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The map label for this gene is hisC

Identifier: 222150725

GI number: 222150725

Start: 503945

End: 504997

Strand: Direct

Name: hisC

Synonym: MCCL_0475

Alternate gene names: 222150725

Gene position: 503945-504997 (Clockwise)

Preceding gene: 222150724

Following gene: 222150726

Centisome position: 23.97

GC content: 38.37

Gene sequence:

>1053_bases
ATGAAACCACAACTAGAAAGTCTAGGCGTCTACAAGGCTGGATTATCAGAGGAAGCATTAAAGCGCAAGTTTAATGTTGA
AGGAGAATTCAGTCGACTCGCATCGAATGAAAATCCAATTGGTCCATCACCACAAGTGTATGAAGCCATTCGTTCACAAG
ATGCGCTCAACTATTATCCTGATCCAGAAGCCATACAGCTGAAGGCATCGCTCTCAGAATTCTACCAGGTAGATAGTGAA
CAAATTCTTGTAGGAGCTGGACTAGATGAAATTATAATGATGATTTCGCGTGCACGTCTGAATCCTAAAGGACATATATT
GACGAGTGAAGGTACTTTTATTCAGTATACGACACATGCACTGATTGAAGATAATGAAGTGGTCAGTATACCGTTGAAAG
AAGGGAAGTTTGACCTGGAAAGTTTTAAAGATAAGATGAATGATGAGACAAGTATCATCTGGATCTGTAACCCAAATAAT
CCAACAGGTACTTATGTTACTGAAACAGAATTAACTGGATTTTTAGAAAGTGTACATGAAGATGTAATGGTCGTACTGGA
TGAAGCATATTTTGAATTTGTTCTGCGTGAGGATTATCCAGATGGCGTAGCGTTACTTAAACGCTTCCCGAATCTGATTG
TGCTCAGAACATTCTCTAAAGCCTATGGATTAGCAGGACTACGTGTAGGGTATGCCATAACATCTAAAGCATATATTGAT
GTATTCAATAAAGTAAAGCTGCCGTTTAACGTGACAGCACTTTCGCTAGTCGGAGCAATTGCTGCATTAAAAGACCAGCA
ATATTTAAAGGATTATGTTGCTCATAATGACAAAGAGCGCAATAAATTCTTTGAAGCGGATTACAAAGAACACCTTATAG
ATAGCGTAACAAACTTTATATTTGTTAAGACGAATCAGCCTGAAGCGTTATTCGAAGCATTGATTAAGGGTGGAGTAATT
GCTAGACCGATGCCTAACGGGGTAAGAATATCAATTGGCACGCGTGACGATAATGAAAAAGTTCATAAAGTAATCAATTC
ATTCTTCAGTTAA

Upstream 100 bases:

>100_bases
GAAGATTATAAAATAAATTAATTTGTTAAAAAGATAGCAAAAATTTGCTATCTTTTTTTATTTTCTCTATCATAATATAA
AACGAACTGGAGGGTCTAAT

Downstream 100 bases:

>100_bases
TCAAATAACTACAATTAGCAATCTAGATTGCTTATAATGATAGTAATATAGGATAAAGGATGATTATGATGAGACAGTCA
ATTGCAATTGATATGGATGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKPQLESLGVYKAGLSEEALKRKFNVEGEFSRLASNENPIGPSPQVYEAIRSQDALNYYPDPEAIQLKASLSEFYQVDSE
QILVGAGLDEIIMMISRARLNPKGHILTSEGTFIQYTTHALIEDNEVVSIPLKEGKFDLESFKDKMNDETSIIWICNPNN
PTGTYVTETELTGFLESVHEDVMVVLDEAYFEFVLREDYPDGVALLKRFPNLIVLRTFSKAYGLAGLRVGYAITSKAYID
VFNKVKLPFNVTALSLVGAIAALKDQQYLKDYVAHNDKERNKFFEADYKEHLIDSVTNFIFVKTNQPEALFEALIKGGVI
ARPMPNGVRISIGTRDDNEKVHKVINSFFS

Sequences:

