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The map label for this gene is dapL [H]

Identifier: 222111082

GI number: 222111082

Start: 2012499

End: 2013713

Strand: Direct

Name: dapL [H]

Synonym: Dtpsy_1889

Alternate gene names: 222111082

Gene position: 2012499-2013713 (Clockwise)

Preceding gene: 222111080

Following gene: 222111083

Centisome position: 53.01

GC content: 66.91

Gene sequence:

>1215_bases
ATGAATCCCCTGCTCTCCCTACTGCAGCCCTATCCGTTCGAGCGGCTGCGACAGCTTTTTGCGGGGGTGACGCCCTCGGC
CGCACACCGCGCCATCAGCCTGGGCATCGGCGAGCCACGCCATGCAACGCCGCCGTTCATCCAGGAGGCCCTGGCCGCCA
ACCTGGCAGGCCTGGCCAGCTACCCCTCCACCGCCGGTGACCCCAGCCTGCGCGAAGCCTGTGCCGGCTGGATGCAGCGG
CGCTACCATATTCCCGTCAACCCCGCCACGCAGGTGCTGCCGGTGAACGGTTCGCGCGAGGCGTTGTTCGCATTCGCGCA
AACCGTGGTGGACCCCACCCGCGCAGGCGCCACCGTGGTGTGCCCCAACCCGTTCTACCAAATCTATGAAGGCGCCACGC
TGCTGGCCGGCGCCACGCCGTACTACGCCCCGAGCGATCCAGCGCGCAACTTTGCCGTGGACTGGGACAGCGTGCCCGAG
GAGGTATGGCAGCGCACGCAACTGCTCTTCGTGTGCTCGCCCGGCAACCCCACGGGCGCCGTGATGCCCCTGCCCGAGTG
GGAGAAGCTCTTCGCGCTGAGCGACCGTTACGGTTTCGTGATCGCCTCGGATGAGTGCTACAGCGAAATCTACTTCCGCG
ACGAGCCACCACTGGGCGGCCTGGAGGCTGCAGCCAAGCTCGGACGCAGCGACTACCGCAACCTGATCGCCTTCACCAGC
CTGTCCAAGCGCAGCAACGTGCCGGGCCTGCGCAGCGGCTTCGTGGCGGGCGACGCGGCACTCATCAAGGCGTTTTTGCT
GTACCGCACCTACCACGGCAGTGCCATGGGGCCCGCCGTGCAGGCCGCCAGCGTGGCTGCCTGGAACGATGAGGTGCACG
TGGAAGAAAACCGTGCCCTTTACCGCCAGAAGTTCGCCCAGGTCACGCCCATGCTCGCCGAGGTGATGGACGTGCGCCTG
CCCGACGCGGGTTTCTACCTCTGGGCCAAGGTGCCCGACGCCCTGGGCATGAGCGATGCGGAGTTCGCCCAGGCCCTGCT
GGCTCAATACAATGTCACGGTATTGCCGGGCAGCTATCTCGCCCGCGATTCCGGTGGCGCCAACCCCGGCGCCCAGCGCT
TGCGCATGGCCCTTGTGGCCGAGACCGCGGAATGCGCCGAAGCGGCCTCGCGCATCGTGCAATTCATCCAATCCCGTACG
TTATTCCATCCATGA

Upstream 100 bases:

>100_bases
ACGGCTGTGTAGAGCGATCAAACCCTGTAGTTGTTTTTGGGAACGGGTGGCGGGGCCGCGCCCTGTGGCGCCCGGCCGCA
TCCCTGATAATCGCCCCCCT

Downstream 100 bases:

>100_bases
CCCAACAATTGCAGACCCTGATCGACAACGCCTGGGACAACCGCGCCAGCCTCTCGCCCTCCGCCGCGCCCAAGGAAGTG
GTGGATGCCGTCGAGCATGT

Product: succinyldiaminopimelate transaminase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNPLLSLLQPYPFERLRQLFAGVTPSAAHRAISLGIGEPRHATPPFIQEALAANLAGLASYPSTAGDPSLREACAGWMQR
RYHIPVNPATQVLPVNGSREALFAFAQTVVDPTRAGATVVCPNPFYQIYEGATLLAGATPYYAPSDPARNFAVDWDSVPE
EVWQRTQLLFVCSPGNPTGAVMPLPEWEKLFALSDRYGFVIASDECYSEIYFRDEPPLGGLEAAAKLGRSDYRNLIAFTS
LSKRSNVPGLRSGFVAGDAALIKAFLLYRTYHGSAMGPAVQAASVAAWNDEVHVEENRALYRQKFAQVTPMLAEVMDVRL
PDAGFYLWAKVPDALGMSDAEFAQALLAQYNVTVLPGSYLARDSGGANPGAQRLRMALVAETAECAEAASRIVQFIQSRT
LFHP

Sequences:

>Translated_404_residues
MNPLLSLLQPYPFERLRQLFAGVTPSAAHRAISLGIGEPRHATPPFIQEALAANLAGLASYPSTAGDPSLREACAGWMQR
RYHIPVNPATQVLPVNGSREALFAFAQTVVDPTRAGATVVCPNPFYQIYEGATLLAGATPYYAPSDPARNFAVDWDSVPE
EVWQRTQLLFVCSPGNPTGAVMPLPEWEKLFALSDRYGFVIASDECYSEIYFRDEPPLGGLEAAAKLGRSDYRNLIAFTS
LSKRSNVPGLRSGFVAGDAALIKAFLLYRTYHGSAMGPAVQAASVAAWNDEVHVEENRALYRQKFAQVTPMLAEVMDVRL
PDAGFYLWAKVPDALGMSDAEFAQALLAQYNVTVLPGSYLARDSGGANPGAQRLRMALVAETAECAEAASRIVQFIQSRT
LFHP
>Mature_404_residues
MNPLLSLLQPYPFERLRQLFAGVTPSAAHRAISLGIGEPRHATPPFIQEALAANLAGLASYPSTAGDPSLREACAGWMQR
RYHIPVNPATQVLPVNGSREALFAFAQTVVDPTRAGATVVCPNPFYQIYEGATLLAGATPYYAPSDPARNFAVDWDSVPE
EVWQRTQLLFVCSPGNPTGAVMPLPEWEKLFALSDRYGFVIASDECYSEIYFRDEPPLGGLEAAAKLGRSDYRNLIAFTS
LSKRSNVPGLRSGFVAGDAALIKAFLLYRTYHGSAMGPAVQAASVAAWNDEVHVEENRALYRQKFAQVTPMLAEVMDVRL
PDAGFYLWAKVPDALGMSDAEFAQALLAQYNVTVLPGSYLARDSGGANPGAQRLRMALVAETAECAEAASRIVQFIQSRT
LFHP

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=394, Percent_Identity=23.8578680203046, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI56713254, Length=394, Percent_Identity=23.8578680203046, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI95147551, Length=296, Percent_Identity=25.3378378378378, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI169881279, Length=296, Percent_Identity=25.3378378378378, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788722, Length=377, Percent_Identity=28.3819628647215, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786816, Length=374, Percent_Identity=27.0053475935829, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790797, Length=301, Percent_Identity=24.2524916943522, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787909, Length=365, Percent_Identity=24.3835616438356, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=423, Percent_Identity=24.822695035461, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994472, Length=423, Percent_Identity=24.822695035461, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17567369, Length=404, Percent_Identity=21.5346534653465, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573069, Length=248, Percent_Identity=24.5967741935484, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646114, Length=248, Percent_Identity=24.5967741935484, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573067, Length=248, Percent_Identity=24.5967741935484, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573065, Length=248, Percent_Identity=24.5967741935484, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 43904; Mature: 43904

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLLSLLQPYPFERLRQLFAGVTPSAAHRAISLGIGEPRHATPPFIQEALAANLAGLAS
CCHHHHHHCCCCHHHHHHHHCCCCCHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
YPSTAGDPSLREACAGWMQRRYHIPVNPATQVLPVNGSREALFAFAQTVVDPTRAGATVV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEE
CPNPFYQIYEGATLLAGATPYYAPSDPARNFAVDWDSVPEEVWQRTQLLFVCSPGNPTGA
CCCCHHHHHCCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHCEEEEEECCCCCCCC
VMPLPEWEKLFALSDRYGFVIASDECYSEIYFRDEPPLGGLEAAAKLGRSDYRNLIAFTS
CCCCCCHHHHHHCCCCCEEEEECCHHHHHHEECCCCCCCHHHHHHHHCHHHHHHHHHHHH
LSKRSNVPGLRSGFVAGDAALIKAFLLYRTYHGSAMGPAVQAASVAAWNDEVHVEENRAL
HHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHEEECCCCEEEHHHHHH
YRQKFAQVTPMLAEVMDVRLPDAGFYLWAKVPDALGMSDAEFAQALLAQYNVTVLPGSYL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCHHHHHHHHHHHCCEEEECCCHH
ARDSGGANPGAQRLRMALVAETAECAEAASRIVQFIQSRTLFHP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNPLLSLLQPYPFERLRQLFAGVTPSAAHRAISLGIGEPRHATPPFIQEALAANLAGLAS
CCHHHHHHCCCCHHHHHHHHCCCCCHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHC
YPSTAGDPSLREACAGWMQRRYHIPVNPATQVLPVNGSREALFAFAQTVVDPTRAGATVV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEE
CPNPFYQIYEGATLLAGATPYYAPSDPARNFAVDWDSVPEEVWQRTQLLFVCSPGNPTGA
CCCCHHHHHCCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHCEEEEEECCCCCCCC
VMPLPEWEKLFALSDRYGFVIASDECYSEIYFRDEPPLGGLEAAAKLGRSDYRNLIAFTS
CCCCCCHHHHHHCCCCCEEEEECCHHHHHHEECCCCCCCHHHHHHHHCHHHHHHHHHHHH
LSKRSNVPGLRSGFVAGDAALIKAFLLYRTYHGSAMGPAVQAASVAAWNDEVHVEENRAL
HHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHEEECCCCEEEHHHHHH
YRQKFAQVTPMLAEVMDVRLPDAGFYLWAKVPDALGMSDAEFAQALLAQYNVTVLPGSYL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCHHHHHHHHHHHCCEEEECCCHH
ARDSGGANPGAQRLRMALVAETAECAEAASRIVQFIQSRTLFHP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA