTTCCATCCTTCATTACTTGATGAAGGTAACAAGAAAATTCACGAATCACAAAGCAAAGGTT
ACGGCGGAATGATATCATTTGATGTAGGATCTAAAGAAAATGCCGAAAACTTAGTAAAATCAACGAAATATTTCACTTTA
GCAGAATCATTGGGTGCAGTAGAAAGTTTAATTTCTGTGCCTAGCCAGATGACTCATGCTTCAATCCCTAGAGAACGCCG
CCTGGAACTTGGTATCACTGACGGTTTAGTTCGAATCTCTGTGGGTATTGAAGATAGTGAAGATTTAATCGCAGACTTAG
AACAAGCATTTAAACAATTAAACTAG

Upstream 100 bases:

>100_bases
CCAAGAAAATATGACTGATAGCAATATCGTCGTAATATTCCCTGATGCAGCAGAGCGATACTTATCACAACAAATATTTG
ATATTAAAGGAGAATAGATT

Downstream 100 bases:

>100_bases
GAGTGACACTTATGACTAAAAAAATGAACGTTGAAAGTTTCAACTTAGACCACACAATCGTAGATGCACCATTTGTACGA
TTAGCTGGTATCAAAGAAGG

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MQKKTMMIHGGNTIDEYTGAVNPPIYQTSTYKQDGIGNMRQGYEYSRSANPTRTALESLIRDLESGDAGFAFGSGMAAIS
SVIMLLNAGDHIVVGSDVYGGTYRVFTKVFERIGIKSTFVDTTDIEAVEAAISENTKMLYIETPTNPLLNVTDIRKMVEI
SKAHNLISVVDNTFMTPFFQNPLELGADIVLHSATKYIGGHSDVVAGLVVTRTPELSEAVGFIQNSVGGVLGPQDSFLLV
RGIKTLAIRMEQTEQTTLKIIEFLQKQNVVTNIFHPSLLDEGNKKIHESQSKGYGGMISFDVGSKENAENLVKSTKYFTL
AESLGAVESLISVPSQMTHASIPRERRLELGITDGLVRISVGIEDSEDLIADLEQAFKQLN

Sequences:

>Translated_381_residues
MQKKTMMIHGGNTIDEYTGAVNPPIYQTSTYKQDGIGNMRQGYEYSRSANPTRTALESLIRDLESGDAGFAFGSGMAAIS
SVIMLLNAGDHIVVGSDVYGGTYRVFTKVFERIGIKSTFVDTTDIEAVEAAISENTKMLYIETPTNPLLNVTDIRKMVEI
SKAHNLISVVDNTFMTPFFQNPLELGADIVLHSATKYIGGHSDVVAGLVVTRTPELSEAVGFIQNSVGGVLGPQDSFLLV
RGIKTLAIRMEQTEQTTLKIIEFLQKQNVVTNIFHPSLLDEGNKKIHESQSKGYGGMISFDVGSKENAENLVKSTKYFTL
AESLGAVESLISVPSQMTHASIPRERRLELGITDGLVRISVGIEDSEDLIADLEQAFKQLN
>Mature_381_residues
MQKKTMMIHGGNTIDEYTGAVNPPIYQTSTYKQDGIGNMRQGYEYSRSANPTRTALESLIRDLESGDAGFAFGSGMAAIS
SVIMLLNAGDHIVVGSDVYGGTYRVFTKVFERIGIKSTFVDTTDIEAVEAAISENTKMLYIETPTNPLLNVTDIRKMVEI
SKAHNLISVVDNTFMTPFFQNPLELGADIVLHSATKYIGGHSDVVAGLVVTRTPELSEAVGFIQNSVGGVLGPQDSFLLV
RGIKTLAIRMEQTEQTTLKIIEFLQKQNVVTNIFHPSLLDEGNKKIHESQSKGYGGMISFDVGSKENAENLVKSTKYFTL
AESLGAVESLISVPSQMTHASIPRERRLELGITDGLVRISVGIEDSEDLIADLEQAFKQLN

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=377, Percent_Identity=46.1538461538462, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI299473759, Length=377, Percent_Identity=41.6445623342175, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI25453487, Length=376, Percent_Identity=40.1595744680851, Blast_Score=248, Evalue=8e-66,
Organism=Escherichia coli, GI1790375, Length=382, Percent_Identity=43.1937172774869, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=26.0204081632653, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=379, Percent_Identity=47.2295514511873, Blast_Score=330, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17538055, Length=379, Percent_Identity=47.4934036939314, Blast_Score=327, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=38.4196185286104, Blast_Score=251, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319307, Length=384, Percent_Identity=46.6145833333333, Blast_Score=324, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=398, Percent_Identity=35.929648241206, Blast_Score=238, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=34.1743119266055, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=29.7709923664122, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=28.2608695652174, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322590, Length=272, Percent_Identity=27.5735294117647, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323557, Length=335, Percent_Identity=25.0746268656716, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322970, Length=346, Percent_Identity=23.6994219653179, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=46.5608465608466, Blast_Score=357, Evalue=7e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41595; Mature: 41595

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKTMMIHGGNTIDEYTGAVNPPIYQTSTYKQDGIGNMRQGYEYSRSANPTRTALESLI
CCCCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHH
RDLESGDAGFAFGSGMAAISSVIMLLNAGDHIVVGSDVYGGTYRVFTKVFERIGIKSTFV
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEC
DTTDIEAVEAAISENTKMLYIETPTNPLLNVTDIRKMVEISKAHNLISVVDNTFMTPFFQ
CCCHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
NPLELGADIVLHSATKYIGGHSDVVAGLVVTRTPELSEAVGFIQNSVGGVLGPQDSFLLV
CHHHHCHHHHHHHHHHHHCCCHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCEEHH
RGIKTLAIRMEQTEQTTLKIIEFLQKQNVVTNIFHPSLLDEGNKKIHESQSKGYGGMISF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCCCHHHHHHHCCCCCCEEEE
DVGSKENAENLVKSTKYFTLAESLGAVESLISVPSQMTHASIPRERRLELGITDGLVRIS
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHCEEECCCCCEEEEE
VGIEDSEDLIADLEQAFKQLN
ECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKKTMMIHGGNTIDEYTGAVNPPIYQTSTYKQDGIGNMRQGYEYSRSANPTRTALESLI
CCCCEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHH
RDLESGDAGFAFGSGMAAISSVIMLLNAGDHIVVGSDVYGGTYRVFTKVFERIGIKSTFV
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEC
DTTDIEAVEAAISENTKMLYIETPTNPLLNVTDIRKMVEISKAHNLISVVDNTFMTPFFQ
CCCHHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHC
NPLELGADIVLHSATKYIGGHSDVVAGLVVTRTPELSEAVGFIQNSVGGVLGPQDSFLLV
CHHHHCHHHHHHHHHHHHCCCHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCEEHH
RGIKTLAIRMEQTEQTTLKIIEFLQKQNVVTNIFHPSLLDEGNKKIHESQSKGYGGMISF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCCCHHHHHHHCCCCCCEEEE
DVGSKENAENLVKSTKYFTLAESLGAVESLISVPSQMTHASIPRERRLELGITDGLVRIS
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHCEEECCCCCEEEEE
VGIEDSEDLIADLEQAFKQLN
ECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]