Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 222151399

GI number: 222151399

Start: 1258189

End: 1258992

Strand: Direct

Name: proC [H]

Synonym: MCCL_1152

Alternate gene names: 222151399

Gene position: 1258189-1258992 (Clockwise)

Preceding gene: 222151397

Following gene: 222151401

Centisome position: 59.85

GC content: 36.94

Gene sequence:

>804_bases
ATGAAAATCGTGTTCTTTGGTTCAGGTAATATGGCAAGCGCCATTTTTATCGGACTTGTTGAGAGTAAAACGATTCAAGG
CAAGGATATATTTATCACGAATCGCTCTAATGAAGAAGAATTAAAACGCTTTAATCAACTTTATCAAATAAATTATAGCT
ATGATGACGAGGCTCTGTTAAAAGATGCTGATTTCGTCTTCCTGGCGGTAAAACCGTATGACTTTGATTCAGTAGCACAA
CGAATCAAACCTTATCTATTTGAAGAAAACCACTTTGTATCAATGATGGCTGGTATCCCAATCAATCAAATCAAGAATAA
ATTAAATGCACATAACCCGGTTGCACGCATTATGCCGAATACGAATGCACACGTTCAACAATCGGTTACTGGCATTTCTT
ATTCTGATAATTTCAGTGAAAACGCTAAATCAAATCTTAATGCATTACTGGAAGCATTTGGTACATCTATCGAAGTGAAA
GAAGAATCTCTTCATGATGTCACTGCAATAACAGGAAGTGGCCCTGCATTTCTCTACTATGTATATGAAGAATATATAAA
AGCTGCAAAACATCTTGGACTGTCTCCTGATGATACGGACATGGCCGTAAGAAACTTAATCATAGGGACTGGAAGAATGC
TGGAAAACTCAGAACTTTCAATTGATCAGCTTCGCGAAAACATTACTTCTAAAGGTGGAACAACTAAAGCCGGATTAGAT
GCTCTGCGCAAGCATCCAATAGAAGAGATGTTTATTGATTGTTTAGAACAGGCATTGAACAGAAGCAAGGAACTAAGTGA
ATAA

Upstream 100 bases:

>100_bases
TTATCAATATTCTTTTACTCATAATCCTCACCATCGCAATTGTAAATTATATATAGTTTACACTATAATAAATGCTATAA
ACAATTTATGGAGGGATAGT

Downstream 100 bases:

>100_bases
AAAGGTCGCGACACCGATATACATGAATAAAATCAAAAAGACGGAAGGAAATAATCTTTGTTTCCTTCCGTCTTTTTGAT
TTTAATCGTATCTGTGCTCT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKIVFFGSGNMASAIFIGLVESKTIQGKDIFITNRSNEEELKRFNQLYQINYSYDDEALLKDADFVFLAVKPYDFDSVAQ
RIKPYLFEENHFVSMMAGIPINQIKNKLNAHNPVARIMPNTNAHVQQSVTGISYSDNFSENAKSNLNALLEAFGTSIEVK
EESLHDVTAITGSGPAFLYYVYEEYIKAAKHLGLSPDDTDMAVRNLIIGTGRMLENSELSIDQLRENITSKGGTTKAGLD
ALRKHPIEEMFIDCLEQALNRSKELSE

Sequences:

>Translated_267_residues
MKIVFFGSGNMASAIFIGLVESKTIQGKDIFITNRSNEEELKRFNQLYQINYSYDDEALLKDADFVFLAVKPYDFDSVAQ
RIKPYLFEENHFVSMMAGIPINQIKNKLNAHNPVARIMPNTNAHVQQSVTGISYSDNFSENAKSNLNALLEAFGTSIEVK
EESLHDVTAITGSGPAFLYYVYEEYIKAAKHLGLSPDDTDMAVRNLIIGTGRMLENSELSIDQLRENITSKGGTTKAGLD
ALRKHPIEEMFIDCLEQALNRSKELSE
>Mature_267_residues
MKIVFFGSGNMASAIFIGLVESKTIQGKDIFITNRSNEEELKRFNQLYQINYSYDDEALLKDADFVFLAVKPYDFDSVAQ
RIKPYLFEENHFVSMMAGIPINQIKNKLNAHNPVARIMPNTNAHVQQSVTGISYSDNFSENAKSNLNALLEAFGTSIEVK
EESLHDVTAITGSGPAFLYYVYEEYIKAAKHLGLSPDDTDMAVRNLIIGTGRMLENSELSIDQLRENITSKGGTTKAGLD
ALRKHPIEEMFIDCLEQALNRSKELSE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=27.0676691729323, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=26.7399267399267, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=27.037037037037, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=26.7399267399267, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=25.187969924812, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=28.8973384030418, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=24.6428571428571, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320861, Length=208, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=28.1954887218045, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=26.1818181818182, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=28.9940828402367, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29934; Mature: 29934

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFFGSGNMASAIFIGLVESKTIQGKDIFITNRSNEEELKRFNQLYQINYSYDDEALL
CEEEEECCCCHHHHHHEEHHHCCEECCCEEEEECCCCHHHHHHHHHHEEEECCCCCHHHH
KDADFVFLAVKPYDFDSVAQRIKPYLFEENHFVSMMAGIPINQIKNKLNAHNPVARIMPN
CCCCEEEEEECCCCHHHHHHHHHHHEECCCCEEEHHHCCCHHHHHHHHCCCCCHHEECCC
TNAHVQQSVTGISYSDNFSENAKSNLNALLEAFGTSIEVKEESLHDVTAITGSGPAFLYY
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECHHHHHHHEEEECCCCEEEHH
VYEEYIKAAKHLGLSPDDTDMAVRNLIIGTGRMLENSELSIDQLRENITSKGGTTKAGLD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCCCCHHHHH
ALRKHPIEEMFIDCLEQALNRSKELSE
HHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIVFFGSGNMASAIFIGLVESKTIQGKDIFITNRSNEEELKRFNQLYQINYSYDDEALL
CEEEEECCCCHHHHHHEEHHHCCEECCCEEEEECCCCHHHHHHHHHHEEEECCCCCHHHH
KDADFVFLAVKPYDFDSVAQRIKPYLFEENHFVSMMAGIPINQIKNKLNAHNPVARIMPN
CCCCEEEEEECCCCHHHHHHHHHHHEECCCCEEEHHHCCCHHHHHHHHCCCCCHHEECCC
TNAHVQQSVTGISYSDNFSENAKSNLNALLEAFGTSIEVKEESLHDVTAITGSGPAFLYY
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECHHHHHHHEEEECCCCEEEHH
VYEEYIKAAKHLGLSPDDTDMAVRNLIIGTGRMLENSELSIDQLRENITSKGGTTKAGLD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCCCCHHHHH
ALRKHPIEEMFIDCLEQALNRSKELSE
HHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA