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The map label for this gene is adk [H]

Identifier: 222150466

GI number: 222150466

Start: 213949

End: 214596

Strand: Direct

Name: adk [H]

Synonym: MCCL_0216

Alternate gene names: 222150466

Gene position: 213949-214596 (Clockwise)

Preceding gene: 222150465

Following gene: 222150467

Centisome position: 10.18

GC content: 36.42

Gene sequence:

>648_bases
ATGAATATCATTTTAATGGGCTTACCTGGAGCAGGTAAAGGAACTCAAGCGAGTGAAATTATTAAGAAATACCCGATTCC
CCATATTTCTACTGGAGATATGTTTAGAGCTGCTATCAAGAACAACACCGAACTTGGACAAAAGGCAAAAAGCTTTATGG
ACAACGGTGAACTTGTTCCTGATGAAGTGACAATTGGTATCGTTCGTGAAAGATTATTAGAAGAAGATGCTAAGCGCGGA
TTTCTACTTGATGGTTTTCCAAGAACAGTTGAACAAGCTGTTGCATTGAATGATATTTTAGCAGAAGCTGATCGCAAGAT
CGAAGCAGTTGTTAATATTGATGTTCAAGAAGAAGAGTTGATGAATCGTCTGACAGGACGACGTATTTGTGAAACCTGTG
GAACAACTTATCATTTAGTATTTAATCCACCTAAAGTAGAAGGTATATGTGATATCGACGGTGGTAAATTATATCAACGT
GCAGATGACAATCCTGAAACAGTTCGAAATCGTTTAGATGTTAACATCAAACAAACGAAACCTCTTGTTGATTTTTACAC
TGAACAAGGTGTATTATTTAATATTGACGGTTCGAAAGATATTAAGGACGTAACTGCTGAAGTTGAAGCTGTATTACAAA
AGCTTTAA

Upstream 100 bases:

>100_bases
TAATCGGGGTAGCGTTAGAAACAATTGCACAATTAAAAGCTCAACTTGGTCAGCGTGAATATAGAGGATTCAAAAGACAT
TAATGTCTGGAGGGCATTTT

Downstream 100 bases:

>100_bases
TCGTTTACCTAGAATTCACCTCTTTGGTGAGATACAAGCGTGGATGTGATCAGTTTGAATCAAGCGAACATTGGTCAAAT
TGTCACGATAAGTCGTGGCA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNIILMGLPGAGKGTQASEIIKKYPIPHISTGDMFRAAIKNNTELGQKAKSFMDNGELVPDEVTIGIVRERLLEEDAKRG
FLLDGFPRTVEQAVALNDILAEADRKIEAVVNIDVQEEELMNRLTGRRICETCGTTYHLVFNPPKVEGICDIDGGKLYQR
ADDNPETVRNRLDVNIKQTKPLVDFYTEQGVLFNIDGSKDIKDVTAEVEAVLQKL

Sequences:

>Translated_215_residues
MNIILMGLPGAGKGTQASEIIKKYPIPHISTGDMFRAAIKNNTELGQKAKSFMDNGELVPDEVTIGIVRERLLEEDAKRG
FLLDGFPRTVEQAVALNDILAEADRKIEAVVNIDVQEEELMNRLTGRRICETCGTTYHLVFNPPKVEGICDIDGGKLYQR
ADDNPETVRNRLDVNIKQTKPLVDFYTEQGVLFNIDGSKDIKDVTAEVEAVLQKL
>Mature_215_residues
MNIILMGLPGAGKGTQASEIIKKYPIPHISTGDMFRAAIKNNTELGQKAKSFMDNGELVPDEVTIGIVRERLLEEDAKRG
FLLDGFPRTVEQAVALNDILAEADRKIEAVVNIDVQEEELMNRLTGRRICETCGTTYHLVFNPPKVEGICDIDGGKLYQR
ADDNPETVRNRLDVNIKQTKPLVDFYTEQGVLFNIDGSKDIKDVTAEVEAVLQKL

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=40.7582938388626, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=40.7582938388626, Blast_Score=171, Evalue=5e-43,
Organism=Homo sapiens, GI19923437, Length=213, Percent_Identity=40.3755868544601, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=38.3084577114428, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=38.3084577114428, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=38.3084577114428, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=38.3084577114428, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=30, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=30.5936073059361, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=28.2296650717703, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144899, Length=218, Percent_Identity=30.7339449541284, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI28144897, Length=218, Percent_Identity=30.7339449541284, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=48.3870967741936, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=40.9302325581395, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17567503, Length=214, Percent_Identity=34.1121495327103, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17537943, Length=211, Percent_Identity=32.2274881516588, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=24.7663551401869, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17550688, Length=214, Percent_Identity=21.9626168224299, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=40.6698564593301, Blast_Score=175, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=38.5786802030457, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=25.2336448598131, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=41.588785046729, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17737899, Length=209, Percent_Identity=37.3205741626794, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24645822, Length=209, Percent_Identity=37.3205741626794, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=27.9620853080569, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=27.9620853080569, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24663208, Length=217, Percent_Identity=24.8847926267281, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=24.8847926267281, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR008144 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23916; Mature: 23916

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00113 ADENYLATE_KINASE ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILMGLPGAGKGTQASEIIKKYPIPHISTGDMFRAAIKNNTELGQKAKSFMDNGELVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCC
DEVTIGIVRERLLEEDAKRGFLLDGFPRTVEQAVALNDILAEADRKIEAVVNIDVQEEEL
CHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
MNRLTGRRICETCGTTYHLVFNPPKVEGICDIDGGKLYQRADDNPETVRNRLDVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCEEECCCCCCHHHHHHHHCCCCCCCC
PLVDFYTEQGVLFNIDGSKDIKDVTAEVEAVLQKL
CHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNIILMGLPGAGKGTQASEIIKKYPIPHISTGDMFRAAIKNNTELGQKAKSFMDNGELVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCC
DEVTIGIVRERLLEEDAKRGFLLDGFPRTVEQAVALNDILAEADRKIEAVVNIDVQEEEL
CHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
MNRLTGRRICETCGTTYHLVFNPPKVEGICDIDGGKLYQRADDNPETVRNRLDVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCEEECCCCCCHHHHHHHHCCCCCCCC
PLVDFYTEQGVLFNIDGSKDIKDVTAEVEAVLQKL
CHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA