Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 222111163

GI number: 222111163

Start: 2108740

End: 2110098

Strand: Direct

Name: moeA [H]

Synonym: Dtpsy_1971

Alternate gene names: 222111163

Gene position: 2108740-2110098 (Clockwise)

Preceding gene: 222111162

Following gene: 222111164

Centisome position: 55.54

GC content: 67.55

Gene sequence:

>1359_bases
ATGAAAACCATTGACCAGATCGCCGCCGAGTTGCAGGGCTACGACCCGCAGGCGCTGCGTGCCGCCGATGTGAACACCTT
CCTGGAGCGCCTGGTCGCGCCCGTCACCCGCACCGAAGAAGTCGGCATCTTCGACGCCCTGGGCCGCGTGCTGGCGCGGG
ACGTGGTCTCGCCCGTCAGCGTGCCGCCGCACGACAACTCGGCCATGGACGGCTACGCCTTCGACGGCGCCCAACTGCAG
CCCGGCCAACCGCTGGTGCTGCGCCCGGTGGGCTCCACAGCCTTTGCCGGCGCCGCCTGGACCGGCACCGTGGCCGCAGG
CGAGTGCGTGAAGATCATGACCGGCGCCATCATGCCGGCAGGGCTGGACACCGTGGTGCCGCAGGAGTTCACCACTGCCG
AGCCCGACGGCCACATCCGCATCGCACCCGACGTGCTGCGCCGGGGCGACAACCGCCGCCTGCTGGGGGAAGACCTCATG
CAAGGCCGCGTAGCGCTATCAAAAGGAGAGCTTTTAGCGCCTGCTGCTATTGGCCTGGTGGCCAGTTTGGGTCTAAAAAC
GGTGACGGTGTACCGCCGGGTGCGCGTGGCCTATTTCTCCACGGGCGACGAGATCCTCAGCCTGGGCGAGCCACCGCGCG
AGGGCGCGGTGTACGACAGCAACCGCTACACGGTCTTTGGCCTGCTGACACGTCTGGGCGTCCAGGTGATCGACCTGGGT
GTGGTGCGCGACGAGCCCACACTGCTGGAAGCCGCCTTCCGCCGTGCGGCCGCGGAGGCCGACGCCATCATTACCAGCGG
CGGGGTGAGCGTGGGCGAGGCCGACCACACGCGCACCATGATGAAGCAGCTGGGCGACGTGGCGTTCTGGCGCATCGCCA
TGCGCCCGGGCCGGCCGATGGCGGTGGGCCGCCTTCGGCCTGAATTACAAGCCAAATCCGGCCCTAACGCTCGTCCATCA
AGCGTTAACAGCTATCAAAATGGAAGCATTCAGAGTGCAGACGGCAGCAGCGTGCTGTTCGGCCTGCCGGGCAATCCGGT
GGCGGTGATGGTCACCTTCCTGGCTTTCGTCCGCCCCGCGCTGCTGCGCATGATGGGCTGCACGCGCAGCGCACCGCCAC
TGCTGCGCGCCGTCAGCACCGAGGCCATGCGCAAGAAACCCGGCCGCACCGAATACCAGCGCGGCCTGGTCACCACGGCC
GCGGACGGCACGTTGCAGGTGCGCACCACGGGCAACCAGGGCTCAGGGGTGCTCAGTTCCATGGTGCAAGCCAACGGCCT
CATCGTGCTGCACCACGGCCAGGGCAACGTGGCCCCTGGCGACATGGTTGATGTGATGATGTTTGACGGCGTGATCTGA

Upstream 100 bases:

>100_bases
ACGACCCGCATGCTTTCTACAACGCCAACACCCTGGCCGAGCTGCACGCCCTGGAAGGCCTGGGCCACCGCTGAGCTGCA
ACCCTCCTTGCCCATACCGC

Downstream 100 bases:

>100_bases
CACGCCCGCGCAGCGGCGGCCGGCTTGGCCGCGTGCGCCGCAGCCTTACCCTGCCCCCATCGCCGTCCTTGCAGGAGCCG
CCATGCCGTTTGCCGCCACC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKTIDQIAAELQGYDPQALRAADVNTFLERLVAPVTRTEEVGIFDALGRVLARDVVSPVSVPPHDNSAMDGYAFDGAQLQ
PGQPLVLRPVGSTAFAGAAWTGTVAAGECVKIMTGAIMPAGLDTVVPQEFTTAEPDGHIRIAPDVLRRGDNRRLLGEDLM
QGRVALSKGELLAPAAIGLVASLGLKTVTVYRRVRVAYFSTGDEILSLGEPPREGAVYDSNRYTVFGLLTRLGVQVIDLG
VVRDEPTLLEAAFRRAAAEADAIITSGGVSVGEADHTRTMMKQLGDVAFWRIAMRPGRPMAVGRLRPELQAKSGPNARPS
SVNSYQNGSIQSADGSSVLFGLPGNPVAVMVTFLAFVRPALLRMMGCTRSAPPLLRAVSTEAMRKKPGRTEYQRGLVTTA
ADGTLQVRTTGNQGSGVLSSMVQANGLIVLHHGQGNVAPGDMVDVMMFDGVI

Sequences:

>Translated_452_residues
MKTIDQIAAELQGYDPQALRAADVNTFLERLVAPVTRTEEVGIFDALGRVLARDVVSPVSVPPHDNSAMDGYAFDGAQLQ
PGQPLVLRPVGSTAFAGAAWTGTVAAGECVKIMTGAIMPAGLDTVVPQEFTTAEPDGHIRIAPDVLRRGDNRRLLGEDLM
QGRVALSKGELLAPAAIGLVASLGLKTVTVYRRVRVAYFSTGDEILSLGEPPREGAVYDSNRYTVFGLLTRLGVQVIDLG
VVRDEPTLLEAAFRRAAAEADAIITSGGVSVGEADHTRTMMKQLGDVAFWRIAMRPGRPMAVGRLRPELQAKSGPNARPS
SVNSYQNGSIQSADGSSVLFGLPGNPVAVMVTFLAFVRPALLRMMGCTRSAPPLLRAVSTEAMRKKPGRTEYQRGLVTTA
ADGTLQVRTTGNQGSGVLSSMVQANGLIVLHHGQGNVAPGDMVDVMMFDGVI
>Mature_452_residues
MKTIDQIAAELQGYDPQALRAADVNTFLERLVAPVTRTEEVGIFDALGRVLARDVVSPVSVPPHDNSAMDGYAFDGAQLQ
PGQPLVLRPVGSTAFAGAAWTGTVAAGECVKIMTGAIMPAGLDTVVPQEFTTAEPDGHIRIAPDVLRRGDNRRLLGEDLM
QGRVALSKGELLAPAAIGLVASLGLKTVTVYRRVRVAYFSTGDEILSLGEPPREGAVYDSNRYTVFGLLTRLGVQVIDLG
VVRDEPTLLEAAFRRAAAEADAIITSGGVSVGEADHTRTMMKQLGDVAFWRIAMRPGRPMAVGRLRPELQAKSGPNARPS
SVNSYQNGSIQSADGSSVLFGLPGNPVAVMVTFLAFVRPALLRMMGCTRSAPPLLRAVSTEAMRKKPGRTEYQRGLVTTA
ADGTLQVRTTGNQGSGVLSSMVQANGLIVLHHGQGNVAPGDMVDVMMFDGVI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=440, Percent_Identity=34.3181818181818, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI66932975, Length=440, Percent_Identity=34.3181818181818, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1787049, Length=414, Percent_Identity=43.719806763285, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI25147659, Length=401, Percent_Identity=29.925187032419, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=248, Percent_Identity=29.8387096774194, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=402, Percent_Identity=27.363184079602, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24638841, Length=402, Percent_Identity=27.363184079602, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47883; Mature: 47883

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIDQIAAELQGYDPQALRAADVNTFLERLVAPVTRTEEVGIFDALGRVLARDVVSPVS
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
VPPHDNSAMDGYAFDGAQLQPGQPLVLRPVGSTAFAGAAWTGTVAAGECVKIMTGAIMPA
CCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
GLDTVVPQEFTTAEPDGHIRIAPDVLRRGDNRRLLGEDLMQGRVALSKGELLAPAAIGLV
CCHHCCCCCCCCCCCCCCEEECHHHHHCCCCCCHHHHHHHHCHHEECCCCEECHHHHHHH
ASLGLKTVTVYRRVRVAYFSTGDEILSLGEPPREGAVYDSNRYTVFGLLTRLGVQVIDLG
HHHHHHHHHHHHHEEEEEECCCHHHHHCCCCCCCCCEECCCCEEHHHHHHHHCCEEEEEE
VVRDEPTLLEAAFRRAAAEADAIITSGGVSVGEADHTRTMMKQLGDVAFWRIAMRPGRPM
EECCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCE
AVGRLRPELQAKSGPNARPSSVNSYQNGSIQSADGSSVLFGLPGNPVAVMVTFLAFVRPA
EHHCCCCHHHCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHHH
LLRMMGCTRSAPPLLRAVSTEAMRKKPGRTEYQRGLVTTAADGTLQVRTTGNQGSGVLSS
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCEEEECCCEEEEEECCCCCCHHHHH
MVQANGLIVLHHGQGNVAPGDMVDVMMFDGVI
HHHHCCEEEEECCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKTIDQIAAELQGYDPQALRAADVNTFLERLVAPVTRTEEVGIFDALGRVLARDVVSPVS
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
VPPHDNSAMDGYAFDGAQLQPGQPLVLRPVGSTAFAGAAWTGTVAAGECVKIMTGAIMPA
CCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
GLDTVVPQEFTTAEPDGHIRIAPDVLRRGDNRRLLGEDLMQGRVALSKGELLAPAAIGLV
CCHHCCCCCCCCCCCCCCEEECHHHHHCCCCCCHHHHHHHHCHHEECCCCEECHHHHHHH
ASLGLKTVTVYRRVRVAYFSTGDEILSLGEPPREGAVYDSNRYTVFGLLTRLGVQVIDLG
HHHHHHHHHHHHHEEEEEECCCHHHHHCCCCCCCCCEECCCCEEHHHHHHHHCCEEEEEE
VVRDEPTLLEAAFRRAAAEADAIITSGGVSVGEADHTRTMMKQLGDVAFWRIAMRPGRPM
EECCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCE
AVGRLRPELQAKSGPNARPSSVNSYQNGSIQSADGSSVLFGLPGNPVAVMVTFLAFVRPA
EHHCCCCHHHCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHHH
LLRMMGCTRSAPPLLRAVSTEAMRKKPGRTEYQRGLVTTAADGTLQVRTTGNQGSGVLSS
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCEEEECCCEEEEEECCCCCCHHHHH
MVQANGLIVLHHGQGNVAPGDMVDVMMFDGVI
HHHHCCEEEEECCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]