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The map label for this gene is thrB [H]

Identifier: 222151236

GI number: 222151236

Start: 1087424

End: 1088326

Strand: Direct

Name: thrB [H]

Synonym: MCCL_0987

Alternate gene names: 222151236

Gene position: 1087424-1088326 (Clockwise)

Preceding gene: 222151235

Following gene: 222151237

Centisome position: 51.72

GC content: 37.32

Gene sequence:

>903_bases
ATGCTATATATAAAAGTCCCAGCGTCAACATCAAATTTAGGGCCAGGGTTTGATTCAATCGGTATGGCTGTAAACATTTA
TCTTGAACTTGAAGTAGAAGAAAGTGAAAACTGGGAAATTCAGCATCTCGGTGATGTACTATCTGAACTGGATGATAATG
ATGATCATTATATCAGAAAAATGTGTCGACTGTTTATGCAGCAGTTTAATCTAGAAGAAAAAAAGTTTAAAGTTATAATG
TATTCTGATATCCCATTAGCGCGTGGCCTGGGAAGTAGTGGTTCAGCACTCATTGCAAGTCTTGAAATTATCAATCATTT
CTATCGATTAAATTTAACGAGAGAAGAACGTATTCGTATACTCTCTCGAATTGAAGGACATCCAGATAATGTTGCACCGA
GTATTAAAGGTGGTATTGTTGCAGGATATTATAATAATGTAACCAATGAAACGGTAACATTAGATGTTCCTGTGATTAAG
TGGCCGATCATGGTTGTAATTCCTAATTATGAACTGAAAACTGAAGCATCAAGAAATGTCCTTCCGAATCACATATCGTT
TGAAAATGCAGTGCGCGCAGGTGCGATAGGAAATATGCTTATAGCCGCATTATACTCTGAAGATTATAGGACAATGGGGA
AGATGATGACTAGTGATCTTTATCACGAACAGTATCGTGCACACCTTGTACCACATTATCAGATGGTGAAAGATGTTATC
ACCGAGGACTGCTTTGCATTTTTAAGTGGGGCAGGGCCATCGATCTTTATTGTATCTCATCCTAAGCAATACGATGAAAA
TCGTTTCAATCTACTAAAGTTACCCGACTGTGACGTAAAAAGCATAGAACCCGATCATGAAGGTGTAATTACCTATGAAA
AAGAAGGTCGTATGGTAAACTAA

Upstream 100 bases:

>100_bases
TTAAAGACCCACAGACTGCGATTGATTCAATTGAAATACAGCCTGCTGTACTGAAGAACGATGAATCAGCGATTATTAGA
TACATTGAGGAGCGAGTATA

Downstream 100 bases:

>100_bases
TACTATCAATTTTTAGGAGTGAGAAAATGAACTATAAACTGATAGTACTCGATATGGATGATACATTACTAACATCTAAG
AACGAAATACTGCCTTCAAC

Product: hypothetical protein

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MLYIKVPASTSNLGPGFDSIGMAVNIYLELEVEESENWEIQHLGDVLSELDDNDDHYIRKMCRLFMQQFNLEEKKFKVIM
YSDIPLARGLGSSGSALIASLEIINHFYRLNLTREERIRILSRIEGHPDNVAPSIKGGIVAGYYNNVTNETVTLDVPVIK
WPIMVVIPNYELKTEASRNVLPNHISFENAVRAGAIGNMLIAALYSEDYRTMGKMMTSDLYHEQYRAHLVPHYQMVKDVI
TEDCFAFLSGAGPSIFIVSHPKQYDENRFNLLKLPDCDVKSIEPDHEGVITYEKEGRMVN

Sequences:

>Translated_300_residues
MLYIKVPASTSNLGPGFDSIGMAVNIYLELEVEESENWEIQHLGDVLSELDDNDDHYIRKMCRLFMQQFNLEEKKFKVIM
YSDIPLARGLGSSGSALIASLEIINHFYRLNLTREERIRILSRIEGHPDNVAPSIKGGIVAGYYNNVTNETVTLDVPVIK
WPIMVVIPNYELKTEASRNVLPNHISFENAVRAGAIGNMLIAALYSEDYRTMGKMMTSDLYHEQYRAHLVPHYQMVKDVI
TEDCFAFLSGAGPSIFIVSHPKQYDENRFNLLKLPDCDVKSIEPDHEGVITYEKEGRMVN
>Mature_300_residues
MLYIKVPASTSNLGPGFDSIGMAVNIYLELEVEESENWEIQHLGDVLSELDDNDDHYIRKMCRLFMQQFNLEEKKFKVIM
YSDIPLARGLGSSGSALIASLEIINHFYRLNLTREERIRILSRIEGHPDNVAPSIKGGIVAGYYNNVTNETVTLDVPVIK
WPIMVVIPNYELKTEASRNVLPNHISFENAVRAGAIGNMLIAALYSEDYRTMGKMMTSDLYHEQYRAHLVPHYQMVKDVI
TEDCFAFLSGAGPSIFIVSHPKQYDENRFNLLKLPDCDVKSIEPDHEGVITYEKEGRMVN

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=275, Percent_Identity=25.0909090909091, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34122; Mature: 34122

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYIKVPASTSNLGPGFDSIGMAVNIYLELEVEESENWEIQHLGDVLSELDDNDDHYIRK
CEEEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHH
MCRLFMQQFNLEEKKFKVIMYSDIPLARGLGSSGSALIASLEIINHFYRLNLTREERIRI
HHHHHHHHCCCCCHHEEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
LSRIEGHPDNVAPSIKGGIVAGYYNNVTNETVTLDVPVIKWPIMVVIPNYELKTEASRNV
HHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECEEEEEEEEEECCCEECCCCCCCC
LPNHISFENAVRAGAIGNMLIAALYSEDYRTMGKMMTSDLYHEQYRAHLVPHYQMVKDVI
CCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TEDCFAFLSGAGPSIFIVSHPKQYDENRFNLLKLPDCDVKSIEPDHEGVITYEKEGRMVN
HHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MLYIKVPASTSNLGPGFDSIGMAVNIYLELEVEESENWEIQHLGDVLSELDDNDDHYIRK
CEEEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHH
MCRLFMQQFNLEEKKFKVIMYSDIPLARGLGSSGSALIASLEIINHFYRLNLTREERIRI
HHHHHHHHCCCCCHHEEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
LSRIEGHPDNVAPSIKGGIVAGYYNNVTNETVTLDVPVIKWPIMVVIPNYELKTEASRNV
HHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECEEEEEEEEEECCCEECCCCCCCC
LPNHISFENAVRAGAIGNMLIAALYSEDYRTMGKMMTSDLYHEQYRAHLVPHYQMVKDVI
CCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TEDCFAFLSGAGPSIFIVSHPKQYDENRFNLLKLPDCDVKSIEPDHEGVITYEKEGRMVN
HHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA