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The map label for this gene is prpC [H]

Identifier: 222111270

GI number: 222111270

Start: 2230529

End: 2231689

Strand: Direct

Name: prpC [H]

Synonym: Dtpsy_2079

Alternate gene names: 222111270

Gene position: 2230529-2231689 (Clockwise)

Preceding gene: 222111269

Following gene: 222111271

Centisome position: 58.75

GC content: 68.48

Gene sequence:

>1161_bases
ATGAGCACCATCGACACCGCAGCCGCCCTTCCGCGGGCCAAGAAATCCGTCGCCCTCTCGGGCGTGGCCGCCGGCACCAC
CGCGCTGTGCACCGTGGGCAGGAGCGGCAACGATCTGCACTACCGCGGCTACGACATCCTGGACATCGCCGAGGTCTGCG
AGTTCGAGGAGATCGCCCACCTGCTGGTGCACGGCAAGCTGCCCACGCGCGCCGAACTGCGCGCCTACAAGGCCCGGCTG
CGTGCGCTGCGCGGCCTGCCCGGCAGCGTGAAGGCCGCTCTGGAGCAACTGCCCGCGGCCAGCCACCCCATGGACGTGAT
GCGCACCGGCGTATCCGCCCTGGGCTGCGCCCTGCCCGAGAAAGACGACCACAACCTGGCCGGCAGCCGCGACATCGCGG
ACCGGCTGCTGGCATCGCTGGGCAGCATGCTGCTGTACTGGTACCACTTCAGCAACTCGGGCCGGCGCATCGCGGTGGAG
ACACAGGACGACTCCATCGGCGGGCATTTCCTGCACCTGCTGCACGGCGACAAGCCCTCGGACGGCTGGGTGCGCGCCAT
GCACACGTCGCTGAACCTGTACGCCGAGCACGAGTTCAACGCCAGCACCTTCGCCGCGCGCGTGATCGCCGGCACGGGCA
GCGACCTGTATTCCTGCATCGCCGGCGCCATCGGTGCGTTGCGCGGGCCCAAGCACGGCGGCGCGAACGAAGTGGCCTTC
GAGATCCAGAAGCGCTACGACACGCCCGACGCGGCCGAGGCCGACATCCGCCGCCGCGTGCAGGCCAAGGAGGTGGTGAT
CGGCTTCGGCCACCCGGTCTACACCGTGAGCGACCCGCGCAACGGGGTTATCAAGGCCGTGGCCAAGCGCCTGTCGGATA
CCGCCGGCTCGACCAAGATGTACGACATCGCCGAGCGGCTGGAGCGCGTGATGTGGCAGGAAAAGCAGATGTTCCCCAAC
CTGGACTGGTTCAGCGCCGTGAGCTACCACATGATGCAGGTGCCCACCGCCATGTTCACGCCGCTGTTCGTCATCGCCCG
CACCAGCGGCTGGGCGGCGCACGTGATCGAGCAGCGCGCGGACAACAAGATCATCCGCCCCAGCGCCCACTACACCGGCC
CCGACGACCAGAAGTTCGTGCCCATCGAGGAACGCGTTTGA

Upstream 100 bases:

>100_bases
GCGTCTTCGAGATGGTGGCCGTGAACGCCCACGGGCGGCCCACAGCCATCGCGCATACCTACCTGAACACCCCGCCACAC
CCCTTCCGACAGGAGACTCC

Downstream 100 bases:

>100_bases
CAAAAACCATAGCTGGCAGCGCTTGTCTTTACTGGATTTCCAGCACTTTTTGCATGAAATCTGTTGACAGGCAAGCGCCA
GCAGCTATCACAACAAGAGC

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSTIDTAAALPRAKKSVALSGVAAGTTALCTVGRSGNDLHYRGYDILDIAEVCEFEEIAHLLVHGKLPTRAELRAYKARL
RALRGLPGSVKAALEQLPAASHPMDVMRTGVSALGCALPEKDDHNLAGSRDIADRLLASLGSMLLYWYHFSNSGRRIAVE
TQDDSIGGHFLHLLHGDKPSDGWVRAMHTSLNLYAEHEFNASTFAARVIAGTGSDLYSCIAGAIGALRGPKHGGANEVAF
EIQKRYDTPDAAEADIRRRVQAKEVVIGFGHPVYTVSDPRNGVIKAVAKRLSDTAGSTKMYDIAERLERVMWQEKQMFPN
LDWFSAVSYHMMQVPTAMFTPLFVIARTSGWAAHVIEQRADNKIIRPSAHYTGPDDQKFVPIEERV

Sequences:

>Translated_386_residues
MSTIDTAAALPRAKKSVALSGVAAGTTALCTVGRSGNDLHYRGYDILDIAEVCEFEEIAHLLVHGKLPTRAELRAYKARL
RALRGLPGSVKAALEQLPAASHPMDVMRTGVSALGCALPEKDDHNLAGSRDIADRLLASLGSMLLYWYHFSNSGRRIAVE
TQDDSIGGHFLHLLHGDKPSDGWVRAMHTSLNLYAEHEFNASTFAARVIAGTGSDLYSCIAGAIGALRGPKHGGANEVAF
EIQKRYDTPDAAEADIRRRVQAKEVVIGFGHPVYTVSDPRNGVIKAVAKRLSDTAGSTKMYDIAERLERVMWQEKQMFPN
LDWFSAVSYHMMQVPTAMFTPLFVIARTSGWAAHVIEQRADNKIIRPSAHYTGPDDQKFVPIEERV
>Mature_385_residues
STIDTAAALPRAKKSVALSGVAAGTTALCTVGRSGNDLHYRGYDILDIAEVCEFEEIAHLLVHGKLPTRAELRAYKARLR
ALRGLPGSVKAALEQLPAASHPMDVMRTGVSALGCALPEKDDHNLAGSRDIADRLLASLGSMLLYWYHFSNSGRRIAVET
QDDSIGGHFLHLLHGDKPSDGWVRAMHTSLNLYAEHEFNASTFAARVIAGTGSDLYSCIAGAIGALRGPKHGGANEVAFE
IQKRYDTPDAAEADIRRRVQAKEVVIGFGHPVYTVSDPRNGVIKAVAKRLSDTAGSTKMYDIAERLERVMWQEKQMFPNL
DWFSAVSYHMMQVPTAMFTPLFVIARTSGWAAHVIEQRADNKIIRPSAHYTGPDDQKFVPIEERV

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=374, Percent_Identity=75.9358288770053, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1786939, Length=363, Percent_Identity=31.129476584022, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17555174, Length=373, Percent_Identity=24.1286863270777, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42262; Mature: 42130

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIDTAAALPRAKKSVALSGVAAGTTALCTVGRSGNDLHYRGYDILDIAEVCEFEEIAH
CCCCHHHHHCCHHHHHHHHHHHHCCCHHEEEECCCCCCCEECCCCHHHHHHHHCHHHHHH
LLVHGKLPTRAELRAYKARLRALRGLPGSVKAALEQLPAASHPMDVMRTGVSALGCALPE
HHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
KDDHNLAGSRDIADRLLASLGSMLLYWYHFSNSGRRIAVETQDDSIGGHFLHLLHGDKPS
CCCCCCCCCHHHHHHHHHHHHHHHEEHEEECCCCCEEEEECCCCCCCCCEEEEECCCCCC
DGWVRAMHTSLNLYAEHEFNASTFAARVIAGTGSDLYSCIAGAIGALRGPKHGGANEVAF
CHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
EIQKRYDTPDAAEADIRRRVQAKEVVIGFGHPVYTVSDPRNGVIKAVAKRLSDTAGSTKM
HHHHHCCCCCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCCCHH
YDIAERLERVMWQEKQMFPNLDWFSAVSYHMMQVPTAMFTPLFVIARTSGWAAHVIEQRA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHEEEECCCHHHHHHHHHC
DNKIIRPSAHYTGPDDQKFVPIEERV
CCCEECCCCCCCCCCCCEECCHHCCC
>Mature Secondary Structure 
STIDTAAALPRAKKSVALSGVAAGTTALCTVGRSGNDLHYRGYDILDIAEVCEFEEIAH
CCCHHHHHCCHHHHHHHHHHHHCCCHHEEEECCCCCCCEECCCCHHHHHHHHCHHHHHH
LLVHGKLPTRAELRAYKARLRALRGLPGSVKAALEQLPAASHPMDVMRTGVSALGCALPE
HHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
KDDHNLAGSRDIADRLLASLGSMLLYWYHFSNSGRRIAVETQDDSIGGHFLHLLHGDKPS
CCCCCCCCCHHHHHHHHHHHHHHHEEHEEECCCCCEEEEECCCCCCCCCEEEEECCCCCC
DGWVRAMHTSLNLYAEHEFNASTFAARVIAGTGSDLYSCIAGAIGALRGPKHGGANEVAF
CHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
EIQKRYDTPDAAEADIRRRVQAKEVVIGFGHPVYTVSDPRNGVIKAVAKRLSDTAGSTKM
HHHHHCCCCCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHHCCCCCHH
YDIAERLERVMWQEKQMFPNLDWFSAVSYHMMQVPTAMFTPLFVIARTSGWAAHVIEQRA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHEEEECCCHHHHHHHHHC
DNKIIRPSAHYTGPDDQKFVPIEERV
CCCEECCCCCCCCCCCCEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]