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The map label for this gene is dnaA

Identifier: 222150251

GI number: 222150251

Start: 348

End: 1685

Strand: Direct

Name: dnaA

Synonym: MCCL_0001

Alternate gene names: 222150251

Gene position: 348-1685 (Clockwise)

Preceding gene: NA

Following gene: 222150252

Centisome position: 0.02

GC content: 36.4

Gene sequence:

>1338_bases
ATGAGTGGAATAGATACCATTTGGGAAAAAGTACTCGCAAATATAAAGCATCGGCTTGCACCTGCAAGTTATGATACATG
GTTTAAAGAGACAAAGATTAAAGTGCTAAATAACCACCAAGTAGTGATTCAAGCGCCTACTTCTTTTATTTCAGAATGGC
TGCAAACAAATTATATTGATTTTATTCAAGAAGCATTTATCGAAGAGATCGGAGAAAAACTCAATATAAAAGTGATTTCT
TCTGAAGACGAACTTATGAATAATGAAAAAGAAGCCCCTGTAAGAAAGACTCAACAAACAAGTCAAGAACTATTACCGAA
TCAGTTAAATACAGATAATACATTTGATACGTTCGTAATCGGCAGTGGAAATCGATTCAGTCATGCAGCTAGTTTAGCTG
TCGCAGAAGCACCCGCAAAAGCTTATAATCCCTTATTTATCTATGGCGGTGTAGGCCTTGGTAAAACCCACCTCATGCAC
GCAATCGGGCATTACGTGATGGAGCATAAAGAAAATGCGAAAGTTGTTTATATTTCTAGTGAAAAGTTTATGAATGAATT
TATTAACTCGATTAAAGATAACAAGACTGAAGAGTTCAGATCAAAATATAGAAATGTTGACGTTCTTCTAATTGATGATA
TTCAGTTTCTTGCTGGTAAAGAATCTACCCAGGAAGAATTCTTCCATACTTTCAATGAGTTACATCAGAACCATAAACAA
ATTGTTATTTCTAGTGACCGGGCACCGAAAGAAATCCCAACATTAGAAGAGCGCCTTCGTACCCGCTTCGAGTGGGGATT
AATTACCGATGTAACGCCACCTGATCTGGAAACTAGGATTGCTATCCTAAGAAAGAAGTCAGAAGAAGAAAATATTGATA
TTCCGAACGAAGCGATGCTTTATATCGCTACGCAAATTCAGTCCAATATTCGTGAATTAGAAGGTGCGTTAACACGTGTC
TCCGCATATTCTAAACTTGTAAATCGTGAACTTAATTCTGACCTTGTCGCTGAAGCATTGAAAGATATTATTGCTACTAG
TAAACCTAAGAAAGTAACGATTAAAGATATTCAACTTGCAGTCGGAGAATATTATAATGTGCGTCTCGAAGATTTTAGTG
CTAAGAAACGTACGAAATCGATTGCTTTTCCTAGACAAATAGCAATGTACCTTGCACGTGAACTCACGGACTTCTCTTTA
CCAAAGATTGGTGAAGAATTTGGTGGACGAGATCATACTACAGTGATACACGCACATGAAAAGATAAAAAATCAACTGGA
AACAGACGAGAGTTTAAAAAATGAACTGAAAAATATCGAAAAAGATATCACCAGCTAA

Upstream 100 bases:

>100_bases
AGTTGTGGATAAATAAAATTGAACTTGTTATTACTATTATACACAATTAGATTTTATGTGAATAACTAAAAAAGAATTTT
AATTAGAAAGAGGATATATT

Downstream 100 bases:

>100_bases
CTGTGGATAGTGTGGATAGTGATGCAAAGCTTACACACAAGTTATGCACATGTGGATACTTACAGACTCTAATCATTTAT
CCACTTATCCACGTATTCAC

Product: chromosomal replication initiation protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSGIDTIWEKVLANIKHRLAPASYDTWFKETKIKVLNNHQVVIQAPTSFISEWLQTNYIDFIQEAFIEEIGEKLNIKVIS
SEDELMNNEKEAPVRKTQQTSQELLPNQLNTDNTFDTFVIGSGNRFSHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMH
AIGHYVMEHKENAKVVYISSEKFMNEFINSIKDNKTEEFRSKYRNVDVLLIDDIQFLAGKESTQEEFFHTFNELHQNHKQ
IVISSDRAPKEIPTLEERLRTRFEWGLITDVTPPDLETRIAILRKKSEEENIDIPNEAMLYIATQIQSNIRELEGALTRV
SAYSKLVNRELNSDLVAEALKDIIATSKPKKVTIKDIQLAVGEYYNVRLEDFSAKKRTKSIAFPRQIAMYLARELTDFSL
PKIGEEFGGRDHTTVIHAHEKIKNQLETDESLKNELKNIEKDITS

Sequences:

>Translated_445_residues
MSGIDTIWEKVLANIKHRLAPASYDTWFKETKIKVLNNHQVVIQAPTSFISEWLQTNYIDFIQEAFIEEIGEKLNIKVIS
SEDELMNNEKEAPVRKTQQTSQELLPNQLNTDNTFDTFVIGSGNRFSHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMH
AIGHYVMEHKENAKVVYISSEKFMNEFINSIKDNKTEEFRSKYRNVDVLLIDDIQFLAGKESTQEEFFHTFNELHQNHKQ
IVISSDRAPKEIPTLEERLRTRFEWGLITDVTPPDLETRIAILRKKSEEENIDIPNEAMLYIATQIQSNIRELEGALTRV
SAYSKLVNRELNSDLVAEALKDIIATSKPKKVTIKDIQLAVGEYYNVRLEDFSAKKRTKSIAFPRQIAMYLARELTDFSL
PKIGEEFGGRDHTTVIHAHEKIKNQLETDESLKNELKNIEKDITS
>Mature_444_residues
SGIDTIWEKVLANIKHRLAPASYDTWFKETKIKVLNNHQVVIQAPTSFISEWLQTNYIDFIQEAFIEEIGEKLNIKVISS
EDELMNNEKEAPVRKTQQTSQELLPNQLNTDNTFDTFVIGSGNRFSHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHA
IGHYVMEHKENAKVVYISSEKFMNEFINSIKDNKTEEFRSKYRNVDVLLIDDIQFLAGKESTQEEFFHTFNELHQNHKQI
VISSDRAPKEIPTLEERLRTRFEWGLITDVTPPDLETRIAILRKKSEEENIDIPNEAMLYIATQIQSNIRELEGALTRVS
AYSKLVNRELNSDLVAEALKDIIATSKPKKVTIKDIQLAVGEYYNVRLEDFSAKKRTKSIAFPRQIAMYLARELTDFSLP
KIGEEFGGRDHTTVIHAHEKIKNQLETDESLKNELKNIEKDITS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=469, Percent_Identity=41.36460554371, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI226510964, Length=245, Percent_Identity=23.265306122449, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_MACCJ (B9E8Z7)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002559404.1
- GeneID:   7389666
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0001
- OMA:   CHTLNAL
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 50986; Mature: 50855

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIDTIWEKVLANIKHRLAPASYDTWFKETKIKVLNNHQVVIQAPTSFISEWLQTNYID
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCEEEEECCHHHHHHHHHHHHHH
FIQEAFIEEIGEKLNIKVISSEDELMNNEKEAPVRKTQQTSQELLPNQLNTDNTFDTFVI
HHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEE
GSGNRFSHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVMEHKENAKVVYISS
ECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
EKFMNEFINSIKDNKTEEFRSKYRNVDVLLIDDIQFLAGKESTQEEFFHTFNELHQNHKQ
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCCE
IVISSDRAPKEIPTLEERLRTRFEWGLITDVTPPDLETRIAILRKKSEEENIDIPNEAML
EEEECCCCCCCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
YIATQIQSNIRELEGALTRVSAYSKLVNRELNSDLVAEALKDIIATSKPKKVTIKDIQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEHHHHHHH
VGEYYNVRLEDFSAKKRTKSIAFPRQIAMYLARELTDFSLPKIGEEFGGRDHTTVIHAHE
HCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEHHH
KIKNQLETDESLKNELKNIEKDITS
HHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGIDTIWEKVLANIKHRLAPASYDTWFKETKIKVLNNHQVVIQAPTSFISEWLQTNYID
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCEEEEECCHHHHHHHHHHHHHH
FIQEAFIEEIGEKLNIKVISSEDELMNNEKEAPVRKTQQTSQELLPNQLNTDNTFDTFVI
HHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEE
GSGNRFSHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVMEHKENAKVVYISS
ECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
EKFMNEFINSIKDNKTEEFRSKYRNVDVLLIDDIQFLAGKESTQEEFFHTFNELHQNHKQ
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCCE
IVISSDRAPKEIPTLEERLRTRFEWGLITDVTPPDLETRIAILRKKSEEENIDIPNEAML
EEEECCCCCCCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
YIATQIQSNIRELEGALTRVSAYSKLVNRELNSDLVAEALKDIIATSKPKKVTIKDIQLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEHHHHHHH
VGEYYNVRLEDFSAKKRTKSIAFPRQIAMYLARELTDFSLPKIGEEFGGRDHTTVIHAHE
HCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEHHH
KIKNQLETDESLKNELKNIEKDITS
HHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA