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The map label for this gene is recQ [H]

Identifier: 222150722

GI number: 222150722

Start: 499595

End: 501361

Strand: Direct

Name: recQ [H]

Synonym: MCCL_0472

Alternate gene names: 222150722

Gene position: 499595-501361 (Clockwise)

Preceding gene: 222150721

Following gene: 222150723

Centisome position: 23.76

GC content: 37.86

Gene sequence:

>1767_bases
ATGAAACACATATTACAAGAATATTTTGGTTATTCCAGCTTTAGGCCCGGACAGCAACAATTAATAGATTATGCGATAAA
TAATATTCCGACACTGGGCATTCTTCCGACAGGTGGCGGGAAATCTATATGCTATCAAGTTCCGGGTATCTACAAAGGAG
GATTGACGCTTGTCATAAGCCCGCTCATCTCATTGATGAAAGACCAGGTGGATGCACTCAATGCGAGTGGTATTAAAGCT
AGTTATATCAATTCTTCATTAACGAAACAAGAAGTGCGTGCAGTTGAAGCACAATTAATTTCAGGTGAGTGTCAATTTCT
ATATGTTGCGCCTGAACGATTTGATAATCATTCTTTTCAGCAGCTGTTATACTCCCTTGATATTCGACTTGTTGCTTTCG
ATGAGGCACACTGCATATCAAAATGGGGACATGACTTTAGACCAAGCTACCGTGACGTCGTACAAAAAGTGATGACGTTA
CCTCATCATTTTACGCTTATGGCATTAACAGCGACGGCTACTGTAGATGTTAAGGAGGATATATGCAGCTTACTGCATAT
TCAACTAGAACATGTTGTCGAAACAAGTACAAAAAGAGAAAACTTGAAGTTCATCGTAGACCCAACGTATCAGAAACAAA
AGATGGTGATTGACTATATAAAGAGTCATAGTGATGCATCAGGAATTATCTACGCCAGCACAAGAAAGCAAGTAGAGTTG
TTAAGTGAAGTGTTTGAAGTGAATCAGATTCGTCATACACTTTATCATGCCGGACTTAAGAAGGAAGAAAAAGAACGTAA
TCAAAGTGCCTTCGTTCGAGATGATATTCCAGTAATGATTGCAACGAATGCATTTGGAATGGGGATTGATAAATCCAATG
TCAGATATGTCATTCATTATAATATGCCGCAGGACTTAGAGAGCTATTATCAGGAGGCCGGTCGTGCAGGCCGTGATGGA
TTGAAGAGTGAGTGTATTTTAATGTATTCAGAAGCGGATATTAAGCTGCAGTATTTCTTTATTGAGACAGCACCGGAGGC
AGTACAGGAATTAAAGAAAGACAAACTGAGTAAAATGATTCAATATACGAAGACGAAGCGCTGTCTGCAGTCAACCATCA
TTAATTACTTTAATCCTAATGAGCCACTGAAAAATTGTGGTCAGTGCTCCAGCTGTCTGAGACAGGATGAGAATTATAAT
ATGACAACAGAAGCGAAACAAATATTAAGTTGTCTCATCCGTATAAAGGTTCCTGTAACCAAACTTCTGCTTTCTAAAGT
ACTGCATGGAGAAAGTGATAATCAGATTCACAACGAATCACTGCACAAGCTCTCTACTTACGGCTTATTAAAAAACTATG
AAGCAAGCGCTGTTCAATCATTTATCGATACGTTAATCTTTAATGGCTATATAAGAATTCATGATCACCATCTATATTGT
GATGATTCAGCAAAAGCTATCTTATTTAATGAGAAACAGGTGATGACATATTATAAACCAAATCAATACAATGAGAAAGT
CAAGATTACAACGATAGACGCTGTAGATGATACGTTACTAAGGGCACTTAAGACAGCGCGTAAAGAGTTAAGTGAGCGGC
TGGATGTACCACCGTTTACGATATTTTCTGATCATACACTCGAGCTTTTTGCTGATAAAAAACCTATATCTAAAGAAGAT
ATGATACTGATCGAAGGGGTTGGATCCTATAAACTAAAGCATTATTGTCCTAAGTTTATTGAAGTGATTCAAGATTATGT
AAGCTAA

Upstream 100 bases:

>100_bases
TAAACTCAATCAATTGACGACTGAACGTCAGGAGAAAGAAAGACTATATGAAACATACTTTGAAGAATGGGATGAACTTT
CTGCGCGAATGGAGTAGATT

Downstream 100 bases:

>100_bases
TTAGTTGTTTAACCTCTGGCGTTTAGGTTATATGTATTACATTAAATTCTATAAGAGGTGCAACATGATAAAATTTAAAC
ATGTATCAAAACGTTATGCT

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MKHILQEYFGYSSFRPGQQQLIDYAINNIPTLGILPTGGGKSICYQVPGIYKGGLTLVISPLISLMKDQVDALNASGIKA
SYINSSLTKQEVRAVEAQLISGECQFLYVAPERFDNHSFQQLLYSLDIRLVAFDEAHCISKWGHDFRPSYRDVVQKVMTL
PHHFTLMALTATATVDVKEDICSLLHIQLEHVVETSTKRENLKFIVDPTYQKQKMVIDYIKSHSDASGIIYASTRKQVEL
LSEVFEVNQIRHTLYHAGLKKEEKERNQSAFVRDDIPVMIATNAFGMGIDKSNVRYVIHYNMPQDLESYYQEAGRAGRDG
LKSECILMYSEADIKLQYFFIETAPEAVQELKKDKLSKMIQYTKTKRCLQSTIINYFNPNEPLKNCGQCSSCLRQDENYN
MTTEAKQILSCLIRIKVPVTKLLLSKVLHGESDNQIHNESLHKLSTYGLLKNYEASAVQSFIDTLIFNGYIRIHDHHLYC
DDSAKAILFNEKQVMTYYKPNQYNEKVKITTIDAVDDTLLRALKTARKELSERLDVPPFTIFSDHTLELFADKKPISKED
MILIEGVGSYKLKHYCPKFIEVIQDYVS

Sequences:

>Translated_588_residues
MKHILQEYFGYSSFRPGQQQLIDYAINNIPTLGILPTGGGKSICYQVPGIYKGGLTLVISPLISLMKDQVDALNASGIKA
SYINSSLTKQEVRAVEAQLISGECQFLYVAPERFDNHSFQQLLYSLDIRLVAFDEAHCISKWGHDFRPSYRDVVQKVMTL
PHHFTLMALTATATVDVKEDICSLLHIQLEHVVETSTKRENLKFIVDPTYQKQKMVIDYIKSHSDASGIIYASTRKQVEL
LSEVFEVNQIRHTLYHAGLKKEEKERNQSAFVRDDIPVMIATNAFGMGIDKSNVRYVIHYNMPQDLESYYQEAGRAGRDG
LKSECILMYSEADIKLQYFFIETAPEAVQELKKDKLSKMIQYTKTKRCLQSTIINYFNPNEPLKNCGQCSSCLRQDENYN
MTTEAKQILSCLIRIKVPVTKLLLSKVLHGESDNQIHNESLHKLSTYGLLKNYEASAVQSFIDTLIFNGYIRIHDHHLYC
DDSAKAILFNEKQVMTYYKPNQYNEKVKITTIDAVDDTLLRALKTARKELSERLDVPPFTIFSDHTLELFADKKPISKED
MILIEGVGSYKLKHYCPKFIEVIQDYVS
>Mature_588_residues
MKHILQEYFGYSSFRPGQQQLIDYAINNIPTLGILPTGGGKSICYQVPGIYKGGLTLVISPLISLMKDQVDALNASGIKA
SYINSSLTKQEVRAVEAQLISGECQFLYVAPERFDNHSFQQLLYSLDIRLVAFDEAHCISKWGHDFRPSYRDVVQKVMTL
PHHFTLMALTATATVDVKEDICSLLHIQLEHVVETSTKRENLKFIVDPTYQKQKMVIDYIKSHSDASGIIYASTRKQVEL
LSEVFEVNQIRHTLYHAGLKKEEKERNQSAFVRDDIPVMIATNAFGMGIDKSNVRYVIHYNMPQDLESYYQEAGRAGRDG
LKSECILMYSEADIKLQYFFIETAPEAVQELKKDKLSKMIQYTKTKRCLQSTIINYFNPNEPLKNCGQCSSCLRQDENYN
MTTEAKQILSCLIRIKVPVTKLLLSKVLHGESDNQIHNESLHKLSTYGLLKNYEASAVQSFIDTLIFNGYIRIHDHHLYC
DDSAKAILFNEKQVMTYYKPNQYNEKVKITTIDAVDDTLLRALKTARKELSERLDVPPFTIFSDHTLELFADKKPISKED
MILIEGVGSYKLKHYCPKFIEVIQDYVS

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI110735439, Length=501, Percent_Identity=33.7325349301397, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI169218196, Length=501, Percent_Identity=33.7325349301397, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI148612816, Length=420, Percent_Identity=35.7142857142857, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI51242943, Length=377, Percent_Identity=37.1352785145889, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI51242947, Length=377, Percent_Identity=37.1352785145889, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI14591902, Length=431, Percent_Identity=34.8027842227378, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI14591904, Length=431, Percent_Identity=34.8027842227378, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI4557365, Length=639, Percent_Identity=30.829420970266, Blast_Score=239, Evalue=7e-63,
Organism=Homo sapiens, GI284005309, Length=389, Percent_Identity=31.1053984575836, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI13514831, Length=392, Percent_Identity=24.4897959183673, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI222352149, Length=373, Percent_Identity=21.9839142091153, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI55749865, Length=369, Percent_Identity=21.1382113821138, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI50659095, Length=160, Percent_Identity=28.125, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI188035877, Length=331, Percent_Identity=21.1480362537764, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994977, Length=601, Percent_Identity=35.7737104825291, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI87082221, Length=338, Percent_Identity=19.8224852071006, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987993, Length=493, Percent_Identity=32.8600405679513, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71987997, Length=493, Percent_Identity=32.8600405679513, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI32564293, Length=498, Percent_Identity=32.9317269076305, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25145561, Length=512, Percent_Identity=31.8359375, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17552866, Length=410, Percent_Identity=35.609756097561, Blast_Score=235, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17510307, Length=339, Percent_Identity=24.188790560472, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17510309, Length=339, Percent_Identity=24.188790560472, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71995514, Length=339, Percent_Identity=24.188790560472, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17509811, Length=357, Percent_Identity=22.96918767507, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532546, Length=358, Percent_Identity=20.9497206703911, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115532548, Length=358, Percent_Identity=20.9497206703911, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995718, Length=264, Percent_Identity=23.8636363636364, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987143, Length=131, Percent_Identity=29.0076335877863, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71995724, Length=237, Percent_Identity=23.6286919831224, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17507121, Length=237, Percent_Identity=23.6286919831224, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=486, Percent_Identity=34.3621399176955, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324217, Length=363, Percent_Identity=23.1404958677686, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324778, Length=256, Percent_Identity=23.828125, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320224, Length=239, Percent_Identity=24.2677824267782, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325138, Length=254, Percent_Identity=23.6220472440945, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322427, Length=324, Percent_Identity=25.3086419753086, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321856, Length=346, Percent_Identity=21.0982658959538, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321360, Length=373, Percent_Identity=22.7882037533512, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646066, Length=638, Percent_Identity=31.0344827586207, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24664226, Length=427, Percent_Identity=34.192037470726, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24664230, Length=427, Percent_Identity=34.192037470726, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI62472181, Length=427, Percent_Identity=34.192037470726, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21358123, Length=351, Percent_Identity=34.1880341880342, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI281361218, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644481, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644487, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45551833, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644485, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644483, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24644479, Length=378, Percent_Identity=23.015873015873, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21355075, Length=386, Percent_Identity=21.2435233160622, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584399, Length=227, Percent_Identity=23.3480176211454, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17977678, Length=376, Percent_Identity=23.6702127659574, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17985987, Length=378, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67283; Mature: 67283

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHILQEYFGYSSFRPGQQQLIDYAINNIPTLGILPTGGGKSICYQVPGIYKGGLTLVIS
CHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCHHHHHH
PLISLMKDQVDALNASGIKASYINSSLTKQEVRAVEAQLISGECQFLYVAPERFDNHSFQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
QLLYSLDIRLVAFDEAHCISKWGHDFRPSYRDVVQKVMTLPHHFTLMALTATATVDVKED
HHHHHHCEEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHCCCHHEEEEEEEHEEEEHHHH
ICSLLHIQLEHVVETSTKRENLKFIVDPTYQKQKMVIDYIKSHSDASGIIYASTRKQVEL
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHH
LSEVFEVNQIRHTLYHAGLKKEEKERNQSAFVRDDIPVMIATNAFGMGIDKSNVRYVIHY
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEE
NMPQDLESYYQEAGRAGRDGLKSECILMYSEADIKLQYFFIETAPEAVQELKKDKLSKMI
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEEEEECCHHHHHHHHHHHHHHHH
QYTKTKRCLQSTIINYFNPNEPLKNCGQCSSCLRQDENYNMTTEAKQILSCLIRIKVPVT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
KLLLSKVLHGESDNQIHNESLHKLSTYGLLKNYEASAVQSFIDTLIFNGYIRIHDHHLYC
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEEEEE
DDSAKAILFNEKQVMTYYKPNQYNEKVKITTIDAVDDTLLRALKTARKELSERLDVPPFT
CCCCCEEEEECCEEEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEE
IFSDHTLELFADKKPISKEDMILIEGVGSYKLKHYCPKFIEVIQDYVS
EECCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHCHHHHHHHHHHHC
>Mature Secondary Structure
MKHILQEYFGYSSFRPGQQQLIDYAINNIPTLGILPTGGGKSICYQVPGIYKGGLTLVIS
CHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCCCHHHHHH
PLISLMKDQVDALNASGIKASYINSSLTKQEVRAVEAQLISGECQFLYVAPERFDNHSFQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
QLLYSLDIRLVAFDEAHCISKWGHDFRPSYRDVVQKVMTLPHHFTLMALTATATVDVKED
HHHHHHCEEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHCCCHHEEEEEEEHEEEEHHHH
ICSLLHIQLEHVVETSTKRENLKFIVDPTYQKQKMVIDYIKSHSDASGIIYASTRKQVEL
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHH
LSEVFEVNQIRHTLYHAGLKKEEKERNQSAFVRDDIPVMIATNAFGMGIDKSNVRYVIHY
HHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEE
NMPQDLESYYQEAGRAGRDGLKSECILMYSEADIKLQYFFIETAPEAVQELKKDKLSKMI
CCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEEEEECCHHHHHHHHHHHHHHHH
QYTKTKRCLQSTIINYFNPNEPLKNCGQCSSCLRQDENYNMTTEAKQILSCLIRIKVPVT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
KLLLSKVLHGESDNQIHNESLHKLSTYGLLKNYEASAVQSFIDTLIFNGYIRIHDHHLYC
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEEEEE
DDSAKAILFNEKQVMTYYKPNQYNEKVKITTIDAVDDTLLRALKTARKELSERLDVPPFT
CCCCCEEEEECCEEEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEE
IFSDHTLELFADKKPISKEDMILIEGVGSYKLKHYCPKFIEVIQDYVS
EECCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]