Click here to switch to the map view.

The map label for this gene is exp5 [H]

Identifier: 222150528

GI number: 222150528

Start: 280442

End: 282610

Strand: Direct

Name: exp5 [H]

Synonym: MCCL_0278

Alternate gene names: 222150528

Gene position: 280442-282610 (Clockwise)

Preceding gene: 222150526

Following gene: 222150529

Centisome position: 13.34

GC content: 39.19

Gene sequence:

>2169_bases
GTGAAGAAATTATTAAGTTTTGAATTCTGGCAAAAGTTTGGAAAAGCATTGATGGTCGTTGTTGCAGTAATGCCAGCTGC
TGGGTTGATGATCAGTATCGGGAAATCGATTCCATTAATCAGTCCGGATATGCAGATGTTGATTACAATTGGTAGTGTTA
TAGAGAGTATAGGTTGGGCGATTATTGGAAACCTACATCTGCTCTTTGCATTAGCGATTGGAGGAAGCTGGGCGAAAGAG
CGTGCTGGGGGTGCGTTTGCAGCAGGGATAGCCTTTATATTAATCAACCGTATTACAGGTGCTATCTTTGGTGTTAACAG
TACAATGTTAGCAGATGACAAAGCATTTACTCACACGTTATTCGGCACTAAGATTATGGTAAAAGGGTTCTTTACGAGTG
TGTTAGAGGCACCTGCATTAAACATGGGTGTATTCGTAGGGATTATCGCAGGATTTGTTGGTGCCAATGCATATAACAAA
TATTATAACTACCGTAAGTTACCAGATGCATTATCATTCTTCAATGGTAAACGTTTCGTACCATTTGTCGTTATTTTATG
GTCGACAATTGTAGCGATTGTACTATCAATCGTATGGCCTTATATACAAGCCGGTATTAACAACTTCGGTCTATGGATTG
CAACATCTAAGGATACAGCGCCTATCTTAGCACCATTTTTATTTGGATTTTTAGAGCGTTTATTATTACCATTCGGATTA
CATCATATGCTTACAATTCCAATTAACTATACGCAACTTGGTGGAACATATGAAATTCTTTCTGGTGCACAAGCAGGGAC
GAAAGTGTATGGACAAGATCCTTTGTGGCTAGCATGGGCAACAGACTTAGTAAACTTAAATCATGCTGGAGATACTACGC
AATATAATCACGTATTAAATACATTTACACCTGCACGTTTTAAAGTAGGACAAATGATTGGTTCAAGCGGTATTTTAATG
GGACTTGCTTATGCGATGTACCGTAATGTTGACAAAGATAAGAAGCCAAAATATAAATCAATGTATTTATCAGCTGCAAT
CGCAGTATTCTTAACTGGTGTAACAGAACCTTTAGAATTTATGTTCATGTTTGTAGCAGCACCACTTTATGCGGTGTATG
CAGTTATTCAAGGTGCAGCATTCGCGATGGCAGACGTCATCAATCTACGCGTTCATTCATTTGGGACAATCGAATTATTA
ACACGTACACCTCTTGCGCTTAAAGCGGGACTTGGTGGCGACTTGATTAACTTTGTTTTAACAACGATTGGGTTTGCAAT
CGCAACATATTTCATTGCAAATCTCTTAATTAAAAAGTTCAATTTTGCAACACCGGGACGTAACGGAAATTATGAGATTG
ATGGTGAAACTAACGCAACAGAAGTTGTAGCAGCAGATAAGCAAGTGATTCAAGTCATTCACTTATTAGGTGGGAAAGAG
AATATTAAAGATGTCGACGCTTGTATGACAAGACTGCGAGTAAGTGTTAATGATAAAGCTAAAGTTGCGACAGAAACAGA
ATGGAAGAAAGCTGGAGCAATGGGATTAATCGTTAAAGATAACGGTGTACAGGCTGTTTATGGTCCTAAAGCAGACGTAT
TAAAATCAGATATCGAAGATTTATTACAGTCGGGCGCTGATATTCCAGAACCAGAAGAAACAATAGTTCAGCCAACTGTA
CTGGACAACTCTGATGGTGCTGGGTTTACAGGTCATGCTCACCAACTACGTGCAGTTGCAGACGGAGAAGTTATCGATAT
TACTTCTGTGAACGACCCTGTATTCTCACAGAAGATGATGGGTGAAGGCTATGCAGTAAAGCCGGAATCAGAAGAAGTTG
TGTCACCGGTAGATGGAGAAATTATTAGTATCTTCCCGACGAAACATGCAATCGGTATTAGAACGAATGATGGGATAGAA
GTCCTCGTGCATATGGGTATTGAAACAGTTCAAATGAAACAACCAGCTTCACGCGTTGTTGTCAATGACGGTCAGAAGGT
AAAAGCCGGAGATACATTAGCTTATATGGATCTCGTAGCAGTAAGAGCAGAAGGTAAGGATACGACAATTATTATCGTAA
TGACCAATAGCGATAAAGTTGATACATTACAATTAAATAAAACAGGAATCGTTCAAAAAGGTGAAACAGTTGGTACGATG
ACAGTTTAA

Upstream 100 bases:

>100_bases
CATTTAAAAACATATTAATATTACTATTTACAAAAATAAATTCAAATGATATATTGAATTCAACGAAACCGATTGCATAA
AATAAAAGGAGTTGAATGTA

Downstream 100 bases:

>100_bases
TCAAAAAGACAGTCTTTGGACTGTCTTTTCGTTATAATAGGGATAATTAATGATAAGGAGCGAATGCAGTGAAAGTATTA
ACATTAAATACCCACAGCTG

Product: sugar-specific permease EIIA 1 domain

Products: NA

Alternate protein names: EII-Glc/EIII-Glc; EIICBA-Glc; Glucose permease IIC component; PTS system glucose-specific EIIC component; Glucose-specific phosphotransferase enzyme IIB component; PTS system glucose-specific EIIB component; Glucose-specific phosphotransferase enzyme IIA component; PTS system glucose-specific EIIA component [H]

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MKKLLSFEFWQKFGKALMVVVAVMPAAGLMISIGKSIPLISPDMQMLITIGSVIESIGWAIIGNLHLLFALAIGGSWAKE
RAGGAFAAGIAFILINRITGAIFGVNSTMLADDKAFTHTLFGTKIMVKGFFTSVLEAPALNMGVFVGIIAGFVGANAYNK
YYNYRKLPDALSFFNGKRFVPFVVILWSTIVAIVLSIVWPYIQAGINNFGLWIATSKDTAPILAPFLFGFLERLLLPFGL
HHMLTIPINYTQLGGTYEILSGAQAGTKVYGQDPLWLAWATDLVNLNHAGDTTQYNHVLNTFTPARFKVGQMIGSSGILM
GLAYAMYRNVDKDKKPKYKSMYLSAAIAVFLTGVTEPLEFMFMFVAAPLYAVYAVIQGAAFAMADVINLRVHSFGTIELL
TRTPLALKAGLGGDLINFVLTTIGFAIATYFIANLLIKKFNFATPGRNGNYEIDGETNATEVVAADKQVIQVIHLLGGKE
NIKDVDACMTRLRVSVNDKAKVATETEWKKAGAMGLIVKDNGVQAVYGPKADVLKSDIEDLLQSGADIPEPEETIVQPTV
LDNSDGAGFTGHAHQLRAVADGEVIDITSVNDPVFSQKMMGEGYAVKPESEEVVSPVDGEIISIFPTKHAIGIRTNDGIE
VLVHMGIETVQMKQPASRVVVNDGQKVKAGDTLAYMDLVAVRAEGKDTTIIIVMTNSDKVDTLQLNKTGIVQKGETVGTM
TV

Sequences:

>Translated_722_residues
MKKLLSFEFWQKFGKALMVVVAVMPAAGLMISIGKSIPLISPDMQMLITIGSVIESIGWAIIGNLHLLFALAIGGSWAKE
RAGGAFAAGIAFILINRITGAIFGVNSTMLADDKAFTHTLFGTKIMVKGFFTSVLEAPALNMGVFVGIIAGFVGANAYNK
YYNYRKLPDALSFFNGKRFVPFVVILWSTIVAIVLSIVWPYIQAGINNFGLWIATSKDTAPILAPFLFGFLERLLLPFGL
HHMLTIPINYTQLGGTYEILSGAQAGTKVYGQDPLWLAWATDLVNLNHAGDTTQYNHVLNTFTPARFKVGQMIGSSGILM
GLAYAMYRNVDKDKKPKYKSMYLSAAIAVFLTGVTEPLEFMFMFVAAPLYAVYAVIQGAAFAMADVINLRVHSFGTIELL
TRTPLALKAGLGGDLINFVLTTIGFAIATYFIANLLIKKFNFATPGRNGNYEIDGETNATEVVAADKQVIQVIHLLGGKE
NIKDVDACMTRLRVSVNDKAKVATETEWKKAGAMGLIVKDNGVQAVYGPKADVLKSDIEDLLQSGADIPEPEETIVQPTV
LDNSDGAGFTGHAHQLRAVADGEVIDITSVNDPVFSQKMMGEGYAVKPESEEVVSPVDGEIISIFPTKHAIGIRTNDGIE
VLVHMGIETVQMKQPASRVVVNDGQKVKAGDTLAYMDLVAVRAEGKDTTIIIVMTNSDKVDTLQLNKTGIVQKGETVGTM
TV
>Mature_722_residues
MKKLLSFEFWQKFGKALMVVVAVMPAAGLMISIGKSIPLISPDMQMLITIGSVIESIGWAIIGNLHLLFALAIGGSWAKE
RAGGAFAAGIAFILINRITGAIFGVNSTMLADDKAFTHTLFGTKIMVKGFFTSVLEAPALNMGVFVGIIAGFVGANAYNK
YYNYRKLPDALSFFNGKRFVPFVVILWSTIVAIVLSIVWPYIQAGINNFGLWIATSKDTAPILAPFLFGFLERLLLPFGL
HHMLTIPINYTQLGGTYEILSGAQAGTKVYGQDPLWLAWATDLVNLNHAGDTTQYNHVLNTFTPARFKVGQMIGSSGILM
GLAYAMYRNVDKDKKPKYKSMYLSAAIAVFLTGVTEPLEFMFMFVAAPLYAVYAVIQGAAFAMADVINLRVHSFGTIELL
TRTPLALKAGLGGDLINFVLTTIGFAIATYFIANLLIKKFNFATPGRNGNYEIDGETNATEVVAADKQVIQVIHLLGGKE
NIKDVDACMTRLRVSVNDKAKVATETEWKKAGAMGLIVKDNGVQAVYGPKADVLKSDIEDLLQSGADIPEPEETIVQPTV
LDNSDGAGFTGHAHQLRAVADGEVIDITSVNDPVFSQKMMGEGYAVKPESEEVVSPVDGEIISIFPTKHAIGIRTNDGIE
VLVHMGIETVQMKQPASRVVVNDGQKVKAGDTLAYMDLVAVRAEGKDTTIIIVMTNSDKVDTLQLNKTGIVQKGETVGTM
TV

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1786894, Length=724, Percent_Identity=32.3204419889503, Blast_Score=286, Evalue=4e-78,
Organism=Escherichia coli, GI1787343, Length=543, Percent_Identity=31.6758747697974, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1787908, Length=573, Percent_Identity=29.4938917975567, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI1790159, Length=134, Percent_Identity=39.5522388059701, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788757, Length=135, Percent_Identity=40, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011055
- InterPro:   IPR018113
- InterPro:   IPR001127
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- InterPro:   IPR011535
- InterPro:   IPR011300 [H]

Pfam domain/function: PF00358 PTS_EIIA_1; PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 78021; Mature: 78021

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00371 PTS_EIIA_TYPE_1_HIS ; PS51093 PTS_EIIA_TYPE_1 ; PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLSFEFWQKFGKALMVVVAVMPAAGLMISIGKSIPLISPDMQMLITIGSVIESIGWA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
IIGNLHLLFALAIGGSWAKERAGGAFAAGIAFILINRITGAIFGVNSTMLADDKAFTHTL
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHH
FGTKIMVKGFFTSVLEAPALNMGVFVGIIAGFVGANAYNKYYNYRKLPDALSFFNGKRFV
HCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCCCHH
PFVVILWSTIVAIVLSIVWPYIQAGINNFGLWIATSKDTAPILAPFLFGFLERLLLPFGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
HHMLTIPINYTQLGGTYEILSGAQAGTKVYGQDPLWLAWATDLVNLNHAGDTTQYNHVLN
CCEEEEEEEHEECCCHHHHHCCCCCCCEEECCCCEEEEEEHHHEECCCCCCCCHHHHHHH
TFTPARFKVGQMIGSSGILMGLAYAMYRNVDKDKKPKYKSMYLSAAIAVFLTGVTEPLEF
CCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
MFMFVAAPLYAVYAVIQGAAFAMADVINLRVHSFGTIELLTRTPLALKAGLGGDLINFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHEECCCCHHHHHHHH
TTIGFAIATYFIANLLIKKFNFATPGRNGNYEIDGETNATEVVAADKQVIQVIHLLGGKE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEHHHHHHHHHHHHHCCCC
NIKDVDACMTRLRVSVNDKAKVATETEWKKAGAMGLIVKDNGVQAVYGPKADVLKSDIED
CCHHHHHHHHHHEECCCCCCCCCCCCHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHH
LLQSGADIPEPEETIVQPTVLDNSDGAGFTGHAHQLRAVADGEVIDITSVNDPVFSQKMM
HHHCCCCCCCCHHHEECCEEEECCCCCCCCCCHHHEEEECCCCEEEEECCCCCHHHHHHC
GEGYAVKPESEEVVSPVDGEIISIFPTKHAIGIRTNDGIEVLVHMGIETVQMKQPASRVV
CCCEEECCCCHHHCCCCCCCEEEEEECCEEEEEECCCCCEEEEECCCHHEECCCCCCEEE
VNDGQKVKAGDTLAYMDLVAVRAEGKDTTIIIVMTNSDKVDTLQLNKTGIVQKGETVGTM
ECCCCEEECCCCHHHHHHHEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCEE
TV
CC
>Mature Secondary Structure
MKKLLSFEFWQKFGKALMVVVAVMPAAGLMISIGKSIPLISPDMQMLITIGSVIESIGWA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
IIGNLHLLFALAIGGSWAKERAGGAFAAGIAFILINRITGAIFGVNSTMLADDKAFTHTL
HHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHH
FGTKIMVKGFFTSVLEAPALNMGVFVGIIAGFVGANAYNKYYNYRKLPDALSFFNGKRFV
HCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHCCCCHH
PFVVILWSTIVAIVLSIVWPYIQAGINNFGLWIATSKDTAPILAPFLFGFLERLLLPFGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
HHMLTIPINYTQLGGTYEILSGAQAGTKVYGQDPLWLAWATDLVNLNHAGDTTQYNHVLN
CCEEEEEEEHEECCCHHHHHCCCCCCCEEECCCCEEEEEEHHHEECCCCCCCCHHHHHHH
TFTPARFKVGQMIGSSGILMGLAYAMYRNVDKDKKPKYKSMYLSAAIAVFLTGVTEPLEF
CCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
MFMFVAAPLYAVYAVIQGAAFAMADVINLRVHSFGTIELLTRTPLALKAGLGGDLINFVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHEECCCCHHHHHHHH
TTIGFAIATYFIANLLIKKFNFATPGRNGNYEIDGETNATEVVAADKQVIQVIHLLGGKE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEHHHHHHHHHHHHHCCCC
NIKDVDACMTRLRVSVNDKAKVATETEWKKAGAMGLIVKDNGVQAVYGPKADVLKSDIED
CCHHHHHHHHHHEECCCCCCCCCCCCHHHHCCCEEEEEECCCEEEEECCCHHHHHHHHHH
LLQSGADIPEPEETIVQPTVLDNSDGAGFTGHAHQLRAVADGEVIDITSVNDPVFSQKMM
HHHCCCCCCCCHHHEECCEEEECCCCCCCCCCHHHEEEECCCCEEEEECCCCCHHHHHHC
GEGYAVKPESEEVVSPVDGEIISIFPTKHAIGIRTNDGIEVLVHMGIETVQMKQPASRVV
CCCEEECCCCHHHCCCCCCCEEEEEECCEEEEEECCCCCEEEEECCCHHEECCCCCCEEE
VNDGQKVKAGDTLAYMDLVAVRAEGKDTTIIIVMTNSDKVDTLQLNKTGIVQKGETVGTM
ECCCCEEECCCCHHHHHHHEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCEE
TV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 7934910 [H]