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The map label for this gene is lrgA [H]

Identifier: 222150361

GI number: 222150361

Start: 117148

End: 117573

Strand: Direct

Name: lrgA [H]

Synonym: MCCL_0111

Alternate gene names: 222150361

Gene position: 117148-117573 (Clockwise)

Preceding gene: 222150360

Following gene: 222150362

Centisome position: 5.57

GC content: 33.1

Gene sequence:

>426_bases
ATGACAAAAGAAAAAACGTATAATTTCTTTCATCAAGTATCAGTAATCTCAATTGTGTTACTTATTTCAAAGATGATTGA
AAGCTTCATGCCAATTCCAATGCCTGCATCAGTTATCGGACTAATACTGCTCTTCATCTGTTTATGTACTGGAATCATAA
AACTAGGACAAGTAGAAAACGTTGGGACTGCACTTACAGATAATATCGGACTATTATTTGTGCCAGCTGGAATCTCAGTA
GTAAAATCATTAGGACTAATAGCTGAAAATCCAGTATTGATATTAGGTTTAATCTTTATCTCAACCTTATTATTGCTATT
ATGTACAGGGTTCTTCTCTCAAGTGATTGTAAAGTTGACAGACTCAAAGGTAAAAGAACAAAAAGCAAAAGAAACGAAAC
ATCTAAAAGAAATAGAGGTGCGCTAA

Upstream 100 bases:

>100_bases
ATTTCAACACTTAATTTTTGCATTTCATCGTGAAAACTCTCACAAAACAATATGTAAGCGGTATGATGTAATCAAGATAA
AACACGGGAGGTCATTAAAA

Downstream 100 bases:

>100_bases
TATGACATGGCTTGATCATTTAGGTATTAACTCTGTATACTTCGGAATATTATTAACGATATTACCATTTATGTTAGGTC
AATATTTATTTAAAAAAACA

Product: murein hydrolase regulator LrgA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MTKEKTYNFFHQVSVISIVLLISKMIESFMPIPMPASVIGLILLFICLCTGIIKLGQVENVGTALTDNIGLLFVPAGISV
VKSLGLIAENPVLILGLIFISTLLLLLCTGFFSQVIVKLTDSKVKEQKAKETKHLKEIEVR

Sequences:

>Translated_141_residues
MTKEKTYNFFHQVSVISIVLLISKMIESFMPIPMPASVIGLILLFICLCTGIIKLGQVENVGTALTDNIGLLFVPAGISV
VKSLGLIAENPVLILGLIFISTLLLLLCTGFFSQVIVKLTDSKVKEQKAKETKHLKEIEVR
>Mature_140_residues
TKEKTYNFFHQVSVISIVLLISKMIESFMPIPMPASVIGLILLFICLCTGIIKLGQVENVGTALTDNIGLLFVPAGISVV
KSLGLIAENPVLILGLIFISTLLLLLCTGFFSQVIVKLTDSKVKEQKAKETKHLKEIEVR

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in p

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. LrgA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 15443; Mature: 15312

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEKTYNFFHQVSVISIVLLISKMIESFMPIPMPASVIGLILLFICLCTGIIKLGQVEN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
VGTALTDNIGLLFVPAGISVVKSLGLIAENPVLILGLIFISTLLLLLCTGFFSQVIVKLT
CCHHHHCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSKVKEQKAKETKHLKEIEVR
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKEKTYNFFHQVSVISIVLLISKMIESFMPIPMPASVIGLILLFICLCTGIIKLGQVEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
VGTALTDNIGLLFVPAGISVVKSLGLIAENPVLILGLIFISTLLLLLCTGFFSQVIVKLT
CCHHHHCCCCEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSKVKEQKAKETKHLKEIEVR
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA