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The map label for this gene is thrC [H]

Identifier: 222151235

GI number: 222151235

Start: 1086348

End: 1087424

Strand: Direct

Name: thrC [H]

Synonym: MCCL_0986

Alternate gene names: 222151235

Gene position: 1086348-1087424 (Clockwise)

Preceding gene: 222151234

Following gene: 222151236

Centisome position: 51.67

GC content: 42.34

Gene sequence:

>1077_bases
TTGAAGGTGTATAGAATGAACAGATGGTCAGGGTTAATCGCAGAATATAAGCATTTTTTACCCGTAAGTGAGGCAACACC
GAAACTCACATTAAATGAAGGAGGTACGCCATTGATACATTGTGCTCATCTTTCAGAGGTTCTTGAAAATGAAGTATATG
TGAAATATGAAGGGGCGAATCCTACAGGTTCATTTAAAGACCGCGGTATGGTTATGGCTGTAGCAAAAGCTAAGGAAGAG
GGAAAAGAGATTGTCATTTGCGCTTCTACGGGTAACACTTCAGCTTCAGCAGCTGCCTATGCTGCAAGAGCTGGAATGAA
AACGATTGTAGTAATTCCGGAAGGGAAGATAGCTATGGGTAAATTGGCTCAGGCAATCGTTTATGGTGCTGATATCGTTT
CTATCGAAGGTAACTTTGATGAAGCATTGAAGATCGTAAGACATGTTGCAGAAAAACGTGATGATATCGCACTGGTAAAC
TCCGTTAATCCATATCGACTTGAAGGTCAGAAGACAGCTGCTTTTGAAGTGATCGAACAGCTCGGACAAGTTCCGGATGT
GTTAGCGATTCCTGTTGGAAATGCTGGTAATATTTCGGCATACTGGAAGGGGTTTAAAGAATATGATGCAAATCATAACA
TTGGTTTACCAAAAATGTATGGTTTCCAGGCAGAAGGTGCTGCACCGATTGTAAAAGGACGTATTATCGAGCAGCCAGAA
ACGATTGCTACTGCGATTCGTATCGGAAATCCAGCAAGCTGGAGGCTCGCAGAAGCAGCACGCGATGAATCGGAAGGCAT
GATAGATGCTGTAACAGATGATGAGATACTAGAAGCATATGATTTAATTGCAAAGAAAGAAGGTATCTTTGCTGAACCAG
GCAGCAATGCAAGTATCGCTGGTCTGTTAAAGTTAAAACGTGAAGGTCGGCTGTCAAAGGGGCAGACGATTGTTGCAGTA
TTAACCGGAAATGGGCTTAAAGACCCACAGACTGCGATTGATTCAATTGAAATACAGCCTGCTGTACTGAAGAACGATGA
ATCAGCGATTATTAGATACATTGAGGAGCGAGTATAA

Upstream 100 bases:

>100_bases
AGACATATTGTAAGAGATGGCATGCTTGCAGTTGAAACAGAGCTAGAAGTAAATTATGAATATCTGGAAGAAGAGCAATT
AAACTATAAAACTTATAGAA

Downstream 100 bases:

>100_bases
TGCTATATATAAAAGTCCCAGCGTCAACATCAAATTTAGGGCCAGGGTTTGATTCAATCGGTATGGCTGTAAACATTTAT
CTTGAACTTGAAGTAGAAGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKVYRMNRWSGLIAEYKHFLPVSEATPKLTLNEGGTPLIHCAHLSEVLENEVYVKYEGANPTGSFKDRGMVMAVAKAKEE
GKEIVICASTGNTSASAAAYAARAGMKTIVVIPEGKIAMGKLAQAIVYGADIVSIEGNFDEALKIVRHVAEKRDDIALVN
SVNPYRLEGQKTAAFEVIEQLGQVPDVLAIPVGNAGNISAYWKGFKEYDANHNIGLPKMYGFQAEGAAPIVKGRIIEQPE
TIATAIRIGNPASWRLAEAARDESEGMIDAVTDDEILEAYDLIAKKEGIFAEPGSNASIAGLLKLKREGRLSKGQTIVAV
LTGNGLKDPQTAIDSIEIQPAVLKNDESAIIRYIEERV

Sequences:

>Translated_358_residues
MKVYRMNRWSGLIAEYKHFLPVSEATPKLTLNEGGTPLIHCAHLSEVLENEVYVKYEGANPTGSFKDRGMVMAVAKAKEE
GKEIVICASTGNTSASAAAYAARAGMKTIVVIPEGKIAMGKLAQAIVYGADIVSIEGNFDEALKIVRHVAEKRDDIALVN
SVNPYRLEGQKTAAFEVIEQLGQVPDVLAIPVGNAGNISAYWKGFKEYDANHNIGLPKMYGFQAEGAAPIVKGRIIEQPE
TIATAIRIGNPASWRLAEAARDESEGMIDAVTDDEILEAYDLIAKKEGIFAEPGSNASIAGLLKLKREGRLSKGQTIVAV
LTGNGLKDPQTAIDSIEIQPAVLKNDESAIIRYIEERV
>Mature_358_residues
MKVYRMNRWSGLIAEYKHFLPVSEATPKLTLNEGGTPLIHCAHLSEVLENEVYVKYEGANPTGSFKDRGMVMAVAKAKEE
GKEIVICASTGNTSASAAAYAARAGMKTIVVIPEGKIAMGKLAQAIVYGADIVSIEGNFDEALKIVRHVAEKRDDIALVN
SVNPYRLEGQKTAAFEVIEQLGQVPDVLAIPVGNAGNISAYWKGFKEYDANHNIGLPKMYGFQAEGAAPIVKGRIIEQPE
TIATAIRIGNPASWRLAEAARDESEGMIDAVTDDEILEAYDLIAKKEGIFAEPGSNASIAGLLKLKREGRLSKGQTIVAV
LTGNGLKDPQTAIDSIEIQPAVLKNDESAIIRYIEERV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=303, Percent_Identity=28.7128712871287, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790207, Length=310, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=26.5822784810127, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 38623; Mature: 38623

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYRMNRWSGLIAEYKHFLPVSEATPKLTLNEGGTPLIHCAHLSEVLENEVYVKYEGAN
CCEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEHHHHHHHHCCCEEEEECCCC
PTGSFKDRGMVMAVAKAKEEGKEIVICASTGNTSASAAAYAARAGMKTIVVIPEGKIAMG
CCCCCCCCCEEEEEEHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHH
KLAQAIVYGADIVSIEGNFDEALKIVRHVAEKRDDIALVNSVNPYRLEGQKTAAFEVIEQ
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHH
LGQVPDVLAIPVGNAGNISAYWKGFKEYDANHNIGLPKMYGFQAEGAAPIVKGRIIEQPE
HCCCCCEEEEECCCCCCCHHHHCCHHHCCCCCCCCCCCEECCCCCCCCCEEECEECCCCH
TIATAIRIGNPASWRLAEAARDESEGMIDAVTDDEILEAYDLIAKKEGIFAEPGSNASIA
HHEEEEECCCCCCCHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCEECCCCCCCHH
GLLKLKREGRLSKGQTIVAVLTGNGLKDPQTAIDSIEIQPAVLKNDESAIIRYIEERV
HHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHCEECCCCEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MKVYRMNRWSGLIAEYKHFLPVSEATPKLTLNEGGTPLIHCAHLSEVLENEVYVKYEGAN
CCEEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEHHHHHHHHCCCEEEEECCCC
PTGSFKDRGMVMAVAKAKEEGKEIVICASTGNTSASAAAYAARAGMKTIVVIPEGKIAMG
CCCCCCCCCEEEEEEHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHH
KLAQAIVYGADIVSIEGNFDEALKIVRHVAEKRDDIALVNSVNPYRLEGQKTAAFEVIEQ
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHHHHHH
LGQVPDVLAIPVGNAGNISAYWKGFKEYDANHNIGLPKMYGFQAEGAAPIVKGRIIEQPE
HCCCCCEEEEECCCCCCCHHHHCCHHHCCCCCCCCCCCEECCCCCCCCCEEECEECCCCH
TIATAIRIGNPASWRLAEAARDESEGMIDAVTDDEILEAYDLIAKKEGIFAEPGSNASIA
HHEEEEECCCCCCCHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCEECCCCCCCHH
GLLKLKREGRLSKGQTIVAVLTGNGLKDPQTAIDSIEIQPAVLKNDESAIIRYIEERV
HHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHCEECCCCEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]