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The map label for this gene is serS

Identifier: 222150263

GI number: 222150263

Start: 16258

End: 17529

Strand: Direct

Name: serS

Synonym: MCCL_0013

Alternate gene names: 222150263

Gene position: 16258-17529 (Clockwise)

Preceding gene: 222150261

Following gene: 222150264

Centisome position: 0.77

GC content: 37.42

Gene sequence:

>1272_bases
ATGTTAGACATTAAATTATTTAGAACAGAACCAGAATTCGTTAAGAAAAAATTAGAAATGCGTGCGATTGATACTTCCAT
CGTTGATGAAATATTAGAGCTTGATATAGCGGCGCGTGAGCTTACAGCAAGAACTGAAGAATTAAAAGCAAAACGTAATA
AAACGAGCGAAGAAATTGCACAGAAAAAACGTAATAAAGAAAATGCAGATGATGCAATTAAAGCAATGCGTGAAGTAGGT
GAAGAAATAAAGCGTATTGATACGGAGTTGAACGAAGTATCTCAGACGTTGAAGGATAAACTTGTACGTTTGCCGAACTT
AGTAAGCGATGAAACACCATTTGGCAAAGATGAGGATGAAAACGTTGAAGTCAAGAAATGGGGAACACCACGTACATTTG
ATTTCGAAGCAAAAGCGCATTGGGATATCGTCGAAAATTTAAAAATGGCTGATTTTGAGCGTGCTGCTAAAGTTTCAGGT
GCACGTTTCGCATTCTTAACTAAAGATGGTGCGCGTCTAGAACGTGCATTAATGAACTTTATGTTAGATACACATCGTGC
AAATGGATATGAAGAAATGGTGACACCACAACTGGTAAATGCTGCTTCTATGTTCGGTACAGGACAACTTCCTAAGTTTG
AAGAGGACTTATTCAAAGTTGAAAAAGAAGGTCTATATACAATTCCAACTTCAGAAGTGCCATTAACGAACTTCTATCGT
GATGAAATTTTAACCAATGATATGTTACCTACGAAATTTACAGCTATGACAGCATGTTTCAGAAGTGAAGCAGGTTCAGC
AGGCCGTGATACACGTGGATTAATTCGTATGCATCAATTTAACAAAGTCGAAATGGTACGCTTTGAACGTCCTGAAGATT
CTTATGCTGCGTTAGAAGATATGACACGTTCAGCTGAAAGCATTCTGGAGAAATTAAATATTCCTTATCGTACGATCGCT
TTATGTTCAGGAGATATCGGATTTGGCGCTGCAAAAACTTATGATGTTGAAGTATGGTTGCCAAGTTATGATGCCTATAA
AGAAATTAGCTCATGTTCAAATATGACAGACTTTCAGGCACGACGTGCAAATATTCGTTTCAAGCGCGATAAAAATGCAA
AAGCTGAACTTGTAAATACACTGAATGGTTCAGGACTAGCTGTAGGACGTACTTTTGCTGCAGTAGTTGAAAATTATCAA
AATGAGGATGGATCTATCACAGTTCCAGAAGTACTCGTTCCATATATGGGTGGACAAACTGTAATTAAATAA

Upstream 100 bases:

>100_bases
TTGACTATTAATTAGGGTGGCAACGCGTAAATACCACGTCCCTTTTAAGGGATGTGGTATTTTTTGTTACCCATATATAA
AATATGAGGAGGCAATACAA

Downstream 100 bases:

>100_bases
TAATCAGGGGCGGTTCAATGTTATCATTTGAATCGTCTTTTAATGTGATGTTATAATAAGACAGAATTATCAGAATACAA
AAACTTTTTGCTATATAATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDIKLFRTEPEFVKKKLEMRAIDTSIVDEILELDIAARELTARTEELKAKRNKTSEEIAQKKRNKENADDAIKAMREVG
EEIKRIDTELNEVSQTLKDKLVRLPNLVSDETPFGKDEDENVEVKKWGTPRTFDFEAKAHWDIVENLKMADFERAAKVSG
ARFAFLTKDGARLERALMNFMLDTHRANGYEEMVTPQLVNAASMFGTGQLPKFEEDLFKVEKEGLYTIPTSEVPLTNFYR
DEILTNDMLPTKFTAMTACFRSEAGSAGRDTRGLIRMHQFNKVEMVRFERPEDSYAALEDMTRSAESILEKLNIPYRTIA
LCSGDIGFGAAKTYDVEVWLPSYDAYKEISSCSNMTDFQARRANIRFKRDKNAKAELVNTLNGSGLAVGRTFAAVVENYQ
NEDGSITVPEVLVPYMGGQTVIK

Sequences:

>Translated_423_residues
MLDIKLFRTEPEFVKKKLEMRAIDTSIVDEILELDIAARELTARTEELKAKRNKTSEEIAQKKRNKENADDAIKAMREVG
EEIKRIDTELNEVSQTLKDKLVRLPNLVSDETPFGKDEDENVEVKKWGTPRTFDFEAKAHWDIVENLKMADFERAAKVSG
ARFAFLTKDGARLERALMNFMLDTHRANGYEEMVTPQLVNAASMFGTGQLPKFEEDLFKVEKEGLYTIPTSEVPLTNFYR
DEILTNDMLPTKFTAMTACFRSEAGSAGRDTRGLIRMHQFNKVEMVRFERPEDSYAALEDMTRSAESILEKLNIPYRTIA
LCSGDIGFGAAKTYDVEVWLPSYDAYKEISSCSNMTDFQARRANIRFKRDKNAKAELVNTLNGSGLAVGRTFAAVVENYQ
NEDGSITVPEVLVPYMGGQTVIK
>Mature_423_residues
MLDIKLFRTEPEFVKKKLEMRAIDTSIVDEILELDIAARELTARTEELKAKRNKTSEEIAQKKRNKENADDAIKAMREVG
EEIKRIDTELNEVSQTLKDKLVRLPNLVSDETPFGKDEDENVEVKKWGTPRTFDFEAKAHWDIVENLKMADFERAAKVSG
ARFAFLTKDGARLERALMNFMLDTHRANGYEEMVTPQLVNAASMFGTGQLPKFEEDLFKVEKEGLYTIPTSEVPLTNFYR
DEILTNDMLPTKFTAMTACFRSEAGSAGRDTRGLIRMHQFNKVEMVRFERPEDSYAALEDMTRSAESILEKLNIPYRTIA
LCSGDIGFGAAKTYDVEVWLPSYDAYKEISSCSNMTDFQARRANIRFKRDKNAKAELVNTLNGSGLAVGRTFAAVVENYQ
NEDGSITVPEVLVPYMGGQTVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=472, Percent_Identity=33.8983050847458, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI8923421, Length=432, Percent_Identity=28.0092592592593, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI225579074, Length=436, Percent_Identity=26.8348623853211, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=51.8604651162791, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=32.8326180257511, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17542084, Length=320, Percent_Identity=28.75, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=444, Percent_Identity=32.2072072072072, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6321799, Length=443, Percent_Identity=32.2799097065463, Blast_Score=227, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=33.974358974359, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17737985, Length=343, Percent_Identity=30.3206997084548, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_MACCJ (B9E909)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002559416.1
- GeneID:   7390183
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0013
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48020; Mature: 48020

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKLFRTEPEFVKKKLEMRAIDTSIVDEILELDIAARELTARTEELKAKRNKTSEEIA
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QKKRNKENADDAIKAMREVGEEIKRIDTELNEVSQTLKDKLVRLPNLVSDETPFGKDEDE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCC
NVEVKKWGTPRTFDFEAKAHWDIVENLKMADFERAAKVSGARFAFLTKDGARLERALMNF
CEEEEECCCCCEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
MLDTHRANGYEEMVTPQLVNAASMFGTGQLPKFEEDLFKVEKEGLYTIPTSEVPLTNFYR
HHHHHCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCHHHHH
DEILTNDMLPTKFTAMTACFRSEAGSAGRDTRGLIRMHQFNKVEMVRFERPEDSYAALED
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
MTRSAESILEKLNIPYRTIALCSGDIGFGAAKTYDVEVWLPSYDAYKEISSCSNMTDFQA
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCHHHHH
RRANIRFKRDKNAKAELVNTLNGSGLAVGRTFAAVVENYQNEDGSITVPEVLVPYMGGQT
HHCCCEEECCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCC
VIK
CCC
>Mature Secondary Structure
MLDIKLFRTEPEFVKKKLEMRAIDTSIVDEILELDIAARELTARTEELKAKRNKTSEEIA
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QKKRNKENADDAIKAMREVGEEIKRIDTELNEVSQTLKDKLVRLPNLVSDETPFGKDEDE
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCC
NVEVKKWGTPRTFDFEAKAHWDIVENLKMADFERAAKVSGARFAFLTKDGARLERALMNF
CEEEEECCCCCEEECCCCCHHHHHHCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
MLDTHRANGYEEMVTPQLVNAASMFGTGQLPKFEEDLFKVEKEGLYTIPTSEVPLTNFYR
HHHHHCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCHHHHH
DEILTNDMLPTKFTAMTACFRSEAGSAGRDTRGLIRMHQFNKVEMVRFERPEDSYAALED
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
MTRSAESILEKLNIPYRTIALCSGDIGFGAAKTYDVEVWLPSYDAYKEISSCSNMTDFQA
HHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCHHHHH
RRANIRFKRDKNAKAELVNTLNGSGLAVGRTFAAVVENYQNEDGSITVPEVLVPYMGGQT
HHCCCEEECCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCC
VIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA