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The map label for this gene is ipdC [H]

Identifier: 222151578

GI number: 222151578

Start: 1442101

End: 1443741

Strand: Direct

Name: ipdC [H]

Synonym: MCCL_1331

Alternate gene names: 222151578

Gene position: 1442101-1443741 (Clockwise)

Preceding gene: 222151575

Following gene: 222151579

Centisome position: 68.6

GC content: 39.12

Gene sequence:

>1641_bases
ATGAAACAAAGAATCGGTCAATACTTAATCGATGCACTTCATGTTAACGGTGTCGATAAAATTTTTGGGGTACCGGGAGA
TTTTACTTTAGCATTCCTTGACGATATCATTCGTCATGATAATGTAGAGTGGGTAGGCAATACAAATGAACTCAATGCAG
CCTATGCTGCTGACGGCTATGCGAGAGTTAACGGACTTGCAGCAGTAAGTACAACATTTGGCGTAGGAGAACTAAGTGCA
GTAAACGGGATTGCTGGAAGTTATGCTGAACGTGTGCCTGTCATAAAAATTTCGGGCGGTCCTTCATCTGTCGCTCAACA
AGAGGGTCGCTATGTCCACCATTCACTTGGTGAAGGTATTTTCGATTCCTATTCAAAAATGTATGCACATATCACTGCGA
CGACAACAATACTTTCTGTAGACAATGCAGTGGATGAAATTGACCGCGTGATTCATTGCGCACTCAAAGAAAAGCGTCCT
GTGCACATCCACCTACCGATAGATGTTGCTTTGACAGAAATTGAAATTCCCCATGCACCTAAAGTGTATACACATGAATC
ACAAAATGTCGATGCATATATCCAGGCAGTAGAGAAGAAACTCATGTCTGCAAAACAACCTGTAATTATAGCGGGACATG
AGATCAACAGCTTTAAACTACATGAACAGCTAGAGCAGTTCGTAAATCAAACGAATATACCTGTTGCACAGCTTTCTCTT
GGCAAATCTGCATTTAATGAAGAAAATGAACATTACCTAGGGATTTATGACGGTAAGATCGCTAAAGAAAACGTGCGTGA
GTATGTGGATAATGCAGATGTCATCTTAAATATAGGTGCAAAACTGACAGATTCTGCAACAGCAGGTTTCTCATACAAAT
TCGATACTAATAATATTATCTATATTAACCATAATGACTTTAAAGCTGAGGATGTTATAAGCGATAATGTCTCGCTGATT
GATCTTGTAAACGGACTGAATAGTATCGACTACAGGAATGAAACACACTACCCATCATATCAACGTTCGGATATGAAATA
TGAGTTGAACGACGCACCCTTAACACAAAGCAACTACTTCAAAATGATGAATGCATTCTTAGAAAAAGATGATATTTTAC
TTGCAGAGCAAGGCACATCATTCTTTGGTGCTTATGATCTATCTTTATATAAAGGGAATCAATTTATCGGCCAGCCGTTA
TGGGGATCAATCGGCTATACATTCCCATCTCTATTAGGATCTCAGCTTGCTGATATGCATAGACGTAACATCCTGCTTAT
CGGTGACGGTTCATTGCAATTAACTGTTCAGGCACTATCTACAATGATCAGAAAAGACATTAAGCCGATTATCTTCGTAA
TCAATAACGATGGCTATACTGTAGAACGTCTGATACATGGTATGGAAGAACCATACAATGACATCCAGATGTGGAACTAC
AAACAGTTACCAGAAGTATTTGGTGGTAAAGATACGGTTAAGGTCCACGATGCGAAGACTTCAAATGAATTAAAGACAGT
TATGGATAGCGTTAAAGCAGACAAAGACCATATGCACTTTATCGAAGTACATATGGCTGTAGAAGATGCTCCGAAGAAAT
TAATCGATATCGCAAAAGCTTTCTCTGATGCGAACAAATAA

Upstream 100 bases:

>100_bases
TACAGAGAAAAAATAAGATTACAACAAATAGGTCAATTTAGTTGACTTAATGTTATTTTAACTATATATTTAAATTGTTA
ATCACGAAAGGATGAGAGAG

Downstream 100 bases:

>100_bases
TATATTTATTGTAGCCAGGACACGTTACGTTGCTCCTGGCTCTTTTATATCTTTTATAGTAAATGATATTTCATAATAAT
TTGAATTTTTGATATAATTA

Product: indole-3-pyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKQRIGQYLIDALHVNGVDKIFGVPGDFTLAFLDDIIRHDNVEWVGNTNELNAAYAADGYARVNGLAAVSTTFGVGELSA
VNGIAGSYAERVPVIKISGGPSSVAQQEGRYVHHSLGEGIFDSYSKMYAHITATTTILSVDNAVDEIDRVIHCALKEKRP
VHIHLPIDVALTEIEIPHAPKVYTHESQNVDAYIQAVEKKLMSAKQPVIIAGHEINSFKLHEQLEQFVNQTNIPVAQLSL
GKSAFNEENEHYLGIYDGKIAKENVREYVDNADVILNIGAKLTDSATAGFSYKFDTNNIIYINHNDFKAEDVISDNVSLI
DLVNGLNSIDYRNETHYPSYQRSDMKYELNDAPLTQSNYFKMMNAFLEKDDILLAEQGTSFFGAYDLSLYKGNQFIGQPL
WGSIGYTFPSLLGSQLADMHRRNILLIGDGSLQLTVQALSTMIRKDIKPIIFVINNDGYTVERLIHGMEEPYNDIQMWNY
KQLPEVFGGKDTVKVHDAKTSNELKTVMDSVKADKDHMHFIEVHMAVEDAPKKLIDIAKAFSDANK

Sequences:

>Translated_546_residues
MKQRIGQYLIDALHVNGVDKIFGVPGDFTLAFLDDIIRHDNVEWVGNTNELNAAYAADGYARVNGLAAVSTTFGVGELSA
VNGIAGSYAERVPVIKISGGPSSVAQQEGRYVHHSLGEGIFDSYSKMYAHITATTTILSVDNAVDEIDRVIHCALKEKRP
VHIHLPIDVALTEIEIPHAPKVYTHESQNVDAYIQAVEKKLMSAKQPVIIAGHEINSFKLHEQLEQFVNQTNIPVAQLSL
GKSAFNEENEHYLGIYDGKIAKENVREYVDNADVILNIGAKLTDSATAGFSYKFDTNNIIYINHNDFKAEDVISDNVSLI
DLVNGLNSIDYRNETHYPSYQRSDMKYELNDAPLTQSNYFKMMNAFLEKDDILLAEQGTSFFGAYDLSLYKGNQFIGQPL
WGSIGYTFPSLLGSQLADMHRRNILLIGDGSLQLTVQALSTMIRKDIKPIIFVINNDGYTVERLIHGMEEPYNDIQMWNY
KQLPEVFGGKDTVKVHDAKTSNELKTVMDSVKADKDHMHFIEVHMAVEDAPKKLIDIAKAFSDANK
>Mature_546_residues
MKQRIGQYLIDALHVNGVDKIFGVPGDFTLAFLDDIIRHDNVEWVGNTNELNAAYAADGYARVNGLAAVSTTFGVGELSA
VNGIAGSYAERVPVIKISGGPSSVAQQEGRYVHHSLGEGIFDSYSKMYAHITATTTILSVDNAVDEIDRVIHCALKEKRP
VHIHLPIDVALTEIEIPHAPKVYTHESQNVDAYIQAVEKKLMSAKQPVIIAGHEINSFKLHEQLEQFVNQTNIPVAQLSL
GKSAFNEENEHYLGIYDGKIAKENVREYVDNADVILNIGAKLTDSATAGFSYKFDTNNIIYINHNDFKAEDVISDNVSLI
DLVNGLNSIDYRNETHYPSYQRSDMKYELNDAPLTQSNYFKMMNAFLEKDDILLAEQGTSFFGAYDLSLYKGNQFIGQPL
WGSIGYTFPSLLGSQLADMHRRNILLIGDGSLQLTVQALSTMIRKDIKPIIFVINNDGYTVERLIHGMEEPYNDIQMWNY
KQLPEVFGGKDTVKVHDAKTSNELKTVMDSVKADKDHMHFIEVHMAVEDAPKKLIDIAKAFSDANK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=480, Percent_Identity=22.5, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786717, Length=473, Percent_Identity=20.9302325581395, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1787096, Length=485, Percent_Identity=23.0927835051546, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531299, Length=570, Percent_Identity=22.4561403508772, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531301, Length=570, Percent_Identity=22.4561403508772, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323073, Length=557, Percent_Identity=37.5224416517056, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323163, Length=558, Percent_Identity=37.8136200716846, Blast_Score=356, Evalue=6e-99,
Organism=Saccharomyces cerevisiae, GI6321524, Length=569, Percent_Identity=36.9068541300527, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6320123, Length=554, Percent_Identity=33.5740072202166, Blast_Score=315, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6320588, Length=605, Percent_Identity=28.5950413223141, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6323755, Length=501, Percent_Identity=23.5528942115768, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 60911; Mature: 60911

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRIGQYLIDALHVNGVDKIFGVPGDFTLAFLDDIIRHDNVEWVGNTNELNAAYAADGY
CCHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCH
ARVNGLAAVSTTFGVGELSAVNGIAGSYAERVPVIKISGGPSSVAQQEGRYVHHSLGEGI
HHHCCEEEEEHHCCCCCHHHHHCCHHHHHHCCCEEEECCCCHHHHHHCCCCHHHHHCCHH
FDSYSKMYAHITATTTILSVDNAVDEIDRVIHCALKEKRPVHIHLPIDVALTEIEIPHAP
HHHHHHHHEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEEEEEECCCCC
KVYTHESQNVDAYIQAVEKKLMSAKQPVIIAGHEINSFKLHEQLEQFVNQTNIPVAQLSL
CEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEC
GKSAFNEENEHYLGIYDGKIAKENVREYVDNADVILNIGAKLTDSATAGFSYKFDTNNII
CHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEECCCCEE
YINHNDFKAEDVISDNVSLIDLVNGLNSIDYRNETHYPSYQRSDMKYELNDAPLTQSNYF
EEECCCCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHH
KMMNAFLEKDDILLAEQGTSFFGAYDLSLYKGNQFIGQPLWGSIGYTFPSLLGSQLADMH
HHHHHHHCCCCEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RRNILLIGDGSLQLTVQALSTMIRKDIKPIIFVINNDGYTVERLIHGMEEPYNDIQMWNY
HCCEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHCCCH
KQLPEVFGGKDTVKVHDAKTSNELKTVMDSVKADKDHMHFIEVHMAVEDAPKKLIDIAKA
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHH
FSDANK
HHCCCC
>Mature Secondary Structure
MKQRIGQYLIDALHVNGVDKIFGVPGDFTLAFLDDIIRHDNVEWVGNTNELNAAYAADGY
CCHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCH
ARVNGLAAVSTTFGVGELSAVNGIAGSYAERVPVIKISGGPSSVAQQEGRYVHHSLGEGI
HHHCCEEEEEHHCCCCCHHHHHCCHHHHHHCCCEEEECCCCHHHHHHCCCCHHHHHCCHH
FDSYSKMYAHITATTTILSVDNAVDEIDRVIHCALKEKRPVHIHLPIDVALTEIEIPHAP
HHHHHHHHEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEEEEEECCCCC
KVYTHESQNVDAYIQAVEKKLMSAKQPVIIAGHEINSFKLHEQLEQFVNQTNIPVAQLSL
CEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEC
GKSAFNEENEHYLGIYDGKIAKENVREYVDNADVILNIGAKLTDSATAGFSYKFDTNNII
CHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEECCCCEE
YINHNDFKAEDVISDNVSLIDLVNGLNSIDYRNETHYPSYQRSDMKYELNDAPLTQSNYF
EEECCCCCCHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHH
KMMNAFLEKDDILLAEQGTSFFGAYDLSLYKGNQFIGQPLWGSIGYTFPSLLGSQLADMH
HHHHHHHCCCCEEEEECCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RRNILLIGDGSLQLTVQALSTMIRKDIKPIIFVINNDGYTVERLIHGMEEPYNDIQMWNY
HCCEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHCCCH
KQLPEVFGGKDTVKVHDAKTSNELKTVMDSVKADKDHMHFIEVHMAVEDAPKKLIDIAKA
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHH
FSDANK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]