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The map label for this gene is msrA [H]

Identifier: 222150512

GI number: 222150512

Start: 265027

End: 265494

Strand: Direct

Name: msrA [H]

Synonym: MCCL_0262

Alternate gene names: 222150512

Gene position: 265027-265494 (Clockwise)

Preceding gene: 222150511

Following gene: 222150513

Centisome position: 12.61

GC content: 41.45

Gene sequence:

>468_bases
ATGTATACAATATATTTAGCTGGAGGATGCCTCTGGGGTGTACAGGCGTTTTTGAAGACGGTACCTGGTGTAGCTGGAAC
TGAAGCGGGTAGAGCGAACGGCGAGACAGCAACATTAGACGGACCGTATGATGGCTATGCTGAATGTGTGAAGACAATAT
GTGAAGATACACTAGCACTACATGAGCTGTTAGATGATTTCTTTCAGATTATGGATCCGTATAGCGTGAATAAGCAAGGG
ATCGATGAAGGTCCGAAATATAGAACGGGAATCTATAGTGAAGATGAAGCGTTATTACAAGCAGTAAGACGCTATATAAA
TTCACGAGAAGATAAAGAGAAGATTGTTGTAGAAGTGCTGGCATTAAATAATTATGTCCGTAGTGCAGACGAACATCAGG
ATTATCTGGACAGACATCCAGGTGACTATTGTCATGTACCGCTTGAGATGATGAGGAAATATAGATAA

Upstream 100 bases:

>100_bases
CAAAAAGTAATCTCTAGCATTGAGGTAAATGTAGTTATACATTTACCTCAATTTTTTTGTGTATAATTATAATTATTACG
AATCAGAGAGGTGAACGAAA

Downstream 100 bases:

>100_bases
TAAGCTCTAATTAATTTTTTCGAGATATAAACCGTTAGACACACTGACAGAATGATATTTGAGTTCTGAGGTGTGTTTTT
GTATTCATTAAAAGATAACG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MYTIYLAGGCLWGVQAFLKTVPGVAGTEAGRANGETATLDGPYDGYAECVKTICEDTLALHELLDDFFQIMDPYSVNKQG
IDEGPKYRTGIYSEDEALLQAVRRYINSREDKEKIVVEVLALNNYVRSADEHQDYLDRHPGDYCHVPLEMMRKYR

Sequences:

>Translated_155_residues
MYTIYLAGGCLWGVQAFLKTVPGVAGTEAGRANGETATLDGPYDGYAECVKTICEDTLALHELLDDFFQIMDPYSVNKQG
IDEGPKYRTGIYSEDEALLQAVRRYINSREDKEKIVVEVLALNNYVRSADEHQDYLDRHPGDYCHVPLEMMRKYR
>Mature_155_residues
MYTIYLAGGCLWGVQAFLKTVPGVAGTEAGRANGETATLDGPYDGYAECVKTICEDTLALHELLDDFFQIMDPYSVNKQG
IDEGPKYRTGIYSEDEALLQAVRRYINSREDKEKIVVEVLALNNYVRSADEHQDYLDRHPGDYCHVPLEMMRKYR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=27.8145695364238, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=27.8145695364238, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=28.9156626506024, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 17580; Mature: 17580

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTIYLAGGCLWGVQAFLKTVPGVAGTEAGRANGETATLDGPYDGYAECVKTICEDTLAL
CEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
HELLDDFFQIMDPYSVNKQGIDEGPKYRTGIYSEDEALLQAVRRYINSREDKEKIVVEVL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
ALNNYVRSADEHQDYLDRHPGDYCHVPLEMMRKYR
HHHHHHHCCHHHHHHHHCCCCCEEECCHHHHHCCC
>Mature Secondary Structure
MYTIYLAGGCLWGVQAFLKTVPGVAGTEAGRANGETATLDGPYDGYAECVKTICEDTLAL
CEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
HELLDDFFQIMDPYSVNKQGIDEGPKYRTGIYSEDEALLQAVRRYINSREDKEKIVVEVL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
ALNNYVRSADEHQDYLDRHPGDYCHVPLEMMRKYR
HHHHHHHCCHHHHHHHHCCCCCEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA