Click here to switch to the map view.

The map label for this gene is yyxA [H]

Identifier: 222150884

GI number: 222150884

Start: 679169

End: 680578

Strand: Direct

Name: yyxA [H]

Synonym: MCCL_0634

Alternate gene names: 222150884

Gene position: 679169-680578 (Clockwise)

Preceding gene: 222150883

Following gene: 222150885

Centisome position: 32.31

GC content: 41.91

Gene sequence:

>1410_bases
ATGAAGAAGATTACGATAAAAAGAAGAGATTATAGAAGACCGAAACGCCTATTTTATGAGGGGCAGGGTAAACGCCATAT
ATTTCCGTACCTGCATAAGAAAGATGAAGAAAAATTAATCATCGAACCTGATACTCAGGATACAGTGGATGAAAGTGCGG
CTATTCCACCGGTTACAGAAGCCTCCTTACAACAACCGCAGGATGAAACTAAAGAGGTACCTGCTGAGGAAAAAGTAATG
AATGCTGAAACGCCTGAAATACATAAGGAAGCATCTGAACAAGAAGTGAAAGCACCCGAAGTGTCTACCGAACCATTGAT
AGCAGAAACATCTGCAAGCAGCTTCAAATGGTTACTGCCATTGCTTGTGGGTATTCTAGTAGGAATAATGCTTGCTGCAC
TGTTGTTGCCAAAGATGTTCCAGCAAAAAGATAAGCCACAGGAAAAAGCGGCGCTTAGTCAGACGGAACAGATTGCACAG
CATAAGGATACGGTTGTAACGGTTACAAATCTGCAAAAGGCATCAACAGATGAACCCATCGATGCACAGGCTTCTGAAAA
AGCACCTGAAGAAACAGGCATCGGTAGTGGCGTTATCTATAAGATTGATGAAAAATATGCATATATTGTCACGAACCATC
ATGTTGTGGCAAAAGCACCAACAATTGAAGTGACACAAGGGAAACTAAAGGAAAAGGCGACGCTTATCGGCAAAGATATA
TGGACCGATATCGCAGTGATCAGAATACCGAACGGGAACCTAAAATCTACCGTTACTTTTGGTGATAGCAGTAAACTTGA
AGTAGGAGAGCATGTGCTGGCGCTTGGTAGTCCGCTTGGCAAAATATTTGCAGGAAGTGTAACAAGTGGAATCATCTCCG
GGCTTGAGAGAACGGTACCTGTAGATATTGATGGCGATAATGAGTATGACTGGTCAATGGATGTCATTCAGACTGACGCT
GCAATCAATCCAGGTAATTCAGGAGGTGCCTTGTTTAATGATAAGGGTGAGATGATCGGACTGAATTCGCTTAAGATTAC
GATGAACGGTGTCGAAGGGATTGCCTTTTCTATACCTGCAAACGCGGTCAAGAAAAATATTAAAGCTTTAGAAACGGACG
GTTCAATCAAGCGTCCGAAACTAGGTATCAGCGTAGAAGATTTAGCGGCAGCTGAATATGCCGGAAACTTAAAGCAAGGT
GTGCAAATTATGCAAGTAGAAGCAGCATCTGTTGCCCAGCAGGCAGGTCTTATGCAGGGTGATGTTATTACACATCTTGA
TCAGACAAAGATTGAAGATAAGATCCACTTTAGAAAGGTATTGTTCAACGATAAGAAGGTAGGCGAAACCTTAAATGTGA
GCATTGAAAGACAAGGTACCAAAAAGACGATTAAACTTAAATTAAAGTAA

Upstream 100 bases:

>100_bases
CGGATGGTTCAGCGGCAACAAGAAAAAAGCATAATACAATACTCAACTTAATGTATCTATATTATAATAGAAACATTAAG
TTTTTTTAGTGGAGGCAGCG

Downstream 100 bases:

>100_bases
GGAAGAATGATGATGACGAAGCTATTAATGCGGCTTACACCACAGCAAGGTATTGTGCTCTACTATCTTGTTGCGATATT
TATTTCATTCTTATTGTTAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKKITIKRRDYRRPKRLFYEGQGKRHIFPYLHKKDEEKLIIEPDTQDTVDESAAIPPVTEASLQQPQDETKEVPAEEKVM
NAETPEIHKEASEQEVKAPEVSTEPLIAETSASSFKWLLPLLVGILVGIMLAALLLPKMFQQKDKPQEKAALSQTEQIAQ
HKDTVVTVTNLQKASTDEPIDAQASEKAPEETGIGSGVIYKIDEKYAYIVTNHHVVAKAPTIEVTQGKLKEKATLIGKDI
WTDIAVIRIPNGNLKSTVTFGDSSKLEVGEHVLALGSPLGKIFAGSVTSGIISGLERTVPVDIDGDNEYDWSMDVIQTDA
AINPGNSGGALFNDKGEMIGLNSLKITMNGVEGIAFSIPANAVKKNIKALETDGSIKRPKLGISVEDLAAAEYAGNLKQG
VQIMQVEAASVAQQAGLMQGDVITHLDQTKIEDKIHFRKVLFNDKKVGETLNVSIERQGTKKTIKLKLK

Sequences:

>Translated_469_residues
MKKITIKRRDYRRPKRLFYEGQGKRHIFPYLHKKDEEKLIIEPDTQDTVDESAAIPPVTEASLQQPQDETKEVPAEEKVM
NAETPEIHKEASEQEVKAPEVSTEPLIAETSASSFKWLLPLLVGILVGIMLAALLLPKMFQQKDKPQEKAALSQTEQIAQ
HKDTVVTVTNLQKASTDEPIDAQASEKAPEETGIGSGVIYKIDEKYAYIVTNHHVVAKAPTIEVTQGKLKEKATLIGKDI
WTDIAVIRIPNGNLKSTVTFGDSSKLEVGEHVLALGSPLGKIFAGSVTSGIISGLERTVPVDIDGDNEYDWSMDVIQTDA
AINPGNSGGALFNDKGEMIGLNSLKITMNGVEGIAFSIPANAVKKNIKALETDGSIKRPKLGISVEDLAAAEYAGNLKQG
VQIMQVEAASVAQQAGLMQGDVITHLDQTKIEDKIHFRKVLFNDKKVGETLNVSIERQGTKKTIKLKLK
>Mature_469_residues
MKKITIKRRDYRRPKRLFYEGQGKRHIFPYLHKKDEEKLIIEPDTQDTVDESAAIPPVTEASLQQPQDETKEVPAEEKVM
NAETPEIHKEASEQEVKAPEVSTEPLIAETSASSFKWLLPLLVGILVGIMLAALLLPKMFQQKDKPQEKAALSQTEQIAQ
HKDTVVTVTNLQKASTDEPIDAQASEKAPEETGIGSGVIYKIDEKYAYIVTNHHVVAKAPTIEVTQGKLKEKATLIGKDI
WTDIAVIRIPNGNLKSTVTFGDSSKLEVGEHVLALGSPLGKIFAGSVTSGIISGLERTVPVDIDGDNEYDWSMDVIQTDA
AINPGNSGGALFNDKGEMIGLNSLKITMNGVEGIAFSIPANAVKKNIKALETDGSIKRPKLGISVEDLAAAEYAGNLKQG
VQIMQVEAASVAQQAGLMQGDVITHLDQTKIEDKIHFRKVLFNDKKVGETLNVSIERQGTKKTIKLKLK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=269, Percent_Identity=33.457249070632, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=33.6842105263158, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI22129776, Length=274, Percent_Identity=31.021897810219, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI7019477, Length=256, Percent_Identity=32.8125, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786356, Length=283, Percent_Identity=38.86925795053, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1789629, Length=251, Percent_Identity=35.8565737051793, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789630, Length=330, Percent_Identity=32.1212121212121, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646839, Length=374, Percent_Identity=31.8181818181818, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51270; Mature: 51270

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITIKRRDYRRPKRLFYEGQGKRHIFPYLHKKDEEKLIIEPDTQDTVDESAAIPPVTE
CCCEEECHHHCCCCHHHEECCCCCEEECCHHCCCCCCCEEECCCCCCHHHHCCCCCCCCH
ASLQQPQDETKEVPAEEKVMNAETPEIHKEASEQEVKAPEVSTEPLIAETSASSFKWLLP
HHHCCCCHHHHCCCCHHHHCCCCCCHHHHHCCHHHCCCCCCCCCCEEEECCCCHHHHHHH
LLVGILVGIMLAALLLPKMFQQKDKPQEKAALSQTEQIAQHKDTVVTVTNLQKASTDEPI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DAQASEKAPEETGIGSGVIYKIDEKYAYIVTNHHVVAKAPTIEVTQGKLKEKATLIGKDI
CCCCHHCCCHHCCCCCCEEEEECCCEEEEEECCEEEEECCEEEECCCHHHHHHHHHHHHH
WTDIAVIRIPNGNLKSTVTFGDSSKLEVGEHVLALGSPLGKIFAGSVTSGIISGLERTVP
HCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCE
VDIDGDNEYDWSMDVIQTDAAINPGNSGGALFNDKGEMIGLNSLKITMNGVEGIAFSIPA
EEECCCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCEEECCEEEEEEECCCCEEEECCH
NAVKKNIKALETDGSIKRPKLGISVEDLAAAEYAGNLKQGVQIMQVEAASVAQQAGLMQG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCEEEEEHHHHHHHHHCCCCC
DVITHLDQTKIEDKIHFRKVLFNDKKVGETLNVSIERQGTKKTIKLKLK
CHHHHCCHHHHHHHHHHHHHHHCCHHCCCEEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MKKITIKRRDYRRPKRLFYEGQGKRHIFPYLHKKDEEKLIIEPDTQDTVDESAAIPPVTE
CCCEEECHHHCCCCHHHEECCCCCEEECCHHCCCCCCCEEECCCCCCHHHHCCCCCCCCH
ASLQQPQDETKEVPAEEKVMNAETPEIHKEASEQEVKAPEVSTEPLIAETSASSFKWLLP
HHHCCCCHHHHCCCCHHHHCCCCCCHHHHHCCHHHCCCCCCCCCCEEEECCCCHHHHHHH
LLVGILVGIMLAALLLPKMFQQKDKPQEKAALSQTEQIAQHKDTVVTVTNLQKASTDEPI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DAQASEKAPEETGIGSGVIYKIDEKYAYIVTNHHVVAKAPTIEVTQGKLKEKATLIGKDI
CCCCHHCCCHHCCCCCCEEEEECCCEEEEEECCEEEEECCEEEECCCHHHHHHHHHHHHH
WTDIAVIRIPNGNLKSTVTFGDSSKLEVGEHVLALGSPLGKIFAGSVTSGIISGLERTVP
HCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCE
VDIDGDNEYDWSMDVIQTDAAINPGNSGGALFNDKGEMIGLNSLKITMNGVEGIAFSIPA
EEECCCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCEEECCEEEEEEECCCCEEEECCH
NAVKKNIKALETDGSIKRPKLGISVEDLAAAEYAGNLKQGVQIMQVEAASVAQQAGLMQG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCEEEEEHHHHHHHHHCCCCC
DVITHLDQTKIEDKIHFRKVLFNDKKVGETLNVSIERQGTKKTIKLKLK
CHHHHCCHHHHHHHHHHHHHHHCCHHCCCEEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]