>Translated_350_residues
MKPQLESLGVYKAGLSEEALKRKFNVEGEFSRLASNENPIGPSPQVYEAIRSQDALNYYPDPEAIQLKASLSEFYQVDSE
QILVGAGLDEIIMMISRARLNPKGHILTSEGTFIQYTTHALIEDNEVVSIPLKEGKFDLESFKDKMNDETSIIWICNPNN
PTGTYVTETELTGFLESVHEDVMVVLDEAYFEFVLREDYPDGVALLKRFPNLIVLRTFSKAYGLAGLRVGYAITSKAYID
VFNKVKLPFNVTALSLVGAIAALKDQQYLKDYVAHNDKERNKFFEADYKEHLIDSVTNFIFVKTNQPEALFEALIKGGVI
ARPMPNGVRISIGTRDDNEKVHKVINSFFS
>Mature_350_residues
MKPQLESLGVYKAGLSEEALKRKFNVEGEFSRLASNENPIGPSPQVYEAIRSQDALNYYPDPEAIQLKASLSEFYQVDSE
QILVGAGLDEIIMMISRARLNPKGHILTSEGTFIQYTTHALIEDNEVVSIPLKEGKFDLESFKDKMNDETSIIWICNPNN
PTGTYVTETELTGFLESVHEDVMVVLDEAYFEFVLREDYPDGVALLKRFPNLIVLRTFSKAYGLAGLRVGYAITSKAYID
VFNKVKLPFNVTALSLVGAIAALKDQQYLKDYVAHNDKERNKFFEADYKEHLIDSVTNFIFVKTNQPEALFEALIKGGVI
ARPMPNGVRISIGTRDDNEKVHKVINSFFS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=312, Percent_Identity=31.4102564102564, Blast_Score=144, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6322075, Length=351, Percent_Identity=27.9202279202279, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_MACCJ (B9EAC1)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002559878.1
- ProteinModelPortal:   B9EAC1
- GeneID:   7389592
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0475
- OMA:   YAFELRT
- ProtClustDB:   PRK03158
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39399; Mature: 39399

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPQLESLGVYKAGLSEEALKRKFNVEGEFSRLASNENPIGPSPQVYEAIRSQDALNYYP
CCCCCHHCCCHHCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCC
DPEAIQLKASLSEFYQVDSEQILVGAGLDEIIMMISRARLNPKGHILTSEGTFIQYTTHA
CCCCEEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEE
LIEDNEVVSIPLKEGKFDLESFKDKMNDETSIIWICNPNNPTGTYVTETELTGFLESVHE
EECCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHH
DVMVVLDEAYFEFVLREDYPDGVALLKRFPNLIVLRTFSKAYGLAGLRVGYAITSKAYID
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEEHHHHHCCCHHHCCHHHHHHHHHH
VFNKVKLPFNVTALSLVGAIAALKDQQYLKDYVAHNDKERNKFFEADYKEHLIDSVTNFI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCEE
FVKTNQPEALFEALIKGGVIARPMPNGVRISIGTRDDNEKVHKVINSFFS
EEECCCCHHHHHHHHHCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKPQLESLGVYKAGLSEEALKRKFNVEGEFSRLASNENPIGPSPQVYEAIRSQDALNYYP
CCCCCHHCCCHHCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCC
DPEAIQLKASLSEFYQVDSEQILVGAGLDEIIMMISRARLNPKGHILTSEGTFIQYTTHA
CCCCEEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEEE
LIEDNEVVSIPLKEGKFDLESFKDKMNDETSIIWICNPNNPTGTYVTETELTGFLESVHE
EECCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHH
DVMVVLDEAYFEFVLREDYPDGVALLKRFPNLIVLRTFSKAYGLAGLRVGYAITSKAYID
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEEHHHHHCCCHHHCCHHHHHHHHHH
VFNKVKLPFNVTALSLVGAIAALKDQQYLKDYVAHNDKERNKFFEADYKEHLIDSVTNFI
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCEE
FVKTNQPEALFEALIKGGVIARPMPNGVRISIGTRDDNEKVHKVINSFFS
EEECCCCHHHHHHHHHCCEEECCCCCCEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA