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The map label for this gene is pdhA [H]

Identifier: 222150960

GI number: 222150960

Start: 765795

End: 766910

Strand: Direct

Name: pdhA [H]

Synonym: MCCL_0710

Alternate gene names: 222150960

Gene position: 765795-766910 (Clockwise)

Preceding gene: 222150959

Following gene: 222150961

Centisome position: 36.43

GC content: 41.58

Gene sequence:

>1116_bases
ATGGCTCCGAAAAAGCAAGCTCCATTCGATGCAGTTTCGACTCTACAAGAGATCGAATCAAAATTTGAAGTAGTACAAGT
ATTAGATTTAGATGGCAATGTCGTTAATAAAGACTTTATGCCTGACTTAACTGATGAACAATTGGTTGAATTAATGGAGA
GAATGGTCTGGACGCGTGTATTAGATCAACGTTCTATTTCTCTTAACCGCCAAGGACGTTTAGGTTTCTATGCGCCGACT
GCGGGTCAGGAAGCTTCTCAATTAGCATCTCATTATGCTTTAGAGAAACAAGACTACATTTTACCGGGTTACCGTGACGT
ACCACAGTTAATCTGGCACGGTTTACCACTTACAAAGGCTTTCTTATGGTCACGCGGACACTTTGTTGGGTCTCAAATGC
CTGAAGGAATGAACGCTTTAGCACCACAAATCATCATCGGTGCACAATATGTTCAGACTGCAGGGGTAGCACTTGGGCTT
AAGAAACGTGGTCAAGATGCAGTAGCAATCACTTACACAGGTGACGGTGGTTCTTCACAAGGTGACTTCTATGAAGGTAT
CAACTTTGCATCAGCATTTAAAGCGCCTGCAATCTTCGTTATCCAAAATAACAACTATGCAATCTCAACACCACGTAGCA
AACAGACAGCTGCGAAAACACTAGCGCAAAAAGCTGTAGCAGTCGGTATCCCTGGTATCGTTGTTGACGGTATGGATGCT
CTAGCAGTATATCAAGCAACGAAAGAAGCACGTGACCGCGCAGTTGCTGGTGAAGGTCCAACATTAATCGAAACAATCAC
TTATCGTTATGGTCCACATACGATGGCCGGTGATGATCCTACACGTTACAGAACTTCTGATGAAGATGACGAGTGGGTGA
AAAAAGATCCGTTAGTACGTTTCCGTAAATTTTTAGAAGCAAAAGGTTTATGGTCTGAAGAAAAAGAAAATGAAGTAATG
GACAGAGCGAAAGAAGACATTAAAAACGCGATTAAAGAAGCGGATGCGACACCAAAACAAACTGTGACGCAATTAATGGA
GATTATGTACTCTGATAACGTTCCTCAAAATATTAAGGAACAGATGGAAATTTATAAAGAGAAGGAGTCGAAATAA

Upstream 100 bases:

>100_bases
TGCTCTTTATATTGTCACAAACTTTTTCTTTAACAGTAATACAATTTTGTGATATTATGAACTTGTAACGTATAAAAACT
AGAAAGGTTTGGTGAATTGA

Downstream 100 bases:

>100_bases
GTCATGGCACAAATGACAATGATTCAAGCGATTACAAATGCGCTTCAAACAGAACTAAAAAATGACGAAAACGTATTAGT
TTTCGGAGAAGACGTTGGTG

Product: pyruvate dehydrogenase E1 component alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MAPKKQAPFDAVSTLQEIESKFEVVQVLDLDGNVVNKDFMPDLTDEQLVELMERMVWTRVLDQRSISLNRQGRLGFYAPT
AGQEASQLASHYALEKQDYILPGYRDVPQLIWHGLPLTKAFLWSRGHFVGSQMPEGMNALAPQIIIGAQYVQTAGVALGL
KKRGQDAVAITYTGDGGSSQGDFYEGINFASAFKAPAIFVIQNNNYAISTPRSKQTAAKTLAQKAVAVGIPGIVVDGMDA
LAVYQATKEARDRAVAGEGPTLIETITYRYGPHTMAGDDPTRYRTSDEDDEWVKKDPLVRFRKFLEAKGLWSEEKENEVM
DRAKEDIKNAIKEADATPKQTVTQLMEIMYSDNVPQNIKEQMEIYKEKESK

Sequences:

>Translated_371_residues
MAPKKQAPFDAVSTLQEIESKFEVVQVLDLDGNVVNKDFMPDLTDEQLVELMERMVWTRVLDQRSISLNRQGRLGFYAPT
AGQEASQLASHYALEKQDYILPGYRDVPQLIWHGLPLTKAFLWSRGHFVGSQMPEGMNALAPQIIIGAQYVQTAGVALGL
KKRGQDAVAITYTGDGGSSQGDFYEGINFASAFKAPAIFVIQNNNYAISTPRSKQTAAKTLAQKAVAVGIPGIVVDGMDA
LAVYQATKEARDRAVAGEGPTLIETITYRYGPHTMAGDDPTRYRTSDEDDEWVKKDPLVRFRKFLEAKGLWSEEKENEVM
DRAKEDIKNAIKEADATPKQTVTQLMEIMYSDNVPQNIKEQMEIYKEKESK
>Mature_370_residues
APKKQAPFDAVSTLQEIESKFEVVQVLDLDGNVVNKDFMPDLTDEQLVELMERMVWTRVLDQRSISLNRQGRLGFYAPTA
GQEASQLASHYALEKQDYILPGYRDVPQLIWHGLPLTKAFLWSRGHFVGSQMPEGMNALAPQIIIGAQYVQTAGVALGLK
KRGQDAVAITYTGDGGSSQGDFYEGINFASAFKAPAIFVIQNNNYAISTPRSKQTAAKTLAQKAVAVGIPGIVVDGMDAL
AVYQATKEARDRAVAGEGPTLIETITYRYGPHTMAGDDPTRYRTSDEDDEWVKKDPLVRFRKFLEAKGLWSEEKENEVMD
RAKEDIKNAIKEADATPKQTVTQLMEIMYSDNVPQNIKEQMEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=354, Percent_Identity=33.8983050847458, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI258645172, Length=354, Percent_Identity=33.8983050847458, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=30.3680981595092, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI291084742, Length=332, Percent_Identity=29.8192771084337, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4885543, Length=320, Percent_Identity=29.0625, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI291084744, Length=216, Percent_Identity=35.1851851851852, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI291084757, Length=321, Percent_Identity=27.7258566978193, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86563357, Length=349, Percent_Identity=34.9570200573066, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI86563355, Length=349, Percent_Identity=34.9570200573066, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=29.7546012269939, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=293, Percent_Identity=31.3993174061433, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=311, Percent_Identity=32.1543408360129, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21355903, Length=384, Percent_Identity=30.2083333333333, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24639740, Length=326, Percent_Identity=30.3680981595092, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24639744, Length=326, Percent_Identity=30.3680981595092, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28571106, Length=326, Percent_Identity=30.3680981595092, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24639746, Length=293, Percent_Identity=31.3993174061433, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24639748, Length=327, Percent_Identity=27.82874617737, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41350; Mature: 41219

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKKQAPFDAVSTLQEIESKFEVVQVLDLDGNVVNKDFMPDLTDEQLVELMERMVWTRV
CCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
LDQRSISLNRQGRLGFYAPTAGQEASQLASHYALEKQDYILPGYRDVPQLIWHGLPLTKA
HHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHH
FLWSRGHFVGSQMPEGMNALAPQIIIGAQYVQTAGVALGLKKRGQDAVAITYTGDGGSSQ
HHHHCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
GDFYEGINFASAFKAPAIFVIQNNNYAISTPRSKQTAAKTLAQKAVAVGIPGIVVDGMDA
CCHHHCCCHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCHH
LAVYQATKEARDRAVAGEGPTLIETITYRYGPHTMAGDDPTRYRTSDEDDEWVKKDPLVR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
FRKFLEAKGLWSEEKENEVMDRAKEDIKNAIKEADATPKQTVTQLMEIMYSDNVPQNIKE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHH
QMEIYKEKESK
HHHHHHHHCCC
>Mature Secondary Structure 
APKKQAPFDAVSTLQEIESKFEVVQVLDLDGNVVNKDFMPDLTDEQLVELMERMVWTRV
CCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
LDQRSISLNRQGRLGFYAPTAGQEASQLASHYALEKQDYILPGYRDVPQLIWHGLPLTKA
HHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHH
FLWSRGHFVGSQMPEGMNALAPQIIIGAQYVQTAGVALGLKKRGQDAVAITYTGDGGSSQ
HHHHCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
GDFYEGINFASAFKAPAIFVIQNNNYAISTPRSKQTAAKTLAQKAVAVGIPGIVVDGMDA
CCHHHCCCHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCHH
LAVYQATKEARDRAVAGEGPTLIETITYRYGPHTMAGDDPTRYRTSDEDDEWVKKDPLVR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
FRKFLEAKGLWSEEKENEVMDRAKEDIKNAIKEADATPKQTVTQLMEIMYSDNVPQNIKE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHH
QMEIYKEKESK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA