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The map label for this gene is cvrA [H]

Identifier: 222151579

GI number: 222151579

Start: 1443903

End: 1445333

Strand: Direct

Name: cvrA [H]

Synonym: MCCL_1332

Alternate gene names: 222151579

Gene position: 1443903-1445333 (Clockwise)

Preceding gene: 222151578

Following gene: 222151598

Centisome position: 68.68

GC content: 39.2

Gene sequence:

>1431_bases
TTGCTACTTTTTACTGCAGTCATGACCACAACATTATCCAGTAAACTCGGACTTCCCTCATTAATCGTCTTTCTCGCTGT
AGGTATGGCACTGAATTCATTCATTATGTTTGATAATGCTTTCCTCGCACAACTTATTGGAACAATCGCCCTTGTCATCA
TTTTGTTTGATGGTGGTATTCAAACAACTAAATTAACGGTGAAAAATGCAATCTCTTATGCATCTATACTAGCAACCATC
GGTGTTCTCATTACAAGTTTCATTGTAGGTGTAGCAACAGTCTTTATATTAGATCTATCCTGGAAACAGGGGCTGTTATT
TGGAGCCATTGTCGGATCTACGGATGCTGCCGCTGTATTCAGTATTCTTGGTAACAAGCAAATTAAACAGAAGATTAAAA
GCATACTTGAGGTTGAATCTGGAACAAATGACCCTATGGCCTTATTTTTAACCGTTACGATGATCAATCTACTAACAATG
CCAGATGCATCATTGCTAACAAGTGCACTACTATTTGTATGGCAAATGATAGGCGGCGCATTACTTGGCCTGCTCATCGG
ATATATTACAGTGAAACTCATAAACTTTGTAGAGCTTGAAGCGACTGGACTCTATCCTATCCTTGCACTTACTTTAGCCT
TTCTTACATACGGACTATCTTCTCCACTGAAAGTCAGTGGACTCCTTGCTGTATATGTCTTTGCATTATATTTAGGTAAC
CATCCGCTCAGCTATCGTGCAAATATCATCAGATTCGGCGAAAGTTTTGCATGGATGGCTCAGATGACAATGTTTATACT
ATTAGGATTACTCGTATTCCCTAGTCACCTTCCAGGCATAATGATTCAAGGATTACTCATCGCAATCGTCCTGATGTTTG
TGGCAAGGCCTATAAGTGTCTGGCTGACGCTCTTCTGGACGGATCTCTCGAAGAAAGAACTTACCTTTATCTCATGGGCA
GGATTACGGGGTGCAGTACCAATTATTCTTGCAACATATGCACTGTTAGCAGAAGTTGAAAATTCAGAAATTATCTTTAA
CGTCGTCTTCTTTGTCGTATTACTAAGCGCATTACTACAAGGTATGACGCTTGTCCCTCTTGCGAATAAACTCGGACTTA
ATAAAGGAGAGGCACATACAAGTCCTTACCACTTTGATATGGTTGCAAGTGAAGTTACAGAAGTTGATATACGTGAATAC
CTTGTAAAGTCAGGATCACCTTGGGCAAATAAAAAAATACATGAACTTGGTCTACCGAGACAATCCAATATTAATGCGGT
TGTAAGAAACGACAAGTTATACGTGCCTGATGGTAATTTTGAGATACAGACAAACGACATATTATATATCATCGCAAGTA
AGAAACTGCATCTGAACATTCAGAAAGAACTTGCAAAATTAAAAGCGAAAAAAGAACGCCCTGTCAAATAG

Upstream 100 bases:

>100_bases
AATGATATTTCATAATAATTTGAATTTTTGATATAATTATTAGGAAATATCATTTAGGAGTGATCTCATTAATACTGAAA
TTATTATTTTAATTCTTGGT

Downstream 100 bases:

>100_bases
ACAAGGCGTTTTATTATTGCTTCACCACTTTAAAGATGACAAATGACGGGCGATGATTAATTTTTTCGATATCAACATGA
CTCATATGCTCATGGGAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MLLFTAVMTTTLSSKLGLPSLIVFLAVGMALNSFIMFDNAFLAQLIGTIALVIILFDGGIQTTKLTVKNAISYASILATI
GVLITSFIVGVATVFILDLSWKQGLLFGAIVGSTDAAAVFSILGNKQIKQKIKSILEVESGTNDPMALFLTVTMINLLTM
PDASLLTSALLFVWQMIGGALLGLLIGYITVKLINFVELEATGLYPILALTLAFLTYGLSSPLKVSGLLAVYVFALYLGN
HPLSYRANIIRFGESFAWMAQMTMFILLGLLVFPSHLPGIMIQGLLIAIVLMFVARPISVWLTLFWTDLSKKELTFISWA
GLRGAVPIILATYALLAEVENSEIIFNVVFFVVLLSALLQGMTLVPLANKLGLNKGEAHTSPYHFDMVASEVTEVDIREY
LVKSGSPWANKKIHELGLPRQSNINAVVRNDKLYVPDGNFEIQTNDILYIIASKKLHLNIQKELAKLKAKKERPVK

Sequences:

>Translated_476_residues
MLLFTAVMTTTLSSKLGLPSLIVFLAVGMALNSFIMFDNAFLAQLIGTIALVIILFDGGIQTTKLTVKNAISYASILATI
GVLITSFIVGVATVFILDLSWKQGLLFGAIVGSTDAAAVFSILGNKQIKQKIKSILEVESGTNDPMALFLTVTMINLLTM
PDASLLTSALLFVWQMIGGALLGLLIGYITVKLINFVELEATGLYPILALTLAFLTYGLSSPLKVSGLLAVYVFALYLGN
HPLSYRANIIRFGESFAWMAQMTMFILLGLLVFPSHLPGIMIQGLLIAIVLMFVARPISVWLTLFWTDLSKKELTFISWA
GLRGAVPIILATYALLAEVENSEIIFNVVFFVVLLSALLQGMTLVPLANKLGLNKGEAHTSPYHFDMVASEVTEVDIREY
LVKSGSPWANKKIHELGLPRQSNINAVVRNDKLYVPDGNFEIQTNDILYIIASKKLHLNIQKELAKLKAKKERPVK
>Mature_476_residues
MLLFTAVMTTTLSSKLGLPSLIVFLAVGMALNSFIMFDNAFLAQLIGTIALVIILFDGGIQTTKLTVKNAISYASILATI
GVLITSFIVGVATVFILDLSWKQGLLFGAIVGSTDAAAVFSILGNKQIKQKIKSILEVESGTNDPMALFLTVTMINLLTM
PDASLLTSALLFVWQMIGGALLGLLIGYITVKLINFVELEATGLYPILALTLAFLTYGLSSPLKVSGLLAVYVFALYLGN
HPLSYRANIIRFGESFAWMAQMTMFILLGLLVFPSHLPGIMIQGLLIAIVLMFVARPISVWLTLFWTDLSKKELTFISWA
GLRGAVPIILATYALLAEVENSEIIFNVVFFVVLLSALLQGMTLVPLANKLGLNKGEAHTSPYHFDMVASEVTEVDIREY
LVKSGSPWANKKIHELGLPRQSNINAVVRNDKLYVPDGNFEIQTNDILYIIASKKLHLNIQKELAKLKAKKERPVK

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=350, Percent_Identity=26.2857142857143, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI148727259, Length=387, Percent_Identity=21.4470284237726, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87081854, Length=451, Percent_Identity=39.9113082039911, Blast_Score=282, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 52032; Mature: 52032

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLFTAVMTTTLSSKLGLPSLIVFLAVGMALNSFIMFDNAFLAQLIGTIALVIILFDGGI
CEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QTTKLTVKNAISYASILATIGVLITSFIVGVATVFILDLSWKQGLLFGAIVGSTDAAAVF
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHH
SILGNKQIKQKIKSILEVESGTNDPMALFLTVTMINLLTMPDASLLTSALLFVWQMIGGA
HHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LLGLLIGYITVKLINFVELEATGLYPILALTLAFLTYGLSSPLKVSGLLAVYVFALYLGN
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
HPLSYRANIIRFGESFAWMAQMTMFILLGLLVFPSHLPGIMIQGLLIAIVLMFVARPISV
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WLTLFWTDLSKKELTFISWAGLRGAVPIILATYALLAEVENSEIIFNVVFFVVLLSALLQ
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GMTLVPLANKLGLNKGEAHTSPYHFDMVASEVTEVDIREYLVKSGSPWANKKIHELGLPR
CCEEEECHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
QSNINAVVRNDKLYVPDGNFEIQTNDILYIIASKKLHLNIQKELAKLKAKKERPVK
CCCCCEEEECCEEEECCCCEEEEECCEEEEEECCEEEEEHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLLFTAVMTTTLSSKLGLPSLIVFLAVGMALNSFIMFDNAFLAQLIGTIALVIILFDGGI
CEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QTTKLTVKNAISYASILATIGVLITSFIVGVATVFILDLSWKQGLLFGAIVGSTDAAAVF
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHH
SILGNKQIKQKIKSILEVESGTNDPMALFLTVTMINLLTMPDASLLTSALLFVWQMIGGA
HHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LLGLLIGYITVKLINFVELEATGLYPILALTLAFLTYGLSSPLKVSGLLAVYVFALYLGN
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
HPLSYRANIIRFGESFAWMAQMTMFILLGLLVFPSHLPGIMIQGLLIAIVLMFVARPISV
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WLTLFWTDLSKKELTFISWAGLRGAVPIILATYALLAEVENSEIIFNVVFFVVLLSALLQ
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GMTLVPLANKLGLNKGEAHTSPYHFDMVASEVTEVDIREYLVKSGSPWANKKIHELGLPR
CCEEEECHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
QSNINAVVRNDKLYVPDGNFEIQTNDILYIIASKKLHLNIQKELAKLKAKKERPVK
CCCCCEEEECCEEEECCCCEEEEECCEEEEEECCEEEEEHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]