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The map label for this gene is ffh [H]

Identifier: 222151070

GI number: 222151070

Start: 894120

End: 895472

Strand: Direct

Name: ffh [H]

Synonym: MCCL_0821

Alternate gene names: 222151070

Gene position: 894120-895472 (Clockwise)

Preceding gene: 222151069

Following gene: 222151071

Centisome position: 42.53

GC content: 39.62

Gene sequence:

>1353_bases
ATGGCTTTTGAAGGATTATCAGATCGACTCCAGGCTACAATGCAGAAGATTAAAGGTAAAGGTAAAGTTACAGAAGCGGA
TATAAAAGTGATGATGCGTGAAGTACGCTTAGCATTACTTGAAGCCGATGTTAACTTTAAAGTGGTAAAAGAATTTGTTA
AGACAGTATCAGATCGTGCAATTGGTTCAGAAGTGATGCAGTCATTAACGCCTGGGCAACAGATTATTAAAATTGTACAG
GAAGAACTAACGACTTTAATGGGTTCTGAGAATACTCAGATTAATATGAGTAAGAAACCACCGACTGTTGTGATGATGGT
AGGTTTACAAGGGGCAGGTAAAACGACGACTGCAGGTAAACTGGCACTTTTAATGCGCAAGAAATATAACAAGAAACCAT
TGCTCGTCGCATGTGATATCTACAGACCTGCTGCAATACAGCAGCTACAGACAGTAGGGAAGCAGATCGATATACCGGTA
TTTACTTTAGGGGATCAAGTATCACCTAAAGAAATTACAGAACGTGCACTACAACACGCAAAAGAAGAACATCTGGACTT
TGTGATTATCGATACAGCGGGACGCCTGCATATTGATGAAGCATTGATGAATGAGCTTGTTGAAGTTAAAGAAATCAGTC
AACCTGATGAAATTATGCTTGTCGTAGATTCTATGACTGGTCAAGATGCAGTGAATGTCGCTGAGAGTTTCGATAATCAG
CTGGATATTACGGGTGTTACTTTAACGAAACTTGATGGAGATACTCGTGGTGGGGCAGCGCTCTCGATTCGAAGTGTCAC
ACAAAAACCAATTAAGTTTGTCGGTATGAGTGAGAAACTTGATGGACTAGAACCTTTTCATCCAGAACGCATGGCATCTC
GTATTCTAGGTATGGGTGATGTGTTAAGTTTAATCGAAAAAGCACAGTCTCAAGTAGATGAATCTAAAGCGAAAGAACTT
GAACAGAAGATGAAGACCTCATCATTCACTTTTGATGATTTTCTGGAGCAGCTCGAACAGGTTAAAGCTCTAGGCCCTCT
TGATGAACTGCTTAAGATGATTCCTGGTGCGAACAAGATGAAAGGTCTGAATAATGTTAATATGAACGCTAAGCAAATTG
ATCATGTGCAGGCGATTATTCGTTCAATGACGAAAGAAGAACGTAACAATCCGGCGATTATCAATGTATCACGTAAGAAG
AGAATCGCAAAAGGTTCAGGCAGAAGTTTATCTGAAGTGAATAAACTGATTAAACAGTTTGAAGAGATGAAGAAGATGAT
GAAGCAGTTTACAGGAATGAAAAAAGGTAAAAAAGGGCGTAATCCGTTCCAGGGCATGAATTTACCGTTTTAA

Upstream 100 bases:

>100_bases
AGATGCTTCGATTAACTAAACTACAGGGTAATGCACAACGTAATCAGCAGTTAGAAGCATATATAGAACAATTACAAAGA
ATAGAATAGGGGGTCATTGT

Downstream 100 bases:

>100_bases
TATCTACTAAGAGACAGAAAAAACTTGATTTTTTCTGTCTTTTATATTAAATTTATTTTTGTAAAGAAAAAACACTTTAC
AGGAAACAAGTTTCCTGTTA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MAFEGLSDRLQATMQKIKGKGKVTEADIKVMMREVRLALLEADVNFKVVKEFVKTVSDRAIGSEVMQSLTPGQQIIKIVQ
EELTTLMGSENTQINMSKKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPLLVACDIYRPAAIQQLQTVGKQIDIPV
FTLGDQVSPKEITERALQHAKEEHLDFVIIDTAGRLHIDEALMNELVEVKEISQPDEIMLVVDSMTGQDAVNVAESFDNQ
LDITGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLEPFHPERMASRILGMGDVLSLIEKAQSQVDESKAKEL
EQKMKTSSFTFDDFLEQLEQVKALGPLDELLKMIPGANKMKGLNNVNMNAKQIDHVQAIIRSMTKEERNNPAIINVSRKK
RIAKGSGRSLSEVNKLIKQFEEMKKMMKQFTGMKKGKKGRNPFQGMNLPF

Sequences:

>Translated_450_residues
MAFEGLSDRLQATMQKIKGKGKVTEADIKVMMREVRLALLEADVNFKVVKEFVKTVSDRAIGSEVMQSLTPGQQIIKIVQ
EELTTLMGSENTQINMSKKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPLLVACDIYRPAAIQQLQTVGKQIDIPV
FTLGDQVSPKEITERALQHAKEEHLDFVIIDTAGRLHIDEALMNELVEVKEISQPDEIMLVVDSMTGQDAVNVAESFDNQ
LDITGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLEPFHPERMASRILGMGDVLSLIEKAQSQVDESKAKEL
EQKMKTSSFTFDDFLEQLEQVKALGPLDELLKMIPGANKMKGLNNVNMNAKQIDHVQAIIRSMTKEERNNPAIINVSRKK
RIAKGSGRSLSEVNKLIKQFEEMKKMMKQFTGMKKGKKGRNPFQGMNLPF
>Mature_449_residues
AFEGLSDRLQATMQKIKGKGKVTEADIKVMMREVRLALLEADVNFKVVKEFVKTVSDRAIGSEVMQSLTPGQQIIKIVQE
ELTTLMGSENTQINMSKKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPLLVACDIYRPAAIQQLQTVGKQIDIPVF
TLGDQVSPKEITERALQHAKEEHLDFVIIDTAGRLHIDEALMNELVEVKEISQPDEIMLVVDSMTGQDAVNVAESFDNQL
DITGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLEPFHPERMASRILGMGDVLSLIEKAQSQVDESKAKELE
QKMKTSSFTFDDFLEQLEQVKALGPLDELLKMIPGANKMKGLNNVNMNAKQIDHVQAIIRSMTKEERNNPAIINVSRKKR
IAKGSGRSLSEVNKLIKQFEEMKKMMKQFTGMKKGKKGRNPFQGMNLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=446, Percent_Identity=32.0627802690583, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI226371618, Length=383, Percent_Identity=32.6370757180157, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI89061728, Length=161, Percent_Identity=36.0248447204969, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI23308697, Length=316, Percent_Identity=23.4177215189873, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=23.4177215189873, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=50.7075471698113, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=33.8645418326693, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=447, Percent_Identity=28.6353467561521, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=291, Percent_Identity=26.1168384879725, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=434, Percent_Identity=32.0276497695853, Blast_Score=229, Evalue=8e-61,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=31.5909090909091, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24641198, Length=311, Percent_Identity=24.4372990353698, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50029; Mature: 49898

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLSDRLQATMQKIKGKGKVTEADIKVMMREVRLALLEADVNFKVVKEFVKTVSDRA
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGSEVMQSLTPGQQIIKIVQEELTTLMGSENTQINMSKKPPTVVMMVGLQGAGKTTTAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHH
LALLMRKKYNKKPLLVACDIYRPAAIQQLQTVGKQIDIPVFTLGDQVSPKEITERALQHA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
KEEHLDFVIIDTAGRLHIDEALMNELVEVKEISQPDEIMLVVDSMTGQDAVNVAESFDNQ
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCC
LDITGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLEPFHPERMASRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCHHH
VLSLIEKAQSQVDESKAKELEQKMKTSSFTFDDFLEQLEQVKALGPLDELLKMIPGANKM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHH
KGLNNVNMNAKQIDHVQAIIRSMTKEERNNPAIINVSRKKRIAKGSGRSLSEVNKLIKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHH
EEMKKMMKQFTGMKKGKKGRNPFQGMNLPF
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AFEGLSDRLQATMQKIKGKGKVTEADIKVMMREVRLALLEADVNFKVVKEFVKTVSDRA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGSEVMQSLTPGQQIIKIVQEELTTLMGSENTQINMSKKPPTVVMMVGLQGAGKTTTAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHH
LALLMRKKYNKKPLLVACDIYRPAAIQQLQTVGKQIDIPVFTLGDQVSPKEITERALQHA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
KEEHLDFVIIDTAGRLHIDEALMNELVEVKEISQPDEIMLVVDSMTGQDAVNVAESFDNQ
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCCC
LDITGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLEPFHPERMASRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCHHH
VLSLIEKAQSQVDESKAKELEQKMKTSSFTFDDFLEQLEQVKALGPLDELLKMIPGANKM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCHHH
KGLNNVNMNAKQIDHVQAIIRSMTKEERNNPAIINVSRKKRIAKGSGRSLSEVNKLIKQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHH
EEMKKMMKQFTGMKKGKKGRNPFQGMNLPF
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]