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The map label for this gene is msrA [H]

Identifier: 222111032

GI number: 222111032

Start: 1957404

End: 1957949

Strand: Direct

Name: msrA [H]

Synonym: Dtpsy_1839

Alternate gene names: 222111032

Gene position: 1957404-1957949 (Clockwise)

Preceding gene: 222111027

Following gene: 222111033

Centisome position: 51.56

GC content: 66.3

Gene sequence:

>546_bases
ATGTCCGATCTGCAGTCCATCACCCTCGGCGGCGGGTGCTTCTGGTGCACCGAAGCCGTGTTCGACCGCGTGCGCGGCGT
GACCGACGTGCAAAGCGGCTATGCCAATGGCGACGTAGCCGAGCCCACCTACGAGCAGGTGTGCAGCGGCACGACCGGCC
ACGCCGAGGTGGTGCGCGTGACCTTCGACCCCGCGCAGATCGGCGTGCGCGAGATCTTGGAGATCTTCTTCGCCACGCAC
GACCCCACCACCCTCAACCGCCAGGGCAACGACGTGGGCACGCAGTACCGCAGCGCCATCTACTTCGCCGACCCCGCACA
CCAGGACGTGGCCGAAGAGCTGTTGCGCCAGATGGGGCAGGACAAGCTCTTTGGCGCGCCCGTGGTGACCGAGGTGGCAC
CCCTGGTGAACTACTGGCCCGCGGAGGACTACCACCAGGACTACTACCGCAACCACCCCAACCAGGGCTATTGCGCCTTC
GTCGTGGGGCCAAAGGTGGAGAAGTTCCGCAAGACCTTCGCACGGCACCTCAAACCCGGCGCCTGA

Upstream 100 bases:

>100_bases
CAACCCGCCTTGCCCCCGTCAACGCAAGGGCAGACTTCGGGACGGCGCCTTCGCTTCATTTCTATGATGAGGCTTTCATC
CCTTCACGAGGCGCAATCCC

Downstream 100 bases:

>100_bases
CCGCTGTGCGGCCCAGGTCGCCGCCAGCGGGTCCACCGCCTTCCCACAGCGGCGCATCCGCGCAGCCTTTTGGGAATCCC
TGCGGGTTCCTGCGCTATCC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MSDLQSITLGGGCFWCTEAVFDRVRGVTDVQSGYANGDVAEPTYEQVCSGTTGHAEVVRVTFDPAQIGVREILEIFFATH
DPTTLNRQGNDVGTQYRSAIYFADPAHQDVAEELLRQMGQDKLFGAPVVTEVAPLVNYWPAEDYHQDYYRNHPNQGYCAF
VVGPKVEKFRKTFARHLKPGA

Sequences:

>Translated_181_residues
MSDLQSITLGGGCFWCTEAVFDRVRGVTDVQSGYANGDVAEPTYEQVCSGTTGHAEVVRVTFDPAQIGVREILEIFFATH
DPTTLNRQGNDVGTQYRSAIYFADPAHQDVAEELLRQMGQDKLFGAPVVTEVAPLVNYWPAEDYHQDYYRNHPNQGYCAF
VVGPKVEKFRKTFARHLKPGA
>Mature_180_residues
SDLQSITLGGGCFWCTEAVFDRVRGVTDVQSGYANGDVAEPTYEQVCSGTTGHAEVVRVTFDPAQIGVREILEIFFATHD
PTTLNRQGNDVGTQYRSAIYFADPAHQDVAEELLRQMGQDKLFGAPVVTEVAPLVNYWPAEDYHQDYYRNHPNQGYCAFV
VGPKVEKFRKTFARHLKPGA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=43.3962264150943, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=43.3962264150943, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=43.75, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1790665, Length=146, Percent_Identity=43.1506849315069, Blast_Score=119, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=149, Percent_Identity=32.2147651006711, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=39.1304347826087, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24664627, Length=162, Percent_Identity=30.8641975308642, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664631, Length=162, Percent_Identity=30.2469135802469, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20166; Mature: 20034

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLQSITLGGGCFWCTEAVFDRVRGVTDVQSGYANGDVAEPTYEQVCSGTTGHAEVVRV
CCCCCEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEE
TFDPAQIGVREILEIFFATHDPTTLNRQGNDVGTQYRSAIYFADPAHQDVAEELLRQMGQ
EECHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHCC
DKLFGAPVVTEVAPLVNYWPAEDYHQDYYRNHPNQGYCAFVVGPKVEKFRKTFARHLKPG
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCC
A
C
>Mature Secondary Structure 
SDLQSITLGGGCFWCTEAVFDRVRGVTDVQSGYANGDVAEPTYEQVCSGTTGHAEVVRV
CCCCEEEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCCEEEEE
TFDPAQIGVREILEIFFATHDPTTLNRQGNDVGTQYRSAIYFADPAHQDVAEELLRQMGQ
EECHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHCC
DKLFGAPVVTEVAPLVNYWPAEDYHQDYYRNHPNQGYCAFVVGPKVEKFRKTFARHLKPG
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]