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The map label for this gene is sdhA [H]

Identifier: 222151059

GI number: 222151059

Start: 880929

End: 881819

Strand: Direct

Name: sdhA [H]

Synonym: MCCL_0810

Alternate gene names: 222151059

Gene position: 880929-881819 (Clockwise)

Preceding gene: 222151058

Following gene: 222151060

Centisome position: 41.9

GC content: 44.44

Gene sequence:

>891_bases
ATGTTTAAAAGCGTAGAAGAACTGATAAATATTTGTGAGACAGAAAATAAAAGCATAGCAGACGTGATGATTGCACAAGA
GATGTCTGTAAGTAAGCTTGACTATGAAACAGTAATGTCGAATATGGAACGAAATTTAATCGTAATGGAACAAGCTGTAG
CGCGTGGTCTGGATGGCGTTACAAGTCCTACAGGTTTAACAGGAATGGATGCAGTGAAATTACGTGATTATATCGCAAAG
GGTAACACGTTAAGTGGTGCGACTTTGCTGGATGCAGTTTCGAAAGCGGTTGCAACAAATGAAGTGAACGCTGCTATGGG
ATTAATTTGTGCAACACCGACTGCTGGCAGCGCTGGGGTAGTGCCAGGAACATTATTTGCTATGCAAGCACGACTGAATC
CATCGCGCGAACAGATGATTAAATTCTTGTTTACAACTGGAGCATTTGGATTTGTTGTGGCTAATAATGCCTCTATCTCG
GGTGCTGCAGGTGGTTGTCAGGCAGAAGTAGGCAGTGCAGCAGCTATGGCAGCAGCAGCGATCGTAGAGATGGCTGGTGG
ATCGCCACAGATGAGTGCACATGCATTCAGTATTTGCCTTAAAAATATGCTGGGTCTTGTATGTGATCCAGTGGCAGGAC
TTGTAGAAGTGCCGTGTGTGAAAAGAAATGCAGCTGGTGCATCCAACGCTATTGTATCAGCAGATATGGCGCTTGCAGGT
GTGGAGAGCAGAATTCCGACAGATGAAGTAATTGAAGCCATGTATAAGATAGGTTTAACAATGCCAAGTGCACTGCGTGA
GACAGGTCGTGGAGGTCTTGCAGGCACTAAGACTGGCCAGGAAATGAAGGAAAGAATCTTTGGAAAATCAGCATCTTCTA
ATAACAGATAG

Upstream 100 bases:

>100_bases
ATTAGATGATGAGATAACAGATGATGTACTAGAACAGATTAGGCGTTGTGAGGGTATTCAGACGGTGACGTTGATGACAG
AATCGTAGAGGGGGGAAGTT

Downstream 100 bases:

>100_bases
TACATTGAAGGAGTTAAAAGGTGTCGGTCCGAAATCTTTAGAGAGTCTCAATTCACTCAACATACATTCTATTGAAGATC
TCATATTATATCTGCCTTAT

Product: L-serine deaminase alpha subunit

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFKSVEELINICETENKSIADVMIAQEMSVSKLDYETVMSNMERNLIVMEQAVARGLDGVTSPTGLTGMDAVKLRDYIAK
GNTLSGATLLDAVSKAVATNEVNAAMGLICATPTAGSAGVVPGTLFAMQARLNPSREQMIKFLFTTGAFGFVVANNASIS
GAAGGCQAEVGSAAAMAAAAIVEMAGGSPQMSAHAFSICLKNMLGLVCDPVAGLVEVPCVKRNAAGASNAIVSADMALAG
VESRIPTDEVIEAMYKIGLTMPSALRETGRGGLAGTKTGQEMKERIFGKSASSNNR

Sequences:

>Translated_296_residues
MFKSVEELINICETENKSIADVMIAQEMSVSKLDYETVMSNMERNLIVMEQAVARGLDGVTSPTGLTGMDAVKLRDYIAK
GNTLSGATLLDAVSKAVATNEVNAAMGLICATPTAGSAGVVPGTLFAMQARLNPSREQMIKFLFTTGAFGFVVANNASIS
GAAGGCQAEVGSAAAMAAAAIVEMAGGSPQMSAHAFSICLKNMLGLVCDPVAGLVEVPCVKRNAAGASNAIVSADMALAG
VESRIPTDEVIEAMYKIGLTMPSALRETGRGGLAGTKTGQEMKERIFGKSASSNNR
>Mature_296_residues
MFKSVEELINICETENKSIADVMIAQEMSVSKLDYETVMSNMERNLIVMEQAVARGLDGVTSPTGLTGMDAVKLRDYIAK
GNTLSGATLLDAVSKAVATNEVNAAMGLICATPTAGSAGVVPGTLFAMQARLNPSREQMIKFLFTTGAFGFVVANNASIS
GAAGGCQAEVGSAAAMAAAAIVEMAGGSPQMSAHAFSICLKNMLGLVCDPVAGLVEVPCVKRNAAGASNAIVSADMALAG
VESRIPTDEVIEAMYKIGLTMPSALRETGRGGLAGTKTGQEMKERIFGKSASSNNR

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=281, Percent_Identity=37.0106761565836, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1788116, Length=281, Percent_Identity=37.3665480427046, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1789161, Length=285, Percent_Identity=36.4912280701754, Blast_Score=147, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 30500; Mature: 30500

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSVEELINICETENKSIADVMIAQEMSVSKLDYETVMSNMERNLIVMEQAVARGLDGV
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
TSPTGLTGMDAVKLRDYIAKGNTLSGATLLDAVSKAVATNEVNAAMGLICATPTAGSAGV
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCC
VPGTLFAMQARLNPSREQMIKFLFTTGAFGFVVANNASISGAAGGCQAEVGSAAAMAAAA
CCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
IVEMAGGSPQMSAHAFSICLKNMLGLVCDPVAGLVEVPCVKRNAAGASNAIVSADMALAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VESRIPTDEVIEAMYKIGLTMPSALRETGRGGLAGTKTGQEMKERIFGKSASSNNR
HHHCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFKSVEELINICETENKSIADVMIAQEMSVSKLDYETVMSNMERNLIVMEQAVARGLDGV
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
TSPTGLTGMDAVKLRDYIAKGNTLSGATLLDAVSKAVATNEVNAAMGLICATPTAGSAGV
CCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCC
VPGTLFAMQARLNPSREQMIKFLFTTGAFGFVVANNASISGAAGGCQAEVGSAAAMAAAA
CCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
IVEMAGGSPQMSAHAFSICLKNMLGLVCDPVAGLVEVPCVKRNAAGASNAIVSADMALAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VESRIPTDEVIEAMYKIGLTMPSALRETGRGGLAGTKTGQEMKERIFGKSASSNNR
HHHCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]