Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 222151234

GI number: 222151234

Start: 1085147

End: 1086361

Strand: Direct

Name: hom [H]

Synonym: MCCL_0985

Alternate gene names: 222151234

Gene position: 1085147-1086361 (Clockwise)

Preceding gene: 222151231

Following gene: 222151235

Centisome position: 51.62

GC content: 37.53

Gene sequence:

>1215_bases
ATGAAACAAATTAATATTGCATTATTAGGTCTAGGAACGGTGGGTACAGGTGTCGTCCAGATCCTTAAGGAGAACCATGA
ACAGATAAAAGAGAAACTGAATACCGATATTCGAATTACGTGGATACTTGTTTCTGATGTAACAAAGCCAAGAATTATCG
AGACCGCACATTATCAACTCACTGATAATATAGAAGATATCAAAAATGATGCTACGATAGATATGTATGTTGAAGTAATG
GGTGGAATAGAAAATACGAAAGAGATATTACTCTATGCATTAAATCAGAAGAAGCATGTAATTACGGCTAATAAAGATCT
GCTTGCAGAGCATCTAGAAGAGATGGAGCAAGCGGCACATAATAACGGTGTCTCTTTAAAATATGAAGCCAGTATCGCTG
GAGGTATTCCTGTGGTGAATGCCTTGAATTATGGTTTGAACGCGAACGGTATCGGCAAGTTTATGGGAATATTCAATGGA
ACGTCTAATTTTATATTGAGTAAGATGACACATGAAAGACAATCTTATGAAGAAGCATTACGAGTTGCTACAGAATTAGG
TTTTGCTGAAGCAGATCCTACAGCAGATGTAGAGGGTATAGATGCTGCCAGAAAAGTAACTATTATGAGCTATCTTGCCT
TTAATCAATTCAGAAAACTTGAGGGTTGCCGATATACAGGGATCAGAGAAGTGAAGTTATCACATATCGATATTGCCAAA
GCTTTTGGATATCGCATTAAATTGATCGGTAGTGGTGTCATGAATGGTGATGATGTATCGCTATGTGTAGAACCGATGTG
TATTCCATCTGATCATCAGTTATCGCATGTCGAATACGAATATAATGCAATTTACATTGCTGGAAATGCTGTCGGAGATA
CGATGTATTACGGTAAAGGAGCCGGTAGTCTTGCAACAGGAAGTGCTGTTGTCAGTGATATCCTGAACGTAATTGAACTC
ATAGGGACAGATCTTCATAACTTGCCGCTGCATCTTGAAATCAAGCAGGAGACGCGTGAACAGCCTTCTCGTTTACTTTT
GATTATCGATTTGTATGCAGATAGCAATGTTGCAGAAATACTAAATGAAATTTCAGTCGAAAGACATATTGTAAGAGATG
GCATGCTTGCAGTTGAAACAGAGCTAGAAGTAAATTATGAATATCTGGAAGAAGAGCAATTAAACTATAAAACTTATAGA
ATTGAAGGTGTATAG

Upstream 100 bases:

>100_bases
TTTATCTTTACATTGCTGATGTTTTAGTTATACTATATTTATGAATCCTTTTCAAGAATACATTTGTATTTTTGGTAAAT
ACATAATCAGGAGTGAGATA

Downstream 100 bases:

>100_bases
AATGAACAGATGGTCAGGGTTAATCGCAGAATATAAGCATTTTTTACCCGTAAGTGAGGCAACACCGAAACTCACATTAA
ATGAAGGAGGTACGCCATTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKQINIALLGLGTVGTGVVQILKENHEQIKEKLNTDIRITWILVSDVTKPRIIETAHYQLTDNIEDIKNDATIDMYVEVM
GGIENTKEILLYALNQKKHVITANKDLLAEHLEEMEQAAHNNGVSLKYEASIAGGIPVVNALNYGLNANGIGKFMGIFNG
TSNFILSKMTHERQSYEEALRVATELGFAEADPTADVEGIDAARKVTIMSYLAFNQFRKLEGCRYTGIREVKLSHIDIAK
AFGYRIKLIGSGVMNGDDVSLCVEPMCIPSDHQLSHVEYEYNAIYIAGNAVGDTMYYGKGAGSLATGSAVVSDILNVIEL
IGTDLHNLPLHLEIKQETREQPSRLLLIIDLYADSNVAEILNEISVERHIVRDGMLAVETELEVNYEYLEEEQLNYKTYR
IEGV

Sequences:

>Translated_404_residues
MKQINIALLGLGTVGTGVVQILKENHEQIKEKLNTDIRITWILVSDVTKPRIIETAHYQLTDNIEDIKNDATIDMYVEVM
GGIENTKEILLYALNQKKHVITANKDLLAEHLEEMEQAAHNNGVSLKYEASIAGGIPVVNALNYGLNANGIGKFMGIFNG
TSNFILSKMTHERQSYEEALRVATELGFAEADPTADVEGIDAARKVTIMSYLAFNQFRKLEGCRYTGIREVKLSHIDIAK
AFGYRIKLIGSGVMNGDDVSLCVEPMCIPSDHQLSHVEYEYNAIYIAGNAVGDTMYYGKGAGSLATGSAVVSDILNVIEL
IGTDLHNLPLHLEIKQETREQPSRLLLIIDLYADSNVAEILNEISVERHIVRDGMLAVETELEVNYEYLEEEQLNYKTYR
IEGV
>Mature_404_residues
MKQINIALLGLGTVGTGVVQILKENHEQIKEKLNTDIRITWILVSDVTKPRIIETAHYQLTDNIEDIKNDATIDMYVEVM
GGIENTKEILLYALNQKKHVITANKDLLAEHLEEMEQAAHNNGVSLKYEASIAGGIPVVNALNYGLNANGIGKFMGIFNG
TSNFILSKMTHERQSYEEALRVATELGFAEADPTADVEGIDAARKVTIMSYLAFNQFRKLEGCRYTGIREVKLSHIDIAK
AFGYRIKLIGSGVMNGDDVSLCVEPMCIPSDHQLSHVEYEYNAIYIAGNAVGDTMYYGKGAGSLATGSAVVSDILNVIEL
IGTDLHNLPLHLEIKQETREQPSRLLLIIDLYADSNVAEILNEISVERHIVRDGMLAVETELEVNYEYLEEEQLNYKTYR
IEGV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=149, Percent_Identity=32.2147651006711, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44938; Mature: 44938

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQINIALLGLGTVGTGVVQILKENHEQIKEKLNTDIRITWILVSDVTKPRIIETAHYQL
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEECEEE
TDNIEDIKNDATIDMYVEVMGGIENTKEILLYALNQKKHVITANKDLLAEHLEEMEQAAH
CCCHHHHCCCCEEEEHHEECCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHC
NNGVSLKYEASIAGGIPVVNALNYGLNANGIGKFMGIFNGTSNFILSKMTHERQSYEEAL
CCCCEEEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RVATELGFAEADPTADVEGIDAARKVTIMSYLAFNQFRKLEGCRYTGIREVKLSHIDIAK
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
AFGYRIKLIGSGVMNGDDVSLCVEPMCIPSDHQLSHVEYEYNAIYIAGNAVGDTMYYGKG
HCCCEEEEEECCCCCCCCCEEEECCEECCCCCCCEEEEEEEEEEEEECCCCCCCEEECCC
AGSLATGSAVVSDILNVIELIGTDLHNLPLHLEIKQETREQPSRLLLIIDLYADSNVAEI
CCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEEECHHHCCCCCEEEEEEEEECCCCHHHH
LNEISVERHIVRDGMLAVETELEVNYEYLEEEQLNYKTYRIEGV
HHHHHHHHHHHHCCCEEEEEEEECCHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MKQINIALLGLGTVGTGVVQILKENHEQIKEKLNTDIRITWILVSDVTKPRIIETAHYQL
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEECEEE
TDNIEDIKNDATIDMYVEVMGGIENTKEILLYALNQKKHVITANKDLLAEHLEEMEQAAH
CCCHHHHCCCCEEEEHHEECCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHC
NNGVSLKYEASIAGGIPVVNALNYGLNANGIGKFMGIFNGTSNFILSKMTHERQSYEEAL
CCCCEEEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RVATELGFAEADPTADVEGIDAARKVTIMSYLAFNQFRKLEGCRYTGIREVKLSHIDIAK
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
AFGYRIKLIGSGVMNGDDVSLCVEPMCIPSDHQLSHVEYEYNAIYIAGNAVGDTMYYGKG
HCCCEEEEEECCCCCCCCCEEEECCEECCCCCCCEEEEEEEEEEEEECCCCCCCEEECCC
AGSLATGSAVVSDILNVIELIGTDLHNLPLHLEIKQETREQPSRLLLIIDLYADSNVAEI
CCCCCCHHHHHHHHHHHHHHHCCCHHCCCEEEEECHHHCCCCCEEEEEEEEECCCCHHHH
LNEISVERHIVRDGMLAVETELEVNYEYLEEEQLNYKTYRIEGV
HHHHHHHHHHHHCCCEEEEEEEECCHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]