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The map label for this gene is lspA [H]

Identifier: 222151015

GI number: 222151015

Start: 825763

End: 826254

Strand: Direct

Name: lspA [H]

Synonym: MCCL_0766

Alternate gene names: 222151015

Gene position: 825763-826254 (Clockwise)

Preceding gene: 222151014

Following gene: 222151016

Centisome position: 39.28

GC content: 31.71

Gene sequence:

>492_bases
ATGAATCGTAAATATCGCATTATGCCAATGACTTTATACACAGCCATATTAATATTGATGGATCAAATTTCAAAATATAT
TATTGTAAAGACAATGAATATCGGAGAAAGCATATCTGTAATCGGTGAGGTATTACAAATAACGTCTCATCGTAATTACG
GAGCTGCATGGGGAATGCTTCAAAATCAGATGATCTTCTTCTATATTATTACTATCATCGTACTCATTGCACTCATCTAT
TTTTATTATAAGGAAGCAGCAGATAACCTACTGATGCAGTGTGGATTAATGCTTATTTTTGCAGGTGCAATCGGAAACTT
TATCGACAGATTATTTAGAGGGAATGTTGTTGATTTTATCGATACAAAGATTATTAACTATGACTTTCCGATATTTAATG
TTGCAGATAGTTGTCTGACAATCGGCGTATTTATTTTACTTTATGAGCTTTTATTTAACCAAAAAGAGGAGAAATCACAT
GGAAACATTTAA

Upstream 100 bases:

>100_bases
TTTAAGTGTTTTAAAATTAAATAAAAATATTATGTAAACCAATAAGTTTGAAGACGAAACGACGTTTATGTGTTAAAATA
ACAAAGATTGGAGTGAGGAC

Downstream 100 bases:

>100_bases
TTTTGAAATAAACGAAGAAGAAACAGGCATACGTATTGACAAATTTCTTGCGGATGCAAATCCAGATTGGTCACGCAGTC
AGATTCAGGACTGGATTAAA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MNRKYRIMPMTLYTAILILMDQISKYIIVKTMNIGESISVIGEVLQITSHRNYGAAWGMLQNQMIFFYIITIIVLIALIY
FYYKEAADNLLMQCGLMLIFAGAIGNFIDRLFRGNVVDFIDTKIINYDFPIFNVADSCLTIGVFILLYELLFNQKEEKSH
GNI

Sequences:

>Translated_163_residues
MNRKYRIMPMTLYTAILILMDQISKYIIVKTMNIGESISVIGEVLQITSHRNYGAAWGMLQNQMIFFYIITIIVLIALIY
FYYKEAADNLLMQCGLMLIFAGAIGNFIDRLFRGNVVDFIDTKIINYDFPIFNVADSCLTIGVFILLYELLFNQKEEKSH
GNI
>Mature_163_residues
MNRKYRIMPMTLYTAILILMDQISKYIIVKTMNIGESISVIGEVLQITSHRNYGAAWGMLQNQMIFFYIITIIVLIALIY
FYYKEAADNLLMQCGLMLIFAGAIGNFIDRLFRGNVVDFIDTKIINYDFPIFNVADSCLTIGVFILLYELLFNQKEEKSH
GNI

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=147, Percent_Identity=31.2925170068027, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18806; Mature: 18806

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00855 SPASE_II ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKYRIMPMTLYTAILILMDQISKYIIVKTMNIGESISVIGEVLQITSHRNYGAAWGML
CCCCEEEHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHH
QNQMIFFYIITIIVLIALIYFYYKEAADNLLMQCGLMLIFAGAIGNFIDRLFRGNVVDFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DTKIINYDFPIFNVADSCLTIGVFILLYELLFNQKEEKSHGNI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNRKYRIMPMTLYTAILILMDQISKYIIVKTMNIGESISVIGEVLQITSHRNYGAAWGML
CCCCEEEHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHH
QNQMIFFYIITIIVLIALIYFYYKEAADNLLMQCGLMLIFAGAIGNFIDRLFRGNVVDFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DTKIINYDFPIFNVADSCLTIGVFILLYELLFNQKEEKSHGNI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7729667 [H]