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The map label for this gene is panE [C]

Identifier: 222150304

GI number: 222150304

Start: 56382

End: 57314

Strand: Direct

Name: panE [C]

Synonym: MCCL_0054

Alternate gene names: 222150304

Gene position: 56382-57314 (Clockwise)

Preceding gene: 222150303

Following gene: 222150312

Centisome position: 2.68

GC content: 36.66

Gene sequence:

>933_bases
ATGTATAAAATCGCAATCGCCGGAGCAGGTGCAATGGGTGGTAGAATTGGAACTTATTTAAAGCAAAATGGTGAAGACGT
GGTGTTGATTGATCGTTGGCAAGATCACATCGATGAAATCAACAAAAATGGTATGGAAATTCAAACAGAAACTGAAACAT
ATACGCTTGAAATACGAGCGATGCAACCGGAAGAAGTTAAAGAAAAATTTGATTTAATTATATTATTAACGAAAGCAATG
TATGCAGATGATATGTTAAAAGCATTAAAAGATATTGGAGCAATTACTGAAAGCACTGCAATTCTTTCGATGATGAATGG
ATTAGGACATGCAGATTACTTATCGAAGTATGTTCCAAAGTCTCAGATTTTCTTAGCAGTAACAATGTGGACAGCAGGGC
TTAGAGGACCTGGTCAATTGTTGCTTGAAGGGAAAGGTGGTATAGAATGTCAACGTTCAGACGGACAGCCTGATGAACGT
ACTGAAAAGATTGTGCAAGTATTAGATAACGCAGGATTAAATGCCAAGATAAGTGATGATGTATTCTTCTCGATATGGTC
TAAAGCAGCTGTAAATAGTGTACTGAATCCTTTATGTACAATCCTTGATAAAACGATTGGAGAGTTTGGTGAATATGAAG
ATGCACGTGAAATGATAACGCCAATATTAAAAGAACTTGTTGCAGTGGCAAATGCACGTGGTACGAATGTTGTATTTGAA
ACGTTGCTAGCGAAGATTGAAGCTACTTATCCTAATGAAGCACAGGGATTACATTATCCGTCGATGCATCAAGATCACAC
GAATAAACGTCTGACTGAAATTGATTATTTAAACGGACAGATTGCTAAATATGGTGATGAGCTAGGTATTGAAACACCTG
CAAATGACTTAATTACGCATTTGATTCATCAGTTGGAAATGAAATATACGTAA

Upstream 100 bases:

>100_bases
CGGGAAGTACAATCCTCTCAGTGAGATATTTAAATTGAAAAGATAGATGGATTTTTGGTATCAGAACGAAGAATAAGAAG
ACATTTAAGGAGGAATTCGT

Downstream 100 bases:

>100_bases
CAAAAAGAAGCTTCTTAAATTTAGGAAGCTTCTTTTTGTTTAGGATTAACTTTAGGATGAATAATATTATAACGTGTCAC
ATCTTGTGGAGTTAATATTC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MYKIAIAGAGAMGGRIGTYLKQNGEDVVLIDRWQDHIDEINKNGMEIQTETETYTLEIRAMQPEEVKEKFDLIILLTKAM
YADDMLKALKDIGAITESTAILSMMNGLGHADYLSKYVPKSQIFLAVTMWTAGLRGPGQLLLEGKGGIECQRSDGQPDER
TEKIVQVLDNAGLNAKISDDVFFSIWSKAAVNSVLNPLCTILDKTIGEFGEYEDAREMITPILKELVAVANARGTNVVFE
TLLAKIEATYPNEAQGLHYPSMHQDHTNKRLTEIDYLNGQIAKYGDELGIETPANDLITHLIHQLEMKYT

Sequences:

>Translated_310_residues
MYKIAIAGAGAMGGRIGTYLKQNGEDVVLIDRWQDHIDEINKNGMEIQTETETYTLEIRAMQPEEVKEKFDLIILLTKAM
YADDMLKALKDIGAITESTAILSMMNGLGHADYLSKYVPKSQIFLAVTMWTAGLRGPGQLLLEGKGGIECQRSDGQPDER
TEKIVQVLDNAGLNAKISDDVFFSIWSKAAVNSVLNPLCTILDKTIGEFGEYEDAREMITPILKELVAVANARGTNVVFE
TLLAKIEATYPNEAQGLHYPSMHQDHTNKRLTEIDYLNGQIAKYGDELGIETPANDLITHLIHQLEMKYT
>Mature_310_residues
MYKIAIAGAGAMGGRIGTYLKQNGEDVVLIDRWQDHIDEINKNGMEIQTETETYTLEIRAMQPEEVKEKFDLIILLTKAM
YADDMLKALKDIGAITESTAILSMMNGLGHADYLSKYVPKSQIFLAVTMWTAGLRGPGQLLLEGKGGIECQRSDGQPDER
TEKIVQVLDNAGLNAKISDDVFFSIWSKAAVNSVLNPLCTILDKTIGEFGEYEDAREMITPILKELVAVANARGTNVVFE
TLLAKIEATYPNEAQGLHYPSMHQDHTNKRLTEIDYLNGQIAKYGDELGIETPANDLITHLIHQLEMKYT

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=311, Percent_Identity=26.0450160771704, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34471; Mature: 34471

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKIAIAGAGAMGGRIGTYLKQNGEDVVLIDRWQDHIDEINKNGMEIQTETETYTLEIRA
CEEEEEECCCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEEEECCCEEEEEEEE
MQPEEVKEKFDLIILLTKAMYADDMLKALKDIGAITESTAILSMMNGLGHADYLSKYVPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
SQIFLAVTMWTAGLRGPGQLLLEGKGGIECQRSDGQPDERTEKIVQVLDNAGLNAKISDD
CCEEEEEEEHHCCCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEECCH
VFFSIWSKAAVNSVLNPLCTILDKTIGEFGEYEDAREMITPILKELVAVANARGTNVVFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TLLAKIEATYPNEAQGLHYPSMHQDHTNKRLTEIDYLNGQIAKYGDELGIETPANDLITH
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHH
LIHQLEMKYT
HHHHHHHCCC
>Mature Secondary Structure
MYKIAIAGAGAMGGRIGTYLKQNGEDVVLIDRWQDHIDEINKNGMEIQTETETYTLEIRA
CEEEEEECCCCCCCHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCEEEECCCEEEEEEEE
MQPEEVKEKFDLIILLTKAMYADDMLKALKDIGAITESTAILSMMNGLGHADYLSKYVPK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
SQIFLAVTMWTAGLRGPGQLLLEGKGGIECQRSDGQPDERTEKIVQVLDNAGLNAKISDD
CCEEEEEEEHHCCCCCCCCEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEECCH
VFFSIWSKAAVNSVLNPLCTILDKTIGEFGEYEDAREMITPILKELVAVANARGTNVVFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
TLLAKIEATYPNEAQGLHYPSMHQDHTNKRLTEIDYLNGQIAKYGDELGIETPANDLITH
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHH
LIHQLEMKYT
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]