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The map label for this gene is rnc [H]

Identifier: 222151066

GI number: 222151066

Start: 888218

End: 888946

Strand: Direct

Name: rnc [H]

Synonym: MCCL_0817

Alternate gene names: 222151066

Gene position: 888218-888946 (Clockwise)

Preceding gene: 222151065

Following gene: 222151067

Centisome position: 42.25

GC content: 38.68

Gene sequence:

>729_bases
ATGAATAAAAGACAGCTAATAATCGACAAATTTAAAGTAAAGTTAAACAAGGTGCTCACACACCTGGATATTATACCAAA
TGATATTGAACTGTATGTACAGGCATTCTCACACTCGAGTTTCATTAATGATTTCAAGCTTGATAAAAATAAGGACAATG
AACGCCTGGAATTTCTAGGAGACGCGGTGTTAGAATTGATGGTTTCACAATATTTATACCAGCAGCATAGGGATCTGCCA
GAAGGTAGGCTGACAAAGTTACGCGCTGCAATTGTATGTGAACCTTCACTTGTGACATTTGCGAAGATGTTAAAGTTTGA
CCAGTTGATTTTGCTAGGCAAAGGCGAGGAAAAGACAGGTGGCAGAACACGTCCATCTTTAATTGCAGATGTATTTGAGG
CCTTCGTCGGGGCATTGTATCTTGACCAAGGACATGATGTAACAAAAAGATTCTTTAACAGCTATATTTTTCCTGCTATA
ACTGAAGATCTGCTGCATGGCCTTATAGACTATAAGACTTGTTTACAGGAATATATTCATAAAACTAAAAACTTACAAGT
TACCTATCGCCTCGTTAAAGAGGAAGGACCGGCACATTTCAAAGCGTTTACGTCTGAAGTTTATGTTGAAGACAAAGTGA
TTGGTACAGGTACTGGAAGAACGAAGAAAGAATCAGAACAACAGGCAGCCCAAACTGCTTTATTGCTTCTGACAGCAGGA
GAGTCATAA

Upstream 100 bases:

>100_bases
TTTAAATTATTAATGCTGATTATTTAAAAAGTTTATTAAGCAATCACTTTTTTTTACAGCGTATATAACGTAAAATAAAA
GGATAGATAAGGAGGACGAA

Downstream 100 bases:

>100_bases
TGATTTATTTACAGTCGGTAGAAGCAACAGGGTTCAAGTCGTTTGCAGATAAGACAACAGTGCTGTTTGATGAAGGTGTT
ACAGCGATTGTTGGGCCAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNKRQLIIDKFKVKLNKVLTHLDIIPNDIELYVQAFSHSSFINDFKLDKNKDNERLEFLGDAVLELMVSQYLYQQHRDLP
EGRLTKLRAAIVCEPSLVTFAKMLKFDQLILLGKGEEKTGGRTRPSLIADVFEAFVGALYLDQGHDVTKRFFNSYIFPAI
TEDLLHGLIDYKTCLQEYIHKTKNLQVTYRLVKEEGPAHFKAFTSEVYVEDKVIGTGTGRTKKESEQQAAQTALLLLTAG
ES

Sequences:

>Translated_242_residues
MNKRQLIIDKFKVKLNKVLTHLDIIPNDIELYVQAFSHSSFINDFKLDKNKDNERLEFLGDAVLELMVSQYLYQQHRDLP
EGRLTKLRAAIVCEPSLVTFAKMLKFDQLILLGKGEEKTGGRTRPSLIADVFEAFVGALYLDQGHDVTKRFFNSYIFPAI
TEDLLHGLIDYKTCLQEYIHKTKNLQVTYRLVKEEGPAHFKAFTSEVYVEDKVIGTGTGRTKKESEQQAAQTALLLLTAG
ES
>Mature_242_residues
MNKRQLIIDKFKVKLNKVLTHLDIIPNDIELYVQAFSHSSFINDFKLDKNKDNERLEFLGDAVLELMVSQYLYQQHRDLP
EGRLTKLRAAIVCEPSLVTFAKMLKFDQLILLGKGEEKTGGRTRPSLIADVFEAFVGALYLDQGHDVTKRFFNSYIFPAI
TEDLLHGLIDYKTCLQEYIHKTKNLQVTYRLVKEEGPAHFKAFTSEVYVEDKVIGTGTGRTKKESEQQAAQTALLLLTAG
ES

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=246, Percent_Identity=27.6422764227642, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI155030236, Length=246, Percent_Identity=27.6422764227642, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1788920, Length=227, Percent_Identity=32.5991189427313, Blast_Score=104, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17506883, Length=224, Percent_Identity=29.0178571428571, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202651, Length=224, Percent_Identity=29.0178571428571, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323895, Length=226, Percent_Identity=26.5486725663717, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137682, Length=239, Percent_Identity=29.2887029288703, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27618; Mature: 27618

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRQLIIDKFKVKLNKVLTHLDIIPNDIELYVQAFSHSSFINDFKLDKNKDNERLEFLG
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
DAVLELMVSQYLYQQHRDLPEGRLTKLRAAIVCEPSLVTFAKMLKFDQLILLGKGEEKTG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEECCHHHHHHHHHHHHHEEEEECCCCCCC
GRTRPSLIADVFEAFVGALYLDQGHDVTKRFFNSYIFPAITEDLLHGLIDYKTCLQEYIH
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KTKNLQVTYRLVKEEGPAHFKAFTSEVYVEDKVIGTGTGRTKKESEQQAAQTALLLLTAG
HHCCCCEEEEEECCCCCHHHHHHHHHHEEECEEEECCCCCCCHHHHHHHHHHHEEEEECC
ES
CC
>Mature Secondary Structure
MNKRQLIIDKFKVKLNKVLTHLDIIPNDIELYVQAFSHSSFINDFKLDKNKDNERLEFLG
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
DAVLELMVSQYLYQQHRDLPEGRLTKLRAAIVCEPSLVTFAKMLKFDQLILLGKGEEKTG
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEECCHHHHHHHHHHHHHEEEEECCCCCCC
GRTRPSLIADVFEAFVGALYLDQGHDVTKRFFNSYIFPAITEDLLHGLIDYKTCLQEYIH
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KTKNLQVTYRLVKEEGPAHFKAFTSEVYVEDKVIGTGTGRTKKESEQQAAQTALLLLTAG
HHCCCCEEEEEECCCCCHHHHHHHHHHEEECEEEECCCCCCCHHHHHHHHHHHEEEEECC
ES
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA