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The map label for this gene is mutL

Identifier: 222151138

GI number: 222151138

Start: 981927

End: 983828

Strand: Direct

Name: mutL

Synonym: MCCL_0889

Alternate gene names: 222151138

Gene position: 981927-983828 (Clockwise)

Preceding gene: 222151137

Following gene: 222151139

Centisome position: 46.71

GC content: 36.38

Gene sequence:

>1902_bases
TTGGGAATCATTAAAACTTTAGATAGTACGATAAGCAATAAAATAGCAGCAGGTGAGGTGATAGAACGTCCACAATCTGT
CGTTAAAGAACTCGTCGAAAACGCCATTGATGCAAAAAGTACAAGTATCACGATTGAAGTAGAAGAAGCGGGTTTATCAA
AAATCAAAGTAACGGATAACGGATCTGGAATTTTAGAAGAAGATCTGGAGTTAATGTTCAGAAGACATGCGACGAGCAAA
ATAGAAAATGAGCACGATCTGTTTCATATTCGTTCATTAGGATTTAGAGGAGAAGCATTAGCATCTATTGCTTCTGTCAG
TAAAGTGCGCGTCACTACATGTCATGATGGGTCAATTGGCCGCCAAATTGATGTAATTGACGGAGAAACGGTGAACAGAA
CTCTGGCACAAGCACGTCAAGGAACAGAAATAACTGTTGAAAGTCTATTCTATAACACGCCTGCTCGATTAAAATATGTA
AAAAGTCTTCATACAGAGCTCGGAAAAATCACAGATATCATCAACCGATTTGTTATCAGCTTCCCATACATCAAATTTAC
TTTAGTAGCAGATGGCAGAGTACTTATAGCCTCAAATGGCAATGGTAAGATGCAGGAAGCGATGGCCGTTGTCTACGGTA
TGAAAATCGCACAGGACCTAGTTGAAGTCAACGGCCGAACAGGTGATTATGAAGTACATGGTTTTATTGCCAAGCCAGAA
CATACAAGAAGTAACAGGCATTATATGTCTCTTTTTATCAACGGGCGTTATATCAAGAACTTTATGCTCACAAAAGCAAT
ATTATCAGGCTATCATACGTTATTACCTGTTGGAAGGTATCCTATTCTTGCAATTAATATCGTTATGGACCCTGCATTAG
TAGATGTGAATGTTCACCCGACAAAGCAAGAAGTAAGATTATCTAAAGAATCTCAGTTGATGGAGCTTATCGAGAGATTG
ATAAAAGAAAAAATCTGGAAACAGAATTTAATTCCAAAAGTAGAAAAGAAGAAGGTGCTTGAAACATTTCAGCAGCAAAA
GTTTGAATATGATCTATTAAGAGAACATCGGGACAAGACAAAACAATCTGACTACAGTGAGCAGACAGCAGTAAATCAAA
TCGATGAAAAATTTAAAGAACAGCATAAAACAGCACAATTGGATAAACAAAGAGTTCCGGACGGTGAAAGCACCCAAAAA
ACGACAGGATTTATTAGTGATTCAGCAGCAGAATTAGATACAACTTCAGAAATCTTACCAGAAAAAAATGAATCATCTGA
CGTAATTGAAAATATAAGTACTGATACATCTCGTGAAAAAAGAAAGATCCCTTACATGGAAATTGTCGGTCAAGTTCATG
GCACTTATATCATTGCTCAAAATGAGGATGGCATGTTTATGATCGATCAGCACGCAGCACAAGAAAGAATTAAATATGAG
TACTTCAAAAAACAAATTGGTGATGTAGGGCTGGAAATGCAGTCATTACTCATTCCGATCACTGTAACTTTAAGTAAAGA
TGAAGCAATAAACTTAAACAAAATCAATATACTGCTTAAAGATATTGGGATTCATCTTGAACATTTTGGAGGTAATGATT
ATATTATAAATGATATACCTGTATGGTTCCCGGACAACTATGAAGAAACGGTACAGGAATTAATCGATTATGCGCTGCAG
CACAGACAGATAGATTTGAATAAATTCCGTGAAGAGACTGCCATTATGATGAGCTGTAAAAAATCGATAAAAGCGAATCA
TTATTTAAGGATTACAGATATGAACTATTTACTGGAAGAACTTGCACATACTGTAGAACCATACACATGTCCGCATGGCA
GACCTATCATCATTCAATTTACAACTTATGAACTTGAGAAACTATTTAAGAGGGTGATGTAA

Upstream 100 bases:

>100_bases
TATTCAGCAAATTAAAGATATCTCAATCGACGAGTTAACGCCGATTGAAGCGTTATTAAAATTACAGGAAATAAAATCCC
GAATAAAGTAGGTGAAATAC

Downstream 100 bases:

>100_bases
TGATTTTACCGGCAATCCGTTCTATGAAAGATCTTGAAAAGTTTGTGGTGACCCAATACTCGACTTGCGTCATATTAGAT
ATGCATATTGGTCATGTCAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MGIIKTLDSTISNKIAAGEVIERPQSVVKELVENAIDAKSTSITIEVEEAGLSKIKVTDNGSGILEEDLELMFRRHATSK
IENEHDLFHIRSLGFRGEALASIASVSKVRVTTCHDGSIGRQIDVIDGETVNRTLAQARQGTEITVESLFYNTPARLKYV
KSLHTELGKITDIINRFVISFPYIKFTLVADGRVLIASNGNGKMQEAMAVVYGMKIAQDLVEVNGRTGDYEVHGFIAKPE
HTRSNRHYMSLFINGRYIKNFMLTKAILSGYHTLLPVGRYPILAINIVMDPALVDVNVHPTKQEVRLSKESQLMELIERL
IKEKIWKQNLIPKVEKKKVLETFQQQKFEYDLLREHRDKTKQSDYSEQTAVNQIDEKFKEQHKTAQLDKQRVPDGESTQK
TTGFISDSAAELDTTSEILPEKNESSDVIENISTDTSREKRKIPYMEIVGQVHGTYIIAQNEDGMFMIDQHAAQERIKYE
YFKKQIGDVGLEMQSLLIPITVTLSKDEAINLNKINILLKDIGIHLEHFGGNDYIINDIPVWFPDNYEETVQELIDYALQ
HRQIDLNKFREETAIMMSCKKSIKANHYLRITDMNYLLEELAHTVEPYTCPHGRPIIIQFTTYELEKLFKRVM

Sequences:

>Translated_633_residues
MGIIKTLDSTISNKIAAGEVIERPQSVVKELVENAIDAKSTSITIEVEEAGLSKIKVTDNGSGILEEDLELMFRRHATSK
IENEHDLFHIRSLGFRGEALASIASVSKVRVTTCHDGSIGRQIDVIDGETVNRTLAQARQGTEITVESLFYNTPARLKYV
KSLHTELGKITDIINRFVISFPYIKFTLVADGRVLIASNGNGKMQEAMAVVYGMKIAQDLVEVNGRTGDYEVHGFIAKPE
HTRSNRHYMSLFINGRYIKNFMLTKAILSGYHTLLPVGRYPILAINIVMDPALVDVNVHPTKQEVRLSKESQLMELIERL
IKEKIWKQNLIPKVEKKKVLETFQQQKFEYDLLREHRDKTKQSDYSEQTAVNQIDEKFKEQHKTAQLDKQRVPDGESTQK
TTGFISDSAAELDTTSEILPEKNESSDVIENISTDTSREKRKIPYMEIVGQVHGTYIIAQNEDGMFMIDQHAAQERIKYE
YFKKQIGDVGLEMQSLLIPITVTLSKDEAINLNKINILLKDIGIHLEHFGGNDYIINDIPVWFPDNYEETVQELIDYALQ
HRQIDLNKFREETAIMMSCKKSIKANHYLRITDMNYLLEELAHTVEPYTCPHGRPIIIQFTTYELEKLFKRVM
>Mature_632_residues
GIIKTLDSTISNKIAAGEVIERPQSVVKELVENAIDAKSTSITIEVEEAGLSKIKVTDNGSGILEEDLELMFRRHATSKI
ENEHDLFHIRSLGFRGEALASIASVSKVRVTTCHDGSIGRQIDVIDGETVNRTLAQARQGTEITVESLFYNTPARLKYVK
SLHTELGKITDIINRFVISFPYIKFTLVADGRVLIASNGNGKMQEAMAVVYGMKIAQDLVEVNGRTGDYEVHGFIAKPEH
TRSNRHYMSLFINGRYIKNFMLTKAILSGYHTLLPVGRYPILAINIVMDPALVDVNVHPTKQEVRLSKESQLMELIERLI
KEKIWKQNLIPKVEKKKVLETFQQQKFEYDLLREHRDKTKQSDYSEQTAVNQIDEKFKEQHKTAQLDKQRVPDGESTQKT
TGFISDSAAELDTTSEILPEKNESSDVIENISTDTSREKRKIPYMEIVGQVHGTYIIAQNEDGMFMIDQHAAQERIKYEY
FKKQIGDVGLEMQSLLIPITVTLSKDEAINLNKINILLKDIGIHLEHFGGNDYIINDIPVWFPDNYEETVQELIDYALQH
RQIDLNKFREETAIMMSCKKSIKANHYLRITDMNYLLEELAHTVEPYTCPHGRPIIIQFTTYELEKLFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=338, Percent_Identity=37.8698224852071, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=29.0697674418605, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=29.0697674418605, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4505911, Length=336, Percent_Identity=29.4642857142857, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI189458898, Length=333, Percent_Identity=29.1291291291291, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI310128480, Length=301, Percent_Identity=27.5747508305648, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI263191589, Length=242, Percent_Identity=32.2314049586777, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI189458896, Length=326, Percent_Identity=29.4478527607362, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI91992162, Length=439, Percent_Identity=24.373576309795, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI91992160, Length=439, Percent_Identity=24.373576309795, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1790612, Length=576, Percent_Identity=28.125, Blast_Score=210, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=33.75, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=352, Percent_Identity=26.7045454545455, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=425, Percent_Identity=32.7058823529412, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=472, Percent_Identity=26.0593220338983, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6325093, Length=718, Percent_Identity=20.891364902507, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136968, Length=340, Percent_Identity=35, Blast_Score=206, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.0504201680672, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_MACCJ (B9EBI5)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002560292.1
- GeneID:   7390723
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0889
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72296; Mature: 72165

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIIKTLDSTISNKIAAGEVIERPQSVVKELVENAIDAKSTSITIEVEEAGLSKIKVTDN
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GSGILEEDLELMFRRHATSKIENEHDLFHIRSLGFRGEALASIASVSKVRVTTCHDGSIG
CCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHHHHHHCEEEEEEECCCCCC
RQIDVIDGETVNRTLAQARQGTEITVESLFYNTPARLKYVKSLHTELGKITDIINRFVIS
CEEEEECCCHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FPYIKFTLVADGRVLIASNGNGKMQEAMAVVYGMKIAQDLVEVNGRTGDYEVHGFIAKPE
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
HTRSNRHYMSLFINGRYIKNFMLTKAILSGYHTLLPVGRYPILAINIVMDPALVDVNVHP
CCCCCCEEEEEEEECHHHHHHHHHHHHHHCHHHHHCCCCCCEEEEEEEECCEEEEEECCC
TKQEVRLSKESQLMELIERLIKEKIWKQNLIPKVEKKKVLETFQQQKFEYDLLREHRDKT
CHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQSDYSEQTAVNQIDEKFKEQHKTAQLDKQRVPDGESTQKTTGFISDSAAELDTTSEILP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHCCCHHHHCC
EKNESSDVIENISTDTSREKRKIPYMEIVGQVHGTYIIAQNEDGMFMIDQHAAQERIKYE
CCCCCHHHHHHCCCCCCHHHHCCCHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHHHH
YFKKQIGDVGLEMQSLLIPITVTLSKDEAINLNKINILLKDIGIHLEHFGGNDYIINDIP
HHHHHHHHCCCCHHHEEEEEEEEECCCCCCCCHHHEEEEEHHCCEEEEECCCEEEEECCC
VWFPDNYEETVQELIDYALQHRQIDLNKFREETAIMMSCKKSIKANHYLRITDMNYLLEE
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
LAHTVEPYTCPHGRPIIIQFTTYELEKLFKRVM
HHHHCCCCCCCCCCEEEEEECHHHHHHHHHHCC
>Mature Secondary Structure 
GIIKTLDSTISNKIAAGEVIERPQSVVKELVENAIDAKSTSITIEVEEAGLSKIKVTDN
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GSGILEEDLELMFRRHATSKIENEHDLFHIRSLGFRGEALASIASVSKVRVTTCHDGSIG
CCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHHHHHHCEEEEEEECCCCCC
RQIDVIDGETVNRTLAQARQGTEITVESLFYNTPARLKYVKSLHTELGKITDIINRFVIS
CEEEEECCCHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FPYIKFTLVADGRVLIASNGNGKMQEAMAVVYGMKIAQDLVEVNGRTGDYEVHGFIAKPE
CCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
HTRSNRHYMSLFINGRYIKNFMLTKAILSGYHTLLPVGRYPILAINIVMDPALVDVNVHP
CCCCCCEEEEEEEECHHHHHHHHHHHHHHCHHHHHCCCCCCEEEEEEEECCEEEEEECCC
TKQEVRLSKESQLMELIERLIKEKIWKQNLIPKVEKKKVLETFQQQKFEYDLLREHRDKT
CHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQSDYSEQTAVNQIDEKFKEQHKTAQLDKQRVPDGESTQKTTGFISDSAAELDTTSEILP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHCCCHHHHCC
EKNESSDVIENISTDTSREKRKIPYMEIVGQVHGTYIIAQNEDGMFMIDQHAAQERIKYE
CCCCCHHHHHHCCCCCCHHHHCCCHHHHHHHHCCEEEEEECCCCEEEEECHHHHHHHHHH
YFKKQIGDVGLEMQSLLIPITVTLSKDEAINLNKINILLKDIGIHLEHFGGNDYIINDIP
HHHHHHHHCCCCHHHEEEEEEEEECCCCCCCCHHHEEEEEHHCCEEEEECCCEEEEECCC
VWFPDNYEETVQELIDYALQHRQIDLNKFREETAIMMSCKKSIKANHYLRITDMNYLLEE
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
LAHTVEPYTCPHGRPIIIQFTTYELEKLFKRVM
HHHHCCCCCCCCCCEEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA